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Q9QX96 (SALL2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sal-like protein 2
Alternative name(s):
Spalt-like protein 2
Zinc finger protein Spalt-2
Short name=Sal-2
Short name=mSal-2
Gene names
Name:Sall2
Synonyms:Sal2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1004 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probable transcription factor.

Subcellular location

Nucleus Probable.

Tissue specificity

Expressed throughout embryonic development. In adult predominantly in brain.

Sequence similarities

Belongs to the sal C2H2-type zinc-finger protein family.

Contains 7 C2H2-type zinc fingers.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10041004Sal-like protein 2
PRO_0000047023

Regions

Zinc finger372 – 39423C2H2-type 1
Zinc finger400 – 42223C2H2-type 2
Zinc finger629 – 65123C2H2-type 3
Zinc finger657 – 67923C2H2-type 4
Zinc finger689 – 71123C2H2-type 5
Zinc finger908 – 93023C2H2-type 6
Zinc finger937 – 96125C2H2-type 7
Compositional bias135 – 1395Poly-Gly
Compositional bias158 – 17013Poly-Pro
Compositional bias256 – 2649Poly-Ser
Compositional bias762 – 77211Poly-Glu
Compositional bias834 – 8407Poly-Pro

Amino acid modifications

Modified residue2431Phosphoserine By similarity
Modified residue7941Phosphoserine By similarity
Modified residue7991Phosphoserine By similarity
Modified residue8031Phosphoserine Ref.3
Cross-link908Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity

Experimental info

Sequence conflict81R → K in CAB65274. Ref.1
Sequence conflict311D → H in CAB65274. Ref.1
Sequence conflict1071A → P in CAB65274. Ref.1
Sequence conflict2251E → K in CAB65274. Ref.1
Sequence conflict8691T → I in CAB65274. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9QX96 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: AEEBBDEE04DDE5FF

FASTA1,004104,944
        10         20         30         40         50         60 
MSRRKQRRPQ QLISDCEGPS ASENGDASEE DHPQVCAKCC AQFSDPTEFL AHQNSCCTDP 

        70         80         90        100        110        120 
PVMVIIGGQE NPSNSSASSA PRPEGHSRSQ VMDTEHSNPP DSGSSGAPDP TWGPERRGEE 

       130        140        150        160        170        180 
SSGQFLVAAT GTAAGGGGGL ILASPKLGAT PLPPESTPAP PPPPPPPPPP GVGSGHLNIP 

       190        200        210        220        230        240 
LILEELRVLQ QRQIHQMQMT EQICRQVLLL GSLGQTVGAP ASPSELPGTG AASSTKPLLP 

       250        260        270        280        290        300 
LFSPIKPAQT GKTLASSSSS SSSSGAEPPK QAFFHLYHPL GSQHPFSVGG VGRSHKPTPA 

       310        320        330        340        350        360 
PSPALPGSTD QLIASPHLAF PGTTGLLAAQ CLGAARGLEA AASPGLLKPK NGSGELGYGE 

       370        380        390        400        410        420 
VISSLEKPGG RHKCRFCAKV FGSDSALQIH LRSHTGERPY KCNVCGNRFT TRGNLKVHFH 

       430        440        450        460        470        480 
RHREKYPHVQ MNPHPVPEHL DYVITSSGLP YGMSVPPEKA EEEAGTPGGG VERKPLVAST 

       490        500        510        520        530        540 
TALSATESLT LLSTGTSTAV APGLPTFNKF VLMKAVEPKS KADENTPPGS EGSAIAGVAD 

       550        560        570        580        590        600 
SGSATRMQLS KLVTSLPSWA LLTNHLKSTG SFPFPYVLEP LGASPSETSK LQQLVEKIDR 

       610        620        630        640        650        660 
QGAVAVASTA SGAPTTSAPA PSSSASGPNQ CVICLRVLSC PRALRLHYGQ HGGERPFKCK 

       670        680        690        700        710        720 
VCGRAFSTRG NLRAHFVGHK TSPAARAQNS CPICQKKFTN AVTLQQHVRM HLGGQIPNGG 

       730        740        750        760        770        780 
SALSEGGGAA QENSSEQSTA SGPGSFPQPQ SQQPSPEEEM SEEEEEDEEE EEDVTDEDSL 

       790        800        810        820        830        840 
AGRGSESGGE KAISVRGDSE EVSGAEEEVA TSVAAPTTVK EMDSNEKAPQ HTLPPPPPPP 

       850        860        870        880        890        900 
DNLDHPQPME QGTSDVSGAM EEEAKLEGTS SPMAALTQEG EGTSTPLVEE LNLPEAMKKD 

       910        920        930        940        950        960 
PGESSGRKAC EVCGQSFPTQ TALEEHQKTH PKDGPLFTCV FCRQGFLDRA TLKKHMLLAH 

       970        980        990       1000 
HQVPPFAPHG PQNIATLSLV PGCSSSIPSP GLSPFPRKDD PTMP 

« Hide

References

« Hide 'large scale' references
[1]"Genomic cloning, chromosomal mapping, and expression analysis of Msal-2."
Kohlhase J., Altmann M., Archangelo L., Dixkens C., Engel W.
Mamm. Genome 11:64-68(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
[3]"Phosphoproteomic analysis of the developing mouse brain."
Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.
Mol. Cell. Proteomics 3:1093-1101(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-803, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ007396 mRNA. Translation: CAB65274.1.
BC085361 mRNA. Translation: AAH85361.1.
CCDSCCDS27054.1.
RefSeqNP_001231845.1. NM_001244916.1.
NP_056587.2. NM_015772.3.
UniGeneMm.39487.
Mm.489795.

3D structure databases

ProteinModelPortalQ9QX96.
SMRQ9QX96. Positions 342-428, 602-714, 906-967.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid206051. 1 interaction.
IntActQ9QX96. 3 interactions.

PTM databases

PhosphoSiteQ9QX96.

Proteomic databases

PRIDEQ9QX96.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000058326; ENSMUSP00000056401; ENSMUSG00000049532.
GeneID50524.
KEGGmmu:50524.
UCSCuc007tpf.2. mouse.

Organism-specific databases

CTD6297.
MGIMGI:1354373. Sall2.

Phylogenomic databases

eggNOGNOG294998.
GeneTreeENSGT00550000074555.
HOVERGENHBG058921.
InParanoidQ5U3X1.
TreeFamTF317003.

Gene expression databases

BgeeQ9QX96.
CleanExMM_SALL2.
GenevestigatorQ9QX96.

Family and domain databases

Gene3D3.30.160.60. 3 hits.
InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 7 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio307522.
PROQ9QX96.
SOURCESearch...

Entry information

Entry nameSALL2_MOUSE
AccessionPrimary (citable) accession number: Q9QX96
Secondary accession number(s): Q5U3X1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot