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Protein

Sal-like protein 2

Gene

Sall2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable transcription factor that plays a role in eye development before, during, and after optic fissure closure.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri372 – 394C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri629 – 651C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri657 – 679C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri689 – 711C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri908 – 930C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri937 – 961C2H2-type 7PROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

  • eye development Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • neural tube development Source: MGI
  • signal transduction Source: GO_Central
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Sal-like protein 2
Alternative name(s):
Spalt-like protein 2
Zinc finger protein Spalt-2
Short name:
Sal-2
Short name:
mSal-2
Gene namesi
Name:Sall2
Synonyms:Sal2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1354373. Sall2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

No overt phenotypic abnormalities. Histologic analysis of the eyes reveales a colobomatous phenotype, with delayed apposition of the optic fissure margins and persistence of an anterior retinal coloboma phenotype after birth. Deficient embryos display correct posterior closure toward the optic nerve head, and upon contact of the fissure margins, dissolution of the basal lamina occurr and PAX2, known to be critical for this process, is expressed normally. Anterior closure is disrupted with the fissure margins failing to meet, or in some cases misaligning leading to a retinal lesion.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000470231 – 1004Sal-like protein 2Add BLAST1004

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei243PhosphoserineBy similarity1
Modified residuei794PhosphoserineBy similarity1
Modified residuei799PhosphoserineBy similarity1
Modified residuei803PhosphoserineCombined sources1
Cross-linki908Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ9QX96.
PaxDbiQ9QX96.
PRIDEiQ9QX96.

PTM databases

iPTMnetiQ9QX96.
PhosphoSitePlusiQ9QX96.

Expressioni

Tissue specificityi

Expressed throughout embryonic development. In adult predominantly in brain.

Gene expression databases

BgeeiENSMUSG00000049532.
CleanExiMM_SALL2.
GenevisibleiQ9QX96. MM.

Interactioni

Protein-protein interaction databases

BioGridi206051. 1 interactor.
IntActiQ9QX96. 3 interactors.
STRINGi10090.ENSMUSP00000056401.

Structurei

3D structure databases

ProteinModelPortaliQ9QX96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi135 – 139Poly-Gly5
Compositional biasi158 – 170Poly-ProAdd BLAST13
Compositional biasi256 – 264Poly-Ser9
Compositional biasi762 – 772Poly-GluAdd BLAST11
Compositional biasi834 – 840Poly-Pro7

Sequence similaritiesi

Contains 7 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri372 – 394C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri629 – 651C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri657 – 679C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri689 – 711C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri908 – 930C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri937 – 961C2H2-type 7PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1074. Eukaryota.
ENOG410ZE3Z. LUCA.
GeneTreeiENSGT00550000074555.
HOVERGENiHBG058921.
InParanoidiQ9QX96.
KOiK19871.
OMAiAGSFPQQ.
OrthoDBiEOG091G027I.
TreeFamiTF317003.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 7 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QX96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRRKQRRPQ QLISDCEGPS ASENGDASEE DHPQVCAKCC AQFSDPTEFL
60 70 80 90 100
AHQNSCCTDP PVMVIIGGQE NPSNSSASSA PRPEGHSRSQ VMDTEHSNPP
110 120 130 140 150
DSGSSGAPDP TWGPERRGEE SSGQFLVAAT GTAAGGGGGL ILASPKLGAT
160 170 180 190 200
PLPPESTPAP PPPPPPPPPP GVGSGHLNIP LILEELRVLQ QRQIHQMQMT
210 220 230 240 250
EQICRQVLLL GSLGQTVGAP ASPSELPGTG AASSTKPLLP LFSPIKPAQT
260 270 280 290 300
GKTLASSSSS SSSSGAEPPK QAFFHLYHPL GSQHPFSVGG VGRSHKPTPA
310 320 330 340 350
PSPALPGSTD QLIASPHLAF PGTTGLLAAQ CLGAARGLEA AASPGLLKPK
360 370 380 390 400
NGSGELGYGE VISSLEKPGG RHKCRFCAKV FGSDSALQIH LRSHTGERPY
410 420 430 440 450
KCNVCGNRFT TRGNLKVHFH RHREKYPHVQ MNPHPVPEHL DYVITSSGLP
460 470 480 490 500
YGMSVPPEKA EEEAGTPGGG VERKPLVAST TALSATESLT LLSTGTSTAV
510 520 530 540 550
APGLPTFNKF VLMKAVEPKS KADENTPPGS EGSAIAGVAD SGSATRMQLS
560 570 580 590 600
KLVTSLPSWA LLTNHLKSTG SFPFPYVLEP LGASPSETSK LQQLVEKIDR
610 620 630 640 650
QGAVAVASTA SGAPTTSAPA PSSSASGPNQ CVICLRVLSC PRALRLHYGQ
660 670 680 690 700
HGGERPFKCK VCGRAFSTRG NLRAHFVGHK TSPAARAQNS CPICQKKFTN
710 720 730 740 750
AVTLQQHVRM HLGGQIPNGG SALSEGGGAA QENSSEQSTA SGPGSFPQPQ
760 770 780 790 800
SQQPSPEEEM SEEEEEDEEE EEDVTDEDSL AGRGSESGGE KAISVRGDSE
810 820 830 840 850
EVSGAEEEVA TSVAAPTTVK EMDSNEKAPQ HTLPPPPPPP DNLDHPQPME
860 870 880 890 900
QGTSDVSGAM EEEAKLEGTS SPMAALTQEG EGTSTPLVEE LNLPEAMKKD
910 920 930 940 950
PGESSGRKAC EVCGQSFPTQ TALEEHQKTH PKDGPLFTCV FCRQGFLDRA
960 970 980 990 1000
TLKKHMLLAH HQVPPFAPHG PQNIATLSLV PGCSSSIPSP GLSPFPRKDD

