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Q9QX29

- TRPC5_MOUSE

UniProt

Q9QX29 - TRPC5_MOUSE

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Protein

Short transient receptor potential channel 5

Gene

Trpc5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective. May also be activated by intracellular calcium store depletion.

Enzyme regulationi

Calcium channel activity is enhanced by MYLK, that promotes its subcellular localization at the plasma membrane.By similarity

GO - Molecular functioni

  1. calcium channel activity Source: UniProtKB-KW
  2. inositol 1,4,5 trisphosphate binding Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiREACT_227861. TRP channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Short transient receptor potential channel 5
Short name:
TrpC5
Alternative name(s):
Capacitative calcium entry channel 2
Short name:
CCE2
Transient receptor protein 5
Short name:
TRP-5
Short name:
mTRP5
Trp-related protein 5
Gene namesi
Name:Trpc5
Synonyms:Trp5, Trrp5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:109524. Trpc5.

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity

GO - Cellular componenti

  1. calcium channel complex Source: Ensembl
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 975975Short transient receptor potential channel 5PRO_0000215319Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi461 – 4611N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ9QX29.

PTM databases

PhosphoSiteiQ9QX29.

Expressioni

Tissue specificityi

Expressed almost exclusively in brain, in mitral cells of the olfactory bulb, in lateral cerebellar nuclei and in pyramidal neurons of the hippocampus. Very low levels detected in liver kidney, testis, and uterus.1 Publication

Gene expression databases

BgeeiQ9QX29.
ExpressionAtlasiQ9QX29. baseline and differential.
GenevestigatoriQ9QX29.

Interactioni

Subunit structurei

Homotetramer and heterotetramer with TRPC1 and/or TRPC4 (By similarity). Interacts (via C-terminus) with CABP1. Interacts with NHERF (By similarity). Interacts with MX1 and RNF24 (By similarity). Interacts with SESTD1 (via the spectrin 1 repeat) (By similarity). Interacts with TRPC4AP.By similarity2 Publications

Protein-protein interaction databases

BioGridi204331. 1 interaction.
MINTiMINT-144678.

Structurei

3D structure databases

ProteinModelPortaliQ9QX29.
SMRiQ9QX29. Positions 39-173.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 330330CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini352 – 39847ExtracellularSequence AnalysisAdd
BLAST
Topological domaini420 – 43718CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini459 – 47012ExtracellularSequence AnalysisAdd
BLAST
Topological domaini492 – 51221CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini534 – 60370ExtracellularSequence AnalysisAdd
BLAST
Topological domaini625 – 975351CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei331 – 35121HelicalSequence AnalysisAdd
BLAST
Transmembranei399 – 41921HelicalSequence AnalysisAdd
BLAST
Transmembranei438 – 45821HelicalSequence AnalysisAdd
BLAST
Transmembranei471 – 49121HelicalSequence AnalysisAdd
BLAST
Transmembranei513 – 53321HelicalSequence AnalysisAdd
BLAST
Transmembranei604 – 62421HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati31 – 6030ANK 1Add
BLAST
Repeati69 – 9729ANK 2Add
BLAST
Repeati98 – 12427ANK 3Add
BLAST
Repeati141 – 17030ANK 4Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni971 – 9733Essential for binding to NHERF PDZ domainBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi690 – 6934Poly-Arg

Sequence similaritiesi

Contains 4 ANK repeats.Curated

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG254238.
GeneTreeiENSGT00760000119180.
HOGENOMiHOG000020589.
HOVERGENiHBG068337.
InParanoidiQ9QX29.
KOiK04968.
OMAiPPLIRTM.
OrthoDBiEOG72G17P.
PhylomeDBiQ9QX29.
TreeFamiTF313147.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR013555. TRP_dom.
IPR005461. TRPC5_channel.
IPR002153. TRPC_channel.
[Graphical view]
PANTHERiPTHR10117. PTHR10117. 1 hit.
PTHR10117:SF24. PTHR10117:SF24. 1 hit.
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
[Graphical view]
PRINTSiPR01097. TRNSRECEPTRP.
PR01646. TRPCHANNEL5.
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
TIGRFAMsiTIGR00870. trp. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9QX29-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAQLYYKKVN YSPYRDRIPL QIVRAETELS AEEKAFLSAV EKGDYATVKQ
60 70 80 90 100
ALQEAEIYYN VNINCMDPLG RSALLIAIEN ENLEIMELLL NHSVYVGDAL
110 120 130 140 150
LYAIRKEVVG AVELLLSYRK PSGEKQVPTL MMDTQFSEFT PDITPIMLAA
160 170 180 190 200
HTNNYEIIKL LVQKRVTIPR PHQIRCNCVE CVSSSEVDSL RHSRSRLNIY
210 220 230 240 250
KALASPSLIA LSSEDPILTA FRLGWELKEL SKVENEFKAE YEELSQQCKL
260 270 280 290 300
FAKDLLDQAR SSRELEIILN HRDDHSEELD PQKYHDLAKL KVAIKYHQKE
310 320 330 340 350
FVAQPNCQQL LATLWYDGFP GWRRKHWVVK LLTCMTIGFL FPMLSIAYLI
360 370 380 390 400
SPRSNLGLFI KKPFIKFICH TASYLTFLFM LLLASQHIVR TDLHVQGPPP
410 420 430 440 450
TVVEWMILPW VLGFIWGEIK EMWDGGFTEY IHDWWNLMDF AMNSLYLATI
460 470 480 490 500
SLKIVAYVKY NGSRPREEWE MWHPTLIAEA LFAISNILSS LRLISLFTAN
510 520 530 540 550
SHLGPLQISL GRMLLDILKF LFIYCLVLLA FANGLNQLYF YYETRAIDEP
560 570 580 590 600
NNCKGIRCEK QNNAFSTLFE TLQSLFWSVF GLLNLYVTNV KARHEFTEFV
610 620 630 640 650
GATMFGTYNV ISLVVLLNML IAMMNNSYQL IADHADIEWK FARTKLWMSY
660 670 680 690 700
FDEGGTLPPP FNIIPSPKSF LYLGNWFNNT FCPKRDPDGR RRRHNLRSFT
710 720 730 740 750
ERHADSLIQN QHYQEVIRNL VKRYVAAMIR NSKTNEGLTE ENFKELKQDI
760 770 780 790 800
SSFRYEVLDL LGNRKHPRRS LSTSSADFSQ RDDTNDGSGG ARAKSKSVSF
810 820 830 840 850
NVGCKKKACH GAPLIRTVPR ASGAQGKPKS ESSSKRSFMG PSFKKLGLFF
860 870 880 890 900
SKFNGQTSEP TSEPMYTISD GIAQQHCMWQ DIRYSQMEKG KAEACSQSQM
910 920 930 940 950
NLGEVELGEI RGAAARSSEC PLACSSSLHC ASGICSSNSK LLDSSEDVFE
960 970
TWGEACDLLM HKWGDGQEEQ VTTRL
Length:975
Mass (Da):111,458
Last modified:June 20, 2001 - v2
Checksum:iDF9248168D3D2D62
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF029983 mRNA. Translation: AAC13550.1.
AF060107 mRNA. Translation: AAF02200.1.
AJ006204 mRNA. Translation: CAA06912.1.
CCDSiCCDS30457.1.
RefSeqiNP_033454.1. NM_009428.2.
UniGeneiMm.328378.

Genome annotation databases

EnsembliENSMUST00000040184; ENSMUSP00000049063; ENSMUSG00000041710.
GeneIDi22067.
KEGGimmu:22067.
UCSCiuc009umv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF029983 mRNA. Translation: AAC13550.1 .
AF060107 mRNA. Translation: AAF02200.1 .
AJ006204 mRNA. Translation: CAA06912.1 .
CCDSi CCDS30457.1.
RefSeqi NP_033454.1. NM_009428.2.
UniGenei Mm.328378.

3D structure databases

ProteinModelPortali Q9QX29.
SMRi Q9QX29. Positions 39-173.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 204331. 1 interaction.
MINTi MINT-144678.

Chemistry

GuidetoPHARMACOLOGYi 490.

PTM databases

PhosphoSitei Q9QX29.

Proteomic databases

PRIDEi Q9QX29.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000040184 ; ENSMUSP00000049063 ; ENSMUSG00000041710 .
GeneIDi 22067.
KEGGi mmu:22067.
UCSCi uc009umv.1. mouse.

Organism-specific databases

CTDi 7224.
MGIi MGI:109524. Trpc5.

Phylogenomic databases

eggNOGi NOG254238.
GeneTreei ENSGT00760000119180.
HOGENOMi HOG000020589.
HOVERGENi HBG068337.
InParanoidi Q9QX29.
KOi K04968.
OMAi PPLIRTM.
OrthoDBi EOG72G17P.
PhylomeDBi Q9QX29.
TreeFami TF313147.

Enzyme and pathway databases

Reactomei REACT_227861. TRP channels.

Miscellaneous databases

NextBioi 301888.
PROi Q9QX29.
SOURCEi Search...

Gene expression databases

Bgeei Q9QX29.
ExpressionAtlasi Q9QX29. baseline and differential.
Genevestigatori Q9QX29.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR013555. TRP_dom.
IPR005461. TRPC5_channel.
IPR002153. TRPC_channel.
[Graphical view ]
PANTHERi PTHR10117. PTHR10117. 1 hit.
PTHR10117:SF24. PTHR10117:SF24. 1 hit.
Pfami PF00023. Ank. 1 hit.
PF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
[Graphical view ]
PRINTSi PR01097. TRNSRECEPTRP.
PR01646. TRPCHANNEL5.
SMARTi SM00248. ANK. 2 hits.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
TIGRFAMsi TIGR00870. trp. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and functional characterization of a novel receptor-activated TRP Ca2+ channel from mouse brain."
    Okada T., Shimizu S., Wakamori M., Maeda A., Kurosaki T., Takada N., Imoto K., Mori Y.
    J. Biol. Chem. 273:10279-10287(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Molecular cloning and functional expression of mouse TRP5."
    Zhu X., Peyton M., Boulay B., Birnbaumer B.
    Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Association of mammalian trp4 and phospholipase C isozymes with a PDZ domain-containing protein, NHERF."
    Tang Y., Tang J., Chen Z., Trost C., Flockerzi V., Li M., Ramesh V., Zhu M.X.
    J. Biol. Chem. 275:37559-37564(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "A novel capacitative calcium entry channel expressed in excitable cells."
    Philipp S., Hambrecht J., Braslavski L., Schroth G., Freichel M., Murakami M., Cavalie A., Flockerzi V.
    EMBO J. 17:4274-4282(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-966, TISSUE SPECIFICITY.
    Tissue: Brain.
  5. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 354-361, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.
  6. "trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry."
    Zhu X., Jiang M., Peyton M., Boulay G., Hurst R., Stefani E., Birnbaumer L.
    Cell 85:661-671(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 515-637.
  7. "Inhibition of TRPC5 channels by Ca2+-binding protein 1 in Xenopus oocytes."
    Kinoshita-Kawada M., Tang J., Xiao R., Kaneko S., Foskett J.K., Zhu M.X.
    Pflugers Arch. 450:345-354(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CABP1.
  8. "TRUSS, TNF-R1, and TRPC ion channels synergistically reverse endoplasmic reticulum Ca2+ storage reduction in response to m1 muscarinic acetylcholine receptor signaling."
    Mace K.E., Lussier M.P., Boulay G., Terry-Powers J.L., Parfrey H., Perraud A.L., Riches D.W.H.
    J. Cell. Physiol. 225:444-453(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TRPC4AP.

Entry informationi

Entry nameiTRPC5_MOUSE
AccessioniPrimary (citable) accession number: Q9QX29
Secondary accession number(s): Q61059, Q9QWT1, Q9R0D4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: June 20, 2001
Last modified: October 29, 2014
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3