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Q9QX29

- TRPC5_MOUSE

UniProt

Q9QX29 - TRPC5_MOUSE

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Protein
Short transient receptor potential channel 5
Gene
Trpc5, Trp5, Trrp5
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective. May also be activated by intracellular calcium store depletion.

Enzyme regulationi

Calcium channel activity is enhanced by MYLK, that promotes its subcellular localization at the plasma membrane By similarity.

GO - Molecular functioni

  1. calcium channel activity Source: UniProtKB-KW
  2. inositol 1,4,5 trisphosphate binding Source: BHF-UCL
  3. protein binding Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiREACT_227861. TRP channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Short transient receptor potential channel 5
Short name:
TrpC5
Alternative name(s):
Capacitative calcium entry channel 2
Short name:
CCE2
Transient receptor protein 5
Short name:
TRP-5
Short name:
mTRP5
Trp-related protein 5
Gene namesi
Name:Trpc5
Synonyms:Trp5, Trrp5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:109524. Trpc5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 330330Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei331 – 35121Helical; Reviewed prediction
Add
BLAST
Topological domaini352 – 39847Extracellular Reviewed prediction
Add
BLAST
Transmembranei399 – 41921Helical; Reviewed prediction
Add
BLAST
Topological domaini420 – 43718Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei438 – 45821Helical; Reviewed prediction
Add
BLAST
Topological domaini459 – 47012Extracellular Reviewed prediction
Add
BLAST
Transmembranei471 – 49121Helical; Reviewed prediction
Add
BLAST
Topological domaini492 – 51221Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei513 – 53321Helical; Reviewed prediction
Add
BLAST
Topological domaini534 – 60370Extracellular Reviewed prediction
Add
BLAST
Transmembranei604 – 62421Helical; Reviewed prediction
Add
BLAST
Topological domaini625 – 975351Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. calcium channel complex Source: Ensembl
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 975975Short transient receptor potential channel 5
PRO_0000215319Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi461 – 4611N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ9QX29.

PTM databases

PhosphoSiteiQ9QX29.

Expressioni

Tissue specificityi

Expressed almost exclusively in brain, in mitral cells of the olfactory bulb, in lateral cerebellar nuclei and in pyramidal neurons of the hippocampus. Very low levels detected in liver kidney, testis, and uterus.1 Publication

Gene expression databases

BgeeiQ9QX29.
GenevestigatoriQ9QX29.

Interactioni

Subunit structurei

Homotetramer and heterotetramer with TRPC1 and/or TRPC4 By similarity. Interacts (via C-terminus) with CABP1. Interacts with NHERF By similarity. Interacts with MX1 and RNF24 By similarity. Interacts with SESTD1 (via the spectrin 1 repeat) By similarity. Interacts with TRPC4AP.2 Publications

Protein-protein interaction databases

BioGridi204331. 1 interaction.
MINTiMINT-144678.

Structurei

3D structure databases

ProteinModelPortaliQ9QX29.
SMRiQ9QX29. Positions 35-169.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati31 – 6030ANK 1
Add
BLAST
Repeati69 – 9729ANK 2
Add
BLAST
Repeati98 – 12427ANK 3
Add
BLAST
Repeati141 – 17030ANK 4
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni971 – 9733Essential for binding to NHERF PDZ domain By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi690 – 6934Poly-Arg

Sequence similaritiesi

Contains 4 ANK repeats.

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG254238.
GeneTreeiENSGT00680000099866.
HOGENOMiHOG000020589.
HOVERGENiHBG068337.
InParanoidiQ9QX29.
KOiK04968.
OMAiPPLIRTM.
OrthoDBiEOG72G17P.
PhylomeDBiQ9QX29.
TreeFamiTF313147.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR013555. TRP_dom.
IPR005461. TRPC5_channel.
IPR002153. TRPC_channel.
[Graphical view]
PANTHERiPTHR10117. PTHR10117. 1 hit.
PTHR10117:SF24. PTHR10117:SF24. 1 hit.
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
[Graphical view]
PRINTSiPR01097. TRNSRECEPTRP.
PR01646. TRPCHANNEL5.
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
TIGRFAMsiTIGR00870. trp. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9QX29-1 [UniParc]FASTAAdd to Basket

« Hide

MAQLYYKKVN YSPYRDRIPL QIVRAETELS AEEKAFLSAV EKGDYATVKQ    50
ALQEAEIYYN VNINCMDPLG RSALLIAIEN ENLEIMELLL NHSVYVGDAL 100
LYAIRKEVVG AVELLLSYRK PSGEKQVPTL MMDTQFSEFT PDITPIMLAA 150
HTNNYEIIKL LVQKRVTIPR PHQIRCNCVE CVSSSEVDSL RHSRSRLNIY 200
KALASPSLIA LSSEDPILTA FRLGWELKEL SKVENEFKAE YEELSQQCKL 250
FAKDLLDQAR SSRELEIILN HRDDHSEELD PQKYHDLAKL KVAIKYHQKE 300
FVAQPNCQQL LATLWYDGFP GWRRKHWVVK LLTCMTIGFL FPMLSIAYLI 350
SPRSNLGLFI KKPFIKFICH TASYLTFLFM LLLASQHIVR TDLHVQGPPP 400
TVVEWMILPW VLGFIWGEIK EMWDGGFTEY IHDWWNLMDF AMNSLYLATI 450
SLKIVAYVKY NGSRPREEWE MWHPTLIAEA LFAISNILSS LRLISLFTAN 500
SHLGPLQISL GRMLLDILKF LFIYCLVLLA FANGLNQLYF YYETRAIDEP 550
NNCKGIRCEK QNNAFSTLFE TLQSLFWSVF GLLNLYVTNV KARHEFTEFV 600
GATMFGTYNV ISLVVLLNML IAMMNNSYQL IADHADIEWK FARTKLWMSY 650
FDEGGTLPPP FNIIPSPKSF LYLGNWFNNT FCPKRDPDGR RRRHNLRSFT 700
ERHADSLIQN QHYQEVIRNL VKRYVAAMIR NSKTNEGLTE ENFKELKQDI 750
SSFRYEVLDL LGNRKHPRRS LSTSSADFSQ RDDTNDGSGG ARAKSKSVSF 800
NVGCKKKACH GAPLIRTVPR ASGAQGKPKS ESSSKRSFMG PSFKKLGLFF 850
SKFNGQTSEP TSEPMYTISD GIAQQHCMWQ DIRYSQMEKG KAEACSQSQM 900
NLGEVELGEI RGAAARSSEC PLACSSSLHC ASGICSSNSK LLDSSEDVFE 950
TWGEACDLLM HKWGDGQEEQ VTTRL 975
Length:975
Mass (Da):111,458
Last modified:June 20, 2001 - v2
Checksum:iDF9248168D3D2D62
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF029983 mRNA. Translation: AAC13550.1.
AF060107 mRNA. Translation: AAF02200.1.
AJ006204 mRNA. Translation: CAA06912.1.
CCDSiCCDS30457.1.
RefSeqiNP_033454.1. NM_009428.2.
UniGeneiMm.328378.

Genome annotation databases

EnsembliENSMUST00000040184; ENSMUSP00000049063; ENSMUSG00000041710.
GeneIDi22067.
KEGGimmu:22067.
UCSCiuc009umv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF029983 mRNA. Translation: AAC13550.1 .
AF060107 mRNA. Translation: AAF02200.1 .
AJ006204 mRNA. Translation: CAA06912.1 .
CCDSi CCDS30457.1.
RefSeqi NP_033454.1. NM_009428.2.
UniGenei Mm.328378.

3D structure databases

ProteinModelPortali Q9QX29.
SMRi Q9QX29. Positions 35-169.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 204331. 1 interaction.
MINTi MINT-144678.

Chemistry

GuidetoPHARMACOLOGYi 490.

PTM databases

PhosphoSitei Q9QX29.

Proteomic databases

PRIDEi Q9QX29.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000040184 ; ENSMUSP00000049063 ; ENSMUSG00000041710 .
GeneIDi 22067.
KEGGi mmu:22067.
UCSCi uc009umv.1. mouse.

Organism-specific databases

CTDi 7224.
MGIi MGI:109524. Trpc5.

Phylogenomic databases

eggNOGi NOG254238.
GeneTreei ENSGT00680000099866.
HOGENOMi HOG000020589.
HOVERGENi HBG068337.
InParanoidi Q9QX29.
KOi K04968.
OMAi PPLIRTM.
OrthoDBi EOG72G17P.
PhylomeDBi Q9QX29.
TreeFami TF313147.

Enzyme and pathway databases

Reactomei REACT_227861. TRP channels.

Miscellaneous databases

NextBioi 301888.
PROi Q9QX29.
SOURCEi Search...

Gene expression databases

Bgeei Q9QX29.
Genevestigatori Q9QX29.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR013555. TRP_dom.
IPR005461. TRPC5_channel.
IPR002153. TRPC_channel.
[Graphical view ]
PANTHERi PTHR10117. PTHR10117. 1 hit.
PTHR10117:SF24. PTHR10117:SF24. 1 hit.
Pfami PF00023. Ank. 1 hit.
PF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
[Graphical view ]
PRINTSi PR01097. TRNSRECEPTRP.
PR01646. TRPCHANNEL5.
SMARTi SM00248. ANK. 2 hits.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
TIGRFAMsi TIGR00870. trp. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and functional characterization of a novel receptor-activated TRP Ca2+ channel from mouse brain."
    Okada T., Shimizu S., Wakamori M., Maeda A., Kurosaki T., Takada N., Imoto K., Mori Y.
    J. Biol. Chem. 273:10279-10287(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Molecular cloning and functional expression of mouse TRP5."
    Zhu X., Peyton M., Boulay B., Birnbaumer B.
    Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Association of mammalian trp4 and phospholipase C isozymes with a PDZ domain-containing protein, NHERF."
    Tang Y., Tang J., Chen Z., Trost C., Flockerzi V., Li M., Ramesh V., Zhu M.X.
    J. Biol. Chem. 275:37559-37564(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "A novel capacitative calcium entry channel expressed in excitable cells."
    Philipp S., Hambrecht J., Braslavski L., Schroth G., Freichel M., Murakami M., Cavalie A., Flockerzi V.
    EMBO J. 17:4274-4282(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-966, TISSUE SPECIFICITY.
    Tissue: Brain.
  5. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 354-361, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.
  6. "trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry."
    Zhu X., Jiang M., Peyton M., Boulay G., Hurst R., Stefani E., Birnbaumer L.
    Cell 85:661-671(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 515-637.
  7. "Inhibition of TRPC5 channels by Ca2+-binding protein 1 in Xenopus oocytes."
    Kinoshita-Kawada M., Tang J., Xiao R., Kaneko S., Foskett J.K., Zhu M.X.
    Pflugers Arch. 450:345-354(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CABP1.
  8. "TRUSS, TNF-R1, and TRPC ion channels synergistically reverse endoplasmic reticulum Ca2+ storage reduction in response to m1 muscarinic acetylcholine receptor signaling."
    Mace K.E., Lussier M.P., Boulay G., Terry-Powers J.L., Parfrey H., Perraud A.L., Riches D.W.H.
    J. Cell. Physiol. 225:444-453(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TRPC4AP.

Entry informationi

Entry nameiTRPC5_MOUSE
AccessioniPrimary (citable) accession number: Q9QX29
Secondary accession number(s): Q61059, Q9QWT1, Q9R0D4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: June 20, 2001
Last modified: September 3, 2014
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi