Q9QX70 (Q9QX70_RAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Epidermal growth factor receptor EMBL AAF14008.1

Gene names

Name:

Egfr EMBL AAF14008.1 RGD 2543

Organism

Rattus norvegicus (Rat) EMBL AAF14008.1

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	1209 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. SAAS SAAS009030
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. RuleBase RU000307 Contains 1 protein kinase domain.

Ontologies

Keywords
Ligand	ATP-binding SAAS SAAS009030 Nucleotide-binding
Molecular function	Kinase Receptor EMBL AAF14008.1 Transferase Tyrosine-protein kinase RuleBase RU000307 SAAS SAAS009030
PTM	Phosphoprotein SAAS SAAS009030
Gene Ontology (GO)
Biological_process	signal transduction by phosphorylation Inferred from electronic annotation. Source: GOC transmembrane receptor protein tyrosine kinase signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	Shc-EGFR complex Inferred from direct assay PubMed 7513704. Source: BHF-UCL integral to membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW receptor signaling protein tyrosine kinase activity Inferred from electronic annotation. Source: InterPro transmembrane receptor protein tyrosine kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9QX70 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 96FEE7F6CC1B7773	FASTA	1,209	134,891
	10 20 30 40 50 60 MRPSGTARTK LLLLLAALCA AGGALEEKKV CQGTSNRLTQ LGTFEDHFLS LQRMFNNCEV 70 80 90 100 110 120 VLGNLEITYV QRNYDLSFLK TIQEVAGYVL IALNTVERIP LENLQIIRGN ALYENTYALA 130 140 150 160 170 180 VLSNYGTNKT GLRELPMRNL QEILIGAVRF SNNPILCNME TIQWRDIVQD VFLSNMSMDV 190 200 210 220 230 240 QRHLTGCPKC DPSCPNGSCW GRGEENCQKL TKIICAQQCS RRCRGRSPSD CCHNQCAAGC 250 260 270 280 290 300 TGPRESDCLV CHRFRDEATC KDTCPPLMLY NPTTYQMDVN PEGKYSFGAT CVKKCPRNYV 310 320 330 340 350 360 VTDHGSCVRA CGPDYYEVEE DGVSKCKKCD GPCRKVCNGI GIGEFKDTLS INATNIKHFK 370 380 390 400 410 420 YCTAISGDLH ILPVAFKGDS FTRTPPLDPR ELEILKTVKE ITGFLLIQAW PENWTDLHAF 430 440 450 460 470 480 ENLEIIRGRT KQHGQFSLAV VGLNITSLGL RSLKEISDGD VIISGNRNLC YANTINWKKL 490 500 510 520 530 540 FGTPNQKTKI MNNRAEKDCK ATNHVCNPLC SSEGCWGPEP TDCVSCQNVS RGRECVDKCN 550 560 570 580 590 600 ILEGEPREFV ENSECIQCHP ECLPQTMNIT CTGRGPDNCI KCAHYVDGPH CVKTCPSGIM 610 620 630 640 650 660 GENNTLVWKF ADANNVCHLC HANCTYGCAG PGLKGCQQPE GPKIPSIATG IVGGLLFIVV 670 680 690 700 710 720 VALGIGLFMR RRQLVRKRTL RRLLQERELV EPLTPSGEAP NQAHLRILKE TEFKKIKVLG 730 740 750 760 770 780 SGAFGTVYKG LWIPEGEKVK IPVAIKELRE ATSPKANKEI LDEAYVMASV DNPHVCRLLG 790 800 810 820 830 840 ICLTSTVQLI TQLMPYGCLL DYVREHKDNI GSQYLLNWCV QIAKGMNYLE DRRLVHRDLA 850 860 870 880 890 900 ARNVLVKTPQ HVKITDFGLA KLLGAEEKEY HAEGGKVPIK WMALESILHR IYTHQSDVWS 910 920 930 940 950 960 YGVTVWELMT FGSKPYDGIP ASEISSILEK GERLPQPPIC TIDVYMIMVK CWMIDADSRP 970 980 990 1000 1010 1020 KFRELILEFS KMARDPQRYL VIQGDERMHL PSPTDSNFYR ALMEEEDMED VVDADEYLIP 1030 1040 1050 1060 1070 1080 QQGFFNSPST SRTPLLSSLS ANSNSSTVAC INRNGSCRVK EDAFLQRYSS DPTSVLTEDN 1090 1100 1110 1120 1130 1140 IDDTFLPVPE YINQSVPKRP AGSVQNPVYH NQPLHPAPGR DLHYQNPHSN AVSNPEYLNT 1150 1160 1170 1180 1190 1200 AQPTCLSSGF DSSALWIQKG SHQMSLDNPD YQQDFFPKEA KPNGIFKGPT AENAEYLRVA PPSSEFSGA

References

[1]	"A truncated, secreted form of the epidermal growth factor receptor is encoded by an alternatively spliced transcript in normal rat tissue." Petch L.A., Harris J., Raymond V.W., Blasband A., Lee D.C., Earp H.S. Mol. Cell. Biol. 10:2973-2982(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Fisher EMBL AAF14008.1. Tissue: Liver EMBL AAF14008.1.
[2]	Petch L.A. Submitted (NOV-1991) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Fisher EMBL AAF14008.1. Tissue: Liver EMBL AAF14008.1.
[3]	Guttridge K., Dawson T.L., Earp H.S. Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Fisher EMBL AAF14008.1. Tissue: Liver EMBL AAF14008.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M37394 mRNA. Translation: AAF14008.1.
IPI	IPI00212694.
PIR	A36325.
RefSeq	NP_113695.1. NM_031507.1.
UniGene	Rn.37227.
3D structure databases
HSSP	HSSP built from PDB template 1M17 based on UniProtKB Q9H2C9.
ProteinModelPortal	Q9QX70.
SMR	Q9QX70. Positions 26-636, 670-1004.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-2658N.
IntAct	Q9QX70. 1 interaction.
STRING	Q9QX70.
PTM databases
PhosphoSite	Q9QX70.
Proteomic databases
PRIDE	Q9QX70.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	24329.
KEGG	rno:24329.
Organism-specific databases
CTD	1956.
Phylogenomic databases
HOGENOM	HOG000230982.
HOVERGEN	HBG000490.
InParanoid	Q9QX70.
KO	K04361.
Gene expression databases
ArrayExpress	Q9QX70.
Genevestigator	Q9QX70.
Family and domain databases
InterPro	IPR000494. EGF_rcpt_L. IPR006211. Furin-like_Cys-rich_dom. IPR006212. Furin_repeat. IPR009030. Growth_fac_rcpt. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR001245. Ser-Thr/Tyr_kinase_cat_dom. IPR008266. Tyr_kinase_AS. IPR020635. Tyr_kinase_cat_dom. IPR016245. Tyr_kinase_EGF/ERB/XmrK_rcpt. [Graphical view]
Pfam	PF00757. Furin-like. 1 hit. PF07714. Pkinase_Tyr. 1 hit. PF01030. Recep_L_domain. 2 hits. [Graphical view]
PIRSF	PIRSF000619. TyrPK_EGF-R. 1 hit.
PRINTS	PR00109. TYRKINASE.
SMART	SM00261. FU. 4 hits. SM00219. TyrKc. 1 hit. [Graphical view]
SUPFAM	SSF57184. Grow_fac_recept. 2 hits. SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	602999.

Entry information

Entry name

Q9QX70_RAT

Accession

Primary (citable) accession number: Q9QX70

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2000
Last sequence update:	May 1, 2000
Last modified:	April 3, 2013
This is version 100 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)