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Protein

Death-associated protein 1

Gene

Dap

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis, Autophagy

Names & Taxonomyi

Protein namesi
Recommended name:
Death-associated protein 1
Short name:
DAP-1
Alternative name(s):
Rap7a
Gene namesi
Name:Dap
Synonyms:Rap7a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi620641. Dap.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 102101Death-associated protein 1PRO_0000079784Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei3 – 31Phosphoserine; by MTORBy similarity
Modified residuei29 – 291N6-acetyllysineBy similarity
Modified residuei49 – 491PhosphoserineBy similarity
Modified residuei51 – 511PhosphoserineCombined sources
Modified residuei91 – 911PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated. Phosphorylation by MTOR inhibits the suppressive activity of DAP toward autophagy (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ9QX67.
PRIDEiQ9QX67.

PTM databases

iPTMnetiQ9QX67.
PhosphoSiteiQ9QX67.

Expressioni

Gene expression databases

GenevisibleiQ9QX67. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014439.

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IZ5N. Eukaryota.
ENOG41122SE. LUCA.
GeneTreeiENSGT00510000049345.
HOGENOMiHOG000039719.
HOVERGENiHBG005451.
InParanoidiQ9QX67.
OMAiETRAGHP.
OrthoDBiEOG757D0J.
PhylomeDBiQ9QX67.
TreeFamiTF329716.

Family and domain databases

InterProiIPR024130. DAP1/DAPL1.
[Graphical view]
PANTHERiPTHR13177. PTHR13177. 1 hit.
PfamiPF15228. DAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QX67-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSPPEGKLE TKAGHPPAVK VAGIRIVQKH PHTGDGKEKK DKDDQEWEST
60 70 80 90 100
SPPKPTVYIS GVIARGDKDF PPAAAQVAHQ KPHASMDKHV SPRTQHIQQP

RK
Length:102
Mass (Da):11,166
Last modified:January 23, 2007 - v3
Checksum:iF7DBC05D845DDC92
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U05334 mRNA. Translation: AAF21441.1.
BC060569 mRNA. Translation: AAH60569.1.
RefSeqiNP_071971.1. NM_022526.2.
UniGeneiRn.1531.

Genome annotation databases

EnsembliENSRNOT00000014439; ENSRNOP00000014439; ENSRNOG00000010747.
GeneIDi64322.
KEGGirno:64322.
UCSCiRGD:620641. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U05334 mRNA. Translation: AAF21441.1.
BC060569 mRNA. Translation: AAH60569.1.
RefSeqiNP_071971.1. NM_022526.2.
UniGeneiRn.1531.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014439.

PTM databases

iPTMnetiQ9QX67.
PhosphoSiteiQ9QX67.

Proteomic databases

PaxDbiQ9QX67.
PRIDEiQ9QX67.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000014439; ENSRNOP00000014439; ENSRNOG00000010747.
GeneIDi64322.
KEGGirno:64322.
UCSCiRGD:620641. rat.

Organism-specific databases

CTDi1611.
RGDi620641. Dap.

Phylogenomic databases

eggNOGiENOG410IZ5N. Eukaryota.
ENOG41122SE. LUCA.
GeneTreeiENSGT00510000049345.
HOGENOMiHOG000039719.
HOVERGENiHBG005451.
InParanoidiQ9QX67.
OMAiETRAGHP.
OrthoDBiEOG757D0J.
PhylomeDBiQ9QX67.
TreeFamiTF329716.

Miscellaneous databases

PROiQ9QX67.

Gene expression databases

GenevisibleiQ9QX67. RN.

Family and domain databases

InterProiIPR024130. DAP1/DAPL1.
[Graphical view]
PANTHERiPTHR13177. PTHR13177. 1 hit.
PfamiPF15228. DAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Hartmann E., Goerlich D., Prehn S.
    Submitted (JAN-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary.
  3. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-51, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiDAP1_RAT
AccessioniPrimary (citable) accession number: Q9QX67
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: January 23, 2007
Last modified: June 8, 2016
This is version 85 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.