Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9QX70

- Q9QX70_RAT

UniProt

Q9QX70 - Q9QX70_RAT

Protein
Submitted name:

Epidermal growth factor receptor

Gene

Egfr

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. epidermal growth factor-activated receptor activity Source: RGD
    3. epidermal growth factor binding Source: RGD
    4. glycoprotein binding Source: RGD
    5. integrin binding Source: RGD
    6. protein binding Source: BHF-UCL
    7. protein heterodimerization activity Source: RGD
    8. protein kinase binding Source: RGD
    9. receptor binding Source: RGD
    10. receptor signaling protein tyrosine kinase activity Source: InterPro

    GO - Biological processi

    1. activation of MAPKK activity Source: RGD
    2. alkanesulfonate metabolic process Source: RGD
    3. astrocyte activation Source: RGD
    4. cellular response to dexamethasone stimulus Source: RGD
    5. cellular response to drug Source: RGD
    6. cellular response to growth factor stimulus Source: RGD
    7. cellular response to mechanical stimulus Source: RGD
    8. circadian rhythm Source: RGD
    9. diterpenoid metabolic process Source: RGD
    10. epidermal growth factor receptor signaling pathway Source: RGD
    11. hydrogen peroxide metabolic process Source: RGD
    12. intracellular signal transduction Source: RGD
    13. liver development Source: RGD
    14. lung development Source: RGD
    15. magnesium ion homeostasis Source: RGD
    16. negative regulation of apoptotic process Source: RGD
    17. negative regulation of mitotic cell cycle Source: RGD
    18. neuron projection morphogenesis Source: RGD
    19. ovulation cycle Source: RGD
    20. positive regulation of inflammatory response Source: RGD
    21. positive regulation of smooth muscle cell proliferation Source: RGD
    22. positive regulation of superoxide anion generation Source: RGD
    23. positive regulation of synaptic transmission, glutamatergic Source: RGD
    24. positive regulation of vasoconstriction Source: RGD
    25. positive regulation of vasodilation Source: RGD
    26. protein autophosphorylation Source: RGD
    27. response to calcium ion Source: RGD
    28. response to cobalamin Source: RGD
    29. response to estradiol Source: RGD
    30. response to hydroxyisoflavone Source: RGD
    31. response to lipid Source: RGD
    32. response to organic cyclic compound Source: RGD
    33. response to osmotic stress Source: RGD
    34. response to oxidative stress Source: RGD
    35. signal transduction Source: RGD
    36. tongue development Source: RGD
    37. translation Source: RGD

    Keywords - Molecular functioni

    Kinase, ReceptorImported, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingSAAS annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Epidermal growth factor receptorImported
    Gene namesi
    Name:EgfrImported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

    Organism-specific databases

    RGDi2543. Egfr.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: RGD
    2. basolateral plasma membrane Source: RGD
    3. cell surface Source: RGD
    4. endocytic vesicle Source: RGD
    5. endosome Source: RGD
    6. integral component of membrane Source: InterPro
    7. nucleus Source: RGD
    8. plasma membrane Source: RGD
    9. Shc-EGFR complex Source: BHF-UCL

    PTM / Processingi

    Keywords - PTMi

    PhosphoproteinSAAS annotation

    Proteomic databases

    PRIDEiQ9QX70.

    PTM databases

    PhosphoSiteiQ9QX70.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9QX70.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-2658N.
    IntActiQ9QX70. 1 interaction.
    MINTiMINT-1509350.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QX70.
    SMRiQ9QX70. Positions 26-636, 670-1004.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family.UniRule annotation
    Contains protein kinase domain.SAAS annotation

    Phylogenomic databases

    HOGENOMiHOG000230982.
    HOVERGENiHBG000490.
    InParanoidiQ9QX70.
    KOiK04361.

