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Q9QX60

- DGUOK_MOUSE

UniProt

Q9QX60 - DGUOK_MOUSE

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Protein

Deoxyguanosine kinase, mitochondrial

Gene

Dguok

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Required for the phosphorylation of several deoxyribonucleosides and certain nucleoside analogs widely employed as antiviral and chemotherapeutic agents.By similarity

Catalytic activityi

ATP + deoxyguanosine = ADP + dGMP.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei70 – 701SubstrateBy similarity
Binding sitei100 – 1001SubstrateBy similarity
Binding sitei111 – 1111SubstrateBy similarity
Binding sitei118 – 1181SubstrateBy similarity
Active sitei141 – 1411Proton acceptorSequence Analysis
Binding sitei142 – 1421SubstrateBy similarity
Binding sitei147 – 1471SubstrateBy similarity
Binding sitei211 – 2111SubstrateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi45 – 539ATPBy similarity
Nucleotide bindingi206 – 2083ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. deoxyguanosine kinase activity Source: MGI

GO - Biological processi

  1. deoxyribonucleoside monophosphate biosynthetic process Source: GOC
  2. dGTP metabolic process Source: MGI
  3. negative regulation of neuron projection development Source: Ensembl
  4. nucleobase-containing compound metabolic process Source: MGI
  5. protein phosphorylation Source: MGI
  6. purine deoxyribonucleoside metabolic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.1.113. 3474.
ReactomeiREACT_244050. Purine salvage.
SABIO-RKQ9QX60.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyguanosine kinase, mitochondrial (EC:2.7.1.113)
Short name:
dGK
Gene namesi
Name:Dguok
Synonyms:Dgk
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:1351602. Dguok.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. cytosol Source: MGI
  3. mitochondrion Source: MGI
  4. nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3939MitochondrionSequence AnalysisAdd
BLAST
Chaini40 – 277238Deoxyguanosine kinase, mitochondrialPRO_0000016841Add
BLAST

Proteomic databases

MaxQBiQ9QX60.
PaxDbiQ9QX60.
PRIDEiQ9QX60.

PTM databases

PhosphoSiteiQ9QX60.

Expressioni

Gene expression databases

CleanExiMM_DGUOK.
ExpressionAtlasiQ9QX60. baseline and differential.
GenevestigatoriQ9QX60.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiQ9QX60. 1 interaction.
MINTiMINT-4114990.

Structurei

3D structure databases

ProteinModelPortaliQ9QX60.
SMRiQ9QX60. Positions 37-277.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DCK/DGK family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1428.
GeneTreeiENSGT00510000046588.
HOGENOMiHOG000290165.
HOVERGENiHBG006216.
InParanoidiQ9QX60.
KOiK00904.
OMAiLLTKTYP.
OrthoDBiEOG70PBZM.
TreeFamiTF324413.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR002624. DNK.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10513. PTHR10513. 1 hit.
PfamiPF01712. dNK. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9QX60-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAGRFLLRR LRASFRSPLR NALVDAPHAR AMHDGGGPRR LCIEGNIAVG
60 70 80 90 100
KSTFVKLLMK THPEWQVATE PIAEWQNIQA AGAQKDGTSK RLGNLLEMMY
110 120 130 140 150
QEPARWSYTF QTLSFMSRLK VQLEPIPGRL LQAEKSVRVF ERSVYSDRYI
160 170 180 190 200
FAKNLFENGS LSDIEWHIYQ DWHSFLLQEF ANRLLLHGFI YLQASPQVCM
210 220 230 240 250
ERLYQRDREE EKGIELAYLQ QLHSQHEDWF INKTTKLHFE ALQHVPVLVL
260 270
DVTEDFSENA ARQEELMGQV NTFMRNL
Length:277
Mass (Da):32,281
Last modified:October 3, 2012 - v3
Checksum:i021C3B3335510279
GO
Isoform 2 (identifier: Q9QX60-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-31: Missing.

Show »
Length:246
Mass (Da):28,808
Checksum:i0F9F79B219519A88
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti22 – 232AL → CF in AAF14342. 1 PublicationCurated
Sequence conflicti74 – 741E → A in CAB43121. (PubMed:10455141)Curated
Sequence conflicti74 – 741E → A in CAB43122. (PubMed:10455141)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3131Missing in isoform 2. CuratedVSP_003027Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ133749 mRNA. Translation: CAB43121.1.
AJ133750 mRNA. Translation: CAB43122.1.
U90524 mRNA. Translation: AAF14342.1.
AK035281 mRNA. Translation: BAC29014.1.
AC090648 Genomic DNA. No translation available.
CH466523 Genomic DNA. Translation: EDK99082.1.
CCDSiCCDS20279.1. [Q9QX60-1]
RefSeqiNP_038792.2. NM_013764.2. [Q9QX60-1]
UniGeneiMm.42234.

Genome annotation databases

EnsembliENSMUST00000014698; ENSMUSP00000014698; ENSMUSG00000014554. [Q9QX60-1]
GeneIDi27369.
KEGGimmu:27369.
UCSCiuc009cnn.2. mouse.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ133749 mRNA. Translation: CAB43121.1 .
AJ133750 mRNA. Translation: CAB43122.1 .
U90524 mRNA. Translation: AAF14342.1 .
AK035281 mRNA. Translation: BAC29014.1 .
AC090648 Genomic DNA. No translation available.
CH466523 Genomic DNA. Translation: EDK99082.1 .
CCDSi CCDS20279.1. [Q9QX60-1 ]
RefSeqi NP_038792.2. NM_013764.2. [Q9QX60-1 ]
UniGenei Mm.42234.

3D structure databases

ProteinModelPortali Q9QX60.
SMRi Q9QX60. Positions 37-277.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9QX60. 1 interaction.
MINTi MINT-4114990.

PTM databases

PhosphoSitei Q9QX60.

Proteomic databases

MaxQBi Q9QX60.
PaxDbi Q9QX60.
PRIDEi Q9QX60.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000014698 ; ENSMUSP00000014698 ; ENSMUSG00000014554 . [Q9QX60-1 ]
GeneIDi 27369.
KEGGi mmu:27369.
UCSCi uc009cnn.2. mouse.

Organism-specific databases

CTDi 1716.
MGIi MGI:1351602. Dguok.

Phylogenomic databases

eggNOGi COG1428.
GeneTreei ENSGT00510000046588.
HOGENOMi HOG000290165.
HOVERGENi HBG006216.
InParanoidi Q9QX60.
KOi K00904.
OMAi LLTKTYP.
OrthoDBi EOG70PBZM.
TreeFami TF324413.

Enzyme and pathway databases

BRENDAi 2.7.1.113. 3474.
Reactomei REACT_244050. Purine salvage.
SABIO-RK Q9QX60.

Miscellaneous databases

NextBioi 305266.
PROi Q9QX60.
SOURCEi Search...

Gene expression databases

CleanExi MM_DGUOK.
ExpressionAtlasi Q9QX60. baseline and differential.
Genevestigatori Q9QX60.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR002624. DNK.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR10513. PTHR10513. 1 hit.
Pfami PF01712. dNK. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of mouse deoxyguanosine kinase. Evidence for a cytoplasmic isoform."
    Petrakis T.G., Ktistaki E., Wang L., Eriksson S., Talianidis I.
    J. Biol. Chem. 274:24726-24730(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Spleen.
  2. "Cloning of mouse deoxyguanosine kinase cDNA."
    Johansson M., Holmdahl L., Karlsson A.
    Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Urinary bladder.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiDGUOK_MOUSE
AccessioniPrimary (citable) accession number: Q9QX60
Secondary accession number(s): Q8CBU2, Q9R0Y2, Q9WUT9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: October 3, 2012
Last modified: November 26, 2014
This is version 105 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3