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Q9QX47 (SON_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein SON
Alternative name(s):
Negative regulatory element-binding protein
Short name=NRE-binding protein
Gene names
Name:Son
Synonyms:Nrebp
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length2444 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3' By similarity. May also regulate the ghrelin signaling in hypothalamic neuron by acting as a negative regulator of GHSR expression. Ref.2

Subunit structure

Interacts with SRSF2. Associates with the spliceosome By similarity.

Subcellular location

Nucleus speckle By similarity. Note: Colocalizes with the pre-mRNA splicing factor SRSF2 By similarity. Ref.1

Tissue specificity

Widely expressed. Highly expressed in brain, heart, spleen, liver, skeletal muscle, kidney and testis. Ref.2

Induction

By leptin. Highly expressed in hypothalamus following leptin injection. Ref.2

Domain

Contains 8 types of repeats which are distributed in 3 regions.

Sequence similarities

Contains 1 DRBM (double-stranded RNA-binding) domain.

Contains 1 G-patch domain.

Sequence caution

The sequence AAH46419.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

Ontologies

Keywords
   Biological processCell cycle
mRNA processing
mRNA splicing
Transcription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
   DomainRepeat
   LigandDNA-binding
RNA-binding
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processRNA splicing

Inferred from electronic annotation. Source: UniProtKB-KW

cytokinesis

Inferred from sequence or structural similarity. Source: UniProtKB

mRNA processing

Inferred from sequence or structural similarity. Source: UniProtKB

microtubule cytoskeleton organization

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

regulation of RNA splicing

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of cell cycle

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnuclear speck

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

RNA binding

Inferred from sequence or structural similarity. Source: UniProtKB

RS domain binding

Inferred from physical interaction PubMed 15798186. Source: MGI

Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9QX47-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9QX47-2)

The sequence of this isoform differs from the canonical sequence as follows:
     2126-2126: K → F
     2127-2444: Missing.
Isoform 3 (identifier: Q9QX47-3)

The sequence of this isoform differs from the canonical sequence as follows:
     776-815: Missing.
Isoform 4 (identifier: Q9QX47-4)

The sequence of this isoform differs from the canonical sequence as follows:
     776-815: Missing.
     2238-2444: PVDISTAMSE...PNCMFFLNRY → GRVKRQGRVK...SRLYSSRFWW

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 24442443Protein SON
PRO_0000072038

Regions

Repeat1001 – 100661-1
Repeat1009 – 101461-2
Repeat1016 – 102161-3
Repeat1025 – 103061-4
Repeat1033 – 103861-5
Repeat1041 – 104661-6
Repeat1050 – 105561-7
Repeat1058 – 106361-8
Repeat1066 – 107161-9
Repeat1075 – 108061-10
Repeat1084 – 108961-11
Repeat1095 – 110061-12
Repeat1106 – 111161-13
Repeat1115 – 112061-14
Repeat1950 – 195672-1
Repeat1959 – 1977193-1
Repeat1978 – 198472-2
Repeat1985 – 199172-3
Repeat1992 – 199872-4
Repeat1999 – 200572-5
Repeat2006 – 201272-6
Repeat2013 – 201972-7; approximate
Repeat2020 – 2030113-2; approximate
Domain2323 – 236947G-patch
Domain2389 – 244456DRBM
Region721 – 85013013 X 10 AA tandem repeats of L-A-[ST]-[NSG]-[TS]-MDSQM
Region907 – 9837711 X 7 AA tandem repeats of [DR]-P-Y-R-[LI][AG][QHP]
Region1001 – 112012014 X 6 AA repeats of [ED]-R-S-M-M-S
Region1141 – 1173333 X 11 AA tandem repats of P-P-L-P-P-E-E-P-P-[TME]-[MTG]
Region1950 – 2019707 X 7 AA repeats of P-S-R-R-S-R-[TS]
Region1959 – 2030722 X 19 AA repeats of P-S-R-R-R-R-S-R-S-V-V-R-R-R-S-F-S-I-S
Region2031 – 2057273 X tandem repeats of [ST]-P-[VLI]-R-[RL]-[RK]-[RF]-S-R

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue161N6-acetyllysine By similarity
Modified residue941Phosphoserine By similarity
Modified residue1421Phosphoserine By similarity
Modified residue1501Phosphoserine By similarity
Modified residue1521Phosphoserine By similarity
Modified residue1581Phosphoserine By similarity
Modified residue2841N6-acetyllysine By similarity
Modified residue17231Phosphoserine Ref.6 Ref.7
Modified residue17941Phosphoserine By similarity
Modified residue18081Phosphoserine By similarity
Modified residue19731Phosphoserine By similarity
Modified residue19751Phosphoserine By similarity
Modified residue20271Phosphoserine By similarity
Modified residue20291Phosphoserine By similarity
Modified residue20311Phosphoserine By similarity
Modified residue20731N6-acetyllysine Ref.8
Modified residue21811Phosphothreonine By similarity

Natural variations

Alternative sequence776 – 81540Missing in isoform 3 and isoform 4.
VSP_041557
Alternative sequence21261K → F in isoform 2.
VSP_004416
Alternative sequence2127 – 2444318Missing in isoform 2.
VSP_004417
Alternative sequence2238 – 2444207PVDIS…FLNRY → GRVKRQGRVKRQMKQPAASH LTVTRCNSLCGTKPQSEKHR IAEKSVITSLPNIGPSMHLW EGSPRYNYLASRFASRLYSS RFWW in isoform 4.
VSP_041558

Experimental info

Sequence conflict8571D → E in AAF23120. Ref.1
Sequence conflict8571D → E in AAF23121. Ref.1
Sequence conflict8571D → E in BAJ40169. Ref.2
Sequence conflict13331N → D in AAF23120. Ref.1
Sequence conflict13331N → D in AAF23121. Ref.1
Sequence conflict17341P → L in AAF23120. Ref.1
Sequence conflict17341P → L in AAF23121. Ref.1
Sequence conflict19661R → I in AAF23120. Ref.1
Sequence conflict19661R → I in AAF23121. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 28, 2011. Version 2.
Checksum: E873ADCB51B7123B

FASTA2,444265,651
        10         20         30         40         50         60 
MAADIEQVFR SFVVSKFREI QQELSSGRSE GQLNGETNPP IEGNQAGDTA ASARSLPNEE 

        70         80         90        100        110        120 
IVQKIEEVLS GVLDTELRYK PDLKEASRKS RCVSVQTDPT DEVPTKKSKK HKKHKNKKKK 

       130        140        150        160        170        180 
KKKEKEKKYK RQPEESESKL KSHHDGNLES DSFLKFDSEP SAAALEHPVR AFGLSEASET 

       190        200        210        220        230        240 
ALVLEPPVVS MEVQESHVLE TLKPATKAAE LSVVSTSVIS EQSEQPMPGM LEPSMTKILD 

       250        260        270        280        290        300 
SFTAAPVPMS TAALKSPEPV VTMSVEYQKS VLKSLETMPP ETSKTTLVEL PIAKVVEPSE 

       310        320        330        340        350        360 
TLTIVSETPT EVHPEPSPST MDFPESSTTD VQRLPEQPVE APSEIADSSM TRPQESLELP 

       370        380        390        400        410        420 
KTTAVELQES TVASALELPG PPATSILELQ GPPVTPVPEL PGPSATPVPE LSGPLSTPVP 

       430        440        450        460        470        480 
ELPGPPATVV PELPGPSVTP VPQLSQELPG PPAPSMGLEP PQEVPEPPVM AQELSGVPAV 

       490        500        510        520        530        540 
SAAIELTGQP AVTVAMELTE QPVTTTEFEQ PVAMTTVEHP GHPEVTTATG LLGQPEAAMV 

       550        560        570        580        590        600 
LELPGQPVAT TALELSGQPS VTGVPELSGL PSATRALELS GQSVATGALE LPGQLMATGA 

       610        620        630        640        650        660 
LEFSGQSGAA GALELLGQPL ATGVLELPGQ PGAPELPGQP VATVALEISV QSVVTTSELS 

       670        680        690        700        710        720 
TMTVSQSLEV PSTTALESYN TVAQELPTTL VGETSVTVGV DPLMAQESHM LASNTMETHM 

       730        740        750        760        770        780 
LASNTMDSQM LASNTMDSQM LASNTMDSQM LASSTMDSQM LASSTMDSQM LATSTMDSQM 

       790        800        810        820        830        840 
LATSSMDSQM LATSSMDSQM LATSSMDSQM LATSSMDSQM LATSSMDSQM LATSSMDSQM 

       850        860        870        880        890        900 
LATSSMDSQM LATSSMDSQM LASGAMDSQM LASGTMDAQM LASGTMDAQM LASSTQDSAM 

       910        920        930        940        950        960 
MGSKSPDPYR LAQDPYRLAQ DPYRLGHDPY RLGHDAYRLG QDPYRLGHDP YRLTPDPYRV 

       970        980        990       1000       1010       1020 
SPRPYRIAPR SYRIAPRPYR LAPRPLMLAS RRSMMMSYAA ERSMMSSYER SMMSYERSMM 

