Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Receptor protein-tyrosine kinase

Gene

Egfr

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • calmodulin binding Source: RGD
  • epidermal growth factor-activated receptor activity Source: RGD
  • epidermal growth factor binding Source: RGD
  • glycoprotein binding Source: RGD
  • integrin binding Source: RGD
  • protein heterodimerization activity Source: RGD
  • protein kinase binding Source: RGD
  • protein tyrosine kinase activity Source: RGD
  • receptor binding Source: RGD
  • receptor signaling protein tyrosine kinase activity Source: InterPro

GO - Biological processi

  • activation of MAPKK activity Source: RGD
  • astrocyte activation Source: RGD
  • cellular response to dexamethasone stimulus Source: RGD
  • cellular response to drug Source: RGD
  • cellular response to growth factor stimulus Source: RGD
  • cellular response to mechanical stimulus Source: RGD
  • circadian rhythm Source: RGD
  • diterpenoid metabolic process Source: RGD
  • epidermal growth factor receptor signaling pathway Source: RGD
  • hair follicle development Source: RGD
  • hydrogen peroxide metabolic process Source: RGD
  • intracellular signal transduction Source: RGD
  • liver development Source: RGD
  • liver regeneration Source: RGD
  • lung development Source: RGD
  • magnesium ion homeostasis Source: RGD
  • midgut development Source: RGD
  • negative regulation of apoptotic process Source: RGD
  • negative regulation of mitotic cell cycle Source: RGD
  • neuron projection morphogenesis Source: RGD
  • ovulation cycle Source: RGD
  • peptidyl-tyrosine phosphorylation Source: RGD
  • positive regulation of bone resorption Source: RGD
  • positive regulation of inflammatory response Source: RGD
  • positive regulation of prolactin secretion Source: RGD
  • positive regulation of smooth muscle cell proliferation Source: RGD
  • positive regulation of superoxide anion generation Source: RGD
  • positive regulation of synaptic transmission, glutamatergic Source: RGD
  • positive regulation of vasoconstriction Source: RGD
  • positive regulation of vasodilation Source: RGD
  • protein autophosphorylation Source: RGD
  • response to calcium ion Source: RGD
  • response to cobalamin Source: RGD
  • response to estradiol Source: RGD
  • response to hydroxyisoflavone Source: RGD
  • response to lipid Source: RGD
  • response to organic cyclic compound Source: RGD
  • response to osmotic stress Source: RGD
  • response to oxidative stress Source: RGD
  • signal transduction Source: RGD
  • tongue development Source: RGD
  • translation Source: RGD
  • wound healing Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Kinase, ReceptorImported, Transferase, Tyrosine-protein kinaseSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor protein-tyrosine kinaseSAAS annotation (EC:2.7.10.1SAAS annotation)
Gene namesi
Name:EgfrImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi2543. Egfr.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei647 – 668HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

  • apical plasma membrane Source: RGD
  • basolateral plasma membrane Source: RGD
  • cell surface Source: RGD
  • endocytic vesicle Source: RGD
  • endosome Source: RGD
  • integral component of membrane Source: UniProtKB-KW
  • membrane raft Source: RGD
  • nucleus Source: RGD
  • plasma membrane Source: RGD
  • Shc-EGFR complex Source: BHF-UCL
  • synapse Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_500433129925 – 1209Receptor protein-tyrosine kinaseSequence analysisAdd BLAST1185

Proteomic databases

PaxDbiQ9QX70.
PRIDEiQ9QX70.

PTM databases

iPTMnetiQ9QX70.
PhosphoSitePlusiQ9QX70.

Expressioni

Gene expression databases

GenevisibleiQ9QX70. RN.

Interactioni

GO - Molecular functioni

  • calmodulin binding Source: RGD
  • epidermal growth factor binding Source: RGD
  • integrin binding Source: RGD
  • protein heterodimerization activity Source: RGD
  • protein kinase binding Source: RGD
  • receptor binding Source: RGD

Protein-protein interaction databases

DIPiDIP-2658N.
IntActiQ9QX70. 1 interactor.
MINTiMINT-1509350.
STRINGi10116.ENSRNOP00000006087.

Structurei

3D structure databases

ProteinModelPortaliQ9QX70.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini713 – 980Protein kinaseInterPro annotationAdd BLAST268

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1025. Eukaryota.
ENOG410XNSR. LUCA.
HOGENOMiHOG000230982.
HOVERGENiHBG000490.
KOiK04361.

Family and domain databases

Gene3Di3.80.20.20. 2 hits.
InterProiIPR006211. Furin-like_Cys-rich_dom.
IPR006212. Furin_repeat.
IPR032778. GF_recep_IV.
IPR009030. Growth_fac_rcpt_.
IPR011009. Kinase-like_dom.
IPR032675. L_dom-like.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR000494. Rcpt_L-dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016245. Tyr_kinase_EGF/ERB/XmrK_rcpt.
[Graphical view]
PfamiPF00757. Furin-like. 1 hit.
PF14843. GF_recep_IV. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF01030. Recep_L_domain. 2 hits.
[Graphical view]
PIRSFiPIRSF000619. TyrPK_EGF-R. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00261. FU. 4 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
SSF56112. SSF56112. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QX70-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPSGTARTK LLLLLAALCA AGGALEEKKV CQGTSNRLTQ LGTFEDHFLS
60 70 80 90 100
LQRMFNNCEV VLGNLEITYV QRNYDLSFLK TIQEVAGYVL IALNTVERIP
110 120 130 140 150
LENLQIIRGN ALYENTYALA VLSNYGTNKT GLRELPMRNL QEILIGAVRF
160 170 180 190 200
SNNPILCNME TIQWRDIVQD VFLSNMSMDV QRHLTGCPKC DPSCPNGSCW
210 220 230 240 250
GRGEENCQKL TKIICAQQCS RRCRGRSPSD CCHNQCAAGC TGPRESDCLV
260 270 280 290 300
CHRFRDEATC KDTCPPLMLY NPTTYQMDVN PEGKYSFGAT CVKKCPRNYV
310 320 330 340 350
VTDHGSCVRA CGPDYYEVEE DGVSKCKKCD GPCRKVCNGI GIGEFKDTLS
360 370 380 390 400
INATNIKHFK YCTAISGDLH ILPVAFKGDS FTRTPPLDPR ELEILKTVKE
410 420 430 440 450
ITGFLLIQAW PENWTDLHAF ENLEIIRGRT KQHGQFSLAV VGLNITSLGL
460 470 480 490 500
RSLKEISDGD VIISGNRNLC YANTINWKKL FGTPNQKTKI MNNRAEKDCK
510 520 530 540 550
ATNHVCNPLC SSEGCWGPEP TDCVSCQNVS RGRECVDKCN ILEGEPREFV
560 570 580 590 600
ENSECIQCHP ECLPQTMNIT CTGRGPDNCI KCAHYVDGPH CVKTCPSGIM
610 620 630 640 650
GENNTLVWKF ADANNVCHLC HANCTYGCAG PGLKGCQQPE GPKIPSIATG
660 670 680 690 700
IVGGLLFIVV VALGIGLFMR RRQLVRKRTL RRLLQERELV EPLTPSGEAP
710 720 730 740 750
NQAHLRILKE TEFKKIKVLG SGAFGTVYKG LWIPEGEKVK IPVAIKELRE
760 770 780 790 800
ATSPKANKEI LDEAYVMASV DNPHVCRLLG ICLTSTVQLI TQLMPYGCLL
810 820 830 840 850
DYVREHKDNI GSQYLLNWCV QIAKGMNYLE DRRLVHRDLA ARNVLVKTPQ
860 870 880 890 900
HVKITDFGLA KLLGAEEKEY HAEGGKVPIK WMALESILHR IYTHQSDVWS
910 920 930 940 950
YGVTVWELMT FGSKPYDGIP ASEISSILEK GERLPQPPIC TIDVYMIMVK
960 970 980 990 1000
CWMIDADSRP KFRELILEFS KMARDPQRYL VIQGDERMHL PSPTDSNFYR
1010 1020 1030 1040 1050
ALMEEEDMED VVDADEYLIP QQGFFNSPST SRTPLLSSLS ANSNSSTVAC
1060 1070 1080 1090 1100
INRNGSCRVK EDAFLQRYSS DPTSVLTEDN IDDTFLPVPE YINQSVPKRP
1110 1120 1130 1140 1150
AGSVQNPVYH NQPLHPAPGR DLHYQNPHSN AVSNPEYLNT AQPTCLSSGF
1160 1170 1180 1190 1200
DSSALWIQKG SHQMSLDNPD YQQDFFPKEA KPNGIFKGPT AENAEYLRVA

PPSSEFSGA
Length:1,209
Mass (Da):134,891
Last modified:May 1, 2000 - v1
Checksum:i96FEE7F6CC1B7773
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37394 mRNA. Translation: AAF14008.1.
PIRiA36325.
RefSeqiNP_113695.1. NM_031507.1.
UniGeneiRn.154146.
Rn.231255.
Rn.37227.

Genome annotation databases

GeneIDi24329.
KEGGirno:24329.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37394 mRNA. Translation: AAF14008.1.
PIRiA36325.
RefSeqiNP_113695.1. NM_031507.1.
UniGeneiRn.154146.
Rn.231255.
Rn.37227.

3D structure databases

ProteinModelPortaliQ9QX70.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-2658N.
IntActiQ9QX70. 1 interactor.
MINTiMINT-1509350.
STRINGi10116.ENSRNOP00000006087.

PTM databases

iPTMnetiQ9QX70.
PhosphoSitePlusiQ9QX70.

Proteomic databases

PaxDbiQ9QX70.
PRIDEiQ9QX70.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi24329.
KEGGirno:24329.

Organism-specific databases

CTDi1956.
RGDi2543. Egfr.

Phylogenomic databases

eggNOGiKOG1025. Eukaryota.
ENOG410XNSR. LUCA.
HOGENOMiHOG000230982.
HOVERGENiHBG000490.
KOiK04361.

Gene expression databases

GenevisibleiQ9QX70. RN.

Family and domain databases

Gene3Di3.80.20.20. 2 hits.
InterProiIPR006211. Furin-like_Cys-rich_dom.
IPR006212. Furin_repeat.
IPR032778. GF_recep_IV.
IPR009030. Growth_fac_rcpt_.
IPR011009. Kinase-like_dom.
IPR032675. L_dom-like.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR000494. Rcpt_L-dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016245. Tyr_kinase_EGF/ERB/XmrK_rcpt.
[Graphical view]
PfamiPF00757. Furin-like. 1 hit.
PF14843. GF_recep_IV. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF01030. Recep_L_domain. 2 hits.
[Graphical view]
PIRSFiPIRSF000619. TyrPK_EGF-R. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00261. FU. 4 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
SSF56112. SSF56112. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ9QX70_RAT
AccessioniPrimary (citable) accession number: Q9QX70
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.