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Q9QX70 (Q9QX70_RAT) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Egfr EMBL AAF14008.1 RGD 2543
OrganismRattus norvegicus (Rat) EMBL AAF14008.1
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length1209 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. SAAS SAAS009030

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. RuleBase RU000307

Contains protein kinase domain. SAAS SAAS009030

Ontologies

Keywords
   LigandATP-binding SAAS SAAS009030
Nucleotide-binding
   Molecular functionKinase
Receptor EMBL AAF14008.1
Transferase
Tyrosine-protein kinase RuleBase RU000307 SAAS SAAS009030
   PTMPhosphoprotein SAAS SAAS009030
Gene Ontology (GO)
   Biological_processactivation of MAPKK activity

Inferred from mutant phenotype PubMed 14551192. Source: RGD

alkanesulfonate metabolic process

Inferred from expression pattern PubMed 21251948. Source: RGD

astrocyte activation

Inferred from mutant phenotype PubMed 16837601. Source: RGD

cellular response to dexamethasone stimulus

Inferred from expression pattern PubMed 17585012. Source: RGD

cellular response to drug

Inferred from expression pattern PubMed 21276422PubMed 21389970. Source: RGD

cellular response to growth factor stimulus

Inferred from expression pattern PubMed 3495539. Source: RGD

cellular response to mechanical stimulus

Inferred from expression pattern PubMed 20927110. Source: RGD

circadian rhythm

Inferred from expression pattern PubMed 12454858. Source: RGD

diterpenoid metabolic process

Inferred from expression pattern PubMed 21448670. Source: RGD

epidermal growth factor receptor signaling pathway

Inferred from direct assay PubMed 11796513. Source: RGD

hydrogen peroxide metabolic process

Inferred from expression pattern PubMed 21258655. Source: RGD

intracellular signal transduction

Inferred from direct assay PubMed 12107054. Source: RGD

liver development

Inferred from expression pattern PubMed 12454858. Source: RGD

lung development

Inferred from expression pattern PubMed 20118217. Source: RGD

magnesium ion homeostasis

Inferred from mutant phenotype PubMed 22646904. Source: RGD

negative regulation of apoptotic process

Inferred from mutant phenotype PubMed 16466740. Source: RGD

negative regulation of mitotic cell cycle

Inferred from mutant phenotype PubMed 14551192. Source: RGD

neuron projection morphogenesis

Inferred from mutant phenotype PubMed 16648628. Source: RGD

ovulation cycle

Inferred from mutant phenotype PubMed 11796513. Source: RGD

positive regulation of inflammatory response

Inferred from mutant phenotype PubMed 22824323. Source: RGD

positive regulation of smooth muscle cell proliferation

Inferred from mutant phenotype PubMed 15486316. Source: RGD

positive regulation of superoxide anion generation

Inferred from mutant phenotype PubMed 22966991. Source: RGD

positive regulation of synaptic transmission, glutamatergic

Inferred from mutant phenotype PubMed 16648628. Source: RGD

positive regulation of vasoconstriction

Inferred from mutant phenotype PubMed 22966991. Source: RGD

positive regulation of vasodilation

Inferred from mutant phenotype PubMed 23232926. Source: RGD

protein autophosphorylation

Inferred from direct assay PubMed 3015391. Source: RGD

response to calcium ion

Inferred from mutant phenotype PubMed 15950968. Source: RGD

response to cobalamin

Inferred from expression pattern PubMed 21185268. Source: RGD

response to estradiol

Inferred from expression pattern PubMed 2991264. Source: RGD

response to hydroxyisoflavone

Inferred from expression pattern PubMed 21254785. Source: RGD

response to lipid

Inferred from expression pattern PubMed 15044318. Source: RGD

