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Protein

Sialomucin core protein 24

Gene

Cd164

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sialomucin that may play a key role in hematopoiesis. May be involved in cell adhesion. Promotes myogenesis by enhancing CXCR4-dependent cell motility. Positively regulates myoblast migration and promotes myoblast fusion into myotubes (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processCell adhesion, Myogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Sialomucin core protein 24
Short name:
MUC-24
Alternative name(s):
Endolyn
Multi-glycosylated core protein 24
Short name:
MGC-24
Short name:
MGC-24v
Gene namesi
Name:Cd164
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi70942 Cd164

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 160ExtracellularSequence analysisAdd BLAST137
Transmembranei161 – 181HelicalSequence analysisAdd BLAST21
Topological domaini182 – 195CytoplasmicSequence analysisAdd BLAST14

Keywords - Cellular componenti

Cell membrane, Endosome, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_500006518424 – 195Sialomucin core protein 24Add BLAST172

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi26N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi32N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi68N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi74N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi86N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi97N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi118N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi144N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Highly N- and O-glycosylated; contains sialic acid.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9QX82

Expressioni

Tissue specificityi

Ubiquitous. Expressed at highest levels in the liver, kidney, lung and intestine.1 Publication

Gene expression databases

BgeeiENSRNOG00000000304
ExpressionAtlasiQ9QX82 baseline and differential
GenevisibleiQ9QX82 RN

Interactioni

Subunit structurei

Interacts with CXCR4.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000334

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni189 – 195Required for endosomal and lysosomal localization7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi34 – 150Thr-richAdd BLAST117

Sequence similaritiesi

Belongs to the CD164 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J0NP Eukaryota
ENOG410XVJX LUCA
GeneTreeiENSGT00530000063929
HOGENOMiHOG000070053
InParanoidiQ9QX82
KOiK06546
OMAiVSCFNAS
PhylomeDBiQ9QX82
TreeFamiTF333380

Family and domain databases

InterProiView protein in InterPro
IPR007947 CD164_MGC24
PANTHERiPTHR11337 PTHR11337, 1 hit
PfamiView protein in Pfam
PF05283 MGC-24, 1 hit
PRINTSiPR01701 CD164ANTIGEN

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QX82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGASRGLFW AATCLAALCL SAAQSNSSAS PNVTDPPTTT SKVVPTTLTT
60 70 80 90 100
TKPPETCESF NSCVSCVNAT LTNNITCVWL DCHEANKTYC SSELVSNCTQ
110 120 130 140 150
KTSTDSCSVI PTTPVPTNST AKPTTRPSSP TPTPSVVTSA GATNTTVTPT
160 170 180 190
SQPERKSTFD AASFIGGIVL VLGVQAVIFF LYKFCKSKER NYHTL
Length:195
Mass (Da):20,476
Last modified:May 1, 2000 - v1
Checksum:i6DB7F015B4238C45
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ238574 mRNA Translation: CAB66090.1
CH474025 Genomic DNA Translation: EDL99731.1
BC062064 mRNA Translation: AAH62064.1
RefSeqiNP_114000.1, NM_031812.1
UniGeneiRn.3733

Genome annotation databases

EnsembliENSRNOT00000000334; ENSRNOP00000000334; ENSRNOG00000000304
GeneIDi83689
KEGGirno:83689

Similar proteinsi

Entry informationi

Entry nameiMUC24_RAT
AccessioniPrimary (citable) accession number: Q9QX82
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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