Q9QX10 (Q9QX10_RAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Na-K-Cl cotransporter EMBL AAC27557.1

Gene names

Name:	Slc12a2 RGD 620809
Synonyms:	Nkcc1 EMBL AAC27557.1

Organism

Rattus norvegicus (Rat) EMBL AAC27557.1

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	1203 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Gene Ontology (GO)
Biological_process	gamma-aminobutyric acid signaling pathway Inferred from expression pattern PubMed 15090604. Source: RGD hyperosmotic response Inferred from mutant phenotype PubMed 15284343. Source: RGD positive regulation of cell volume Inferred from mutant phenotype PubMed 15284343. Source: RGD potassium ion transport Inferred from mutant phenotype PubMed 12556450. Source: RGD sodium ion transport Inferred from mutant phenotype PubMed 12556450. Source: RGD
Cellular_component	integral to membrane Inferred from electronic annotation. Source: InterPro plasma membrane Inferred from direct assay PubMed 12556450. Source: RGD
Molecular_function	sodium:potassium:chloride symporter activity Inferred from mutant phenotype PubMed 12556450. Source: RGD
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9QX10 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: F59E4959A7E760FC	FASTA	1,203	130,352
	10 20 30 40 50 60 MEPGPAAPSS GAPRPARDGD APLTAAGVDL PGTAVLSGRE DATAGSQAGG GVRGEGTPAA 70 80 90 100 110 120 GDGLGKPLGP TPSQSRFQVD PVSENAGRAA AAAAAAAAAA AAGAAGKETP AAGKAGTESG 130 140 150 160 170 180 VAKGSEEAKG RFRVNFVDPA ASSSADDSLS DAAGVGGDGP NVSSQNGGDT VLSEGSSLHS 190 200 210 220 230 240 GGGSGHHQQY YYDTHTNTYY LRTFGHNTMD AVPRIDHYRH TAAQLGEKLL RPSLGEFHDE 250 260 270 280 290 300 LEKEPFEDGF ANGEESTPTR DAVVTYTAES KGVVKFGWIK GVLVRCMLNI WGVMLFIRLS 310 320 330 340 350 360 WIVGQAGIGL SVLVIAMATV VTTITGLSTS AIATNGFVRG GGAYYLISRS LGPEFGGAIG 370 380 390 400 410 420 LIFAFPNAVA VAMYVVGFAE TVVELLKEHS ILMIDEINDI RIIGAITVVV LLGISVAGME 430 440 450 460 470 480 WEAKAQIVLL VILLLAIADF VIGTFISLDS KKPKGFFGYK SEIFSENFGP DFREEETFFS 490 500 510 520 530 540 VFAIFFPAAT GILAGANISG DLADPQSAIP KGTLLAILIT TVVYIGIAVS VGSCVVRDAT 550 560 570 580 590 600 GNVNDTITTE LTNCTSAACK LNFDFSYCES NTCSYGLMNN FQVMSMVSGF APLISAGIFS 610 620 630 640 650 660 ATLSSALASL VSAPKIFQAL CKDNIYPAFQ MFAKGYGKNN EPLRGYILTF LIALGFILIA 670 680 690 700 710 720 ELNVIAPIIS NFFLASYALI NFSVFHASLA KSPGWRPAFK YYNMWISLTG AILCCIVMFV 730 740 750 760 770 780 INWWAALLTY VIVLGLYIYV TYKKPDVNWG SSTQALTYLS ALQHSIRLSG VEDHVKNFRP 790 800 810 820 830 840 QCLVMTGSPN SRPALLHLVH DFTKNVGLMI CGHVHMGPRR QAMKEMSIDQ AKYQRWLIKN 850 860 870 880 890 900 KMKAFYAPVH ADDLREGAQY LMQAAGLGRM KPNTLVLGFK KDWLQADMRD VDMYINLFHD 910 920 930 940 950 960 AFDIQYGVVV IRLKEGLDIS HLQGQEELLS SQEKSPGTKD VVVNVDYSKK SDQDAFKASG 970 980 990 1000 1010 1020 EKPITQKDEE EDGKTSTQPL LKKESKGPVA PLNVADQKLL EASTQFQKKQ GKNTIDVWWL 1030 1040 1050 1060 1070 1080 FDDGGLTLLI PYLLTTKKKW KDCKIRVFIG GKINRIDHDR RAMATLLSKF RIDFSDIMVL 1090 1100 1110 1120 1130 1140 GDINTKPKKE NIVAFDDMIE PYRLHEDDKE QDIADKMKED EPWRITDNEL ELYKTKTYRQ 1150 1160 1170 1180 1190 1200 IRLNELLKEH SSTANIIVMS LPVARKGAVS SALYMAWLEA LSKDLPPILL VRGNHQSVLT FYS

References

[1]	"Molecular and topological characterization of the rat parotid Na+-K+-2Cl- cotransporter1." Moore-Hoon M.L., Turner R.J. Biochim. Biophys. Acta 1373:261-269(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Wistar EMBL AAC27557.1. Tissue: Parotid salivary gland EMBL AAC27557.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF051561 mRNA. Translation: AAC27557.1.
IPI	IPI00212590.
RefSeq	NP_113986.1. NM_031798.1.
UniGene	Rn.11523.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000021921.
PTM databases
PhosphoSite	Q9QX10.
Proteomic databases
PRIDE	Q9QX10.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	83629.
KEGG	rno:83629.
Organism-specific databases
CTD	6558.
RGD	620809. Slc12a2.
Phylogenomic databases
HOGENOM	HOG000062855.
HOVERGEN	HBG052851.
InParanoid	Q9QX10.
KO	K10951.
Gene expression databases
ArrayExpress	Q9QX10.
Genevestigator	Q9QX10.
Family and domain databases
InterPro	IPR004841. AA-permease_dom. IPR013612. AA_permease_N. IPR002443. Na/K/Cl_cotranspt. IPR002444. Na/K/Cl_cotranspt1. IPR004842. Na/K/Cl_cotransptS. [Graphical view]
Pfam	PF00324. AA_permease. 1 hit. PF08403. AA_permease_N. 1 hit. [Graphical view]
PRINTS	PR01207. NAKCLTRNSPRT. PR01208. NAKCLTRSPRT1.
TIGRFAMs	TIGR00930. 2a30. 1 hit.
ProtoNet	Search...
Other
NextBio	616211.

Entry information

Entry name

Q9QX10_RAT

Accession

Primary (citable) accession number: Q9QX10

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2000
Last sequence update:	May 1, 2000
Last modified:	May 29, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)