      1030       1040       1050       1060       1070       1080 
SPMAERSMMS AYERSMMSAY ERSMMSPMAE RSMMSAYERS MMSAYERSMM SPMADRSMMS 

      1090       1100       1110       1120       1130       1140 
MGADRSMMSS YSAADRSMMS SYSAADRSMM SSYTDRSMMS MAADSYTDSY TDSYTEAYMV 

      1150       1160       1170       1180       1190       1200 
PPLPPEEPPT MPPLPPEEPP MTPPLPPEEP PEGPALSTEQ SALTADNTWS TEVTLSTGES 

      1210       1220       1230       1240       1250       1260 
LSQPEPPVSQ SEISEPMAVP ANYSMSESET SMLASEAVMT VPEPAREPES SVTSAPVESA 

      1270       1280       1290       1300       1310       1320 
VVAEHEMVPE RPMTYMVSET TMSVEPAVLT SEASVISETS ETYDSMRPSG HAISEVTMSL 

      1330       1340       1350       1360       1370       1380 
LEPAVTISQP AENSLELPSM TVPAPSTMTT TESPVVAVTE IPPVAVPEPP IMAVPELPTM 

      1390       1400       1410       1420       1430       1440 
AVVKTPAVAV PEPLVAAPEP PTMATPELCS LSVSEPPVAV SELPALADPE HAITAVSGVS 

      1450       1460       1470       1480       1490       1500 
SLEPSVPILE PAVSVLQPVM IVSEPSVPVQ EPTVAVSEPA VIVSEHTQIT SPEMAVESSP 

      1510       1520       1530       1540       1550       1560 
VIVDSSVMSS QIMKGMNLLG GDENLGPEVG MQETLLHPGE EPRDGGHLKS DLYENEYDRN 

      1570       1580       1590       1600       1610       1620 
ADLTVNSHLI VKDAEHNTVC ATTVGPVGEA SEEKILPISE TKEITELATC AAVSEADIGR 

      1630       1640       1650       1660       1670       1680 
SLSSQLALEL DTVGTSKGFE FVTASALISE SKYDVEVSVT TQDTEHDMVI STSPSGGSEA 

      1690       1700       1710       1720       1730       1740 
DIEGPLPAKD IHLDLPSTNF VCKDVEDSLP IKESAQAVAV ALSPKESSED TEVPLPNKEI 

      1750       1760       1770       1780       1790       1800 
VPESGYSASI DEINEADLVR PLLPKDMERL TSLRAGIEGP LLASEVERDK SAASPVVISI 

      1810       1820       1830       1840       1850       1860 
PERASESSSE EKDDYEIFVK VKDTHEKSKK NKNRDKGEKE KKRDSSLRSR SKRSKSSEHK 

      1870       1880       1890       1900       1910       1920 
SRKRTSESRS RARKRSSKSK SHRSQTRSRS RSRRRRRSSR SRSKSRGRRS VSKEKRKRSP 

      1930       1940       1950       1960       1970       1980 
KHRSKSRERK RKRSSSRDNR KAARARSRTP SRRSRSHTPS RRRRSRSVGR RRSFSISPSR 

      1990       2000       2010       2020       2030       2040 
RSRTPSRRSR TPSRRSRTPS RRSRTPSRRS RTPSRRRRSR SAVRRRSFSI SPVRLRRSRT 

      2050       2060       2070       2080       2090       2100 
PLRRRFSRSP IRRKRSRSSE RGRSPKRLTD LDKAQLLEIA KANAAAMCAK AGVPLPPNLK 

      2110       2120       2130       2140       2150       2160 
PAPPPTIEEK VAKKSGGATI EELTEKCKQI AQSKEDDDVI VNKPHVSDEE EEEPPFYHHP 

      2170       2180       2190       2200       2210       2220 
FKLSEPKPIF FNLNIAAAKP TPPKSQVTLT KEFPVSSGSQ HRKKEADSVY GEWVPVEKNG 

      2230       2240       2250       2260       2270       2280 
EESKDDDNVF SSSLPSEPVD ISTAMSERAL AQKRLSENAF DLEAMSMLNR AQERIDAWAQ 

      2290       2300       2310       2320       2330       2340 
LNSIPGQFTG STGVQVLTQE QLANTGAQAW IKKDQFLRAA PVTGGMGAVL MRKMGWREGE 

      2350       2360       2370       2380       2390       2400 
GLGKNKEGNK EPILVDFKTD RKGLVAVGER AQKRSGNFSA AMKDLSGKHP VSALMEICNK 

      2410       2420       2430       2440 
RRWQPPEFLL VHDSGPDHRK HFLFRVLRNG SPYQPNCMFF LNRY 

« Hide

Isoform 2 [UniParc].

