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Q9QX47

- SON_MOUSE

UniProt

Q9QX47 - SON_MOUSE

Protein

Protein SON

Gene

Son

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 2 (28 Jun 2011)
      Previous versions | rss
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    Functioni

    RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3' By similarity. May also regulate the ghrelin signaling in hypothalamic neuron by acting as a negative regulator of GHSR expression.By similarity1 Publication

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. protein binding Source: MGI
    3. RNA binding Source: UniProtKB
    4. RS domain binding Source: MGI

    GO - Biological processi

    1. cytokinesis Source: UniProtKB
    2. microtubule cytoskeleton organization Source: UniProtKB
    3. mRNA processing Source: UniProtKB
    4. negative regulation of apoptotic process Source: Ensembl
    5. regulation of cell cycle Source: UniProtKB
    6. regulation of RNA splicing Source: UniProtKB
    7. regulation of transcription, DNA-templated Source: UniProtKB-KW
    8. RNA splicing Source: UniProtKB-KW
    9. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Cell cycle, mRNA processing, mRNA splicing, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein SON
    Alternative name(s):
    Negative regulatory element-binding protein
    Short name:
    NRE-binding protein
    Gene namesi
    Name:Son
    Synonyms:Nrebp
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:98353. Son.

    Subcellular locationi

    Nucleus speckle By similarity
    Note: Colocalizes with the pre-mRNA splicing factor SRSF2.By similarity

    GO - Cellular componenti

    1. nuclear speck Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 24442443Protein SONPRO_0000072038Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei16 – 161N6-acetyllysineBy similarity
    Modified residuei94 – 941PhosphoserineBy similarity
    Modified residuei142 – 1421PhosphoserineBy similarity
    Modified residuei150 – 1501PhosphoserineBy similarity
    Modified residuei152 – 1521PhosphoserineBy similarity
    Modified residuei158 – 1581PhosphoserineBy similarity
    Modified residuei284 – 2841N6-acetyllysineBy similarity
    Modified residuei1723 – 17231Phosphoserine2 Publications
    Modified residuei1794 – 17941PhosphoserineBy similarity
    Modified residuei1808 – 18081PhosphoserineBy similarity
    Modified residuei1973 – 19731PhosphoserineBy similarity
    Modified residuei1975 – 19751PhosphoserineBy similarity
    Modified residuei2027 – 20271PhosphoserineBy similarity
    Modified residuei2029 – 20291PhosphoserineBy similarity
    Modified residuei2031 – 20311PhosphoserineBy similarity
    Modified residuei2073 – 20731N6-acetyllysine1 Publication
    Modified residuei2181 – 21811PhosphothreonineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9QX47.
    PaxDbiQ9QX47.
    PRIDEiQ9QX47.

    PTM databases

    PhosphoSiteiQ9QX47.

    Expressioni

    Tissue specificityi

    Widely expressed. Highly expressed in brain, heart, spleen, liver, skeletal muscle, kidney and testis.1 Publication

    Inductioni

    By leptin. Highly expressed in hypothalamus following leptin injection.1 Publication

    Gene expression databases

    ArrayExpressiQ9QX47.
    BgeeiQ9QX47.
    CleanExiMM_SON.
    GenevestigatoriQ9QX47.

    Interactioni

    Subunit structurei

    Interacts with SRSF2. Associates with the spliceosome By similarity.By similarity

    Protein-protein interaction databases

    BioGridi203390. 1 interaction.
    DIPiDIP-49510N.
    IntActiQ9QX47. 6 interactions.
    MINTiMINT-1713045.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati1001 – 100661-1
    Repeati1009 – 101461-2
    Repeati1016 – 102161-3
    Repeati1025 – 103061-4
    Repeati1033 – 103861-5
    Repeati1041 – 104661-6
    Repeati1050 – 105561-7
    Repeati1058 – 106361-8
    Repeati1066 – 107161-9
    Repeati1075 – 108061-10
    Repeati1084 – 108961-11
    Repeati1095 – 110061-12
    Repeati1106 – 111161-13
    Repeati1115 – 112061-14
    Repeati1950 – 195672-1
    Repeati1959 – 1977193-1Add
    BLAST
    Repeati1978 – 198472-2
    Repeati1985 – 199172-3
    Repeati1992 – 199872-4
    Repeati1999 – 200572-5
    Repeati2006 – 201272-6
    Repeati2013 – 201972-7; approximate
    Repeati2020 – 2030113-2; approximateAdd
    BLAST
    Domaini2323 – 236947G-patchPROSITE-ProRule annotationAdd
    BLAST
    Domaini2389 – 244456DRBMPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni721 – 85013013 X 10 AA tandem repeats of L-A-[ST]-[NSG]-[TS]-MDSQMAdd
    BLAST
    Regioni907 – 9837711 X 7 AA tandem repeats of [DR]-P-Y-R-[LI][AG][QHP]Add
    BLAST
    Regioni1001 – 112012014 X 6 AA repeats of [ED]-R-S-M-M-SAdd
    BLAST
    Regioni1141 – 1173333 X 11 AA tandem repats of P-P-L-P-P-E-E-P-P-[TME]-[MTG]Add
    BLAST
    Regioni1950 – 2019707 X 7 AA repeats of P-S-R-R-S-R-[TS]Add
    BLAST
    Regioni1959 – 2030722 X 19 AA repeats of P-S-R-R-R-R-S-R-S-V-V-R-R-R-S-F-S-I-SAdd
    BLAST
    Regioni2031 – 2057273 X tandem repeats of [ST]-P-[VLI]-R-[RL]-[RK]-[RF]-S-RAdd
    BLAST

    Domaini

    Sequence similaritiesi

    Contains 1 DRBM (double-stranded RNA-binding) domain.PROSITE-ProRule annotation
    Contains 1 G-patch domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG84537.
    GeneTreeiENSGT00730000111141.
    HOVERGENiHBG023160.
    InParanoidiQ811G3.
    TreeFamiTF330344.

    Family and domain databases

    Gene3Di3.30.160.20. 1 hit.
    InterProiIPR014720. dsRNA-bd_dom.
    IPR000467. G_patch_dom.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF01585. G-patch. 1 hit.
    [Graphical view]
    SMARTiSM00443. G_patch. 1 hit.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 1 hit.
    PROSITEiPS50137. DS_RBD. 1 hit.
    PS50174. G_PATCH. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9QX47-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAADIEQVFR SFVVSKFREI QQELSSGRSE GQLNGETNPP IEGNQAGDTA     50
    ASARSLPNEE IVQKIEEVLS GVLDTELRYK PDLKEASRKS RCVSVQTDPT 100
    DEVPTKKSKK HKKHKNKKKK KKKEKEKKYK RQPEESESKL KSHHDGNLES 150
    DSFLKFDSEP SAAALEHPVR AFGLSEASET ALVLEPPVVS MEVQESHVLE 200
    TLKPATKAAE LSVVSTSVIS EQSEQPMPGM LEPSMTKILD SFTAAPVPMS 250
    TAALKSPEPV VTMSVEYQKS VLKSLETMPP ETSKTTLVEL PIAKVVEPSE 300
    TLTIVSETPT EVHPEPSPST MDFPESSTTD VQRLPEQPVE APSEIADSSM 350
    TRPQESLELP KTTAVELQES TVASALELPG PPATSILELQ GPPVTPVPEL 400
    PGPSATPVPE LSGPLSTPVP ELPGPPATVV PELPGPSVTP VPQLSQELPG 450
    PPAPSMGLEP PQEVPEPPVM AQELSGVPAV SAAIELTGQP AVTVAMELTE 500
    QPVTTTEFEQ PVAMTTVEHP GHPEVTTATG LLGQPEAAMV LELPGQPVAT 550
    TALELSGQPS VTGVPELSGL PSATRALELS GQSVATGALE LPGQLMATGA 600
    LEFSGQSGAA GALELLGQPL ATGVLELPGQ PGAPELPGQP VATVALEISV 650
    QSVVTTSELS TMTVSQSLEV PSTTALESYN TVAQELPTTL VGETSVTVGV 700
    DPLMAQESHM LASNTMETHM LASNTMDSQM LASNTMDSQM LASNTMDSQM 750
    LASSTMDSQM LASSTMDSQM LATSTMDSQM LATSSMDSQM LATSSMDSQM 800
    LATSSMDSQM LATSSMDSQM LATSSMDSQM LATSSMDSQM LATSSMDSQM 850
    LATSSMDSQM LASGAMDSQM LASGTMDAQM LASGTMDAQM LASSTQDSAM 900
    MGSKSPDPYR LAQDPYRLAQ DPYRLGHDPY RLGHDAYRLG QDPYRLGHDP 950
    YRLTPDPYRV SPRPYRIAPR SYRIAPRPYR LAPRPLMLAS RRSMMMSYAA 1000
    ERSMMSSYER SMMSYERSMM SPMAERSMMS AYERSMMSAY ERSMMSPMAE 1050
    RSMMSAYERS MMSAYERSMM SPMADRSMMS MGADRSMMSS YSAADRSMMS 1100
    SYSAADRSMM SSYTDRSMMS MAADSYTDSY TDSYTEAYMV PPLPPEEPPT 1150
    MPPLPPEEPP MTPPLPPEEP PEGPALSTEQ SALTADNTWS TEVTLSTGES 1200
    LSQPEPPVSQ SEISEPMAVP ANYSMSESET SMLASEAVMT VPEPAREPES 1250
    SVTSAPVESA VVAEHEMVPE RPMTYMVSET TMSVEPAVLT SEASVISETS 1300
    ETYDSMRPSG HAISEVTMSL LEPAVTISQP AENSLELPSM TVPAPSTMTT 1350
    TESPVVAVTE IPPVAVPEPP IMAVPELPTM AVVKTPAVAV PEPLVAAPEP 1400
    PTMATPELCS LSVSEPPVAV SELPALADPE HAITAVSGVS SLEPSVPILE 1450
    PAVSVLQPVM IVSEPSVPVQ EPTVAVSEPA VIVSEHTQIT SPEMAVESSP 1500
    VIVDSSVMSS QIMKGMNLLG GDENLGPEVG MQETLLHPGE EPRDGGHLKS 1550
    DLYENEYDRN ADLTVNSHLI VKDAEHNTVC ATTVGPVGEA SEEKILPISE 1600
    TKEITELATC AAVSEADIGR SLSSQLALEL DTVGTSKGFE FVTASALISE 1650
    SKYDVEVSVT TQDTEHDMVI STSPSGGSEA DIEGPLPAKD IHLDLPSTNF 1700
    VCKDVEDSLP IKESAQAVAV ALSPKESSED TEVPLPNKEI VPESGYSASI 1750
    DEINEADLVR PLLPKDMERL TSLRAGIEGP LLASEVERDK SAASPVVISI 1800
    PERASESSSE EKDDYEIFVK VKDTHEKSKK NKNRDKGEKE KKRDSSLRSR 1850
    SKRSKSSEHK SRKRTSESRS RARKRSSKSK SHRSQTRSRS RSRRRRRSSR 1900
    SRSKSRGRRS VSKEKRKRSP KHRSKSRERK RKRSSSRDNR KAARARSRTP 1950
    SRRSRSHTPS RRRRSRSVGR RRSFSISPSR RSRTPSRRSR TPSRRSRTPS 2000
    RRSRTPSRRS RTPSRRRRSR SAVRRRSFSI SPVRLRRSRT PLRRRFSRSP 2050
    IRRKRSRSSE RGRSPKRLTD LDKAQLLEIA KANAAAMCAK AGVPLPPNLK 2100
    PAPPPTIEEK VAKKSGGATI EELTEKCKQI AQSKEDDDVI VNKPHVSDEE 2150
    EEEPPFYHHP FKLSEPKPIF FNLNIAAAKP TPPKSQVTLT KEFPVSSGSQ 2200
    HRKKEADSVY GEWVPVEKNG EESKDDDNVF SSSLPSEPVD ISTAMSERAL 2250
    AQKRLSENAF DLEAMSMLNR AQERIDAWAQ LNSIPGQFTG STGVQVLTQE 2300
    QLANTGAQAW IKKDQFLRAA PVTGGMGAVL MRKMGWREGE GLGKNKEGNK 2350
    EPILVDFKTD RKGLVAVGER AQKRSGNFSA AMKDLSGKHP VSALMEICNK 2400
    RRWQPPEFLL VHDSGPDHRK HFLFRVLRNG SPYQPNCMFF LNRY 2444
    Length:2,444
    Mass (Da):265,651
    Last modified:June 28, 2011 - v2
    Checksum:iE873ADCB51B7123B
    GO
    Isoform 2 (identifier: Q9QX47-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         2126-2126: K → F
         2127-2444: Missing.

    Show »
    Length:2,126
    Mass (Da):230,022
    Checksum:iD977785966267327
    GO
    Isoform 3 (identifier: Q9QX47-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         776-815: Missing.

    Show »
    Length:2,404
    Mass (Da):261,443
    Checksum:i6163EBD3D5E8FB95
    GO
    Isoform 4 (identifier: Q9QX47-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         776-815: Missing.
         2238-2444: PVDISTAMSE...PNCMFFLNRY → GRVKRQGRVK...SRLYSSRFWW

    Show »
    Length:2,281
    Mass (Da):247,971
    Checksum:i10ABA0C4E10F6C03
    GO

    Sequence cautioni

    The sequence AAH46419.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti857 – 8571D → E in AAF23120. (PubMed:10950926)Curated
    Sequence conflicti857 – 8571D → E in AAF23121. (PubMed:10950926)Curated
    Sequence conflicti857 – 8571D → E in BAJ40169. (PubMed:20876580)Curated
    Sequence conflicti1333 – 13331N → D in AAF23120. (PubMed:10950926)Curated
    Sequence conflicti1333 – 13331N → D in AAF23121. (PubMed:10950926)Curated
    Sequence conflicti1734 – 17341P → L in AAF23120. (PubMed:10950926)Curated
    Sequence conflicti1734 – 17341P → L in AAF23121. (PubMed:10950926)Curated
    Sequence conflicti1966 – 19661R → I in AAF23120. (PubMed:10950926)Curated
    Sequence conflicti1966 – 19661R → I in AAF23121. (PubMed:10950926)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei776 – 81540Missing in isoform 3 and isoform 4. 2 PublicationsVSP_041557Add
    BLAST
    Alternative sequencei2126 – 21261K → F in isoform 2. CuratedVSP_004416
    Alternative sequencei2127 – 2444318Missing in isoform 2. CuratedVSP_004417Add
    BLAST
    Alternative sequencei2238 – 2444207PVDIS…FLNRY → GRVKRQGRVKRQMKQPAASH LTVTRCNSLCGTKPQSEKHR IAEKSVITSLPNIGPSMHLW EGSPRYNYLASRFASRLYSS RFWW in isoform 4. 1 PublicationVSP_041558Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF193606
    , AF193595, AF193596, AF193597, AF193598, AF193599, AF193600, AF193601, AF193602, AF193603, AF193604, AF193605 Genomic DNA. Translation: AAF23120.1.
    AF193607 mRNA. Translation: AAF23121.1.
    AB546195 mRNA. Translation: BAJ40169.1.
    AC131691 Genomic DNA. No translation available.
    BC046419 mRNA. Translation: AAH46419.1. Sequence problems.
    AK019312 mRNA. Translation: BAB31659.1.
    AK019081 mRNA. Translation: BAB31536.1.
    AK008478 mRNA. Translation: BAB25691.1.
    AK008256 mRNA. Translation: BAB25562.1.
    CCDSiCCDS37399.1. [Q9QX47-1]
    CCDS37400.1. [Q9QX47-2]
    RefSeqiNP_849211.3. NM_178880.4. [Q9QX47-1]
    UniGeneiMm.46401.
    Mm.491378.

    Genome annotation databases

    EnsembliENSMUST00000114036; ENSMUSP00000109670; ENSMUSG00000022961. [Q9QX47-2]
    ENSMUST00000114037; ENSMUSP00000109671; ENSMUSG00000022961. [Q9QX47-1]
    GeneIDi20658.
    KEGGimmu:20658.
    UCSCiuc007zxy.1. mouse. [Q9QX47-2]
    uc007zxz.1. mouse. [Q9QX47-1]
    uc012aii.1. mouse. [Q9QX47-4]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF193606
    , AF193595 , AF193596 , AF193597 , AF193598 , AF193599 , AF193600 , AF193601 , AF193602 , AF193603 , AF193604 , AF193605 Genomic DNA. Translation: AAF23120.1 .
    AF193607 mRNA. Translation: AAF23121.1 .
    AB546195 mRNA. Translation: BAJ40169.1 .
    AC131691 Genomic DNA. No translation available.
    BC046419 mRNA. Translation: AAH46419.1 . Sequence problems.
    AK019312 mRNA. Translation: BAB31659.1 .
    AK019081 mRNA. Translation: BAB31536.1 .
    AK008478 mRNA. Translation: BAB25691.1 .
    AK008256 mRNA. Translation: BAB25562.1 .
    CCDSi CCDS37399.1. [Q9QX47-1 ]
    CCDS37400.1. [Q9QX47-2 ]
    RefSeqi NP_849211.3. NM_178880.4. [Q9QX47-1 ]
    UniGenei Mm.46401.
    Mm.491378.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 203390. 1 interaction.
    DIPi DIP-49510N.
    IntActi Q9QX47. 6 interactions.
    MINTi MINT-1713045.

    PTM databases

    PhosphoSitei Q9QX47.

    Proteomic databases

    MaxQBi Q9QX47.
    PaxDbi Q9QX47.
    PRIDEi Q9QX47.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000114036 ; ENSMUSP00000109670 ; ENSMUSG00000022961 . [Q9QX47-2 ]
    ENSMUST00000114037 ; ENSMUSP00000109671 ; ENSMUSG00000022961 . [Q9QX47-1 ]
    GeneIDi 20658.
    KEGGi mmu:20658.
    UCSCi uc007zxy.1. mouse. [Q9QX47-2 ]
    uc007zxz.1. mouse. [Q9QX47-1 ]
    uc012aii.1. mouse. [Q9QX47-4 ]

    Organism-specific databases

    CTDi 6651.
    MGIi MGI:98353. Son.

    Phylogenomic databases

    eggNOGi NOG84537.
    GeneTreei ENSGT00730000111141.
    HOVERGENi HBG023160.
    InParanoidi Q811G3.
    TreeFami TF330344.

    Miscellaneous databases

    ChiTaRSi SON. mouse.
    NextBioi 299093.
    PROi Q9QX47.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9QX47.
    Bgeei Q9QX47.
    CleanExi MM_SON.
    Genevestigatori Q9QX47.

    Family and domain databases

    Gene3Di 3.30.160.20. 1 hit.
    InterProi IPR014720. dsRNA-bd_dom.
    IPR000467. G_patch_dom.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF01585. G-patch. 1 hit.
    [Graphical view ]
    SMARTi SM00443. G_patch. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 1 hit.
    PROSITEi PS50137. DS_RBD. 1 hit.
    PS50174. G_PATCH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Organization and conservation of the GART/SON/DONSON locus in mouse and human genomes."
      Wynn S.L., Fisher R.A., Pagel C., Price M., Liu Q.Y., Khan I.M., Zammit P., Dadrah K., Mazrani W., Kessling A., Lee J.S., Buluwela L.
      Genomics 68:57-62(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 2 AND 3), NUCLEOTIDE SEQUENCE [MRNA] OF 1-2125 (ISOFORM 3), SUBCELLULAR LOCATION.
      Strain: 129/Sv.
    2. "Regulation of ghrelin signaling by a leptin-induced gene, negative regulatory element-binding protein, in the hypothalamic neurons."
      Komori T., Doi A., Furuta H., Wakao H., Nakao N., Nakazato M., Nanjo K., Senba E., Morikawa Y.
      J. Biol. Chem. 285:37884-37894(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), FUNCTION, TISSUE SPECIFICITY, INDUCTION.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1827 (ISOFORM 1).
      Strain: FVB/N.
      Tissue: Kidney.
    5. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-116.
      Strain: C57BL/6J.
      Tissue: Hippocampus, Small intestine and Tongue.
    6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1723, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    7. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1723, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-2073, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiSON_MOUSE
    AccessioniPrimary (citable) accession number: Q9QX47
    Secondary accession number(s): E3WC91
    , E9PXW2, E9Q3H8, E9Q3I0, E9Q6M4, E9Q7G2, E9QAR8, E9QMT0, Q811G3, Q9CQ12, Q9CQK6, Q9QXP5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2002
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 118 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3