Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

C-X-C motif chemokine

Gene

Cxcl13

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. heparin binding Source: Ensembl

GO - Biological processi

  1. B cell chemotaxis Source: Ensembl
  2. cell-cell signaling Source: Ensembl
  3. chemokine-mediated signaling pathway Source: GO_Central
  4. defense response to bacterium Source: Ensembl
  5. endothelial cell chemotaxis to fibroblast growth factor Source: Ensembl
  6. G-protein coupled receptor signaling pathway Source: GO_Central
  7. immune response Source: GO_Central
  8. inflammatory response Source: GO_Central
  9. negative regulation of endothelial cell chemotaxis to fibroblast growth factor Source: Ensembl
  10. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  11. positive regulation of leukocyte chemotaxis Source: GO_Central
  12. positive regulation of T cell chemotaxis Source: Ensembl
  13. regulation of cell proliferation Source: GO_Central
  14. response to lipopolysaccharide Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

CytokineUniRule annotationSAAS annotation

Keywords - Biological processi

ChemotaxisUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokineUniRule annotation
Gene namesi
Name:Cxcl13Imported
Synonyms:angie2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1888499. Cxcl13.

Subcellular locationi

  1. Secreted UniRule annotationSAAS annotation

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

SecretedUniRule annotationSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121UniRule annotationAdd
BLAST
Chaini22 – 8665C-X-C motif chemokineUniRule annotationPRO_5001353929Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiQ9QX28.
ExpressionAtlasiQ9QX28. baseline and differential.
GenevestigatoriQ9QX28.

Structurei

3D structure databases

ProteinModelPortaliQ9QX28.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the intercrine alpha (chemokine CxC) family.UniRule annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

HOVERGENiHBG098474.

Family and domain databases

InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QX28-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLSTATLLL LLASCLSPGH GILEAHYTNL KCRCSGVIST VVGLNIIDRI
60 70 80
QVTPPGNGCP KTEVVIWTKM KKVICVNPRA KWLQRL
Length:86
Mass (Da):9,440
Last modified:May 1, 2000 - v1
Checksum:iFB302753161C1EC5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030636 mRNA. Translation: AAC34603.1.
UniGeneiMm.10116.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030636 mRNA. Translation: AAC34603.1.
UniGeneiMm.10116.

3D structure databases

ProteinModelPortaliQ9QX28.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1888499. Cxcl13.

Phylogenomic databases

HOVERGENiHBG098474.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiQ9QX28.
ExpressionAtlasiQ9QX28. baseline and differential.
GenevestigatoriQ9QX28.

Family and domain databases

InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Napolitano M., Spinetti G., Capogrossi M.C.
    Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9QX28_MOUSE
AccessioniPrimary (citable) accession number: Q9QX28
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: April 1, 2015
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.