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Protein

2-hydroxyacyl-CoA lyase 1

Gene

Hacl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes a carbon-carbon cleavage reaction; cleaves a 2-hydroxy-3-methylacyl-CoA into formyl-CoA and a 2-methyl-branched fatty aldehyde.By similarity

Catalytic activityi

2-hydroxyphytanoyl-CoA = pristanal + formyl-CoA.

Cofactori

Protein has several cofactor binding sites:
  • Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity
  • thiamine diphosphateBy similarityNote: Binds 1 thiamine pyrophosphate per subunit.By similarity

Pathwayi: fatty acid metabolism

This protein is involved in the pathway fatty acid metabolism, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid metabolism and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei63Thiamine pyrophosphateBy similarity1
Metal bindingi458MagnesiumBy similarity1
Metal bindingi485MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
LigandMagnesium, Metal-binding, Thiamine pyrophosphate

Enzyme and pathway databases

ReactomeiR-MMU-389599 Alpha-oxidation of phytanate
R-MMU-9033241 Peroxisomal protein import
UniPathwayiUPA00199

Names & Taxonomyi

Protein namesi
Recommended name:
2-hydroxyacyl-CoA lyase 1 (EC:4.1.-.-)
Alternative name(s):
2-hydroxyphytanoyl-CoA lyase
Short name:
2-HPCL
Phytanoyl-CoA 2-hydroxylase 2
Gene namesi
Name:Hacl1
Synonyms:Hpcl, Phyh2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1929657 Hacl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000908171 – 5812-hydroxyacyl-CoA lyase 1Add BLAST581

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4PhosphoserineBy similarity1
Modified residuei6PhosphoserineBy similarity1
Modified residuei354N6-succinyllysineCombined sources1
Modified residuei361N6-succinyllysineCombined sources1
Modified residuei368N6-succinyllysineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9QXE0
MaxQBiQ9QXE0
PaxDbiQ9QXE0
PRIDEiQ9QXE0

PTM databases

iPTMnetiQ9QXE0
PhosphoSitePlusiQ9QXE0
SwissPalmiQ9QXE0

Expressioni

Gene expression databases

BgeeiENSMUSG00000021884
CleanExiMM_HACL1
ExpressionAtlasiQ9QXE0 baseline and differential
GenevisibleiQ9QXE0 MM

Interactioni

Subunit structurei

Homotetramer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9QXE0, 4 interactors
MINTiQ9QXE0
STRINGi10090.ENSMUSP00000022437

Structurei

3D structure databases

ProteinModelPortaliQ9QXE0
SMRiQ9QXE0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni404 – 487Thiamine pyrophosphate bindingAdd BLAST84

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi579 – 581Microbody targeting signalBy similarity3

Sequence similaritiesi

Belongs to the TPP enzyme family.Curated

Phylogenomic databases

eggNOGiKOG1185 Eukaryota
COG0028 LUCA
GeneTreeiENSGT00530000063412
HOGENOMiHOG000053808
HOVERGENiHBG027302
InParanoidiQ9QXE0
KOiK12261
OMAiQGMVRQW
OrthoDBiEOG091G03OS
PhylomeDBiQ9QXE0
TreeFamiTF105690

Family and domain databases

InterProiView protein in InterPro
IPR029035 DHS-like_NAD/FAD-binding_dom
IPR029061 THDP-binding
IPR012000 Thiamin_PyroP_enz_cen_dom
IPR012001 Thiamin_PyroP_enz_TPP-bd_dom
IPR011766 TPP_enzyme-bd_C
PfamiView protein in Pfam
PF02775 TPP_enzyme_C, 1 hit
PF00205 TPP_enzyme_M, 1 hit
PF02776 TPP_enzyme_N, 1 hit
SUPFAMiSSF52467 SSF52467, 1 hit
SSF52518 SSF52518, 2 hits

Sequencei

Sequence statusi: Complete.

Q9QXE0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPESNSAEGS DRSEEQVSGA KVIAQALKTQ DVEYMFGVVG IPVTEIALAA
60 70 80 90 100
QELGIKYIGM RNEQAACYAA SAVGYLTGRP GVCLVVSGPG LIHALGGMAN
110 120 130 140 150
ANMNCWPLIV IGGSSERNQE AMGAFQEFPQ VEACRLYTKF SARPSTIELI
160 170 180 190 200
PFIIEKAVRS SIYGRPGACY IDIPADFVTL QANVTSIKYK ECCMPPPVSM
210 220 230 240 250
AETSAVCAAA SVLRDAKQPL LIIGKGAAYS HAEDSIRKLV EQCSLPFLPT
260 270 280 290 300
PMGKGVVPDN HPNCVGAARS RALQSADVIV LFGARLNWIL HFGLPPRYQA
310 320 330 340 350
DVKFIQIDIC AEELGNNVRP SVILLGDIDA VSKQLLEQFD KTPWQCPPDS
360 370 380 390 400
QWWKTLREKM KSNEAISKEL ASQKSLPMNY YTVFYHVQEQ LPRDSFIVSE
410 420 430 440 450
GANTMDIGRT MLQNCLPRHR LDAGSFGTMG VGLGFAIAAA LVAKDRSPGQ
460 470 480 490 500
RVICVEGDSA FGFSGMEVET ICRYNLPIIL LVVNNNGIYQ GFDADTWEKM
510 520 530 540 550
LHFQEAATTV PPMCLLPNSH YEQVMTAFGG KGYFVRTPEE LQHSLRQALQ
560 570 580
DTSKPCLLNI MIEPQSTRKA QDFHWLTRSN M
Length:581
Mass (Da):63,660
Last modified:May 2, 2002 - v2
Checksum:i7CABBFC780A32A69
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti252M → I in CAB65550 (PubMed:11171065).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132139 mRNA Translation: CAB65550.1
AK005505 mRNA Translation: BAB24085.1
AK041686 mRNA Translation: BAC31032.1
AK050078 mRNA Translation: BAC34059.1
BC021360 mRNA Translation: AAH21360.1
CCDSiCCDS26915.1
RefSeqiNP_064359.2, NM_019975.3
UniGeneiMm.38887

Genome annotation databases

EnsembliENSMUST00000022437; ENSMUSP00000022437; ENSMUSG00000021884
ENSMUST00000156431; ENSMUSP00000114922; ENSMUSG00000021884
GeneIDi56794
KEGGimmu:56794
UCSCiuc007sxx.2 mouse

Similar proteinsi

Entry informationi

Entry nameiHACL1_MOUSE
AccessioniPrimary (citable) accession number: Q9QXE0
Secondary accession number(s): Q543K1, Q9DAV1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: May 2, 2002
Last modified: May 23, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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