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Protein
Submitted name:

Na-K-Cl cotransporter

Gene

Slc12a2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • cation:chloride symporter activity Source: RGD
  • sodium:potassium:chloride symporter activity Source: RGD

GO - Biological processi

  • aging Source: RGD
  • chloride transport Source: RGD
  • gamma-aminobutyric acid signaling pathway Source: RGD
  • hyperosmotic response Source: RGD
  • positive regulation of cell volume Source: RGD
  • potassium ion transport Source: RGD
  • sodium ion transport Source: RGD

Names & Taxonomyi

Protein namesi
Submitted name:
Na-K-Cl cotransporterImported
Gene namesi
Name:Slc12a2Imported
Synonyms:Nkcc1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi620809 Slc12a2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei282 – 302HelicalSequence analysisAdd BLAST21
Transmembranei308 – 334HelicalSequence analysisAdd BLAST27
Transmembranei355 – 379HelicalSequence analysisAdd BLAST25
Transmembranei399 – 418HelicalSequence analysisAdd BLAST20
Transmembranei427 – 448HelicalSequence analysisAdd BLAST22
Transmembranei478 – 500HelicalSequence analysisAdd BLAST23
Transmembranei512 – 532HelicalSequence analysisAdd BLAST21
Transmembranei590 – 613HelicalSequence analysisAdd BLAST24
Transmembranei646 – 666HelicalSequence analysisAdd BLAST21
Transmembranei672 – 690HelicalSequence analysisAdd BLAST19
Transmembranei702 – 721HelicalSequence analysisAdd BLAST20
Transmembranei727 – 742HelicalSequence analysisAdd BLAST16

Keywords - Cellular componenti

Membrane

PTM / Processingi

PTM databases

iPTMnetiQ9QX10
PhosphoSitePlusiQ9QX10

Expressioni

Gene expression databases

GenevisibleiQ9QX10 RN

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini193 – 246AA_permease_NInterPro annotationAdd BLAST54
Domaini281 – 783AA_permeaseInterPro annotationAdd BLAST503
Domaini792 – 1203SLC12InterPro annotationAdd BLAST412

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG2083 Eukaryota
COG0531 LUCA
HOGENOMiHOG000062855
HOVERGENiHBG052851
KOiK10951

Family and domain databases

InterProiView protein in InterPro
IPR004841 AA-permease/SLC12A_dom
IPR013612 AA_permease_N
IPR002443 Na/K/Cl_cotranspt
IPR002444 NKCC1
IPR018491 SLC12_C
IPR004842 SLC12A_fam
PANTHERiPTHR11827:SF58 PTHR11827:SF58, 1 hit
PfamiView protein in Pfam
PF00324 AA_permease, 1 hit
PF08403 AA_permease_N, 1 hit
PF03522 SLC12, 1 hit
PRINTSiPR01207 NAKCLTRNSPRT
PR01208 NAKCLTRSPRT1
TIGRFAMsiTIGR00930 2a30, 1 hit

Sequencei

Sequence statusi: Complete.

Q9QX10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPGPAAPSS GAPRPARDGD APLTAAGVDL PGTAVLSGRE DATAGSQAGG
60 70 80 90 100
GVRGEGTPAA GDGLGKPLGP TPSQSRFQVD PVSENAGRAA AAAAAAAAAA
110 120 130 140 150
AAGAAGKETP AAGKAGTESG VAKGSEEAKG RFRVNFVDPA ASSSADDSLS
160 170 180 190 200
DAAGVGGDGP NVSSQNGGDT VLSEGSSLHS GGGSGHHQQY YYDTHTNTYY
210 220 230 240 250
LRTFGHNTMD AVPRIDHYRH TAAQLGEKLL RPSLGEFHDE LEKEPFEDGF
260 270 280 290 300
ANGEESTPTR DAVVTYTAES KGVVKFGWIK GVLVRCMLNI WGVMLFIRLS
310 320 330 340 350
WIVGQAGIGL SVLVIAMATV VTTITGLSTS AIATNGFVRG GGAYYLISRS
360 370 380 390 400
LGPEFGGAIG LIFAFPNAVA VAMYVVGFAE TVVELLKEHS ILMIDEINDI
410 420 430 440 450
RIIGAITVVV LLGISVAGME WEAKAQIVLL VILLLAIADF VIGTFISLDS
460 470 480 490 500
KKPKGFFGYK SEIFSENFGP DFREEETFFS VFAIFFPAAT GILAGANISG
510 520 530 540 550
DLADPQSAIP KGTLLAILIT TVVYIGIAVS VGSCVVRDAT GNVNDTITTE
560 570 580 590 600
LTNCTSAACK LNFDFSYCES NTCSYGLMNN FQVMSMVSGF APLISAGIFS
610 620 630 640 650
ATLSSALASL VSAPKIFQAL CKDNIYPAFQ MFAKGYGKNN EPLRGYILTF
660 670 680 690 700
LIALGFILIA ELNVIAPIIS NFFLASYALI NFSVFHASLA KSPGWRPAFK
710 720 730 740 750
YYNMWISLTG AILCCIVMFV INWWAALLTY VIVLGLYIYV TYKKPDVNWG
760 770 780 790 800
SSTQALTYLS ALQHSIRLSG VEDHVKNFRP QCLVMTGSPN SRPALLHLVH
810 820 830 840 850
DFTKNVGLMI CGHVHMGPRR QAMKEMSIDQ AKYQRWLIKN KMKAFYAPVH
860 870 880 890 900
ADDLREGAQY LMQAAGLGRM KPNTLVLGFK KDWLQADMRD VDMYINLFHD
910 920 930 940 950
AFDIQYGVVV IRLKEGLDIS HLQGQEELLS SQEKSPGTKD VVVNVDYSKK
960 970 980 990 1000
SDQDAFKASG EKPITQKDEE EDGKTSTQPL LKKESKGPVA PLNVADQKLL
1010 1020 1030 1040 1050
EASTQFQKKQ GKNTIDVWWL FDDGGLTLLI PYLLTTKKKW KDCKIRVFIG
1060 1070 1080 1090 1100
GKINRIDHDR RAMATLLSKF RIDFSDIMVL GDINTKPKKE NIVAFDDMIE
1110 1120 1130 1140 1150
PYRLHEDDKE QDIADKMKED EPWRITDNEL ELYKTKTYRQ IRLNELLKEH
1160 1170 1180 1190 1200
SSTANIIVMS LPVARKGAVS SALYMAWLEA LSKDLPPILL VRGNHQSVLT

FYS
Length:1,203
Mass (Da):130,352
Last modified:May 1, 2000 - v1
Checksum:iF59E4959A7E760FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF051561 mRNA Translation: AAC27557.1
RefSeqiNP_113986.1, NM_031798.1
UniGeneiRn.11523

Genome annotation databases

GeneIDi83629
KEGGirno:83629

Similar proteinsi

Entry informationi

Entry nameiQ9QX10_RAT
AccessioniPrimary (citable) accession number: Q9QX10
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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