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Protein

Thymus-specific serine protease

Gene

Prss16

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Protease that may play a role in T-cell development.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei184Charge relay systemSequence analysis1
Active sitei446Charge relay systemSequence analysis1
Active sitei471Charge relay systemSequence analysis1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

ESTHERimouse-tssp. Prolylcarboxypeptidase.
MEROPSiS28.003.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymus-specific serine protease (EC:3.4.-.-)
Alternative name(s):
Serine protease 16
Gene namesi
Name:Prss16
Synonyms:Tssp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1859181. Prss16.

Subcellular locationi

GO - Cellular componenti

  • cytoplasmic, membrane-bounded vesicle Source: UniProtKB-SubCell
  • endosome Source: UniProtKB
  • lysosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000002732123 – 509Thymus-specific serine proteaseAdd BLAST487

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi69N-linked (GlcNAc...)Sequence analysis1
Glycosylationi171N-linked (GlcNAc...)Sequence analysis1
Glycosylationi320N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9QXE5.
PaxDbiQ9QXE5.
PRIDEiQ9QXE5.

PTM databases

iPTMnetiQ9QXE5.
PhosphoSitePlusiQ9QXE5.

Expressioni

Tissue specificityi

Expressed predominantly in cortical thymic epithelial cells, with highest expression around vessels and the thymic capsule.

Developmental stagei

Expressed in developing thymus at 14 to 18 dpc, with maximal expression at 16 dpc.

Gene expression databases

BgeeiENSMUSG00000006179.
CleanExiMM_PRSS16.
ExpressionAtlasiQ9QXE5. baseline and differential.
GenevisibleiQ9QXE5. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006341.

Structurei

3D structure databases

ProteinModelPortaliQ9QXE5.
SMRiQ9QXE5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S28 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2182. Eukaryota.
ENOG410XSGG. LUCA.
GeneTreeiENSGT00530000063027.
HOGENOMiHOG000267153.
HOVERGENiHBG018007.
InParanoidiQ9QXE5.
KOiK09649.
OMAiYVTCEVP.
OrthoDBiEOG091G05N0.
PhylomeDBiQ9QXE5.
TreeFamiTF314855.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR008758. Peptidase_S28.
[Graphical view]
PfamiPF05577. Peptidase_S28. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QXE5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVKAPWLGF LLLVSLWGLS TPALLLRRLR EHIQKFQESS SLHPGFGLGH
60 70 80 90 100
GPGAVPKQGW LEQPLDPFNA SDRRTFLQRY WVNDQHRTGQ DVPVFLHIGG
110 120 130 140 150
EGSLGPGSVM AGHPAALAPA WGALVISLEH RFYGLSMPAG GLDLALLRYL
160 170 180 190 200
SSRHALADVA SARQALSGLL NVSSSSPWIC FGGSYAGSLA TWARLKFPHL
210 220 230 240 250
VFAAVASSAP LSAVVDFSAY NQVVARSLTQ VAIGGSLECL AAASTAFTEV
260 270 280 290 300
ERLLRAGPAA QAVLREELGA CGSLDLTEDQ AELLGALQAL VGGTVQYDGQ
310 320 330 340 350
AGAPLSVRQL CGLLLGKWGN RSRSTPYLGL RRAVQIVLRS MGQKCLSFSR
360 370 380 390 400
AETVAQLSNT EPQVSGVGDR QWLYQTCTEF GFYVTCEGLQ CPFSQLPALP
410 420 430 440 450
FQLELCEQVF GLSPASVAQA VAQTNSYYGG QSPGATQVLF VNGDTDPWHV
460 470 480 490 500
LSVTQDLGLS EPALLIPSAS HCFDMAPMRP SDSPSLRLGR QKISQQLQDW

LKDIKKSQS
Length:509
Mass (Da):54,523
Last modified:May 1, 2000 - v1
Checksum:iCD8425F3F71EE43C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ131775 mRNA. Translation: CAB66137.1.
AK088019 mRNA. Translation: BAC40100.1.
CCDSiCCDS26303.1.
RefSeqiNP_062302.1. NM_019429.2.
UniGeneiMm.32043.

Genome annotation databases

EnsembliENSMUST00000006341; ENSMUSP00000006341; ENSMUSG00000006179.
GeneIDi54373.
KEGGimmu:54373.
UCSCiuc007prz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ131775 mRNA. Translation: CAB66137.1.
AK088019 mRNA. Translation: BAC40100.1.
CCDSiCCDS26303.1.
RefSeqiNP_062302.1. NM_019429.2.
UniGeneiMm.32043.

3D structure databases

ProteinModelPortaliQ9QXE5.
SMRiQ9QXE5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006341.

Protein family/group databases

ESTHERimouse-tssp. Prolylcarboxypeptidase.
MEROPSiS28.003.

PTM databases

iPTMnetiQ9QXE5.
PhosphoSitePlusiQ9QXE5.

Proteomic databases

MaxQBiQ9QXE5.
PaxDbiQ9QXE5.
PRIDEiQ9QXE5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000006341; ENSMUSP00000006341; ENSMUSG00000006179.
GeneIDi54373.
KEGGimmu:54373.
UCSCiuc007prz.1. mouse.

Organism-specific databases

CTDi10279.
MGIiMGI:1859181. Prss16.

Phylogenomic databases

eggNOGiKOG2182. Eukaryota.
ENOG410XSGG. LUCA.
GeneTreeiENSGT00530000063027.
HOGENOMiHOG000267153.
HOVERGENiHBG018007.
InParanoidiQ9QXE5.
KOiK09649.
OMAiYVTCEVP.
OrthoDBiEOG091G05N0.
PhylomeDBiQ9QXE5.
TreeFamiTF314855.

Miscellaneous databases

PROiQ9QXE5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000006179.
CleanExiMM_PRSS16.
ExpressionAtlasiQ9QXE5. baseline and differential.
GenevisibleiQ9QXE5. MM.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR008758. Peptidase_S28.
[Graphical view]
PfamiPF05577. Peptidase_S28. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiTSSP_MOUSE
AccessioniPrimary (citable) accession number: Q9QXE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.