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Protein

Selenocysteine insertion sequence-binding protein 2

Gene

Secisbp2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to the SECIS element in the 3'-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB.

GO - Molecular functioni

  • mRNA 3'-UTR binding Source: RGD
  • ribonucleoprotein complex binding Source: GO_Central
  • RNA binding Source: RGD
  • selenocysteine insertion sequence binding Source: RGD
  • translation factor activity, RNA binding Source: RGD

GO - Biological processi

  • positive regulation of selenocysteine incorporation Source: RGD
  • selenocysteine incorporation Source: RGD

Keywordsi

Molecular functionRNA-binding
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Selenocysteine insertion sequence-binding protein 2
Short name:
SECIS-binding protein 2
Gene namesi
Name:Secisbp2
Synonyms:Sbp2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620991 Secisbp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2176808

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000976561 – 846Selenocysteine insertion sequence-binding protein 2Add BLAST846

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei220PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9QX72
PeptideAtlasiQ9QX72
PRIDEiQ9QX72

PTM databases

CarbonylDBiQ9QX72
iPTMnetiQ9QX72
PhosphoSitePlusiQ9QX72

Expressioni

Tissue specificityi

Ubiquitous.

Interactioni

Subunit structurei

Interacts with SELB.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000039532

Structurei

3D structure databases

ProteinModelPortaliQ9QX72
SMRiQ9QX72
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni666 – 687RNA-bindingSequence analysisAdd BLAST22

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi370 – 380Nuclear localization signalSequence analysisAdd BLAST11

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi370 – 380Poly-LysAdd BLAST11

Phylogenomic databases

eggNOGiENOG410IEN2 Eukaryota
ENOG410Z16U LUCA
HOGENOMiHOG000132996
HOVERGENiHBG056137
InParanoidiQ9QX72
KOiK19539
PhylomeDBiQ9QX72

Family and domain databases

Gene3Di3.30.1330.30, 1 hit
InterProiView protein in InterPro
IPR029064 L30e-like
IPR004038 Ribosomal_L7Ae/L30e/S12e/Gad45
PfamiView protein in Pfam
PF01248 Ribosomal_L7Ae, 1 hit
SUPFAMiSSF55315 SSF55315, 1 hit

Sequencei

Sequence statusi: Complete.

Q9QX72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASERPREPE GEDSIKLSAD VKPFVPKFAG LNVAWSESSE ACVFPGCAAT
60 70 80 90 100
YYPFVQESPA AEQKMYPEDM AFGAPAFPAQ YVSSEIALHP FAYPTYALES
110 120 130 140 150
TQSVCSVPTL QYDYSQAQCH PGFRPAKPRN EHACPPQEAK CVFKKKSSDE
160 170 180 190 200
RRAWEEQKSS NRRADGAVPC EARPARGSCH LKSDGYHKRP DRKSRILTKS
210 220 230 240 250
ASTSKPEFEF SRLDFPELQS PKNSNLPETQ KQPRWGPLGP AASNMSLLGE
260 270 280 290 300
AGKPVADMVE GKMVKTDHTD GAVTNNAATS SPSCTRELSW TPMGYIVRQT
310 320 330 340 350
VSSDSAAATE TVNSIINLKK TTSSADAKNV SVTSEALSSD PSFSREKRVH
360 370 380 390 400
PGPKAKASQG SELEQNESSK KNKKKKEKSK SSYEVLPVQE PPRIEDAEEF
410 420 430 440 450
PNLSVASERR HRGESPKLQS KQQAQNDFKT GGKKSQVPVQ LDLGGMLAAL
460 470 480 490 500
EKQQHAPHAK PSSRPVVFSV GAVPVLSKDA SSGERGRRSS QVKTPHNPLD
510 520 530 540 550
SSAPLMKKGK QREIPKAKKP TSLKKIILKE RQERMQQRLQ ESAVSPTVAS
560 570 580 590 600
DDSQDVESGV TNQIPSPDNP TGPEKTEEPM SSTPVVEGES EEPAGTEFQR
610 620 630 640 650
DPEACQPAPD SATFPKIHSR RFRDYCSQML SKEVDACVTG LLKELVRFQD
660 670 680 690 700
RMYQKDPVKA KTKRRLVLGL REVLKHLKLR KLKCIIISPN CEKTQSKGGL
710 720 730 740 750
DDTLHTIIDC ACEQNIPFVF ALNRKALGRS LNKAVPVSIV GIFSYDGAQD
760 770 780 790 800
QFHKMVELTM AARQAYKTML ETMRQEQAGE PGPQTPPSPP MQDPIQSTDE
810 820 830 840
GTLASTGEEP HYIEIWRKHL EAYSQHALEL EDSLEASTSQ MMNLNL
Length:846
Mass (Da):93,300
Last modified:May 1, 2000 - v1
Checksum:i416EDFDEA38A4A13
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ251245 mRNA Translation: CAB61692.1
RefSeqiNP_076492.1, NM_024002.1
UniGeneiRn.25076

Genome annotation databases

GeneIDi79049
KEGGirno:79049

Similar proteinsi

Entry informationi

Entry nameiSEBP2_RAT
AccessioniPrimary (citable) accession number: Q9QX72
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health