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Protein

Death-associated protein 1

Gene

Dap

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis, Autophagy

Names & Taxonomyi

Protein namesi
Recommended name:
Death-associated protein 1
Short name:
DAP-1
Alternative name(s):
Rap7a
Gene namesi
Name:Dap
Synonyms:Rap7a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi620641. Dap.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000797842 – 102Death-associated protein 1Add BLAST101

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei3Phosphoserine; by MTORBy similarity1
Modified residuei29N6-acetyllysineBy similarity1
Modified residuei49PhosphoserineBy similarity1
Modified residuei51PhosphoserineCombined sources1
Modified residuei91PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated. Phosphorylation by MTOR inhibits the suppressive activity of DAP toward autophagy (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ9QX67.
PRIDEiQ9QX67.

PTM databases

iPTMnetiQ9QX67.
PhosphoSitePlusiQ9QX67.

Expressioni

Gene expression databases

BgeeiENSRNOG00000010747.
GenevisibleiQ9QX67. RN.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014439.

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IZ5N. Eukaryota.
ENOG41122SE. LUCA.
GeneTreeiENSGT00510000049345.
HOGENOMiHOG000039719.
HOVERGENiHBG005451.
InParanoidiQ9QX67.
OMAiVQKHPHS.
OrthoDBiEOG091G14AS.
PhylomeDBiQ9QX67.
TreeFamiTF329716.

Family and domain databases

InterProiView protein in InterPro
IPR024130. DAP1/DAPL1.
PANTHERiPTHR13177. PTHR13177. 1 hit.
PfamiView protein in Pfam
PF15228. DAP. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QX67-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSPPEGKLE TKAGHPPAVK VAGIRIVQKH PHTGDGKEKK DKDDQEWEST
60 70 80 90 100
SPPKPTVYIS GVIARGDKDF PPAAAQVAHQ KPHASMDKHV SPRTQHIQQP

RK
Length:102
Mass (Da):11,166
Last modified:January 23, 2007 - v3
Checksum:iF7DBC05D845DDC92
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U05334 mRNA. Translation: AAF21441.1.
BC060569 mRNA. Translation: AAH60569.1.
RefSeqiNP_071971.1. NM_022526.2.
UniGeneiRn.1531.

Genome annotation databases

EnsembliENSRNOT00000014439; ENSRNOP00000014439; ENSRNOG00000010747.
GeneIDi64322.
KEGGirno:64322.
UCSCiRGD:620641. rat.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiDAP1_RAT
AccessioniPrimary (citable) accession number: Q9QX67
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: January 23, 2007
Last modified: June 7, 2017
This is version 92 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome