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Q9QX96

- SALL2_MOUSE

UniProt

Q9QX96 - SALL2_MOUSE

Protein

Sal-like protein 2

Gene

Sall2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Probable transcription factor.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri372 – 39423C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri400 – 42223C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri629 – 65123C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri657 – 67923C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri689 – 71123C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri908 – 93023C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri937 – 96125C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. negative regulation of transcription, DNA-templated Source: UniProtKB
    2. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    3. neural tube development Source: MGI
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sal-like protein 2
    Alternative name(s):
    Spalt-like protein 2
    Zinc finger protein Spalt-2
    Short name:
    Sal-2
    Short name:
    mSal-2
    Gene namesi
    Name:Sall2
    Synonyms:Sal2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:1354373. Sall2.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10041004Sal-like protein 2PRO_0000047023Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei243 – 2431PhosphoserineBy similarity
    Modified residuei794 – 7941PhosphoserineBy similarity
    Modified residuei799 – 7991PhosphoserineBy similarity
    Modified residuei803 – 8031Phosphoserine1 Publication
    Cross-linki908 – 908Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

    Keywords - PTMi

    Isopeptide bond, Phosphoprotein, Ubl conjugation

    Proteomic databases

    PRIDEiQ9QX96.

    PTM databases

    PhosphoSiteiQ9QX96.

    Expressioni

    Tissue specificityi

    Expressed throughout embryonic development. In adult predominantly in brain.

    Gene expression databases

    BgeeiQ9QX96.
    CleanExiMM_SALL2.
    GenevestigatoriQ9QX96.

    Interactioni

    Protein-protein interaction databases

    BioGridi206051. 1 interaction.
    IntActiQ9QX96. 3 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QX96.
    SMRiQ9QX96. Positions 342-428, 602-714, 906-967.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi135 – 1395Poly-Gly
    Compositional biasi158 – 17013Poly-ProAdd
    BLAST
    Compositional biasi256 – 2649Poly-Ser
    Compositional biasi762 – 77211Poly-GluAdd
    BLAST
    Compositional biasi834 – 8407Poly-Pro

    Sequence similaritiesi

    Contains 7 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri372 – 39423C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri400 – 42223C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri629 – 65123C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri657 – 67923C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri689 – 71123C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri908 – 93023C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri937 – 96125C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG294998.
    GeneTreeiENSGT00550000074555.
    HOVERGENiHBG058921.
    InParanoidiQ5U3X1.
    TreeFamiTF317003.