response to organic cyclic compound

Inferred from expression pattern PubMed 21475988. Source: RGD

response to osmotic stress

Inferred from expression pattern PubMed 11208719. Source: RGD

response to oxidative stress

Inferred from expression pattern PubMed 11208719. Source: RGD

signal transduction

Inferred from direct assay PubMed 12107054. Source: RGD

tongue development

Inferred from expression pattern PubMed 10908606. Source: RGD

translation

Inferred from direct assay PubMed 12107054. Source: RGD

   Cellular_componentShc-EGFR complex

Inferred from direct assay PubMed 7513704. Source: BHF-UCL

apical plasma membrane

Inferred from direct assay PubMed 15631999. Source: RGD

basolateral plasma membrane

Inferred from direct assay PubMed 15631999. Source: RGD

cell surface

Inferred from direct assay PubMed 21349584. Source: RGD

endocytic vesicle

Inferred from direct assay PubMed 11071913. Source: RGD

endosome

Inferred from direct assay PubMed 21172338. Source: RGD

integral component of membrane

Inferred from electronic annotation. Source: InterPro

nucleus

Inferred from direct assay PubMed 17553674. Source: RGD

plasma membrane

Inferred from direct assay PubMed 11071913. Source: RGD

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

epidermal growth factor binding

Inferred from mutant phenotype PubMed 15486316. Source: RGD

epidermal growth factor-activated receptor activity

Inferred from direct assay PubMed 11796513. Source: RGD

glycoprotein binding

Inferred from physical interaction PubMed 21349584. Source: RGD

integrin binding

Inferred from physical interaction PubMed 21349584. Source: RGD

protein binding

Inferred from physical interaction PubMed 7513704. Source: BHF-UCL

protein heterodimerization activity

Inferred from physical interaction PubMed 16769812. Source: RGD

protein kinase binding

Inferred from physical interaction PubMed 21037565. Source: RGD

receptor binding

Inferred from physical interaction PubMed 21349584. Source: RGD

receptor signaling protein tyrosine kinase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q9QX70 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 96FEE7F6CC1B7773

FASTA1,209134,891
        10         20         30         40         50         60 
MRPSGTARTK LLLLLAALCA AGGALEEKKV CQGTSNRLTQ LGTFEDHFLS LQRMFNNCEV 

        70         80         90        100        110        120 
VLGNLEITYV QRNYDLSFLK TIQEVAGYVL IALNTVERIP LENLQIIRGN ALYENTYALA 

       130        140        150        160        170        180 
VLSNYGTNKT GLRELPMRNL QEILIGAVRF SNNPILCNME TIQWRDIVQD VFLSNMSMDV 

       190        200        210        220        230        240 
QRHLTGCPKC DPSCPNGSCW GRGEENCQKL TKIICAQQCS RRCRGRSPSD CCHNQCAAGC 

       250        260        270        280        290        300 
TGPRESDCLV CHRFRDEATC KDTCPPLMLY NPTTYQMDVN PEGKYSFGAT CVKKCPRNYV 

       310        320        330        340        350        360 
VTDHGSCVRA CGPDYYEVEE DGVSKCKKCD GPCRKVCNGI GIGEFKDTLS INATNIKHFK 

       370        380        390        400        410        420 
YCTAISGDLH ILPVAFKGDS FTRTPPLDPR ELEILKTVKE ITGFLLIQAW PENWTDLHAF 

       430        440        450        460        470        480 
ENLEIIRGRT KQHGQFSLAV VGLNITSLGL RSLKEISDGD VIISGNRNLC YANTINWKKL 

       490        500        510        520        530        540 
FGTPNQKTKI MNNRAEKDCK ATNHVCNPLC SSEGCWGPEP TDCVSCQNVS RGRECVDKCN 

       550        560        570        580        590        600 
ILEGEPREFV ENSECIQCHP ECLPQTMNIT CTGRGPDNCI KCAHYVDGPH CVKTCPSGIM 

       610        620        630        640        650        660 
GENNTLVWKF ADANNVCHLC HANCTYGCAG PGLKGCQQPE GPKIPSIATG IVGGLLFIVV 

