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Protein

b(0,+)-type amino acid transporter 1

Gene

Slc7a9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system B(0,+)-like activity). Thought to be responsible for the high-affinity reabsorption of cystine in the kidney proximal tubule.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-210991. Basigin interactions.
R-MMU-352230. Amino acid transport across the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
b(0,+)-type amino acid transporter 1
Short name:
b(0,+)AT1
Alternative name(s):
Glycoprotein-associated amino acid transporter b0,+AT1
Solute carrier family 7 member 9
Gene namesi
Name:Slc7a9
Synonyms:Bat1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1353656. Slc7a9.

Subcellular locationi

  • Apical cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2929CytoplasmicSequence analysisAdd
BLAST
Transmembranei30 – 5021HelicalSequence analysisAdd
BLAST
Topological domaini51 – 6313ExtracellularSequence analysisAdd
BLAST
Transmembranei64 – 8421HelicalSequence analysisAdd
BLAST
Topological domaini85 – 9915CytoplasmicSequence analysisAdd
BLAST
Transmembranei100 – 12021HelicalSequence analysisAdd
BLAST
Topological domaini121 – 1233ExtracellularSequence analysis
Transmembranei124 – 14421HelicalSequence analysisAdd
BLAST
Topological domaini145 – 1473CytoplasmicSequence analysis
Transmembranei148 – 16821HelicalSequence analysisAdd
BLAST
Topological domaini169 – 17810ExtracellularSequence analysis
Transmembranei179 – 19921HelicalSequence analysisAdd
BLAST
Topological domaini200 – 25455CytoplasmicSequence analysisAdd
BLAST
Transmembranei255 – 27521HelicalSequence analysisAdd
BLAST
Topological domaini276 – 29621ExtracellularSequence analysisAdd
BLAST
Transmembranei297 – 31721HelicalSequence analysisAdd
BLAST
Topological domaini318 – 34831CytoplasmicSequence analysisAdd
BLAST
Transmembranei349 – 36921HelicalSequence analysisAdd
BLAST
Topological domaini370 – 3745ExtracellularSequence analysis
Transmembranei375 – 39521HelicalSequence analysisAdd
BLAST
Topological domaini396 – 40914CytoplasmicSequence analysisAdd
BLAST
Transmembranei410 – 43021HelicalSequence analysisAdd
BLAST
Topological domaini431 – 4344ExtracellularSequence analysis
Transmembranei435 – 45521HelicalSequence analysisAdd
BLAST
Topological domaini456 – 48732CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 487487b(0,+)-type amino acid transporter 1PRO_0000054259Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei18 – 181PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiQ9QXA6.
PRIDEiQ9QXA6.

PTM databases

PhosphoSiteiQ9QXA6.

Expressioni

Tissue specificityi

Expressed in the brush border membrane in the kidney (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000030492.
ExpressionAtlasiQ9QXA6. baseline and differential.
GenevisibleiQ9QXA6. MM.

Interactioni

Subunit structurei

Disulfide-linked heterodimer with the amino acid transport protein SLC3A1. Interacts with CAV1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032703.

