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Q9QX60 (DGUOK_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Deoxyguanosine kinase, mitochondrial

Short name=dGK
EC=2.7.1.113
Gene names
Name:Dguok
Synonyms:Dgk
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length277 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Required for the phosphorylation of several deoxyribonucleosides and certain nucleoside analogs widely employed as antiviral and chemotherapeutic agents By similarity.

Catalytic activity

ATP + deoxyguanosine = ADP + dGMP.

Subunit structure

Homodimer By similarity.

Subcellular location

Isoform 1: Mitochondrion.

Isoform 2: Cytoplasm.

Sequence similarities

Belongs to the DCK/DGK family.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9QX60-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9QX60-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-31: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 3939Mitochondrion Potential
Chain40 – 277238Deoxyguanosine kinase, mitochondrial
PRO_0000016841

Regions

Nucleotide binding45 – 539ATP By similarity
Nucleotide binding206 – 2083ATP By similarity

Sites

Active site1411Proton acceptor Potential
Binding site701Substrate By similarity
Binding site1001Substrate By similarity
Binding site1111Substrate By similarity
Binding site1181Substrate By similarity
Binding site1421Substrate By similarity
Binding site1471Substrate By similarity
Binding site2111Substrate By similarity

Natural variations

Alternative sequence1 – 3131Missing in isoform 2.
VSP_003027

Experimental info

Sequence conflict22 – 232AL → CF in AAF14342. Ref.2
Sequence conflict741E → A in CAB43121. Ref.1
Sequence conflict741E → A in CAB43122. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 3, 2012. Version 3.
Checksum: 021C3B3335510279

FASTA27732,281
        10         20         30         40         50         60 
MAAGRFLLRR LRASFRSPLR NALVDAPHAR AMHDGGGPRR LCIEGNIAVG KSTFVKLLMK 

        70         80         90        100        110        120 
THPEWQVATE PIAEWQNIQA AGAQKDGTSK RLGNLLEMMY QEPARWSYTF QTLSFMSRLK 

       130        140        150        160        170        180 
VQLEPIPGRL LQAEKSVRVF ERSVYSDRYI FAKNLFENGS LSDIEWHIYQ DWHSFLLQEF 

       190        200        210        220        230        240 
ANRLLLHGFI YLQASPQVCM ERLYQRDREE EKGIELAYLQ QLHSQHEDWF INKTTKLHFE 

       250        260        270 
ALQHVPVLVL DVTEDFSENA ARQEELMGQV NTFMRNL 

« Hide

Isoform 2 [UniParc].

Checksum: 0F9F79B219519A88
Show »

FASTA24628,808

References

« Hide 'large scale' references
[1]"Cloning and characterization of mouse deoxyguanosine kinase. Evidence for a cytoplasmic isoform."
Petrakis T.G., Ktistaki E., Wang L., Eriksson S., Talianidis I.
J. Biol. Chem. 274:24726-24730(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Spleen.
[2]"Cloning of mouse deoxyguanosine kinase cDNA."
Johansson M., Holmdahl L., Karlsson A.
Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Urinary bladder.
[4]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[5]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ133749 mRNA. Translation: CAB43121.1.
AJ133750 mRNA. Translation: CAB43122.1.
U90524 mRNA. Translation: AAF14342.1.
AK035281 mRNA. Translation: BAC29014.1.
AC090648 Genomic DNA. No translation available.
CH466523 Genomic DNA. Translation: EDK99082.1.
CCDSCCDS20279.1. [Q9QX60-1]
RefSeqNP_038792.2. NM_013764.2. [Q9QX60-1]
UniGeneMm.42234.

3D structure databases

ProteinModelPortalQ9QX60.
SMRQ9QX60. Positions 37-277.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9QX60. 1 interaction.
MINTMINT-4114990.

PTM databases

PhosphoSiteQ9QX60.

Proteomic databases

MaxQBQ9QX60.
PaxDbQ9QX60.
PRIDEQ9QX60.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000014698; ENSMUSP00000014698; ENSMUSG00000014554. [Q9QX60-1]
GeneID27369.
KEGGmmu:27369.
UCSCuc009cnn.2. mouse.

Organism-specific databases

CTD1716.
MGIMGI:1351602. Dguok.

Phylogenomic databases

eggNOGCOG1428.
GeneTreeENSGT00510000046588.
HOGENOMHOG000290165.
HOVERGENHBG006216.
InParanoidQ9QX60.
KOK00904.
OMALLTKTYP.
OrthoDBEOG70PBZM.
TreeFamTF324413.

Enzyme and pathway databases

BRENDA2.7.1.113. 3474.
SABIO-RKQ9QX60.

Gene expression databases

ArrayExpressQ9QX60.
CleanExMM_DGUOK.
GenevestigatorQ9QX60.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR002624. Deoxynucleoside_kinase.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERPTHR10513. PTHR10513. 1 hit.
PfamPF01712. dNK. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
ProtoNetSearch...

Other

NextBio305266.
PROQ9QX60.
SOURCESearch...

Entry information

Entry nameDGUOK_MOUSE
AccessionPrimary (citable) accession number: Q9QX60
Secondary accession number(s): Q8CBU2, Q9R0Y2, Q9WUT9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: October 3, 2012
Last modified: July 9, 2014
This is version 101 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot