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Q9QX70

- Q9QX70_RAT

UniProt

Q9QX70 - Q9QX70_RAT

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Protein
Submitted name:

Epidermal growth factor receptor

Gene

Egfr

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. epidermal growth factor-activated receptor activity Source: RGD
  3. epidermal growth factor binding Source: RGD
  4. glycoprotein binding Source: RGD
  5. integrin binding Source: RGD
  6. protein heterodimerization activity Source: RGD
  7. protein kinase binding Source: RGD
  8. receptor binding Source: RGD
  9. receptor signaling protein tyrosine kinase activity Source: InterPro

GO - Biological processi

  1. activation of MAPKK activity Source: RGD
  2. alkanesulfonate metabolic process Source: RGD
  3. astrocyte activation Source: RGD
  4. cellular response to dexamethasone stimulus Source: RGD
  5. cellular response to drug Source: RGD
  6. cellular response to growth factor stimulus Source: RGD
  7. cellular response to mechanical stimulus Source: RGD
  8. circadian rhythm Source: RGD
  9. diterpenoid metabolic process Source: RGD
  10. epidermal growth factor receptor signaling pathway Source: RGD
  11. hydrogen peroxide metabolic process Source: RGD
  12. intracellular signal transduction Source: RGD
  13. liver development Source: RGD
  14. lung development Source: RGD
  15. magnesium ion homeostasis Source: RGD
  16. negative regulation of apoptotic process Source: RGD
  17. negative regulation of mitotic cell cycle Source: RGD
  18. neuron projection morphogenesis Source: RGD
  19. ovulation cycle Source: RGD
  20. positive regulation of inflammatory response Source: RGD
  21. positive regulation of smooth muscle cell proliferation Source: RGD
  22. positive regulation of superoxide anion generation Source: RGD
  23. positive regulation of synaptic transmission, glutamatergic Source: RGD
  24. positive regulation of vasoconstriction Source: RGD
  25. positive regulation of vasodilation Source: RGD
  26. protein autophosphorylation Source: RGD
  27. response to calcium ion Source: RGD
  28. response to cobalamin Source: RGD
  29. response to estradiol Source: RGD
  30. response to hydroxyisoflavone Source: RGD
  31. response to lipid Source: RGD
  32. response to organic cyclic compound Source: RGD
  33. response to osmotic stress Source: RGD
  34. response to oxidative stress Source: RGD
  35. signal transduction Source: RGD
  36. tongue development Source: RGD
  37. translation Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Kinase, ReceptorImported, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Epidermal growth factor receptorImported
Gene namesi
Name:EgfrImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi2543. Egfr.

Subcellular locationi

GO - Cellular componenti

  1. apical plasma membrane Source: RGD
  2. basolateral plasma membrane Source: RGD
  3. cell surface Source: RGD
  4. endocytic vesicle Source: RGD
  5. endosome Source: RGD
  6. integral component of membrane Source: InterPro
  7. nucleus Source: RGD
  8. plasma membrane Source: RGD
  9. Shc-EGFR complex Source: BHF-UCL
Complete GO annotation...

PTM / Processingi

Keywords - PTMi

PhosphoproteinSAAS annotation

Proteomic databases

PRIDEiQ9QX70.

PTM databases

PhosphoSiteiQ9QX70.

Expressioni

Gene expression databases

GenevestigatoriQ9QX70.

Interactioni

Protein-protein interaction databases

DIPiDIP-2658N.
IntActiQ9QX70. 1 interaction.
MINTiMINT-1509350.

Structurei

3D structure databases

ProteinModelPortaliQ9QX70.
SMRiQ9QX70. Positions 26-636, 670-1004.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.UniRule annotation
Contains protein kinase domain.SAAS annotation

Phylogenomic databases

HOGENOMiHOG000230982.
HOVERGENiHBG000490.
KOiK04361.

