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Protein

Selenocysteine insertion sequence-binding protein 2

Gene

Secisbp2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the SECIS element in the 3'-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB.

GO - Molecular functioni

  • mRNA 3'-UTR binding Source: RGD
  • RNA binding Source: RGD
  • selenocysteine insertion sequence binding Source: RGD
  • translation factor activity, RNA binding Source: RGD

GO - Biological processi

  • positive regulation of selenocysteine incorporation Source: RGD
  • selenocysteine incorporation Source: RGD
  • selenocysteine metabolic process Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-RNO-2408557. Selenocysteine synthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Selenocysteine insertion sequence-binding protein 2
Short name:
SECIS-binding protein 2
Gene namesi
Name:Secisbp2
Synonyms:Sbp2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620991. Secisbp2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2176808.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 846846Selenocysteine insertion sequence-binding protein 2PRO_0000097656Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei220 – 2201PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9QX72.
PeptideAtlasiQ9QX72.
PRIDEiQ9QX72.

PTM databases

iPTMnetiQ9QX72.
PhosphoSiteiQ9QX72.

Expressioni

Tissue specificityi

Ubiquitous.

Interactioni

Subunit structurei

Interacts with SELB.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000039532.

Structurei

3D structure databases

ProteinModelPortaliQ9QX72.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni666 – 68722RNA-bindingSequence analysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi370 – 38011Nuclear localization signalSequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi370 – 38011Poly-LysAdd
BLAST

Phylogenomic databases

eggNOGiENOG410IEN2. Eukaryota.
ENOG410Z16U. LUCA.
HOGENOMiHOG000132996.
HOVERGENiHBG056137.
InParanoidiQ9QX72.
KOiK19539.
PhylomeDBiQ9QX72.

Family and domain databases

Gene3Di3.30.1330.30. 1 hit.
InterProiIPR029064. L30e-like.
IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
[Graphical view]
PfamiPF01248. Ribosomal_L7Ae. 1 hit.
[Graphical view]
SUPFAMiSSF55315. SSF55315. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9QX72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASERPREPE GEDSIKLSAD VKPFVPKFAG LNVAWSESSE ACVFPGCAAT
60 70 80 90 100
YYPFVQESPA AEQKMYPEDM AFGAPAFPAQ YVSSEIALHP FAYPTYALES
110 120 130 140 150
TQSVCSVPTL QYDYSQAQCH PGFRPAKPRN EHACPPQEAK CVFKKKSSDE
160 170 180 190 200
RRAWEEQKSS NRRADGAVPC EARPARGSCH LKSDGYHKRP DRKSRILTKS
210 220 230 240 250
ASTSKPEFEF SRLDFPELQS PKNSNLPETQ KQPRWGPLGP AASNMSLLGE
260 270 280 290 300
AGKPVADMVE GKMVKTDHTD GAVTNNAATS SPSCTRELSW TPMGYIVRQT
310 320 330 340 350
VSSDSAAATE TVNSIINLKK TTSSADAKNV SVTSEALSSD PSFSREKRVH
360 370 380 390 400
PGPKAKASQG SELEQNESSK KNKKKKEKSK SSYEVLPVQE PPRIEDAEEF
410 420 430 440 450
PNLSVASERR HRGESPKLQS KQQAQNDFKT GGKKSQVPVQ LDLGGMLAAL
460 470 480 490 500
EKQQHAPHAK PSSRPVVFSV GAVPVLSKDA SSGERGRRSS QVKTPHNPLD
510 520 530 540 550
SSAPLMKKGK QREIPKAKKP TSLKKIILKE RQERMQQRLQ ESAVSPTVAS
560 570 580 590 600
DDSQDVESGV TNQIPSPDNP TGPEKTEEPM SSTPVVEGES EEPAGTEFQR
610 620 630 640 650
DPEACQPAPD SATFPKIHSR RFRDYCSQML SKEVDACVTG LLKELVRFQD
660 670 680 690 700
RMYQKDPVKA KTKRRLVLGL REVLKHLKLR KLKCIIISPN CEKTQSKGGL
710 720 730 740 750
DDTLHTIIDC ACEQNIPFVF ALNRKALGRS LNKAVPVSIV GIFSYDGAQD
760 770 780 790 800
QFHKMVELTM AARQAYKTML ETMRQEQAGE PGPQTPPSPP MQDPIQSTDE
810 820 830 840
GTLASTGEEP HYIEIWRKHL EAYSQHALEL EDSLEASTSQ MMNLNL
Length:846
Mass (Da):93,300
Last modified:May 1, 2000 - v1
Checksum:i416EDFDEA38A4A13
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ251245 mRNA. Translation: CAB61692.1.
RefSeqiNP_076492.1. NM_024002.1.
UniGeneiRn.25076.

Genome annotation databases

GeneIDi79049.
KEGGirno:79049.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ251245 mRNA. Translation: CAB61692.1.
RefSeqiNP_076492.1. NM_024002.1.
UniGeneiRn.25076.

3D structure databases

ProteinModelPortaliQ9QX72.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000039532.

Chemistry

ChEMBLiCHEMBL2176808.

PTM databases

iPTMnetiQ9QX72.
PhosphoSiteiQ9QX72.

Proteomic databases

PaxDbiQ9QX72.
PeptideAtlasiQ9QX72.
PRIDEiQ9QX72.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi79049.
KEGGirno:79049.

Organism-specific databases

CTDi79048.
RGDi620991. Secisbp2.

Phylogenomic databases

eggNOGiENOG410IEN2. Eukaryota.
ENOG410Z16U. LUCA.
HOGENOMiHOG000132996.
HOVERGENiHBG056137.
InParanoidiQ9QX72.
KOiK19539.
PhylomeDBiQ9QX72.

Enzyme and pathway databases

ReactomeiR-RNO-2408557. Selenocysteine synthesis.

Miscellaneous databases

PROiQ9QX72.

Family and domain databases

Gene3Di3.30.1330.30. 1 hit.
InterProiIPR029064. L30e-like.
IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
[Graphical view]
PfamiPF01248. Ribosomal_L7Ae. 1 hit.
[Graphical view]
SUPFAMiSSF55315. SSF55315. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSEBP2_RAT
AccessioniPrimary (citable) accession number: Q9QX72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 2000
Last modified: July 6, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.