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Q9QX38

- Q9QX38_RAT

UniProt

Q9QX38 - Q9QX38_RAT

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Protein
Submitted name:

Neuropilin

Gene

Nrp1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi194 – 1941CalciumUniRule annotation
Metal bindingi208 – 2081CalciumUniRule annotation
Metal bindingi249 – 2491CalciumUniRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. semaphorin receptor activity Source: InterPro
  3. vascular endothelial growth factor-activated receptor activity Source: InterPro

GO - Biological processi

  1. angiogenesis Source: InterPro
  2. axon guidance Source: InterPro
  3. cell adhesion Source: InterPro
  4. endothelial cell chemotaxis Source: InterPro
  5. organ morphogenesis Source: InterPro
  6. vascular endothelial growth factor receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Ligandi

CalciumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
NeuropilinImported
Gene namesi
Name:Nrp1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi621588. Nrp1.

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: InterPro
Complete GO annotation...

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi26 ↔ 53UniRule annotation
Disulfide bondi26 ↔ 53 By similarity
Disulfide bondi81 ↔ 103UniRule annotation
Disulfide bondi81 ↔ 103 By similarity
Disulfide bondi146 ↔ 172UniRule annotation
Disulfide bondi146 ↔ 172 By similarity
Disulfide bondi205 ↔ 227UniRule annotation
Disulfide bondi205 ↔ 227 By similarity

Keywords - PTMi

Disulfide bondUniRule annotation

Proteomic databases

PRIDEiQ9QX38.

Expressioni

Gene expression databases

GenevestigatoriQ9QX38.

Structurei

3D structure databases

ProteinModelPortaliQ9QX38.
SMRiQ9QX38. Positions 144-585.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 2 F5/8 type C domains.UniRule annotation

Phylogenomic databases

HOVERGENiHBG000502.

Family and domain databases

Gene3Di2.60.120.260. 2 hits.
2.60.120.290. 2 hits.
InterProiIPR000421. Coagulation_fac_5/8-C_type_dom.
IPR013320. ConA-like_dom.
IPR000859. CUB_dom.
IPR008979. Galactose-bd-like.
IPR000998. MAM_dom.
IPR014648. Neuropilin.
IPR022579. Neuropilin1_C.
IPR027146. NRP1.
[Graphical view]
PANTHERiPTHR10127:SF616. PTHR10127:SF616. 1 hit.
PfamiPF00431. CUB. 2 hits.
PF11980. DUF3481. 1 hit.
PF00754. F5_F8_type_C. 2 hits.
PF00629. MAM. 1 hit.
[Graphical view]
PIRSFiPIRSF036960. Neuropilin. 1 hit.
PRINTSiPR00020. MAMDOMAIN.
SMARTiSM00042. CUB. 2 hits.
SM00231. FA58C. 2 hits.
SM00137. MAM. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 2 hits.
SSF49854. SSF49854. 2 hits.
SSF49899. SSF49899. 1 hit.
PROSITEiPS01180. CUB. 2 hits.
PS01285. FA58C_1. 2 hits.
PS01286. FA58C_2. 2 hits.
PS50022. FA58C_3. 2 hits.
PS00740. MAM_1. 1 hit.
PS50060. MAM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QX38-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MERGLPLLCA TLALALALGA FRSDKCGGTI KIENPGYLTS PGYPHSYHPS
60 70 80 90 100
EKCEWLIQAP EPYQRIMINF NPHFDLEDRD CKYDYVEVID GENEGGRLWG
110 120 130 140 150
KFCGKIAPSP VVSSGPFLFI KFVSDYETHG AGFSIRYEIF KRGPECSQNY
160 170 180 190 200
TAPTGVIKSP GFPEKYPNSL ECTYIIFAPK MSEIILEFES FDLEQDSNPP
210 220 230 240 250
GGMFCRYDRL EIWDGFPEVG PHIGRYCGQK TPGRIRSSSG ILSMVFYTDS
260 270 280 290 300
AIAKEGFSAN YSVLQSSISE DFKCMEALGM ESGEIHSDQI TASSQYGTNW
310 320 330 340 350
SVERSRLNYP ENGWTPGEDS YREWIQVDLG LLRFVTAVGT QGAISKETKK
360 370 380 390 400
KYYVKTYRVD ISSNGEDWIT LKEGNKAIIF QGNTNPTDVV FGVFPKPLIT
410 420 430 440 450
RFVRIKPASW ETGISMRFEV YGCKITDYPC SGMLGMVSGL ISDSQITASN
460 470 480 490 500
QGDRNWMPEN IRLVTSRTGW ALPPSPHPYI NEWLQVDLGD EKIVRGVIIQ
510 520 530 540 550
GGKHRENKVF MRKFKIAYSN NGSDWKMIMD DSKRKAKSFE GNNNYDTPEL
560 570 580 590 600
RAFTPLSTRF IRIYPERATH SGLGLRMELL GCEVEVPTAG PTTPNGNPVD
610 620 630 640 650
ECDDDQANCH SGTGDDFQLT GGTTVLATEK PTIIDSTIQS EFPTYGFNCE
660 670 680 690 700
FGWGSHKTFC HWEHDSHAQL RWRVLTSKTG PIQDHTGDGN FIYSQADENQ
710 720 730 740 750
KGKVARLVSP VVYSQSSAHC MTFWYHMSGS HVGTLRVKLH YQKPEEYDQL
760 770 780 790 800
VWMVVGHQGD HWKEGRVLLH KSLKLYQVIF EGEIGKGNLG GIAVDDISIN
810 820 830 840 850
NHIPQEDCAK PTDLDKKNTE IKIDETGSTP GYEEGKGDKN ISRKPGNVLK
860 870 880 890 900
TLDPILITII AMSALGVLLG AVCGVVLYCA CWHNGMSERN LSALENYNFE
910 920
LVDGVKLKKD KLNPHSNYSE A
Length:921
Mass (Da):103,052
Last modified:May 1, 2000 - v1
Checksum:i58B29A9AA4978971
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF018957 mRNA. Translation: AAC53345.1.
UniGeneiRn.10815.
Rn.165344.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF018957 mRNA. Translation: AAC53345.1 .
UniGenei Rn.10815.
Rn.165344.

3D structure databases

ProteinModelPortali Q9QX38.
SMRi Q9QX38. Positions 144-585.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q9QX38.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

RGDi 621588. Nrp1.

Phylogenomic databases

HOVERGENi HBG000502.

Gene expression databases

Genevestigatori Q9QX38.

Family and domain databases

Gene3Di 2.60.120.260. 2 hits.
2.60.120.290. 2 hits.
InterProi IPR000421. Coagulation_fac_5/8-C_type_dom.
IPR013320. ConA-like_dom.
IPR000859. CUB_dom.
IPR008979. Galactose-bd-like.
IPR000998. MAM_dom.
IPR014648. Neuropilin.
IPR022579. Neuropilin1_C.
IPR027146. NRP1.
[Graphical view ]
PANTHERi PTHR10127:SF616. PTHR10127:SF616. 1 hit.
Pfami PF00431. CUB. 2 hits.
PF11980. DUF3481. 1 hit.
PF00754. F5_F8_type_C. 2 hits.
PF00629. MAM. 1 hit.
[Graphical view ]
PIRSFi PIRSF036960. Neuropilin. 1 hit.
PRINTSi PR00020. MAMDOMAIN.
SMARTi SM00042. CUB. 2 hits.
SM00231. FA58C. 2 hits.
SM00137. MAM. 1 hit.
[Graphical view ]
SUPFAMi SSF49785. SSF49785. 2 hits.
SSF49854. SSF49854. 2 hits.
SSF49899. SSF49899. 1 hit.
PROSITEi PS01180. CUB. 2 hits.
PS01285. FA58C_1. 2 hits.
PS01286. FA58C_2. 2 hits.
PS50022. FA58C_3. 2 hits.
PS00740. MAM_1. 1 hit.
PS50060. MAM_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Neuropilin is a receptor for the axonal chemorepellent semaphorin III."
    He Z., Tessier-Lavigne M.
    Cell 90:739-751(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9QX38_RAT
AccessioniPrimary (citable) accession number: Q9QX38
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)