Family and domain databases

Gene3Di3.80.20.20. 2 hits.
InterProiIPR000494. EGF_rcpt_L.
IPR006211. Furin-like_Cys-rich_dom.
IPR006212. Furin_repeat.
IPR009030. Growth_fac_rcpt_N_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016245. Tyr_kinase_EGF/ERB/XmrK_rcpt.
[Graphical view]
PfamiPF00757. Furin-like. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF01030. Recep_L_domain. 2 hits.
[Graphical view]
PIRSFiPIRSF000619. TyrPK_EGF-R. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00261. FU. 4 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QX70-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRPSGTARTK LLLLLAALCA AGGALEEKKV CQGTSNRLTQ LGTFEDHFLS
60 70 80 90 100
LQRMFNNCEV VLGNLEITYV QRNYDLSFLK TIQEVAGYVL IALNTVERIP
110 120 130 140 150
LENLQIIRGN ALYENTYALA VLSNYGTNKT GLRELPMRNL QEILIGAVRF
160 170 180 190 200
SNNPILCNME TIQWRDIVQD VFLSNMSMDV QRHLTGCPKC DPSCPNGSCW
210 220 230 240 250
GRGEENCQKL TKIICAQQCS RRCRGRSPSD CCHNQCAAGC TGPRESDCLV
260 270 280 290 300
CHRFRDEATC KDTCPPLMLY NPTTYQMDVN PEGKYSFGAT CVKKCPRNYV
310 320 330 340 350
VTDHGSCVRA CGPDYYEVEE DGVSKCKKCD GPCRKVCNGI GIGEFKDTLS
360 370 380 390 400
INATNIKHFK YCTAISGDLH ILPVAFKGDS FTRTPPLDPR ELEILKTVKE
410 420 430 440 450
ITGFLLIQAW PENWTDLHAF ENLEIIRGRT KQHGQFSLAV VGLNITSLGL
460 470 480 490 500
RSLKEISDGD VIISGNRNLC YANTINWKKL FGTPNQKTKI MNNRAEKDCK
510 520 530 540 550
ATNHVCNPLC SSEGCWGPEP TDCVSCQNVS RGRECVDKCN ILEGEPREFV
560 570 580 590 600
ENSECIQCHP ECLPQTMNIT CTGRGPDNCI KCAHYVDGPH CVKTCPSGIM
610 620 630 640 650
GENNTLVWKF ADANNVCHLC HANCTYGCAG PGLKGCQQPE GPKIPSIATG
660 670 680 690 700
IVGGLLFIVV VALGIGLFMR RRQLVRKRTL RRLLQERELV EPLTPSGEAP
710 720 730 740 750
NQAHLRILKE TEFKKIKVLG SGAFGTVYKG LWIPEGEKVK IPVAIKELRE
760 770 780 790 800
ATSPKANKEI LDEAYVMASV DNPHVCRLLG ICLTSTVQLI TQLMPYGCLL
810 820 830 840 850
DYVREHKDNI GSQYLLNWCV QIAKGMNYLE DRRLVHRDLA ARNVLVKTPQ
860 870 880 890 900
HVKITDFGLA KLLGAEEKEY HAEGGKVPIK WMALESILHR IYTHQSDVWS
910 920 930 940 950
YGVTVWELMT FGSKPYDGIP ASEISSILEK GERLPQPPIC TIDVYMIMVK
960 970 980 990 1000
CWMIDADSRP KFRELILEFS KMARDPQRYL VIQGDERMHL PSPTDSNFYR
1010 1020 1030 1040 1050
ALMEEEDMED VVDADEYLIP QQGFFNSPST SRTPLLSSLS ANSNSSTVAC
1060 1070 1080 1090 1100
INRNGSCRVK EDAFLQRYSS DPTSVLTEDN IDDTFLPVPE YINQSVPKRP
1110 1120 1130 1140 1150
AGSVQNPVYH NQPLHPAPGR DLHYQNPHSN AVSNPEYLNT AQPTCLSSGF
1160 1170 1180 1190 1200
DSSALWIQKG SHQMSLDNPD YQQDFFPKEA KPNGIFKGPT AENAEYLRVA

PPSSEFSGA
Length:1,209
Mass (Da):134,891
Last modified:May 1, 2000 - v1
Checksum:i96FEE7F6CC1B7773
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37394 mRNA. Translation: AAF14008.1.
PIRiA36325.
RefSeqiNP_113695.1. NM_031507.1.
UniGeneiRn.37227.

Genome annotation databases

GeneIDi24329.
KEGGirno:24329.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37394 mRNA. Translation: AAF14008.1 .
PIRi A36325.
RefSeqi NP_113695.1. NM_031507.1.
UniGenei Rn.37227.

3D structure databases

ProteinModelPortali Q9QX70.
SMRi Q9QX70. Positions 26-636, 670-1004.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-2658N.
IntActi Q9QX70. 1 interaction.
MINTi MINT-1509350.

PTM databases

PhosphoSitei Q9QX70.

Proteomic databases

PRIDEi Q9QX70.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 24329.
KEGGi rno:24329.

Organism-specific databases

CTDi 1956.
RGDi 2543. Egfr.

Phylogenomic databases

HOGENOMi HOG000230982.
HOVERGENi HBG000490.
KOi K04361.

Miscellaneous databases

NextBioi 602999.

Gene expression databases

Genevestigatori Q9QX70.

Family and domain databases

Gene3Di 3.80.20.20. 2 hits.
InterProi IPR000494. EGF_rcpt_L.
IPR006211. Furin-like_Cys-rich_dom.
IPR006212. Furin_repeat.
IPR009030. Growth_fac_rcpt_N_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016245. Tyr_kinase_EGF/ERB/XmrK_rcpt.
[Graphical view ]
Pfami PF00757. Furin-like. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF01030. Recep_L_domain. 2 hits.
[Graphical view ]
PIRSFi PIRSF000619. TyrPK_EGF-R. 1 hit.
PRINTSi PR00109. TYRKINASE.
SMARTi SM00261. FU. 4 hits.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A truncated, secreted form of the epidermal growth factor receptor is encoded by an alternatively spliced transcript in normal rat tissue."
    Petch L.A., Harris J., Raymond V.W., Blasband A., Lee D.C., Earp H.S.
    Mol. Cell. Biol. 10:2973-2982(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: FisherImported.
    Tissue: LiverImported.
  2. Petch L.A.
    Submitted (NOV-1991) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: FisherImported.
    Tissue: LiverImported.
  3. Guttridge K., Dawson T.L., Earp H.S.
    Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: FisherImported.
    Tissue: LiverImported.

Entry informationi

Entry nameiQ9QX70_RAT
AccessioniPrimary (citable) accession number: Q9QX70
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)