    Family and domain databases

    Gene3Di3.30.160.60. 3 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF00096. zf-C2H2. 1 hit.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 7 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 7 hits.
    PS50157. ZINC_FINGER_C2H2_2. 7 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9QX96-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRRKQRRPQ QLISDCEGPS ASENGDASEE DHPQVCAKCC AQFSDPTEFL     50
    AHQNSCCTDP PVMVIIGGQE NPSNSSASSA PRPEGHSRSQ VMDTEHSNPP 100
    DSGSSGAPDP TWGPERRGEE SSGQFLVAAT GTAAGGGGGL ILASPKLGAT 150
    PLPPESTPAP PPPPPPPPPP GVGSGHLNIP LILEELRVLQ QRQIHQMQMT 200
    EQICRQVLLL GSLGQTVGAP ASPSELPGTG AASSTKPLLP LFSPIKPAQT 250
    GKTLASSSSS SSSSGAEPPK QAFFHLYHPL GSQHPFSVGG VGRSHKPTPA 300
    PSPALPGSTD QLIASPHLAF PGTTGLLAAQ CLGAARGLEA AASPGLLKPK 350
    NGSGELGYGE VISSLEKPGG RHKCRFCAKV FGSDSALQIH LRSHTGERPY 400
    KCNVCGNRFT TRGNLKVHFH RHREKYPHVQ MNPHPVPEHL DYVITSSGLP 450
    YGMSVPPEKA EEEAGTPGGG VERKPLVAST TALSATESLT LLSTGTSTAV 500
    APGLPTFNKF VLMKAVEPKS KADENTPPGS EGSAIAGVAD SGSATRMQLS 550
    KLVTSLPSWA LLTNHLKSTG SFPFPYVLEP LGASPSETSK LQQLVEKIDR 600
    QGAVAVASTA SGAPTTSAPA PSSSASGPNQ CVICLRVLSC PRALRLHYGQ 650
    HGGERPFKCK VCGRAFSTRG NLRAHFVGHK TSPAARAQNS CPICQKKFTN 700
    AVTLQQHVRM HLGGQIPNGG SALSEGGGAA QENSSEQSTA SGPGSFPQPQ 750
    SQQPSPEEEM SEEEEEDEEE EEDVTDEDSL AGRGSESGGE KAISVRGDSE 800
    EVSGAEEEVA TSVAAPTTVK EMDSNEKAPQ HTLPPPPPPP DNLDHPQPME 850
    QGTSDVSGAM EEEAKLEGTS SPMAALTQEG EGTSTPLVEE LNLPEAMKKD 900
    PGESSGRKAC EVCGQSFPTQ TALEEHQKTH PKDGPLFTCV FCRQGFLDRA 950
    TLKKHMLLAH HQVPPFAPHG PQNIATLSLV PGCSSSIPSP GLSPFPRKDD 1000
    PTMP 1004
    Length:1,004
    Mass (Da):104,944
    Last modified:July 27, 2011 - v2
    Checksum:iAEEBBDEE04DDE5FF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti8 – 81R → K in CAB65274. (PubMed:10602995)Curated
    Sequence conflicti31 – 311D → H in CAB65274. (PubMed:10602995)Curated
    Sequence conflicti107 – 1071A → P in CAB65274. (PubMed:10602995)Curated
    Sequence conflicti225 – 2251E → K in CAB65274. (PubMed:10602995)Curated
    Sequence conflicti869 – 8691T → I in CAB65274. (PubMed:10602995)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ007396 mRNA. Translation: CAB65274.1.
    BC085361 mRNA. Translation: AAH85361.1.
    CCDSiCCDS27054.1.
    RefSeqiNP_001231845.1. NM_001244916.1.
    NP_056587.2. NM_015772.3.
    UniGeneiMm.39487.
    Mm.489795.

    Genome annotation databases

    EnsembliENSMUST00000058326; ENSMUSP00000056401; ENSMUSG00000049532.
    GeneIDi50524.
    KEGGimmu:50524.
    UCSCiuc007tpf.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ007396 mRNA. Translation: CAB65274.1 .
    BC085361 mRNA. Translation: AAH85361.1 .
    CCDSi CCDS27054.1.
    RefSeqi NP_001231845.1. NM_001244916.1.
    NP_056587.2. NM_015772.3.
    UniGenei Mm.39487.
    Mm.489795.

    3D structure databases

    ProteinModelPortali Q9QX96.
    SMRi Q9QX96. Positions 342-428, 602-714, 906-967.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 206051. 1 interaction.
    IntActi Q9QX96. 3 interactions.

    PTM databases

    PhosphoSitei Q9QX96.

    Proteomic databases

    PRIDEi Q9QX96.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000058326 ; ENSMUSP00000056401 ; ENSMUSG00000049532 .
    GeneIDi 50524.
    KEGGi mmu:50524.
    UCSCi uc007tpf.2. mouse.

    Organism-specific databases

    CTDi 6297.
    MGIi MGI:1354373. Sall2.

    Phylogenomic databases

    eggNOGi NOG294998.
    GeneTreei ENSGT00550000074555.
    HOVERGENi HBG058921.
    InParanoidi Q5U3X1.
    TreeFami TF317003.

    Miscellaneous databases

    NextBioi 307522.
    PROi Q9QX96.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9QX96.
    CleanExi MM_SALL2.
    Genevestigatori Q9QX96.

    Family and domain databases

    Gene3Di 3.30.160.60. 3 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF00096. zf-C2H2. 1 hit.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 7 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 7 hits.
    PS50157. ZINC_FINGER_C2H2_2. 7 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic cloning, chromosomal mapping, and expression analysis of Msal-2."
      Kohlhase J., Altmann M., Archangelo L., Dixkens C., Engel W.
      Mamm. Genome 11:64-68(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-803, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic brain.

    Entry informationi

    Entry nameiSALL2_MOUSE
    AccessioniPrimary (citable) accession number: Q9QX96
    Secondary accession number(s): Q5U3X1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2002
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 104 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3