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Protein

Sialomucin core protein 24

Gene

Cd164

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sialomucin that may play a key role in hematopoiesis. May be involved in cell adhesion. Promotes myogenesis by enhancing CXCR4-dependent cell motility. Positively regulates myoblast migration and promotes myoblast fusion into myotubes (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Myogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Sialomucin core protein 24
Short name:
MUC-24
Alternative name(s):
Endolyn
Multi-glycosylated core protein 24
Short name:
MGC-24
Short name:
MGC-24v
Gene namesi
Name:Cd164
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi70942. Cd164.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 160137ExtracellularSequence analysisAdd
BLAST
Transmembranei161 – 18121HelicalSequence analysisAdd
BLAST
Topological domaini182 – 19514CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • endosome Source: RGD
  • endosome membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • lysosomal membrane Source: UniProtKB-SubCell
  • lysosome Source: RGD
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 195172Sialomucin core protein 24PRO_5000065184Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi26 – 261N-linked (GlcNAc...)Sequence analysis
Glycosylationi32 – 321N-linked (GlcNAc...)Sequence analysis
Glycosylationi68 – 681N-linked (GlcNAc...)Sequence analysis
Glycosylationi74 – 741N-linked (GlcNAc...)Sequence analysis
Glycosylationi86 – 861N-linked (GlcNAc...)Sequence analysis
Glycosylationi97 – 971N-linked (GlcNAc...)Sequence analysis
Glycosylationi118 – 1181N-linked (GlcNAc...)Sequence analysis
Glycosylationi144 – 1441N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

Highly N- and O-glycosylated; contains sialic acid.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9QX82.
PRIDEiQ9QX82.

Expressioni

Tissue specificityi

Ubiquitous. Expressed at highest levels in the liver, kidney, lung and intestine.1 Publication

Gene expression databases

ExpressionAtlasiQ9QX82. baseline and differential.
GenevisibleiQ9QX82. RN.

Interactioni

Subunit structurei

Interacts with CXCR4.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000334.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni189 – 1957Required for endosomal and lysosomal localization

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi34 – 150117Thr-richAdd
BLAST

Sequence similaritiesi

Belongs to the CD164 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J0NP. Eukaryota.
ENOG410XVJX. LUCA.
GeneTreeiENSGT00530000063929.
HOGENOMiHOG000070053.
InParanoidiQ9QX82.
KOiK06546.
OMAiCESRNSC.
OrthoDBiEOG7XDBJ6.
PhylomeDBiQ9QX82.
TreeFamiTF333380.

Family and domain databases

InterProiIPR007947. CD164_MGC24.
[Graphical view]
PANTHERiPTHR11337. PTHR11337. 1 hit.
PfamiPF05283. MGC-24. 1 hit.
[Graphical view]
PRINTSiPR01701. CD164ANTIGEN.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QX82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGASRGLFW AATCLAALCL SAAQSNSSAS PNVTDPPTTT SKVVPTTLTT
60 70 80 90 100
TKPPETCESF NSCVSCVNAT LTNNITCVWL DCHEANKTYC SSELVSNCTQ
110 120 130 140 150
KTSTDSCSVI PTTPVPTNST AKPTTRPSSP TPTPSVVTSA GATNTTVTPT
160 170 180 190
SQPERKSTFD AASFIGGIVL VLGVQAVIFF LYKFCKSKER NYHTL
Length:195
Mass (Da):20,476
Last modified:May 1, 2000 - v1
Checksum:i6DB7F015B4238C45
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ238574 mRNA. Translation: CAB66090.1.
CH474025 Genomic DNA. Translation: EDL99731.1.
BC062064 mRNA. Translation: AAH62064.1.
RefSeqiNP_114000.1. NM_031812.1.
UniGeneiRn.3733.

Genome annotation databases

EnsembliENSRNOT00000000334; ENSRNOP00000000334; ENSRNOG00000000304.
GeneIDi83689.
KEGGirno:83689.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ238574 mRNA. Translation: CAB66090.1.
CH474025 Genomic DNA. Translation: EDL99731.1.
BC062064 mRNA. Translation: AAH62064.1.
RefSeqiNP_114000.1. NM_031812.1.
UniGeneiRn.3733.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000334.

Proteomic databases

PaxDbiQ9QX82.
PRIDEiQ9QX82.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000000334; ENSRNOP00000000334; ENSRNOG00000000304.
GeneIDi83689.
KEGGirno:83689.

Organism-specific databases

CTDi8763.
RGDi70942. Cd164.

Phylogenomic databases

eggNOGiENOG410J0NP. Eukaryota.
ENOG410XVJX. LUCA.
GeneTreeiENSGT00530000063929.
HOGENOMiHOG000070053.
InParanoidiQ9QX82.
KOiK06546.
OMAiCESRNSC.
OrthoDBiEOG7XDBJ6.
PhylomeDBiQ9QX82.
TreeFamiTF333380.

Miscellaneous databases

NextBioi616265.
PROiQ9QX82.

Gene expression databases

ExpressionAtlasiQ9QX82. baseline and differential.
GenevisibleiQ9QX82. RN.

Family and domain databases

InterProiIPR007947. CD164_MGC24.
[Graphical view]
PANTHERiPTHR11337. PTHR11337. 1 hit.
PfamiPF05283. MGC-24. 1 hit.
[Graphical view]
PRINTSiPR01701. CD164ANTIGEN.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Endolyn is a mucin-like type I membrane protein targeted to lysosomes by its cytoplasmic tail."
    Ihrke G., Gray S.R., Luzio J.P.
    Biochem. J. 345:287-296(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 102-112 AND 189-195, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: Sprague-Dawley.
    Tissue: Liver.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.

Entry informationi

Entry nameiMUC24_RAT
AccessioniPrimary (citable) accession number: Q9QX82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: May 1, 2000
Last modified: November 11, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.