       670        680        690        700        710        720 
VALGIGLFMR RRQLVRKRTL RRLLQERELV EPLTPSGEAP NQAHLRILKE TEFKKIKVLG 

       730        740        750        760        770        780 
SGAFGTVYKG LWIPEGEKVK IPVAIKELRE ATSPKANKEI LDEAYVMASV DNPHVCRLLG 

       790        800        810        820        830        840 
ICLTSTVQLI TQLMPYGCLL DYVREHKDNI GSQYLLNWCV QIAKGMNYLE DRRLVHRDLA 

       850        860        870        880        890        900 
ARNVLVKTPQ HVKITDFGLA KLLGAEEKEY HAEGGKVPIK WMALESILHR IYTHQSDVWS 

       910        920        930        940        950        960 
YGVTVWELMT FGSKPYDGIP ASEISSILEK GERLPQPPIC TIDVYMIMVK CWMIDADSRP 

       970        980        990       1000       1010       1020 
KFRELILEFS KMARDPQRYL VIQGDERMHL PSPTDSNFYR ALMEEEDMED VVDADEYLIP 

      1030       1040       1050       1060       1070       1080 
QQGFFNSPST SRTPLLSSLS ANSNSSTVAC INRNGSCRVK EDAFLQRYSS DPTSVLTEDN 

      1090       1100       1110       1120       1130       1140 
IDDTFLPVPE YINQSVPKRP AGSVQNPVYH NQPLHPAPGR DLHYQNPHSN AVSNPEYLNT 

      1150       1160       1170       1180       1190       1200 
AQPTCLSSGF DSSALWIQKG SHQMSLDNPD YQQDFFPKEA KPNGIFKGPT AENAEYLRVA 


PPSSEFSGA 

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References

[1]"A truncated, secreted form of the epidermal growth factor receptor is encoded by an alternatively spliced transcript in normal rat tissue."
Petch L.A., Harris J., Raymond V.W., Blasband A., Lee D.C., Earp H.S.
Mol. Cell. Biol. 10:2973-2982(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Fisher EMBL AAF14008.1.
Tissue: Liver EMBL AAF14008.1.
[2]Petch L.A.
Submitted (NOV-1991) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Fisher EMBL AAF14008.1.
Tissue: Liver EMBL AAF14008.1.
[3]Guttridge K., Dawson T.L., Earp H.S.
Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Fisher EMBL AAF14008.1.
Tissue: Liver EMBL AAF14008.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M37394 mRNA. Translation: AAF14008.1.
PIRA36325.
RefSeqNP_113695.1. NM_031507.1.
UniGeneRn.37227.

3D structure databases

ProteinModelPortalQ9QX70.
SMRQ9QX70. Positions 26-636, 670-1004.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-2658N.
IntActQ9QX70. 1 interaction.
MINTMINT-1509350.

PTM databases

PhosphoSiteQ9QX70.

Proteomic databases

PRIDEQ9QX70.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID24329.
KEGGrno:24329.

Organism-specific databases

CTD1956.
RGD2543. Egfr.

Phylogenomic databases

HOGENOMHOG000230982.
HOVERGENHBG000490.
InParanoidQ9QX70.
KOK04361.

Gene expression databases

GenevestigatorQ9QX70.

Family and domain databases

Gene3D3.80.20.20. 2 hits.
InterProIPR000494. EGF_rcpt_L.
IPR006211. Furin-like_Cys-rich_dom.
IPR006212. Furin_repeat.
IPR009030. Growth_fac_rcpt_N_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016245. Tyr_kinase_EGF/ERB/XmrK_rcpt.
[Graphical view]
PfamPF00757. Furin-like. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF01030. Recep_L_domain. 2 hits.
[Graphical view]
PIRSFPIRSF000619. TyrPK_EGF-R. 1 hit.
PRINTSPR00109. TYRKINASE.
SMARTSM00261. FU. 4 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio602999.

Entry information

Entry nameQ9QX70_RAT
AccessionPrimary (citable) accession number: Q9QX70
Entry history
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: June 11, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)