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Protein

Tripartite motif-containing protein 44

Gene

Trim44

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the process of differentiation and maturation of neuronal cells. May regulate the activity of TRIM17 (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri176 – 217B box-typePROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 44
Alternative name(s):
Protein DIPB
Protein Mc7
Gene namesi
Name:Trim44
Synonyms:Dipb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1931835. Trim44.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002203731 – 346Tripartite motif-containing protein 44Add BLAST346

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei338PhosphoserineCombined sources1
Modified residuei341PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9QXA7.
MaxQBiQ9QXA7.
PaxDbiQ9QXA7.
PRIDEiQ9QXA7.

PTM databases

iPTMnetiQ9QXA7.
PhosphoSitePlusiQ9QXA7.

Expressioni

Tissue specificityi

Expressed mainly in brain with high level in cerebral hemispheres and cerebellum. Lower expression in kidney, lung and spleen. In brain is detected in the hippocampus, thalamic and pretectal nuclei, substantia nigra, the dorsal part of the medulla, the cerebellum, in the olfactory nucleus, other cortical areas apart from hyppocampus and the striatum. Indeed expression is confined in neuronal somata namely in the CA3 region and dentate gyrus of the hyppocampus, caudate-putamen, parabranchial nucleus, olfactory nucleus, cortex, deep cerebellar nuclei and thalamus. Also highly expressed in the spleen. thymus and testis.1 Publication

Developmental stagei

Expression was detected in brain at E14 and E18. At P5 expression in cerebellum is detected in both the dividing neuroblasts and post-mitotic neurons of the external granular layer as well as in the developing granule neurons of the internal granular layer while the expression in Purkinje cells was lower. At P10 the expression in external and internal granular layers remained strong while at the same time the Purkinje cells also acquired significant level of expression.

Gene expression databases

CleanExiMM_TRIM44.

Interactioni

Subunit structurei

Interacts (via coiled coil) with TRIM17 (via coiled coil).By similarity

Protein-protein interaction databases

IntActiQ9QXA7. 1 interactor.
STRINGi10090.ENSMUSP00000099633.

Structurei

3D structure databases

ProteinModelPortaliQ9QXA7.
SMRiQ9QXA7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili292 – 327Sequence analysisAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi80 – 174Glu-richAdd BLAST95

Sequence similaritiesi

Contains 1 B box-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri176 – 217B box-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IPQC. Eukaryota.
ENOG4111H1M. LUCA.
HOGENOMiHOG000134694.
HOVERGENiHBG057191.
InParanoidiQ9QXA7.
KOiK12020.
PhylomeDBiQ9QXA7.

Family and domain databases

Gene3Di4.10.45.10. 1 hit.
InterProiIPR000315. Znf_B-box.
[Graphical view]
PfamiPF00643. zf-B_box. 1 hit.
[Graphical view]
SMARTiSM00336. BBOX. 1 hit.
[Graphical view]
PROSITEiPS50119. ZF_BBOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QXA7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASGVGAACE ELPPDGTCDE CEPDEAPGAE EVCRDCGFCY CRRHADAHRQ
60 70 80 90 100
KFLSHRLAAY VHGAQAWTPP ASGGDDALPE DAEAKGEAEG EVESEVGEEE
110 120 130 140 150
SETEVDSESE EESETEEDSE DESDEESEED SEEEMEDEQE SEAEEDNQEE
160 170 180 190 200
GESEAEGETE AESEFDPEIE MEAERVAKRK CPDHGLDLST YCQEDRQLIC
210 220 230 240 250
VLCPVIGAHR GHQLSTLDEA FEELRSKDSG GLKAAMIELV ERLKFKSSDP
260 270 280 290 300
KVTRDQMKIF IQQEFKKVQK VIADEEQKAL HLVDIQEAMA TAHVTEILAD
310 320 330 340
IQSHMDRLMT QMAQAKEQLD TSNESAEPKA EGDEEGPSGA SEEEDT
Length:346
Mass (Da):38,272
Last modified:December 7, 2004 - v2
Checksum:i8FE36AB7C1F198E1
GO

Sequence cautioni

The sequence AAH39979 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH45602 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti82A → G in CAB95697 (PubMed:11165382).Curated1
Sequence conflicti139Q → R in CAB65270 (Ref. 2) Curated1
Sequence conflicti150Missing in CAB95697 (PubMed:11165382).Curated1
Sequence conflicti150Missing in AAH39979 (PubMed:15489334).Curated1
Sequence conflicti150Missing in AAH45602 (PubMed:15489334).Curated1
Sequence conflicti228D → H in CAB65270 (Ref. 2) Curated1
Sequence conflicti246K → T in CAB65270 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278191 mRNA. Translation: CAB95697.1.
AJ249129 mRNA. Translation: CAB65270.1.
BC039979 mRNA. Translation: AAH39979.1. Different initiation.
BC045602 mRNA. Translation: AAH45602.1. Different initiation.
RefSeqiNP_064663.2. NM_020267.2.
UniGeneiMm.315002.

Genome annotation databases

GeneIDi80985.
KEGGimmu:80985.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278191 mRNA. Translation: CAB95697.1.
AJ249129 mRNA. Translation: CAB65270.1.
BC039979 mRNA. Translation: AAH39979.1. Different initiation.
BC045602 mRNA. Translation: AAH45602.1. Different initiation.
RefSeqiNP_064663.2. NM_020267.2.
UniGeneiMm.315002.

3D structure databases

ProteinModelPortaliQ9QXA7.
SMRiQ9QXA7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9QXA7. 1 interactor.
STRINGi10090.ENSMUSP00000099633.

PTM databases

iPTMnetiQ9QXA7.
PhosphoSitePlusiQ9QXA7.

Proteomic databases

EPDiQ9QXA7.
MaxQBiQ9QXA7.
PaxDbiQ9QXA7.
PRIDEiQ9QXA7.

Protocols and materials databases

DNASUi80985.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi80985.
KEGGimmu:80985.

Organism-specific databases

CTDi54765.
MGIiMGI:1931835. Trim44.

Phylogenomic databases

eggNOGiENOG410IPQC. Eukaryota.
ENOG4111H1M. LUCA.
HOGENOMiHOG000134694.
HOVERGENiHBG057191.
InParanoidiQ9QXA7.
KOiK12020.
PhylomeDBiQ9QXA7.

Miscellaneous databases

ChiTaRSiTrim44. mouse.
PROiQ9QXA7.
SOURCEiSearch...

Gene expression databases

CleanExiMM_TRIM44.

Family and domain databases

Gene3Di4.10.45.10. 1 hit.
InterProiIPR000315. Znf_B-box.
[Graphical view]
PfamiPF00643. zf-B_box. 1 hit.
[Graphical view]
SMARTiSM00336. BBOX. 1 hit.
[Graphical view]
PROSITEiPS50119. ZF_BBOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRI44_MOUSE
AccessioniPrimary (citable) accession number: Q9QXA7
Secondary accession number(s): Q80SV9, Q9JHR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: December 7, 2004
Last modified: November 2, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.