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Protein

LanC-like protein 1

Gene

Lancl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in EPS8 signaling. Binds glutathione (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi276ZincBy similarity1
Binding sitei317GlutathioneBy similarity1
Metal bindingi322ZincBy similarity1
Metal bindingi323ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
LanC-like protein 1
Alternative name(s):
40 kDa erythrocyte membrane protein
Short name:
p40
Gene namesi
Name:Lancl1
Synonyms:Gpr69a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi69416 Lancl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001912702 – 399LanC-like protein 1Add BLAST398

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei142N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9QX69
PRIDEiQ9QX69

PTM databases

iPTMnetiQ9QX69
PhosphoSitePlusiQ9QX69

Expressioni

Tissue specificityi

Strongly expressed in the brain, testis and skeletal muscle. Expressed in the neurons of the cerebellum, the germinal cells of the seminiferous tubules in testis, in liver hepoatocytes and in cardiac myocytes.1 Publication

Gene expression databases

BgeeiENSRNOG00000013557
GenevisibleiQ9QX69 RN

Interactioni

Subunit structurei

Interacts with the C-terminal of STOM. Interacts with the EPS8 SH3 domain. Interaction with EPS8 is inhibited by glutathione binding (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi250361, 1 interactor
IntActiQ9QX69, 1 interactor
MINTiQ9QX69
STRINGi10116.ENSRNOP00000018293

Structurei

3D structure databases

ProteinModelPortaliQ9QX69
SMRiQ9QX69
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni364 – 367Glutathione bindingBy similarity4

Sequence similaritiesi

Belongs to the LanC-like protein family.Curated

Phylogenomic databases

eggNOGiKOG2787 Eukaryota
ENOG410XQIA LUCA
GeneTreeiENSGT00530000063186
HOGENOMiHOG000240926
HOVERGENiHBG065387
InParanoidiQ9QX69
OMAiNYPPCVD
OrthoDBiEOG091G02TS
PhylomeDBiQ9QX69
TreeFamiTF300068

Family and domain databases

CDDicd04794 euk_LANCL, 1 hit
Gene3Di1.50.10.10, 1 hit
InterProiView protein in InterPro
IPR012341 6hp_glycosidase-like_sf
IPR007822 LANC-like
IPR020464 LanC-like_prot_euk
PfamiView protein in Pfam
PF05147 LANC_like, 1 hit
PRINTSiPR01951 LANCEUKARYTE
PR01950 LANCSUPER
SMARTiView protein in SMART
SM01260 LANC_like, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QX69-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQRAFPNPY ADYNKSLAEN YFDSTGRLTP EFSHRLTNKI RELLQQMERG
60 70 80 90 100
LKSADPQDGT GYTGWAGIAV LYLHLHNVFG DPAYLQMAHS YVKHSLNCLS
110 120 130 140 150
RRSITFLCGD AGPLAVAAVL YHKMNSGKQA EDCITRLIHL NKIDPHVPNE
160 170 180 190 200
MLYGRIGYIF ALLFVNKNFG EEKIPQSHIQ QICETILTSG EKLSRKRNFT
210 220 230 240 250
TKSPLMYEWY QEYYVGAAHG LAGIYYYLMQ PSLHVSQGKL HSLVKPSVDF
260 270 280 290 300
VCQLKFPSGN YPSCLDDTRD LLVHWCHGAP GVIYMLIQAY KVFKEEHYLC
310 320 330 340 350
DAQQCADVIW QYGLLKKGYG LCHGAAGNAY AFLALYNLTQ DAKYLYRACK
360 370 380 390
FAEWCLDYGE HGCRTPDTPF SLFEGMAGTI YFLADLLVPT KAKFPAFEL
Length:399
Mass (Da):45,240
Last modified:December 1, 2001 - v2
Checksum:iF7D4968CB2CFE257
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ131111 mRNA Translation: CAB63943.1
AJ295233 mRNA Translation: CAC16089.1
BC085811 mRNA Translation: AAH85811.1
RefSeqiNP_446175.1, NM_053723.1
UniGeneiRn.38972

Genome annotation databases

EnsembliENSRNOT00000018293; ENSRNOP00000018293; ENSRNOG00000013557
GeneIDi114515
KEGGirno:114515
UCSCiRGD:69416 rat

Similar proteinsi

Entry informationi

Entry nameiLANC1_RAT
AccessioniPrimary (citable) accession number: Q9QX69
Secondary accession number(s): Q9ER29
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: December 1, 2001
Last modified: April 25, 2018
This is version 107 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health