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Protein

U6 snRNA-associated Sm-like protein LSm4

Gene

Lsm4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds specifically to the 3'-terminal U-tract of U6 snRNA.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
U6 snRNA-associated Sm-like protein LSm4
Gene namesi
Name:Lsm4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1354692. Lsm4.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • nucleoplasm Source: MGI
  • P-body Source: GO_Central
  • spliceosomal complex Source: MGI
  • spliceosomal tri-snRNP complex Source: GO_Central
  • U6 snRNP Source: GO_Central

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001255651 – 137U6 snRNA-associated Sm-like protein LSm4Add BLAST137

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9QXA5.
MaxQBiQ9QXA5.
PaxDbiQ9QXA5.
PRIDEiQ9QXA5.

PTM databases

iPTMnetiQ9QXA5.
PhosphoSitePlusiQ9QXA5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000031848.

Interactioni

Subunit structurei

LSm subunits form a heteromer with a doughnut shape.

Protein-protein interaction databases

DIPiDIP-60115N.
STRINGi10090.ENSMUSP00000034311.

Structurei

3D structure databases

ProteinModelPortaliQ9QXA5.
SMRiQ9QXA5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the snRNP Sm proteins family.Curated

Phylogenomic databases

eggNOGiKOG3293. Eukaryota.
ENOG4111TZU. LUCA.
HOVERGENiHBG000486.
InParanoidiQ9QXA5.
KOiK12623.

Family and domain databases

CDDicd01723. LSm4. 1 hit.
InterProiView protein in InterPro
IPR034101. Lsm4.
IPR027141. LSm4/Sm_D1/D3.
IPR010920. LSM_dom.
IPR001163. LSM_dom_euk/arc.
PANTHERiPTHR23338. PTHR23338. 1 hit.
PfamiView protein in Pfam
PF01423. LSM. 1 hit.
SMARTiView protein in SMART
SM00651. Sm. 1 hit.
SUPFAMiSSF50182. SSF50182. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9QXA5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPLSLLKTA QNHPMLVELK NGETYNGHLV SCDNWMNINL REVICTSRDG
60 70 80 90 100
DKFWRMPECY IRGSTIKYLR IPDEIIDMVR EEAAKGRGRG GPQQKQQKGR
110 120 130
GMGGAGRGVF GGRGRGGIPG AGRGQPEKKP GRQAGKQ
Length:137
Mass (Da):15,076
Last modified:May 1, 2000 - v1
Checksum:iA917E16E61467940
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ249439 mRNA. Translation: CAB65729.1.
RefSeqiNP_056631.2. NM_015816.4.
UniGeneiMm.248188.

Genome annotation databases

GeneIDi50783.
KEGGimmu:50783.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ249439 mRNA. Translation: CAB65729.1.
RefSeqiNP_056631.2. NM_015816.4.
UniGeneiMm.248188.

3D structure databases

ProteinModelPortaliQ9QXA5.
SMRiQ9QXA5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60115N.
STRINGi10090.ENSMUSP00000034311.

PTM databases

iPTMnetiQ9QXA5.
PhosphoSitePlusiQ9QXA5.

Proteomic databases

EPDiQ9QXA5.
MaxQBiQ9QXA5.
PaxDbiQ9QXA5.
PRIDEiQ9QXA5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi50783.
KEGGimmu:50783.

Organism-specific databases

CTDi25804.
MGIiMGI:1354692. Lsm4.

Phylogenomic databases

eggNOGiKOG3293. Eukaryota.
ENOG4111TZU. LUCA.
HOVERGENiHBG000486.
InParanoidiQ9QXA5.
KOiK12623.

Miscellaneous databases

PROiQ9QXA5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031848.

Family and domain databases

CDDicd01723. LSm4. 1 hit.
InterProiView protein in InterPro
IPR034101. Lsm4.
IPR027141. LSm4/Sm_D1/D3.
IPR010920. LSM_dom.
IPR001163. LSM_dom_euk/arc.
PANTHERiPTHR23338. PTHR23338. 1 hit.
PfamiView protein in Pfam
PF01423. LSM. 1 hit.
SMARTiView protein in SMART
SM00651. Sm. 1 hit.
SUPFAMiSSF50182. SSF50182. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLSM4_MOUSE
AccessioniPrimary (citable) accession number: Q9QXA5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: March 15, 2017
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.