    Family and domain databases

    Gene3Di3.80.20.20. 2 hits.
    InterProiIPR000494. EGF_rcpt_L.
    IPR006211. Furin-like_Cys-rich_dom.
    IPR006212. Furin_repeat.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR016245. Tyr_kinase_EGF/ERB/XmrK_rcpt.
    [Graphical view]
    PfamiPF00757. Furin-like. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    PF01030. Recep_L_domain. 2 hits.
    [Graphical view]
    PIRSFiPIRSF000619. TyrPK_EGF-R. 1 hit.
    PRINTSiPR00109. TYRKINASE.
    SMARTiSM00261. FU. 4 hits.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    SSF57184. SSF57184. 2 hits.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9QX70-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRPSGTARTK LLLLLAALCA AGGALEEKKV CQGTSNRLTQ LGTFEDHFLS     50
    LQRMFNNCEV VLGNLEITYV QRNYDLSFLK TIQEVAGYVL IALNTVERIP 100
    LENLQIIRGN ALYENTYALA VLSNYGTNKT GLRELPMRNL QEILIGAVRF 150
    SNNPILCNME TIQWRDIVQD VFLSNMSMDV QRHLTGCPKC DPSCPNGSCW 200
    GRGEENCQKL TKIICAQQCS RRCRGRSPSD CCHNQCAAGC TGPRESDCLV 250
    CHRFRDEATC KDTCPPLMLY NPTTYQMDVN PEGKYSFGAT CVKKCPRNYV 300
    VTDHGSCVRA CGPDYYEVEE DGVSKCKKCD GPCRKVCNGI GIGEFKDTLS 350
    INATNIKHFK YCTAISGDLH ILPVAFKGDS FTRTPPLDPR ELEILKTVKE 400
    ITGFLLIQAW PENWTDLHAF ENLEIIRGRT KQHGQFSLAV VGLNITSLGL 450
    RSLKEISDGD VIISGNRNLC YANTINWKKL FGTPNQKTKI MNNRAEKDCK 500
    ATNHVCNPLC SSEGCWGPEP TDCVSCQNVS RGRECVDKCN ILEGEPREFV 550
    ENSECIQCHP ECLPQTMNIT CTGRGPDNCI KCAHYVDGPH CVKTCPSGIM 600
    GENNTLVWKF ADANNVCHLC HANCTYGCAG PGLKGCQQPE GPKIPSIATG 650
    IVGGLLFIVV VALGIGLFMR RRQLVRKRTL RRLLQERELV EPLTPSGEAP 700
    NQAHLRILKE TEFKKIKVLG SGAFGTVYKG LWIPEGEKVK IPVAIKELRE 750
    ATSPKANKEI LDEAYVMASV DNPHVCRLLG ICLTSTVQLI TQLMPYGCLL 800
    DYVREHKDNI GSQYLLNWCV QIAKGMNYLE DRRLVHRDLA ARNVLVKTPQ 850
    HVKITDFGLA KLLGAEEKEY HAEGGKVPIK WMALESILHR IYTHQSDVWS 900
    YGVTVWELMT FGSKPYDGIP ASEISSILEK GERLPQPPIC TIDVYMIMVK 950
    CWMIDADSRP KFRELILEFS KMARDPQRYL VIQGDERMHL PSPTDSNFYR 1000
    ALMEEEDMED VVDADEYLIP QQGFFNSPST SRTPLLSSLS ANSNSSTVAC 1050
    INRNGSCRVK EDAFLQRYSS DPTSVLTEDN IDDTFLPVPE YINQSVPKRP 1100
    AGSVQNPVYH NQPLHPAPGR DLHYQNPHSN AVSNPEYLNT AQPTCLSSGF 1150
    DSSALWIQKG SHQMSLDNPD YQQDFFPKEA KPNGIFKGPT AENAEYLRVA 1200
    PPSSEFSGA 1209
    Length:1,209
    Mass (Da):134,891
    Last modified:May 1, 2000 - v1
    Checksum:i96FEE7F6CC1B7773
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M37394 mRNA. Translation: AAF14008.1.
    PIRiA36325.
    RefSeqiNP_113695.1. NM_031507.1.
    UniGeneiRn.37227.

    Genome annotation databases

    GeneIDi24329.
    KEGGirno:24329.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M37394 mRNA. Translation: AAF14008.1 .
    PIRi A36325.
    RefSeqi NP_113695.1. NM_031507.1.
    UniGenei Rn.37227.

    3D structure databases

    ProteinModelPortali Q9QX70.
    SMRi Q9QX70. Positions 26-636, 670-1004.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-2658N.
    IntActi Q9QX70. 1 interaction.
    MINTi MINT-1509350.

    PTM databases

    PhosphoSitei Q9QX70.

    Proteomic databases

    PRIDEi Q9QX70.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 24329.
    KEGGi rno:24329.

    Organism-specific databases

    CTDi 1956.
    RGDi 2543. Egfr.

    Phylogenomic databases

    HOGENOMi HOG000230982.
    HOVERGENi HBG000490.
    InParanoidi Q9QX70.
    KOi K04361.

    Miscellaneous databases

    NextBioi 602999.

    Gene expression databases

    Genevestigatori Q9QX70.

    Family and domain databases

    Gene3Di 3.80.20.20. 2 hits.
    InterProi IPR000494. EGF_rcpt_L.
    IPR006211. Furin-like_Cys-rich_dom.
    IPR006212. Furin_repeat.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR016245. Tyr_kinase_EGF/ERB/XmrK_rcpt.
    [Graphical view ]
    Pfami PF00757. Furin-like. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    PF01030. Recep_L_domain. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF000619. TyrPK_EGF-R. 1 hit.
    PRINTSi PR00109. TYRKINASE.
    SMARTi SM00261. FU. 4 hits.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    SSF57184. SSF57184. 2 hits.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A truncated, secreted form of the epidermal growth factor receptor is encoded by an alternatively spliced transcript in normal rat tissue."
      Petch L.A., Harris J., Raymond V.W., Blasband A., Lee D.C., Earp H.S.
      Mol. Cell. Biol. 10:2973-2982(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: FisherImported.
      Tissue: LiverImported.
    2. Petch L.A.
      Submitted (NOV-1991) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: FisherImported.
      Tissue: LiverImported.
    3. Guttridge K., Dawson T.L., Earp H.S.
      Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: FisherImported.
      Tissue: LiverImported.

    Entry informationi

    Entry nameiQ9QX70_RAT
    AccessioniPrimary (citable) accession number: Q9QX70
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)