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Protein

Thymus-specific serine protease

Gene

Prss16

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Protease that may play a role in T-cell development.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei184Charge relay systemSequence analysis1
Active sitei446Charge relay systemSequence analysis1
Active sitei471Charge relay systemSequence analysis1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Protein family/group databases

ESTHERimouse-tssp Prolylcarboxypeptidase
MEROPSiS28.003

Names & Taxonomyi

Protein namesi
Recommended name:
Thymus-specific serine protease (EC:3.4.-.-)
Alternative name(s):
Serine protease 16
Gene namesi
Name:Prss16
Synonyms:Tssp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1859181 Prss16

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000002732123 – 509Thymus-specific serine proteaseAdd BLAST487

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi69N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi171N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi320N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9QXE5
PaxDbiQ9QXE5
PRIDEiQ9QXE5

PTM databases

iPTMnetiQ9QXE5
PhosphoSitePlusiQ9QXE5

Expressioni

Tissue specificityi

Expressed predominantly in cortical thymic epithelial cells, with highest expression around vessels and the thymic capsule.

Developmental stagei

Expressed in developing thymus at 14 to 18 dpc, with maximal expression at 16 dpc.

Gene expression databases

BgeeiENSMUSG00000006179
CleanExiMM_PRSS16
ExpressionAtlasiQ9QXE5 baseline and differential
GenevisibleiQ9QXE5 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006341

Structurei

3D structure databases

ProteinModelPortaliQ9QXE5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S28 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2182 Eukaryota
ENOG410XSGG LUCA
GeneTreeiENSGT00530000063027
HOGENOMiHOG000267153
HOVERGENiHBG018007
InParanoidiQ9QXE5
KOiK09649
OMAiNSYYGGQ
OrthoDBiEOG091G05N0
PhylomeDBiQ9QXE5
TreeFamiTF314855

Family and domain databases

Gene3Di3.40.50.18203 hits
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR008758 Peptidase_S28
PfamiView protein in Pfam
PF05577 Peptidase_S28, 1 hit
SUPFAMiSSF53474 SSF53474, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QXE5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVKAPWLGF LLLVSLWGLS TPALLLRRLR EHIQKFQESS SLHPGFGLGH
60 70 80 90 100
GPGAVPKQGW LEQPLDPFNA SDRRTFLQRY WVNDQHRTGQ DVPVFLHIGG
110 120 130 140 150
EGSLGPGSVM AGHPAALAPA WGALVISLEH RFYGLSMPAG GLDLALLRYL
160 170 180 190 200
SSRHALADVA SARQALSGLL NVSSSSPWIC FGGSYAGSLA TWARLKFPHL
210 220 230 240 250
VFAAVASSAP LSAVVDFSAY NQVVARSLTQ VAIGGSLECL AAASTAFTEV
260 270 280 290 300
ERLLRAGPAA QAVLREELGA CGSLDLTEDQ AELLGALQAL VGGTVQYDGQ
310 320 330 340 350
AGAPLSVRQL CGLLLGKWGN RSRSTPYLGL RRAVQIVLRS MGQKCLSFSR
360 370 380 390 400
AETVAQLSNT EPQVSGVGDR QWLYQTCTEF GFYVTCEGLQ CPFSQLPALP
410 420 430 440 450
FQLELCEQVF GLSPASVAQA VAQTNSYYGG QSPGATQVLF VNGDTDPWHV
460 470 480 490 500
LSVTQDLGLS EPALLIPSAS HCFDMAPMRP SDSPSLRLGR QKISQQLQDW

LKDIKKSQS
Length:509
Mass (Da):54,523
Last modified:May 1, 2000 - v1
Checksum:iCD8425F3F71EE43C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ131775 mRNA Translation: CAB66137.1
AK088019 mRNA Translation: BAC40100.1
CCDSiCCDS26303.1
RefSeqiNP_062302.1, NM_019429.2
UniGeneiMm.32043

Genome annotation databases

EnsembliENSMUST00000006341; ENSMUSP00000006341; ENSMUSG00000006179
GeneIDi54373
KEGGimmu:54373
UCSCiuc007prz.1 mouse

Similar proteinsi

Entry informationi

Entry nameiTSSP_MOUSE
AccessioniPrimary (citable) accession number: Q9QXE5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: April 25, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome