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Q9QX10

- Q9QX10_RAT

UniProt

Q9QX10 - Q9QX10_RAT

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Protein
Submitted name:

Na-K-Cl cotransporter

Gene

Slc12a2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. cation:chloride symporter activity Source: RGD
  2. sodium:potassium:chloride symporter activity Source: RGD

GO - Biological processi

  1. chloride transmembrane transport Source: GOC
  2. chloride transport Source: RGD
  3. gamma-aminobutyric acid signaling pathway Source: RGD
  4. hyperosmotic response Source: RGD
  5. positive regulation of cell volume Source: RGD
  6. potassium ion transport Source: RGD
  7. sodium ion transport Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Na-K-Cl cotransporterImported
Gene namesi
Name:Slc12a2Imported
Synonyms:Nkcc1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi620809. Slc12a2.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: InterPro
  2. plasma membrane Source: RGD
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ9QX10.

PTM databases

PhosphoSiteiQ9QX10.

Expressioni

Gene expression databases

GenevestigatoriQ9QX10.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021921.

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000062855.
HOVERGENiHBG052851.
KOiK10951.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR013612. AA_permease_N.
IPR002443. Na/K/Cl_cotranspt.
IPR002444. Na/K/Cl_cotranspt1.
IPR004842. Na/K/Cl_cotransptS.
[Graphical view]
PfamiPF00324. AA_permease. 1 hit.
PF08403. AA_permease_N. 1 hit.
[Graphical view]
PRINTSiPR01207. NAKCLTRNSPRT.
PR01208. NAKCLTRSPRT1.
TIGRFAMsiTIGR00930. 2a30. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9QX10 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEPGPAAPSS GAPRPARDGD APLTAAGVDL PGTAVLSGRE DATAGSQAGG
60 70 80 90 100
GVRGEGTPAA GDGLGKPLGP TPSQSRFQVD PVSENAGRAA AAAAAAAAAA
110 120 130 140 150
AAGAAGKETP AAGKAGTESG VAKGSEEAKG RFRVNFVDPA ASSSADDSLS
160 170 180 190 200
DAAGVGGDGP NVSSQNGGDT VLSEGSSLHS GGGSGHHQQY YYDTHTNTYY
210 220 230 240 250
LRTFGHNTMD AVPRIDHYRH TAAQLGEKLL RPSLGEFHDE LEKEPFEDGF
260 270 280 290 300
ANGEESTPTR DAVVTYTAES KGVVKFGWIK GVLVRCMLNI WGVMLFIRLS
310 320 330 340 350
WIVGQAGIGL SVLVIAMATV VTTITGLSTS AIATNGFVRG GGAYYLISRS
360 370 380 390 400
LGPEFGGAIG LIFAFPNAVA VAMYVVGFAE TVVELLKEHS ILMIDEINDI
410 420 430 440 450
RIIGAITVVV LLGISVAGME WEAKAQIVLL VILLLAIADF VIGTFISLDS
460 470 480 490 500
KKPKGFFGYK SEIFSENFGP DFREEETFFS VFAIFFPAAT GILAGANISG
510 520 530 540 550
DLADPQSAIP KGTLLAILIT TVVYIGIAVS VGSCVVRDAT GNVNDTITTE
560 570 580 590 600
LTNCTSAACK LNFDFSYCES NTCSYGLMNN FQVMSMVSGF APLISAGIFS
610 620 630 640 650
ATLSSALASL VSAPKIFQAL CKDNIYPAFQ MFAKGYGKNN EPLRGYILTF
660 670 680 690 700
LIALGFILIA ELNVIAPIIS NFFLASYALI NFSVFHASLA KSPGWRPAFK
710 720 730 740 750
YYNMWISLTG AILCCIVMFV INWWAALLTY VIVLGLYIYV TYKKPDVNWG
760 770 780 790 800
SSTQALTYLS ALQHSIRLSG VEDHVKNFRP QCLVMTGSPN SRPALLHLVH
810 820 830 840 850
DFTKNVGLMI CGHVHMGPRR QAMKEMSIDQ AKYQRWLIKN KMKAFYAPVH
860 870 880 890 900
ADDLREGAQY LMQAAGLGRM KPNTLVLGFK KDWLQADMRD VDMYINLFHD
910 920 930 940 950
AFDIQYGVVV IRLKEGLDIS HLQGQEELLS SQEKSPGTKD VVVNVDYSKK
960 970 980 990 1000
SDQDAFKASG EKPITQKDEE EDGKTSTQPL LKKESKGPVA PLNVADQKLL
1010 1020 1030 1040 1050
EASTQFQKKQ GKNTIDVWWL FDDGGLTLLI PYLLTTKKKW KDCKIRVFIG
1060 1070 1080 1090 1100
GKINRIDHDR RAMATLLSKF RIDFSDIMVL GDINTKPKKE NIVAFDDMIE
1110 1120 1130 1140 1150
PYRLHEDDKE QDIADKMKED EPWRITDNEL ELYKTKTYRQ IRLNELLKEH
1160 1170 1180 1190 1200
SSTANIIVMS LPVARKGAVS SALYMAWLEA LSKDLPPILL VRGNHQSVLT

FYS
Length:1,203
Mass (Da):130,352
Last modified:May 1, 2000 - v1
Checksum:iF59E4959A7E760FC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF051561 mRNA. Translation: AAC27557.1.
RefSeqiNP_113986.1. NM_031798.1.
UniGeneiRn.11523.

Genome annotation databases

GeneIDi83629.
KEGGirno:83629.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF051561 mRNA. Translation: AAC27557.1 .
RefSeqi NP_113986.1. NM_031798.1.
UniGenei Rn.11523.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000021921.

PTM databases

PhosphoSitei Q9QX10.

Proteomic databases

PRIDEi Q9QX10.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 83629.
KEGGi rno:83629.

Organism-specific databases

CTDi 6558.
RGDi 620809. Slc12a2.

Phylogenomic databases

HOGENOMi HOG000062855.
HOVERGENi HBG052851.
KOi K10951.

Miscellaneous databases

NextBioi 616211.

Gene expression databases

Genevestigatori Q9QX10.

Family and domain databases

InterProi IPR004841. AA-permease/SLC12A_dom.
IPR013612. AA_permease_N.
IPR002443. Na/K/Cl_cotranspt.
IPR002444. Na/K/Cl_cotranspt1.
IPR004842. Na/K/Cl_cotransptS.
[Graphical view ]
Pfami PF00324. AA_permease. 1 hit.
PF08403. AA_permease_N. 1 hit.
[Graphical view ]
PRINTSi PR01207. NAKCLTRNSPRT.
PR01208. NAKCLTRSPRT1.
TIGRFAMsi TIGR00930. 2a30. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Molecular and topological characterization of the rat parotid Na+-K+-2Cl- cotransporter1."
    Moore-Hoon M.L., Turner R.J.
    Biochim. Biophys. Acta 1373:261-269(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: WistarImported.
    Tissue: Parotid salivary glandImported.

Entry informationi

Entry nameiQ9QX10_RAT
AccessioniPrimary (citable) accession number: Q9QX10
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)