PTMP
Length:1,004
Mass (Da):104,944
Last modified:July 27, 2011 - v2
Checksum:iAEEBBDEE04DDE5FF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8R → K in CAB65274 (PubMed:10602995).Curated1
Sequence conflicti31D → H in CAB65274 (PubMed:10602995).Curated1
Sequence conflicti107A → P in CAB65274 (PubMed:10602995).Curated1
Sequence conflicti225E → K in CAB65274 (PubMed:10602995).Curated1
Sequence conflicti869T → I in CAB65274 (PubMed:10602995).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ007396 mRNA. Translation: CAB65274.1.
BC085361 mRNA. Translation: AAH85361.1.
CCDSiCCDS27054.1.
RefSeqiNP_001231845.1. NM_001244916.1.
NP_056587.2. NM_015772.3.
UniGeneiMm.39487.
Mm.489795.

Genome annotation databases

EnsembliENSMUST00000058326; ENSMUSP00000056401; ENSMUSG00000049532.
GeneIDi50524.
KEGGimmu:50524.
UCSCiuc007tpf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ007396 mRNA. Translation: CAB65274.1.
BC085361 mRNA. Translation: AAH85361.1.
CCDSiCCDS27054.1.
RefSeqiNP_001231845.1. NM_001244916.1.
NP_056587.2. NM_015772.3.
UniGeneiMm.39487.
Mm.489795.

3D structure databases

ProteinModelPortaliQ9QX96.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi206051. 1 interactor.
IntActiQ9QX96. 3 interactors.
STRINGi10090.ENSMUSP00000056401.

PTM databases

iPTMnetiQ9QX96.
PhosphoSitePlusiQ9QX96.

Proteomic databases

MaxQBiQ9QX96.
PaxDbiQ9QX96.
PRIDEiQ9QX96.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000058326; ENSMUSP00000056401; ENSMUSG00000049532.
GeneIDi50524.
KEGGimmu:50524.
UCSCiuc007tpf.2. mouse.

Organism-specific databases

CTDi6297.
MGIiMGI:1354373. Sall2.

Phylogenomic databases

eggNOGiKOG1074. Eukaryota.
ENOG410ZE3Z. LUCA.
GeneTreeiENSGT00550000074555.
HOVERGENiHBG058921.
InParanoidiQ9QX96.
KOiK19871.
OMAiAGSFPQQ.
OrthoDBiEOG091G027I.
TreeFamiTF317003.

Miscellaneous databases

ChiTaRSiSall2. mouse.
PROiQ9QX96.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000049532.
CleanExiMM_SALL2.
GenevisibleiQ9QX96. MM.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 7 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSALL2_MOUSE
AccessioniPrimary (citable) accession number: Q9QX96
Secondary accession number(s): Q5U3X1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: July 27, 2011
Last modified: November 30, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.