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Q9QX96

- SALL2_MOUSE

UniProt

Q9QX96 - SALL2_MOUSE

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Protein

Sal-like protein 2

Gene

Sall2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Probable transcription factor.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri372 – 39423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri400 – 42223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri629 – 65123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri657 – 67923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri689 – 71123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri908 – 93023C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri937 – 96125C2H2-type 7PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. negative regulation of transcription, DNA-templated Source: UniProtKB
  2. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  3. neural tube development Source: MGI
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Sal-like protein 2
Alternative name(s):
Spalt-like protein 2
Zinc finger protein Spalt-2
Short name:
Sal-2
Short name:
mSal-2
Gene namesi
Name:Sall2
Synonyms:Sal2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:1354373. Sall2.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10041004Sal-like protein 2PRO_0000047023Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei243 – 2431PhosphoserineBy similarity
Modified residuei794 – 7941PhosphoserineBy similarity
Modified residuei799 – 7991PhosphoserineBy similarity
Modified residuei803 – 8031Phosphoserine1 Publication
Cross-linki908 – 908Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ9QX96.
PRIDEiQ9QX96.

PTM databases

PhosphoSiteiQ9QX96.

Expressioni

Tissue specificityi

Expressed throughout embryonic development. In adult predominantly in brain.

Gene expression databases

BgeeiQ9QX96.
CleanExiMM_SALL2.
GenevestigatoriQ9QX96.

Interactioni

Protein-protein interaction databases

BioGridi206051. 1 interaction.
IntActiQ9QX96. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9QX96.
SMRiQ9QX96. Positions 342-428, 628-713, 906-967.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi135 – 1395Poly-Gly
Compositional biasi158 – 17013Poly-ProAdd
BLAST
Compositional biasi256 – 2649Poly-Ser
Compositional biasi762 – 77211Poly-GluAdd
BLAST
Compositional biasi834 – 8407Poly-Pro

Sequence similaritiesi

Contains 7 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri372 – 39423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri400 – 42223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri629 – 65123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri657 – 67923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri689 – 71123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri908 – 93023C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri937 – 96125C2H2-type 7PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG294998.
GeneTreeiENSGT00550000074555.
HOVERGENiHBG058921.
InParanoidiQ9QX96.
TreeFamiTF317003.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 7 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QX96-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRRKQRRPQ QLISDCEGPS ASENGDASEE DHPQVCAKCC AQFSDPTEFL
60 70 80 90 100
AHQNSCCTDP PVMVIIGGQE NPSNSSASSA PRPEGHSRSQ VMDTEHSNPP
110 120 130 140 150
DSGSSGAPDP TWGPERRGEE SSGQFLVAAT GTAAGGGGGL ILASPKLGAT
160 170 180 190 200
PLPPESTPAP PPPPPPPPPP GVGSGHLNIP LILEELRVLQ QRQIHQMQMT
210 220 230 240 250
EQICRQVLLL GSLGQTVGAP ASPSELPGTG AASSTKPLLP LFSPIKPAQT
260 270 280 290 300
GKTLASSSSS SSSSGAEPPK QAFFHLYHPL GSQHPFSVGG VGRSHKPTPA
310 320 330 340 350
PSPALPGSTD QLIASPHLAF PGTTGLLAAQ CLGAARGLEA AASPGLLKPK
360 370 380 390 400
NGSGELGYGE VISSLEKPGG RHKCRFCAKV FGSDSALQIH LRSHTGERPY
410 420 430 440 450
KCNVCGNRFT TRGNLKVHFH RHREKYPHVQ MNPHPVPEHL DYVITSSGLP
460 470 480 490 500
YGMSVPPEKA EEEAGTPGGG VERKPLVAST TALSATESLT LLSTGTSTAV
510 520 530 540 550
APGLPTFNKF VLMKAVEPKS KADENTPPGS EGSAIAGVAD SGSATRMQLS
560 570 580 590 600
KLVTSLPSWA LLTNHLKSTG SFPFPYVLEP LGASPSETSK LQQLVEKIDR
610 620 630 640 650
QGAVAVASTA SGAPTTSAPA PSSSASGPNQ CVICLRVLSC PRALRLHYGQ
660 670 680 690 700
HGGERPFKCK VCGRAFSTRG NLRAHFVGHK TSPAARAQNS CPICQKKFTN
710 720 730 740 750
AVTLQQHVRM HLGGQIPNGG SALSEGGGAA QENSSEQSTA SGPGSFPQPQ
760 770 780 790 800
SQQPSPEEEM SEEEEEDEEE EEDVTDEDSL AGRGSESGGE KAISVRGDSE
810 820 830 840 850
EVSGAEEEVA TSVAAPTTVK EMDSNEKAPQ HTLPPPPPPP DNLDHPQPME
860 870 880 890 900
QGTSDVSGAM EEEAKLEGTS SPMAALTQEG EGTSTPLVEE LNLPEAMKKD
910 920 930 940 950
PGESSGRKAC EVCGQSFPTQ TALEEHQKTH PKDGPLFTCV FCRQGFLDRA
960 970 980 990 1000
TLKKHMLLAH HQVPPFAPHG PQNIATLSLV PGCSSSIPSP GLSPFPRKDD

PTMP
Length:1,004
Mass (Da):104,944
Last modified:July 27, 2011 - v2
Checksum:iAEEBBDEE04DDE5FF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti8 – 81R → K in CAB65274. (PubMed:10602995)Curated
Sequence conflicti31 – 311D → H in CAB65274. (PubMed:10602995)Curated
Sequence conflicti107 – 1071A → P in CAB65274. (PubMed:10602995)Curated
Sequence conflicti225 – 2251E → K in CAB65274. (PubMed:10602995)Curated
Sequence conflicti869 – 8691T → I in CAB65274. (PubMed:10602995)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ007396 mRNA. Translation: CAB65274.1.
BC085361 mRNA. Translation: AAH85361.1.
CCDSiCCDS27054.1.
RefSeqiNP_001231845.1. NM_001244916.1.
NP_056587.2. NM_015772.3.
UniGeneiMm.39487.
Mm.489795.

Genome annotation databases

EnsembliENSMUST00000058326; ENSMUSP00000056401; ENSMUSG00000049532.
GeneIDi50524.
KEGGimmu:50524.
UCSCiuc007tpf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ007396 mRNA. Translation: CAB65274.1 .
BC085361 mRNA. Translation: AAH85361.1 .
CCDSi CCDS27054.1.
RefSeqi NP_001231845.1. NM_001244916.1.
NP_056587.2. NM_015772.3.
UniGenei Mm.39487.
Mm.489795.

3D structure databases

ProteinModelPortali Q9QX96.
SMRi Q9QX96. Positions 342-428, 628-713, 906-967.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 206051. 1 interaction.
IntActi Q9QX96. 3 interactions.

PTM databases

PhosphoSitei Q9QX96.

Proteomic databases

MaxQBi Q9QX96.
PRIDEi Q9QX96.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000058326 ; ENSMUSP00000056401 ; ENSMUSG00000049532 .
GeneIDi 50524.
KEGGi mmu:50524.
UCSCi uc007tpf.2. mouse.

Organism-specific databases

CTDi 6297.
MGIi MGI:1354373. Sall2.

Phylogenomic databases

eggNOGi NOG294998.
GeneTreei ENSGT00550000074555.
HOVERGENi HBG058921.
InParanoidi Q9QX96.
TreeFami TF317003.

Miscellaneous databases

ChiTaRSi Sall2. mouse.
NextBioi 307522.
PROi Q9QX96.
SOURCEi Search...

Gene expression databases

Bgeei Q9QX96.
CleanExi MM_SALL2.
Genevestigatori Q9QX96.

Family and domain databases

Gene3Di 3.30.160.60. 3 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF00096. zf-C2H2. 1 hit.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 7 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic cloning, chromosomal mapping, and expression analysis of Msal-2."
    Kohlhase J., Altmann M., Archangelo L., Dixkens C., Engel W.
    Mamm. Genome 11:64-68(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-803, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic brain.

Entry informationi

Entry nameiSALL2_MOUSE
AccessioniPrimary (citable) accession number: Q9QX96
Secondary accession number(s): Q5U3X1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: July 27, 2011
Last modified: November 26, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3