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Protein

Developmentally-regulated GTP-binding protein 2

Gene

Drg2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in cell proliferation, differentiation and death.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi69 – 76GTPPROSITE-ProRule annotation8
Nucleotide bindingi115 – 119GTPPROSITE-ProRule annotation5
Nucleotide bindingi246 – 249GTPPROSITE-ProRule annotation4

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Developmentally-regulated GTP-binding protein 2
Short name:
DRG-2
Gene namesi
Name:Drg2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1342307. Drg2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002054281 – 364Developmentally-regulated GTP-binding protein 2Add BLAST364

Post-translational modificationi

Polyubiquitinated; which induces proteolytic degradation and is impaired by interaction with RWDD1.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

EPDiQ9QXB9.
MaxQBiQ9QXB9.
PaxDbiQ9QXB9.
PeptideAtlasiQ9QXB9.
PRIDEiQ9QXB9.

PTM databases

iPTMnetiQ9QXB9.
PhosphoSitePlusiQ9QXB9.

Expressioni

Tissue specificityi

Fairly high levels in liver, heart, kidney, and brain. Very low levels in lung, spleen, testis and skeletal muscle.

Gene expression databases

BgeeiENSMUSG00000020537.
CleanExiMM_DRG2.
GenevisibleiQ9QXB9. MM.

Interactioni

Subunit structurei

Interacts with RWDD1.1 Publication

Protein-protein interaction databases

BioGridi199311. 2 interactors.
IntActiQ9QXB9. 1 interactor.
MINTiMINT-4619155.
STRINGi10090.ENSMUSP00000018568.

Structurei

3D structure databases

ProteinModelPortaliQ9QXB9.
SMRiQ9QXB9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini63 – 288OBG-type GPROSITE-ProRule annotationAdd BLAST226

Sequence similaritiesi

Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.PROSITE-ProRule annotation
Contains 1 OBG-type G (guanine nucleotide-binding) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1486. Eukaryota.
COG1163. LUCA.
GeneTreeiENSGT00550000075059.
HOGENOMiHOG000112078.
HOVERGENiHBG000948.
InParanoidiQ9QXB9.
KOiK06944.
OMAiKYMPCLY.
OrthoDBiEOG091G0A12.
PhylomeDBiQ9QXB9.
TreeFamiTF105706.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR031167. G_OBG.
IPR031662. GTP-binding_2.
IPR006074. GTP1-OBG_CS.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR004095. TGS.
IPR012676. TGS-like.
[Graphical view]
PfamiPF01926. MMR_HSR1. 1 hit.
PF16897. MMR_HSR1_Xtn. 1 hit.
PF02824. TGS. 1 hit.
[Graphical view]
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF81271. SSF81271. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51710. G_OBG. 1 hit.
PS00905. GTP1_OBG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QXB9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGILEKISEI EKEIARTQKN KATEYHLGLL KAKLAKYRAQ LLEPSKSASS
60 70 80 90 100
KGEGFDVMKS GDARVALIGF PSVGKSTFLS LMTSTASEAA SYEFTTLTCI
110 120 130 140 150
PGVIEYKGAN IQLLDLPGII EGAAQGRGRG RQVIAVARTA DVVVMMLDAT
160 170 180 190 200
KGDVQRSLLE KELESVGIRL NKHKPNIYFK PKKGGGISFN STVTLTQCSE
210 220 230 240 250
KLVQLILHEY KIFNAEVLFR EDCSPDDFID VIVGNRVYMP CLYVYNKIDQ
260 270 280 290 300
ISMEEVDRLA RKPNSVVISC GMKLNLDYLL EMLWEYLALT CIYTKKRGQR
310 320 330 340 350
PDFTDAIILR KGASVEHVCH RIHRSLASQF KYALVWGTST KYSPQRVGLT
360
HTMEHEDVIQ IVKK
Length:364
Mass (Da):40,718
Last modified:May 1, 2000 - v1
Checksum:i932353C8FF257BE8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243590 mRNA. Translation: CAB65258.1.
AL596090 Genomic DNA. Translation: CAI24081.1.
BC082564 mRNA. Translation: AAH82564.1.
CCDSiCCDS24791.1.
RefSeqiNP_067329.1. NM_021354.1.
UniGeneiMm.41803.

Genome annotation databases

EnsembliENSMUST00000018568; ENSMUSP00000018568; ENSMUSG00000020537.
GeneIDi13495.
KEGGimmu:13495.
UCSCiuc007jfy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243590 mRNA. Translation: CAB65258.1.
AL596090 Genomic DNA. Translation: CAI24081.1.
BC082564 mRNA. Translation: AAH82564.1.
CCDSiCCDS24791.1.
RefSeqiNP_067329.1. NM_021354.1.
UniGeneiMm.41803.

3D structure databases

ProteinModelPortaliQ9QXB9.
SMRiQ9QXB9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199311. 2 interactors.
IntActiQ9QXB9. 1 interactor.
MINTiMINT-4619155.
STRINGi10090.ENSMUSP00000018568.

PTM databases

iPTMnetiQ9QXB9.
PhosphoSitePlusiQ9QXB9.

Proteomic databases

EPDiQ9QXB9.
MaxQBiQ9QXB9.
PaxDbiQ9QXB9.
PeptideAtlasiQ9QXB9.
PRIDEiQ9QXB9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000018568; ENSMUSP00000018568; ENSMUSG00000020537.
GeneIDi13495.
KEGGimmu:13495.
UCSCiuc007jfy.1. mouse.

Organism-specific databases

CTDi1819.
MGIiMGI:1342307. Drg2.

Phylogenomic databases

eggNOGiKOG1486. Eukaryota.
COG1163. LUCA.
GeneTreeiENSGT00550000075059.
HOGENOMiHOG000112078.
HOVERGENiHBG000948.
InParanoidiQ9QXB9.
KOiK06944.
OMAiKYMPCLY.
OrthoDBiEOG091G0A12.
PhylomeDBiQ9QXB9.
TreeFamiTF105706.

Miscellaneous databases

PROiQ9QXB9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020537.
CleanExiMM_DRG2.
GenevisibleiQ9QXB9. MM.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR031167. G_OBG.
IPR031662. GTP-binding_2.
IPR006074. GTP1-OBG_CS.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR004095. TGS.
IPR012676. TGS-like.
[Graphical view]
PfamiPF01926. MMR_HSR1. 1 hit.
PF16897. MMR_HSR1_Xtn. 1 hit.
PF02824. TGS. 1 hit.
[Graphical view]
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF81271. SSF81271. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51710. G_OBG. 1 hit.
PS00905. GTP1_OBG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDRG2_MOUSE
AccessioniPrimary (citable) accession number: Q9QXB9
Secondary accession number(s): Q5SX94
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.