Reviewed, UniProtKB/Swiss-Prot Q9QX78 (SOCS1_RAT)

Names and origin

Protein names

Recommended name:
    Suppressor of cytokine signaling 1
      Short name=SOCS-1

Gene names

Name:

Socs1

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	212 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity By similarity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival. Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2 By similarity.
Pathway	Protein modification; protein ubiquitination.
Subunit structure	Interacts with multiple activated proteins of the tyrosine kinase signaling pathway including JAK family kinases, TEC, KIT, GRB2 and VAV By similarity. Binding to JAKs is mediated through the KIR and SH2 domain to a phosphorylated tyrosine residue within the JAK JH1 domain By similarity. Binds the SH3 domain of GRB2 via diproline determinants in the N-terminus, and the N-terminal regulatory domain of VAV By similarity. Interacts with the Elongin BC complex (TCEB1 and TCEB2). Component of an ECS CBC(SOCS1) E3 ubiquitin-protein ligase complex which contains Elongin BC, CUL5, RBX1 and SOCS1. Interacts with TRIM8. Interacts with CUL2 By similarity.
Domain	The ESS and SH2 domains are required for JAK phosphotyrosine binding. Further interaction with the KIR domain is necessary for signal and kinase inhibition. The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes. The Elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV] and is part of the SOCS box By similarity.
Sequence similarities	Contains 1 SH2 domain. Contains 1 SOCS box domain.

Ontologies

Keywords
Biological process	Growth regulation Ubl conjugation pathway
Domain	SH2 domain
Molecular function	Signal transduction inhibitor
Gene Ontology (GO)
Biological process	modification-dependent protein catabolic process Inferred from electronic annotation. Source: UniProtKB-KW organ regeneration Inferred from expression pattern. Source: RGD regulation of growth Inferred from electronic annotation. Source: UniProtKB-KW response to cytokine stimulus Inferred from expression pattern. Source: RGD response to drug Inferred from expression pattern. Source: RGD response to estradiol stimulus Inferred from expression pattern. Source: RGD response to lipopolysaccharide Inferred from expression pattern. Source: RGD response to peptide hormone stimulus Inferred from expression pattern. Source: RGD response to progesterone stimulus Inferred from expression pattern. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 212	212	Suppressor of cytokine signaling 1		PRO_0000181237
Regions
	Domain	80 – 175	96	SH2
	Domain	162 – 211	50	SOCS box
	Region	56 – 67	12	Kinase inhibitory region (KIR)
	Region	68 – 79	12	Extended SH2 subdomain (ESS)
	Region	174 – 183	10	Interaction with Elongin BC complex By similarity
	Compositional bias	26 – 33	8	Poly-Ser

Sequences

	Sequence		Length	Mass (Da)
	Q9QX78-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: B40419329F63FED4	FASTA	212	23,826
	10 20 30 40 50 60 MVARNQVAAD NAISPASEPR RRPEPSSSSS SSSPAAPRRP RPCPVVPAPA PGDTHFRTFR 70 80 90 100 110 120 SHSDYRRITR TSALLDACGF YWGPLSVHGA HERLRAEPVG TFLVRDSRQR NCFFALSVKM 130 140 150 160 170 180 ASGPTSIRVH FQAGRFHLDG SRETFDCLFE LLEHYVAAPR RMLGAPLRQR RVRPLQELCR 190 200 210 QRIVAAVGRE NLARIPLNPV LRDYLSSFPF QI

References

[1]	le Cam A. Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Sprague-Dawley.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ243123 Genomic DNA. Translation: CAB64204.1.
IPI	IPI00212707.
RefSeq	NP_665886.1.
UniGene	Rn.82754
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q9QX78.
Proteomic databases
PRIDE	Q9QX78.
Genome annotation databases
Ensembl	ENSRNOT00000003458; ENSRNOP00000003458; ENSRNOG00000002568; Rattus norvegicus. [Genome view]
GeneID	252971.
KEGG	rno:252971.
Organism-specific databases
CTD	252971.
RGD	69272. Socs1.
Phylogenomic databases
HOVERGEN	Q9QX78.
Gene expression databases
ArrayExpress	Q9QX78.
Genevestigator	Q9QX78.
GermOnline	ENSRNOG00000002568. Rattus norvegicus.
Family and domain databases
InterPro	IPR000980. SH2. IPR001496. SOCS_C. [Graphical view]
Gene3D	G3DSA:3.30.505.10. SH2. 1 hit.
Pfam	PF00017. SH2. 1 hit. PF07525. SOCS_box. 1 hit. [Graphical view]
ProDom	PD000093. SH2. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00252. SH2. 1 hit. SM00253. SOCS. 1 hit. [Graphical view]
PROSITE	PS50001. SH2. 1 hit. PS50225. SOCS. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	624162.

Entry information

Entry name

SOCS1_RAT

Accession

Primary (citable) accession number: Q9QX78

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 16, 2002
Last sequence update:	May 1, 2000
Last modified:	October 13, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)