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Protein

LanC-like protein 1

Gene

Lancl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in EPS8 signaling. Binds glutathione (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi276 – 2761ZincBy similarity
Binding sitei317 – 3171GlutathioneBy similarity
Metal bindingi322 – 3221ZincBy similarity
Metal bindingi323 – 3231ZincBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
LanC-like protein 1
Alternative name(s):
40 kDa erythrocyte membrane protein
Short name:
p40
Gene namesi
Name:Lancl1
Synonyms:Gpr69a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi69416. Lancl1.

Subcellular locationi

  • Cytoplasm By similarity
  • Cell membrane By similarity; Peripheral membrane protein By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 399398LanC-like protein 1PRO_0000191270Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei142 – 1421N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9QX69.
PRIDEiQ9QX69.

PTM databases

iPTMnetiQ9QX69.

Expressioni

Tissue specificityi

Strongly expressed in the brain, testis and skeletal muscle. Expressed in the neurons of the cerebellum, the germinal cells of the seminiferous tubules in testis, in liver hepoatocytes and in cardiac myocytes.1 Publication

Gene expression databases

GenevisibleiQ9QX69. RN.

Interactioni

Subunit structurei

Interacts with the C-terminal of STOM. Interacts with the EPS8 SH3 domain. Interaction with EPS8 is inhibited by glutathione binding (By similarity).By similarity

Protein-protein interaction databases

BioGridi250361. 1 interaction.
IntActiQ9QX69. 1 interaction.
MINTiMINT-4567443.
STRINGi10116.ENSRNOP00000018293.

Structurei

3D structure databases

ProteinModelPortaliQ9QX69.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni364 – 3674Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the LanC-like protein family.Curated

Phylogenomic databases

eggNOGiKOG2787. Eukaryota.
ENOG410XQIA. LUCA.
GeneTreeiENSGT00530000063186.
HOGENOMiHOG000240926.
HOVERGENiHBG065387.
InParanoidiQ9QX69.
OMAiFAEWCLS.
OrthoDBiEOG71VSTN.
PhylomeDBiQ9QX69.
TreeFamiTF300068.

Family and domain databases

Gene3Di1.50.10.10. 1 hit.
InterProiIPR012341. 6hp_glycosidase.
IPR007822. LANC-like.
IPR020464. LanC-like_prot_euk.
[Graphical view]
PfamiPF05147. LANC_like. 1 hit.
[Graphical view]
PRINTSiPR01951. LANCEUKARYTE.
PR01950. LANCSUPER.
SMARTiSM01260. LANC_like. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QX69-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQRAFPNPY ADYNKSLAEN YFDSTGRLTP EFSHRLTNKI RELLQQMERG
60 70 80 90 100
LKSADPQDGT GYTGWAGIAV LYLHLHNVFG DPAYLQMAHS YVKHSLNCLS
110 120 130 140 150
RRSITFLCGD AGPLAVAAVL YHKMNSGKQA EDCITRLIHL NKIDPHVPNE
160 170 180 190 200
MLYGRIGYIF ALLFVNKNFG EEKIPQSHIQ QICETILTSG EKLSRKRNFT
210 220 230 240 250
TKSPLMYEWY QEYYVGAAHG LAGIYYYLMQ PSLHVSQGKL HSLVKPSVDF
260 270 280 290 300
VCQLKFPSGN YPSCLDDTRD LLVHWCHGAP GVIYMLIQAY KVFKEEHYLC
310 320 330 340 350
DAQQCADVIW QYGLLKKGYG LCHGAAGNAY AFLALYNLTQ DAKYLYRACK
360 370 380 390
FAEWCLDYGE HGCRTPDTPF SLFEGMAGTI YFLADLLVPT KAKFPAFEL
Length:399
Mass (Da):45,240
Last modified:December 1, 2001 - v2
Checksum:iF7D4968CB2CFE257
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ131111 mRNA. Translation: CAB63943.1.
AJ295233 mRNA. Translation: CAC16089.1.
BC085811 mRNA. Translation: AAH85811.1.
RefSeqiNP_446175.1. NM_053723.1.
UniGeneiRn.38972.

Genome annotation databases

EnsembliENSRNOT00000018293; ENSRNOP00000018293; ENSRNOG00000013557.
GeneIDi114515.
KEGGirno:114515.
UCSCiRGD:69416. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ131111 mRNA. Translation: CAB63943.1.
AJ295233 mRNA. Translation: CAC16089.1.
BC085811 mRNA. Translation: AAH85811.1.
RefSeqiNP_446175.1. NM_053723.1.
UniGeneiRn.38972.

3D structure databases

ProteinModelPortaliQ9QX69.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi250361. 1 interaction.
IntActiQ9QX69. 1 interaction.
MINTiMINT-4567443.
STRINGi10116.ENSRNOP00000018293.

PTM databases

iPTMnetiQ9QX69.

Proteomic databases

PaxDbiQ9QX69.
PRIDEiQ9QX69.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000018293; ENSRNOP00000018293; ENSRNOG00000013557.
GeneIDi114515.
KEGGirno:114515.
UCSCiRGD:69416. rat.

Organism-specific databases

CTDi10314.
RGDi69416. Lancl1.

Phylogenomic databases

eggNOGiKOG2787. Eukaryota.
ENOG410XQIA. LUCA.
GeneTreeiENSGT00530000063186.
HOGENOMiHOG000240926.
HOVERGENiHBG065387.
InParanoidiQ9QX69.
OMAiFAEWCLS.
OrthoDBiEOG71VSTN.
PhylomeDBiQ9QX69.
TreeFamiTF300068.

Miscellaneous databases

PROiQ9QX69.

Gene expression databases

GenevisibleiQ9QX69. RN.

Family and domain databases

Gene3Di1.50.10.10. 1 hit.
InterProiIPR012341. 6hp_glycosidase.
IPR007822. LANC-like.
IPR020464. LanC-like_prot_euk.
[Graphical view]
PfamiPF05147. LANC_like. 1 hit.
[Graphical view]
PRINTSiPR01951. LANCEUKARYTE.
PR01950. LANCSUPER.
SMARTiSM01260. LANC_like. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of p40/GPR69A as a peripheral membrane protein related to the lantibiotic synthetase component C."
    Bauer H., Mayer H., Marchler-Bauer A., Salzer U., Prohaska R.
    Biochem. Biophys. Res. Commun. 275:69-74(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Brain.
  2. "Characterization of rat LANCL1, a novel member of the lanthionine synthetase C-like protein family, highly expressed in testis and brain."
    Mayer H., Bauer H., Breuss J., Ziegler S., Prohaska R.
    Gene 269:73-80(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: Sprague-Dawley.
    Tissue: Brain.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiLANC1_RAT
AccessioniPrimary (citable) accession number: Q9QX69
Secondary accession number(s): Q9ER29
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.