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Q9QX10

- Q9QX10_RAT

UniProt

Q9QX10 - Q9QX10_RAT

Protein
Submitted name:

Na-K-Cl cotransporter

Gene

Slc12a2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. cation:chloride symporter activity Source: RGD
    2. sodium:potassium:chloride symporter activity Source: RGD

    GO - Biological processi

    1. chloride transmembrane transport Source: GOC
    2. chloride transport Source: RGD
    3. gamma-aminobutyric acid signaling pathway Source: RGD
    4. hyperosmotic response Source: RGD
    5. positive regulation of cell volume Source: RGD
    6. potassium ion transport Source: RGD
    7. sodium ion transport Source: RGD

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Na-K-Cl cotransporterImported
    Gene namesi
    Name:Slc12a2Imported
    Synonyms:Nkcc1Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

    Organism-specific databases

    RGDi620809. Slc12a2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: InterPro
    2. plasma membrane Source: RGD

    PTM / Processingi

    Proteomic databases

    PRIDEiQ9QX10.

    PTM databases

    PhosphoSiteiQ9QX10.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9QX10.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000021921.

    Family & Domainsi

    Phylogenomic databases

    HOGENOMiHOG000062855.
    HOVERGENiHBG052851.
    InParanoidiQ9QX10.
    KOiK10951.

    Family and domain databases

    InterProiIPR004841. AA-permease/SLC12A_dom.
    IPR013612. AA_permease_N.
    IPR002443. Na/K/Cl_cotranspt.
    IPR002444. Na/K/Cl_cotranspt1.
    IPR004842. Na/K/Cl_cotransptS.
    [Graphical view]
    PfamiPF00324. AA_permease. 1 hit.
    PF08403. AA_permease_N. 1 hit.
    [Graphical view]
    PRINTSiPR01207. NAKCLTRNSPRT.
    PR01208. NAKCLTRSPRT1.
    TIGRFAMsiTIGR00930. 2a30. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9QX10-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPGPAAPSS GAPRPARDGD APLTAAGVDL PGTAVLSGRE DATAGSQAGG     50
    GVRGEGTPAA GDGLGKPLGP TPSQSRFQVD PVSENAGRAA AAAAAAAAAA 100
    AAGAAGKETP AAGKAGTESG VAKGSEEAKG RFRVNFVDPA ASSSADDSLS 150
    DAAGVGGDGP NVSSQNGGDT VLSEGSSLHS GGGSGHHQQY YYDTHTNTYY 200
    LRTFGHNTMD AVPRIDHYRH TAAQLGEKLL RPSLGEFHDE LEKEPFEDGF 250
    ANGEESTPTR DAVVTYTAES KGVVKFGWIK GVLVRCMLNI WGVMLFIRLS 300
    WIVGQAGIGL SVLVIAMATV VTTITGLSTS AIATNGFVRG GGAYYLISRS 350
    LGPEFGGAIG LIFAFPNAVA VAMYVVGFAE TVVELLKEHS ILMIDEINDI 400
    RIIGAITVVV LLGISVAGME WEAKAQIVLL VILLLAIADF VIGTFISLDS 450
    KKPKGFFGYK SEIFSENFGP DFREEETFFS VFAIFFPAAT GILAGANISG 500
    DLADPQSAIP KGTLLAILIT TVVYIGIAVS VGSCVVRDAT GNVNDTITTE 550
    LTNCTSAACK LNFDFSYCES NTCSYGLMNN FQVMSMVSGF APLISAGIFS 600
    ATLSSALASL VSAPKIFQAL CKDNIYPAFQ MFAKGYGKNN EPLRGYILTF 650
    LIALGFILIA ELNVIAPIIS NFFLASYALI NFSVFHASLA KSPGWRPAFK 700
    YYNMWISLTG AILCCIVMFV INWWAALLTY VIVLGLYIYV TYKKPDVNWG 750
    SSTQALTYLS ALQHSIRLSG VEDHVKNFRP QCLVMTGSPN SRPALLHLVH 800
    DFTKNVGLMI CGHVHMGPRR QAMKEMSIDQ AKYQRWLIKN KMKAFYAPVH 850
    ADDLREGAQY LMQAAGLGRM KPNTLVLGFK KDWLQADMRD VDMYINLFHD 900
    AFDIQYGVVV IRLKEGLDIS HLQGQEELLS SQEKSPGTKD VVVNVDYSKK 950
    SDQDAFKASG EKPITQKDEE EDGKTSTQPL LKKESKGPVA PLNVADQKLL 1000
    EASTQFQKKQ GKNTIDVWWL FDDGGLTLLI PYLLTTKKKW KDCKIRVFIG 1050
    GKINRIDHDR RAMATLLSKF RIDFSDIMVL GDINTKPKKE NIVAFDDMIE 1100
    PYRLHEDDKE QDIADKMKED EPWRITDNEL ELYKTKTYRQ IRLNELLKEH 1150
    SSTANIIVMS LPVARKGAVS SALYMAWLEA LSKDLPPILL VRGNHQSVLT 1200
    FYS 1203
    Length:1,203
    Mass (Da):130,352
    Last modified:May 1, 2000 - v1
    Checksum:iF59E4959A7E760FC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF051561 mRNA. Translation: AAC27557.1.
    RefSeqiNP_113986.1. NM_031798.1.
    UniGeneiRn.11523.

    Genome annotation databases

    GeneIDi83629.
    KEGGirno:83629.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF051561 mRNA. Translation: AAC27557.1 .
    RefSeqi NP_113986.1. NM_031798.1.
    UniGenei Rn.11523.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000021921.

    PTM databases

    PhosphoSitei Q9QX10.

    Proteomic databases

    PRIDEi Q9QX10.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 83629.
    KEGGi rno:83629.

    Organism-specific databases

    CTDi 6558.
    RGDi 620809. Slc12a2.

    Phylogenomic databases

    HOGENOMi HOG000062855.
    HOVERGENi HBG052851.
    InParanoidi Q9QX10.
    KOi K10951.

    Miscellaneous databases

    NextBioi 616211.

    Gene expression databases

    Genevestigatori Q9QX10.

    Family and domain databases

    InterProi IPR004841. AA-permease/SLC12A_dom.
    IPR013612. AA_permease_N.
    IPR002443. Na/K/Cl_cotranspt.
    IPR002444. Na/K/Cl_cotranspt1.
    IPR004842. Na/K/Cl_cotransptS.
    [Graphical view ]
    Pfami PF00324. AA_permease. 1 hit.
    PF08403. AA_permease_N. 1 hit.
    [Graphical view ]
    PRINTSi PR01207. NAKCLTRNSPRT.
    PR01208. NAKCLTRSPRT1.
    TIGRFAMsi TIGR00930. 2a30. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular and topological characterization of the rat parotid Na+-K+-2Cl- cotransporter1."
      Moore-Hoon M.L., Turner R.J.
      Biochim. Biophys. Acta 1373:261-269(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: WistarImported.
      Tissue: Parotid salivary glandImported.

    Entry informationi

    Entry nameiQ9QX10_RAT
    AccessioniPrimary (citable) accession number: Q9QX10
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)