Structurei

3D structure databases

ProteinModelPortaliQ9QXA6.
SMRiQ9QXA6. Positions 29-365.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1287. Eukaryota.
COG0531. LUCA.
GeneTreeiENSGT00760000119037.
HOGENOMiHOG000098892.
HOVERGENiHBG000476.
InParanoidiQ9QXA6.
KOiK13868.
OMAiSFSEYVC.
OrthoDBiEOG091G07EM.
PhylomeDBiQ9QXA6.
TreeFamiTF313355.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9QXA6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEETSLRRRR EDEKSTHSTE LKTTSLQKEV GLLSGICIIV GTIIGSGIFI
60 70 80 90 100
SPKSVLANTE SVGPCLIIWA ACGILATLGA LCFAELGTMI TKSGGEYPYL
110 120 130 140 150
MEAFGPIPAY LFSWTSLIVM KPSSFAIICL SFSEYVCAAF YSGCKPPAVV
160 170 180 190 200
VKLLAAAAIL FITTVNALSV RLGSYVQNVF TAAKMVIVAI IIISGLVFLA
210 220 230 240 250
QGNVKNFQNS FEGTQTSVGA ISLAFYNGLW AYDGWNQLNY ITEELRNPYR
260 270 280 290 300
NLPMAIVIGI PLVTVCYILM NIAYFTVMTP TELLQSQAVA VTFGDRVLYP
310 320 330 340 350
ASWVVPLFVA FSTIGAANGT CFTAGRLIYV AGREGHMLKV LSYISVKRLT
360 370 380 390 400
PAPALIFYGI IAIIYIIPGD INSLVNYFSF AAWLFYGMTI LGLVVMRFTR
410 420 430 440 450
KDLERPIKVP LFIPIIVILV SLFLILAPII SEPAWEYLYC VLFILSGLIF
460 470 480
YFLFVYYKFG WAQRISRPVT KHLQMLMEVV PPEKDPE
Length:487
Mass (Da):53,747
Last modified:May 1, 2000 - v1
Checksum:iA53F3613AA2558BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ249198 mRNA. Translation: CAB54042.1.
AF192310 mRNA. Translation: AAG28396.1.
BC010746 mRNA. Translation: AAH10746.1.
CCDSiCCDS21150.1.
RefSeqiNP_001185944.1. NM_001199015.1.
NP_001185945.1. NM_001199016.1.
NP_067266.1. NM_021291.3.
XP_006540107.1. XM_006540044.2.
XP_006540108.1. XM_006540045.2.
XP_011248893.1. XM_011250591.1.
XP_011248894.1. XM_011250592.1.
UniGeneiMm.45874.

Genome annotation databases

EnsembliENSMUST00000032703; ENSMUSP00000032703; ENSMUSG00000030492.
ENSMUST00000118383; ENSMUSP00000113181; ENSMUSG00000030492.
ENSMUST00000118969; ENSMUSP00000112726; ENSMUSG00000030492.
GeneIDi30962.
KEGGimmu:30962.
UCSCiuc009gjw.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ249198 mRNA. Translation: CAB54042.1.
AF192310 mRNA. Translation: AAG28396.1.
BC010746 mRNA. Translation: AAH10746.1.
CCDSiCCDS21150.1.
RefSeqiNP_001185944.1. NM_001199015.1.
NP_001185945.1. NM_001199016.1.
NP_067266.1. NM_021291.3.
XP_006540107.1. XM_006540044.2.
XP_006540108.1. XM_006540045.2.
XP_011248893.1. XM_011250591.1.
XP_011248894.1. XM_011250592.1.
UniGeneiMm.45874.

3D structure databases

ProteinModelPortaliQ9QXA6.
SMRiQ9QXA6. Positions 29-365.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032703.

PTM databases

PhosphoSiteiQ9QXA6.

Proteomic databases

PaxDbiQ9QXA6.
PRIDEiQ9QXA6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032703; ENSMUSP00000032703; ENSMUSG00000030492.
ENSMUST00000118383; ENSMUSP00000113181; ENSMUSG00000030492.
ENSMUST00000118969; ENSMUSP00000112726; ENSMUSG00000030492.
GeneIDi30962.
KEGGimmu:30962.
UCSCiuc009gjw.2. mouse.

Organism-specific databases

CTDi11136.
MGIiMGI:1353656. Slc7a9.

Phylogenomic databases

eggNOGiKOG1287. Eukaryota.
COG0531. LUCA.
GeneTreeiENSGT00760000119037.
HOGENOMiHOG000098892.
HOVERGENiHBG000476.
InParanoidiQ9QXA6.
KOiK13868.
OMAiSFSEYVC.
OrthoDBiEOG091G07EM.
PhylomeDBiQ9QXA6.
TreeFamiTF313355.

Enzyme and pathway databases

ReactomeiR-MMU-210991. Basigin interactions.
R-MMU-352230. Amino acid transport across the plasma membrane.

Miscellaneous databases

PROiQ9QXA6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030492.
ExpressionAtlasiQ9QXA6. baseline and differential.
GenevisibleiQ9QXA6. MM.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiBAT1_MOUSE
AccessioniPrimary (citable) accession number: Q9QXA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.