Checksum: D977785966267327
Show »

FASTA2,126230,022
Isoform 3 [UniParc].

Checksum: 6163EBD3D5E8FB95
Show »

FASTA2,404261,443
Isoform 4 [UniParc].

Checksum: 10ABA0C4E10F6C03
Show »

FASTA2,281247,971

References

« Hide 'large scale' references
[1]"Organization and conservation of the GART/SON/DONSON locus in mouse and human genomes."
Wynn S.L., Fisher R.A., Pagel C., Price M., Liu Q.Y., Khan I.M., Zammit P., Dadrah K., Mazrani W., Kessling A., Lee J.S., Buluwela L.
Genomics 68:57-62(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 2 AND 3), NUCLEOTIDE SEQUENCE [MRNA] OF 1-2125 (ISOFORM 3), SUBCELLULAR LOCATION.
Strain: 129/Sv.
[2]"Regulation of ghrelin signaling by a leptin-induced gene, negative regulatory element-binding protein, in the hypothalamic neurons."
Komori T., Doi A., Furuta H., Wakao H., Nakao N., Nakazato M., Nanjo K., Senba E., Morikawa Y.
J. Biol. Chem. 285:37884-37894(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), FUNCTION, TISSUE SPECIFICITY, INDUCTION.
[3]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1827 (ISOFORM 1).
Strain: FVB/N.
Tissue: Kidney.
[5]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-116.
Strain: C57BL/6J.
Tissue: Hippocampus, Small intestine and Tongue.
[6]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1723, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
[7]"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1723, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-2073, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic fibroblast.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF193606 expand/collapse EMBL AC list , AF193595, AF193596, AF193597, AF193598, AF193599, AF193600, AF193601, AF193602, AF193603, AF193604, AF193605 Genomic DNA. Translation: AAF23120.1.
AF193607 mRNA. Translation: AAF23121.1.
AB546195 mRNA. Translation: BAJ40169.1.
AC131691 Genomic DNA. No translation available.
BC046419 mRNA. Translation: AAH46419.1. Sequence problems.
AK019312 mRNA. Translation: BAB31659.1.
AK019081 mRNA. Translation: BAB31536.1.
AK008478 mRNA. Translation: BAB25691.1.
AK008256 mRNA. Translation: BAB25562.1.
RefSeqNP_849211.3. NM_178880.4.
UniGeneMm.46401.
Mm.491378.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9QX47. 6 interactions.
MINTMINT-1713045.

PTM databases

PhosphoSiteQ9QX47.

Proteomic databases

PaxDbQ9QX47.
PRIDEQ9QX47.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000114036; ENSMUSP00000109670; ENSMUSG00000022961. [Q9QX47-2]
ENSMUST00000114037; ENSMUSP00000109671; ENSMUSG00000022961. [Q9QX47-1]
GeneID20658.
KEGGmmu:20658.
UCSCuc007zxy.1. mouse. [Q9QX47-2]
uc007zxz.1. mouse. [Q9QX47-1]
uc012aii.1. mouse. [Q9QX47-4]

Organism-specific databases

CTD6651.
MGIMGI:98353. Son.

Phylogenomic databases

eggNOGNOG84537.
GeneTreeENSGT00730000111141.
HOVERGENHBG023160.
InParanoidQ811G3.
TreeFamTF330344.

Gene expression databases

ArrayExpressQ9QX47.
BgeeQ9QX47.
CleanExMM_SON.
GenevestigatorQ9QX47.

Family and domain databases

Gene3D3.30.160.20. 1 hit.
InterProIPR014720. dsRNA-bd_dom.
IPR000467. G_patch_dom.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamPF01585. G-patch. 1 hit.
[Graphical view]
SMARTSM00443. G_patch. 1 hit.
[Graphical view]
SUPFAMSSF50978. SSF50978. 1 hit.
PROSITEPS50137. DS_RBD. 1 hit.
PS50174. G_PATCH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSON. mouse.
NextBio299093.
PROQ9QX47.
SOURCESearch...

Entry information

Entry nameSON_MOUSE
AccessionPrimary (citable) accession number: Q9QX47
Secondary accession number(s): E3WC91 expand/collapse secondary AC list , E9PXW2, E9Q3H8, E9Q3I0, E9Q6M4, E9Q7G2, E9QAR8, E9QMT0, Q811G3, Q9CQ12, Q9CQK6, Q9QXP5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: June 28, 2011
Last modified: April 16, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot