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Q9QX60

- DGUOK_MOUSE

UniProt

Q9QX60 - DGUOK_MOUSE

Protein

Deoxyguanosine kinase, mitochondrial

Gene

Dguok

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 3 (03 Oct 2012)
      Previous versions | rss
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    Functioni

    Required for the phosphorylation of several deoxyribonucleosides and certain nucleoside analogs widely employed as antiviral and chemotherapeutic agents.By similarity

    Catalytic activityi

    ATP + deoxyguanosine = ADP + dGMP.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei70 – 701SubstrateBy similarity
    Binding sitei100 – 1001SubstrateBy similarity
    Binding sitei111 – 1111SubstrateBy similarity
    Binding sitei118 – 1181SubstrateBy similarity
    Active sitei141 – 1411Proton acceptorSequence Analysis
    Binding sitei142 – 1421SubstrateBy similarity
    Binding sitei147 – 1471SubstrateBy similarity
    Binding sitei211 – 2111SubstrateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi45 – 539ATPBy similarity
    Nucleotide bindingi206 – 2083ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. deoxyguanosine kinase activity Source: MGI
    3. phosphotransferase activity, alcohol group as acceptor Source: InterPro

    GO - Biological processi

    1. deoxyribonucleoside monophosphate biosynthetic process Source: GOC
    2. dGTP metabolic process Source: MGI
    3. negative regulation of neuron projection development Source: Ensembl
    4. nucleobase-containing compound metabolic process Source: MGI
    5. protein phosphorylation Source: MGI
    6. purine deoxyribonucleoside metabolic process Source: Ensembl

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.1.113. 3474.
    SABIO-RKQ9QX60.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Deoxyguanosine kinase, mitochondrial (EC:2.7.1.113)
    Short name:
    dGK
    Gene namesi
    Name:Dguok
    Synonyms:Dgk
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:1351602. Dguok.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. cytosol Source: MGI
    3. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Cytoplasm, Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3939MitochondrionSequence AnalysisAdd
    BLAST
    Chaini40 – 277238Deoxyguanosine kinase, mitochondrialPRO_0000016841Add
    BLAST

    Proteomic databases

    MaxQBiQ9QX60.
    PaxDbiQ9QX60.
    PRIDEiQ9QX60.

    PTM databases

    PhosphoSiteiQ9QX60.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9QX60.
    CleanExiMM_DGUOK.
    GenevestigatoriQ9QX60.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    IntActiQ9QX60. 1 interaction.
    MINTiMINT-4114990.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QX60.
    SMRiQ9QX60. Positions 37-277.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DCK/DGK family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG1428.
    GeneTreeiENSGT00510000046588.
    HOGENOMiHOG000290165.
    HOVERGENiHBG006216.
    InParanoidiQ9QX60.
    KOiK00904.
    OMAiLLTKTYP.
    OrthoDBiEOG70PBZM.
    TreeFamiTF324413.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR002624. DNK.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR10513. PTHR10513. 1 hit.
    PfamiPF01712. dNK. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9QX60-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAGRFLLRR LRASFRSPLR NALVDAPHAR AMHDGGGPRR LCIEGNIAVG    50
    KSTFVKLLMK THPEWQVATE PIAEWQNIQA AGAQKDGTSK RLGNLLEMMY 100
    QEPARWSYTF QTLSFMSRLK VQLEPIPGRL LQAEKSVRVF ERSVYSDRYI 150
    FAKNLFENGS LSDIEWHIYQ DWHSFLLQEF ANRLLLHGFI YLQASPQVCM 200
    ERLYQRDREE EKGIELAYLQ QLHSQHEDWF INKTTKLHFE ALQHVPVLVL 250
    DVTEDFSENA ARQEELMGQV NTFMRNL 277
    Length:277
    Mass (Da):32,281
    Last modified:October 3, 2012 - v3
    Checksum:i021C3B3335510279
    GO
    Isoform 2 (identifier: Q9QX60-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-31: Missing.

    Show »
    Length:246
    Mass (Da):28,808
    Checksum:i0F9F79B219519A88
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti22 – 232AL → CF in AAF14342. 1 PublicationCurated
    Sequence conflicti74 – 741E → A in CAB43121. (PubMed:10455141)Curated
    Sequence conflicti74 – 741E → A in CAB43122. (PubMed:10455141)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 3131Missing in isoform 2. CuratedVSP_003027Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ133749 mRNA. Translation: CAB43121.1.
    AJ133750 mRNA. Translation: CAB43122.1.
    U90524 mRNA. Translation: AAF14342.1.
    AK035281 mRNA. Translation: BAC29014.1.
    AC090648 Genomic DNA. No translation available.
    CH466523 Genomic DNA. Translation: EDK99082.1.
    CCDSiCCDS20279.1. [Q9QX60-1]
    RefSeqiNP_038792.2. NM_013764.2. [Q9QX60-1]
    UniGeneiMm.42234.

    Genome annotation databases

    EnsembliENSMUST00000014698; ENSMUSP00000014698; ENSMUSG00000014554. [Q9QX60-1]
    GeneIDi27369.
    KEGGimmu:27369.
    UCSCiuc009cnn.2. mouse.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ133749 mRNA. Translation: CAB43121.1 .
    AJ133750 mRNA. Translation: CAB43122.1 .
    U90524 mRNA. Translation: AAF14342.1 .
    AK035281 mRNA. Translation: BAC29014.1 .
    AC090648 Genomic DNA. No translation available.
    CH466523 Genomic DNA. Translation: EDK99082.1 .
    CCDSi CCDS20279.1. [Q9QX60-1 ]
    RefSeqi NP_038792.2. NM_013764.2. [Q9QX60-1 ]
    UniGenei Mm.42234.

    3D structure databases

    ProteinModelPortali Q9QX60.
    SMRi Q9QX60. Positions 37-277.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9QX60. 1 interaction.
    MINTi MINT-4114990.

    PTM databases

    PhosphoSitei Q9QX60.

    Proteomic databases

    MaxQBi Q9QX60.
    PaxDbi Q9QX60.
    PRIDEi Q9QX60.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000014698 ; ENSMUSP00000014698 ; ENSMUSG00000014554 . [Q9QX60-1 ]
    GeneIDi 27369.
    KEGGi mmu:27369.
    UCSCi uc009cnn.2. mouse.

    Organism-specific databases

    CTDi 1716.
    MGIi MGI:1351602. Dguok.

    Phylogenomic databases

    eggNOGi COG1428.
    GeneTreei ENSGT00510000046588.
    HOGENOMi HOG000290165.
    HOVERGENi HBG006216.
    InParanoidi Q9QX60.
    KOi K00904.
    OMAi LLTKTYP.
    OrthoDBi EOG70PBZM.
    TreeFami TF324413.

    Enzyme and pathway databases

    BRENDAi 2.7.1.113. 3474.
    SABIO-RK Q9QX60.

    Miscellaneous databases

    NextBioi 305266.
    PROi Q9QX60.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9QX60.
    CleanExi MM_DGUOK.
    Genevestigatori Q9QX60.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR002624. DNK.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR10513. PTHR10513. 1 hit.
    Pfami PF01712. dNK. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of mouse deoxyguanosine kinase. Evidence for a cytoplasmic isoform."
      Petrakis T.G., Ktistaki E., Wang L., Eriksson S., Talianidis I.
      J. Biol. Chem. 274:24726-24730(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Spleen.
    2. "Cloning of mouse deoxyguanosine kinase cDNA."
      Johansson M., Holmdahl L., Karlsson A.
      Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Urinary bladder.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    5. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiDGUOK_MOUSE
    AccessioniPrimary (citable) accession number: Q9QX60
    Secondary accession number(s): Q8CBU2, Q9R0Y2, Q9WUT9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 103 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3