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Q9QX96

- SALL2_MOUSE

UniProt

Q9QX96 - SALL2_MOUSE

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Protein
Sal-like protein 2
Gene
Sall2, Sal2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Probable transcription factor.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri372 – 39423C2H2-type 1
Add
BLAST
Zinc fingeri400 – 42223C2H2-type 2
Add
BLAST
Zinc fingeri629 – 65123C2H2-type 3
Add
BLAST
Zinc fingeri657 – 67923C2H2-type 4
Add
BLAST
Zinc fingeri689 – 71123C2H2-type 5
Add
BLAST
Zinc fingeri908 – 93023C2H2-type 6
Add
BLAST
Zinc fingeri937 – 96125C2H2-type 7
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  2. negative regulation of transcription, DNA-templated Source: UniProtKB
  3. neural tube development Source: MGI
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Sal-like protein 2
Alternative name(s):
Spalt-like protein 2
Zinc finger protein Spalt-2
Short name:
Sal-2
Short name:
mSal-2
Gene namesi
Name:Sall2
Synonyms:Sal2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:1354373. Sall2.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10041004Sal-like protein 2
PRO_0000047023Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei243 – 2431Phosphoserine By similarity
Modified residuei794 – 7941Phosphoserine By similarity
Modified residuei799 – 7991Phosphoserine By similarity
Modified residuei803 – 8031Phosphoserine1 Publication
Cross-linki908 – 908Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PRIDEiQ9QX96.

PTM databases

PhosphoSiteiQ9QX96.

Expressioni

Tissue specificityi

Expressed throughout embryonic development. In adult predominantly in brain.

Gene expression databases

BgeeiQ9QX96.
CleanExiMM_SALL2.
GenevestigatoriQ9QX96.

Interactioni

Protein-protein interaction databases

BioGridi206051. 1 interaction.
IntActiQ9QX96. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9QX96.
SMRiQ9QX96. Positions 342-428, 602-714, 906-967.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi135 – 1395Poly-Gly
Compositional biasi158 – 17013Poly-Pro
Add
BLAST
Compositional biasi256 – 2649Poly-Ser
Compositional biasi762 – 77211Poly-Glu
Add
BLAST
Compositional biasi834 – 8407Poly-Pro

Sequence similaritiesi

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG294998.
GeneTreeiENSGT00550000074555.
HOVERGENiHBG058921.
InParanoidiQ5U3X1.
TreeFamiTF317003.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 7 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QX96-1 [UniParc]FASTAAdd to Basket

« Hide

MSRRKQRRPQ QLISDCEGPS ASENGDASEE DHPQVCAKCC AQFSDPTEFL     50
AHQNSCCTDP PVMVIIGGQE NPSNSSASSA PRPEGHSRSQ VMDTEHSNPP 100
DSGSSGAPDP TWGPERRGEE SSGQFLVAAT GTAAGGGGGL ILASPKLGAT 150
PLPPESTPAP PPPPPPPPPP GVGSGHLNIP LILEELRVLQ QRQIHQMQMT 200
EQICRQVLLL GSLGQTVGAP ASPSELPGTG AASSTKPLLP LFSPIKPAQT 250
GKTLASSSSS SSSSGAEPPK QAFFHLYHPL GSQHPFSVGG VGRSHKPTPA 300
PSPALPGSTD QLIASPHLAF PGTTGLLAAQ CLGAARGLEA AASPGLLKPK 350
NGSGELGYGE VISSLEKPGG RHKCRFCAKV FGSDSALQIH LRSHTGERPY 400
KCNVCGNRFT TRGNLKVHFH RHREKYPHVQ MNPHPVPEHL DYVITSSGLP 450
YGMSVPPEKA EEEAGTPGGG VERKPLVAST TALSATESLT LLSTGTSTAV 500
APGLPTFNKF VLMKAVEPKS KADENTPPGS EGSAIAGVAD SGSATRMQLS 550
KLVTSLPSWA LLTNHLKSTG SFPFPYVLEP LGASPSETSK LQQLVEKIDR 600
QGAVAVASTA SGAPTTSAPA PSSSASGPNQ CVICLRVLSC PRALRLHYGQ 650
HGGERPFKCK VCGRAFSTRG NLRAHFVGHK TSPAARAQNS CPICQKKFTN 700
AVTLQQHVRM HLGGQIPNGG SALSEGGGAA QENSSEQSTA SGPGSFPQPQ 750
SQQPSPEEEM SEEEEEDEEE EEDVTDEDSL AGRGSESGGE KAISVRGDSE 800
EVSGAEEEVA TSVAAPTTVK EMDSNEKAPQ HTLPPPPPPP DNLDHPQPME 850
QGTSDVSGAM EEEAKLEGTS SPMAALTQEG EGTSTPLVEE LNLPEAMKKD 900
PGESSGRKAC EVCGQSFPTQ TALEEHQKTH PKDGPLFTCV FCRQGFLDRA 950
TLKKHMLLAH HQVPPFAPHG PQNIATLSLV PGCSSSIPSP GLSPFPRKDD 1000
PTMP 1004
Length:1,004
Mass (Da):104,944
Last modified:July 27, 2011 - v2
Checksum:iAEEBBDEE04DDE5FF
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti8 – 81R → K in CAB65274. 1 Publication
Sequence conflicti31 – 311D → H in CAB65274. 1 Publication
Sequence conflicti107 – 1071A → P in CAB65274. 1 Publication
Sequence conflicti225 – 2251E → K in CAB65274. 1 Publication
Sequence conflicti869 – 8691T → I in CAB65274. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ007396 mRNA. Translation: CAB65274.1.
BC085361 mRNA. Translation: AAH85361.1.
CCDSiCCDS27054.1.
RefSeqiNP_001231845.1. NM_001244916.1.
NP_056587.2. NM_015772.3.
UniGeneiMm.39487.
Mm.489795.

Genome annotation databases

EnsembliENSMUST00000058326; ENSMUSP00000056401; ENSMUSG00000049532.
GeneIDi50524.
KEGGimmu:50524.
UCSCiuc007tpf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ007396 mRNA. Translation: CAB65274.1 .
BC085361 mRNA. Translation: AAH85361.1 .
CCDSi CCDS27054.1.
RefSeqi NP_001231845.1. NM_001244916.1.
NP_056587.2. NM_015772.3.
UniGenei Mm.39487.
Mm.489795.

3D structure databases

ProteinModelPortali Q9QX96.
SMRi Q9QX96. Positions 342-428, 602-714, 906-967.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 206051. 1 interaction.
IntActi Q9QX96. 3 interactions.

PTM databases

PhosphoSitei Q9QX96.

Proteomic databases

PRIDEi Q9QX96.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000058326 ; ENSMUSP00000056401 ; ENSMUSG00000049532 .
GeneIDi 50524.
KEGGi mmu:50524.
UCSCi uc007tpf.2. mouse.

Organism-specific databases

CTDi 6297.
MGIi MGI:1354373. Sall2.

Phylogenomic databases

eggNOGi NOG294998.
GeneTreei ENSGT00550000074555.
HOVERGENi HBG058921.
InParanoidi Q5U3X1.
TreeFami TF317003.

Miscellaneous databases

NextBioi 307522.
PROi Q9QX96.
SOURCEi Search...

Gene expression databases

Bgeei Q9QX96.
CleanExi MM_SALL2.
Genevestigatori Q9QX96.

Family and domain databases

Gene3Di 3.30.160.60. 3 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF00096. zf-C2H2. 1 hit.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 7 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic cloning, chromosomal mapping, and expression analysis of Msal-2."
    Kohlhase J., Altmann M., Archangelo L., Dixkens C., Engel W.
    Mamm. Genome 11:64-68(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-803, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic brain.

Entry informationi

Entry nameiSALL2_MOUSE
AccessioniPrimary (citable) accession number: Q9QX96
Secondary accession number(s): Q5U3X1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi