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Q9QX10

- Q9QX10_RAT

UniProt

Q9QX10 - Q9QX10_RAT

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Protein
Submitted name: Na-K-Cl cotransporter
Gene
Slc12a2, Nkcc1
Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. cation:chloride symporter activity Source: RGD
  2. sodium:potassium:chloride symporter activity Source: RGD

GO - Biological processi

  1. chloride transmembrane transport Source: GOC
  2. chloride transport Source: RGD
  3. gamma-aminobutyric acid signaling pathway Source: RGD
  4. hyperosmotic response Source: RGD
  5. positive regulation of cell volume Source: RGD
  6. potassium ion transport Source: RGD
  7. sodium ion transport Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Na-K-Cl cotransporterImported
Gene namesi
Name:Slc12a2Imported
Synonyms:Nkcc1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi620809. Slc12a2.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: InterPro
  2. plasma membrane Source: RGD
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ9QX10.

PTM databases

PhosphoSiteiQ9QX10.

Expressioni

Gene expression databases

GenevestigatoriQ9QX10.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021921.

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000062855.
HOVERGENiHBG052851.
InParanoidiQ9QX10.
KOiK10951.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR013612. AA_permease_N.
IPR002443. Na/K/Cl_cotranspt.
IPR002444. Na/K/Cl_cotranspt1.
IPR004842. Na/K/Cl_cotransptS.
[Graphical view]
PfamiPF00324. AA_permease. 1 hit.
PF08403. AA_permease_N. 1 hit.
[Graphical view]
PRINTSiPR01207. NAKCLTRNSPRT.
PR01208. NAKCLTRSPRT1.
TIGRFAMsiTIGR00930. 2a30. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9QX10-1 [UniParc]FASTAAdd to Basket

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MEPGPAAPSS GAPRPARDGD APLTAAGVDL PGTAVLSGRE DATAGSQAGG     50
GVRGEGTPAA GDGLGKPLGP TPSQSRFQVD PVSENAGRAA AAAAAAAAAA 100
AAGAAGKETP AAGKAGTESG VAKGSEEAKG RFRVNFVDPA ASSSADDSLS 150
DAAGVGGDGP NVSSQNGGDT VLSEGSSLHS GGGSGHHQQY YYDTHTNTYY 200
LRTFGHNTMD AVPRIDHYRH TAAQLGEKLL RPSLGEFHDE LEKEPFEDGF 250
ANGEESTPTR DAVVTYTAES KGVVKFGWIK GVLVRCMLNI WGVMLFIRLS 300
WIVGQAGIGL SVLVIAMATV VTTITGLSTS AIATNGFVRG GGAYYLISRS 350
LGPEFGGAIG LIFAFPNAVA VAMYVVGFAE TVVELLKEHS ILMIDEINDI 400
RIIGAITVVV LLGISVAGME WEAKAQIVLL VILLLAIADF VIGTFISLDS 450
KKPKGFFGYK SEIFSENFGP DFREEETFFS VFAIFFPAAT GILAGANISG 500
DLADPQSAIP KGTLLAILIT TVVYIGIAVS VGSCVVRDAT GNVNDTITTE 550
LTNCTSAACK LNFDFSYCES NTCSYGLMNN FQVMSMVSGF APLISAGIFS 600
ATLSSALASL VSAPKIFQAL CKDNIYPAFQ MFAKGYGKNN EPLRGYILTF 650
LIALGFILIA ELNVIAPIIS NFFLASYALI NFSVFHASLA KSPGWRPAFK 700
YYNMWISLTG AILCCIVMFV INWWAALLTY VIVLGLYIYV TYKKPDVNWG 750
SSTQALTYLS ALQHSIRLSG VEDHVKNFRP QCLVMTGSPN SRPALLHLVH 800
DFTKNVGLMI CGHVHMGPRR QAMKEMSIDQ AKYQRWLIKN KMKAFYAPVH 850
ADDLREGAQY LMQAAGLGRM KPNTLVLGFK KDWLQADMRD VDMYINLFHD 900
AFDIQYGVVV IRLKEGLDIS HLQGQEELLS SQEKSPGTKD VVVNVDYSKK 950
SDQDAFKASG EKPITQKDEE EDGKTSTQPL LKKESKGPVA PLNVADQKLL 1000
EASTQFQKKQ GKNTIDVWWL FDDGGLTLLI PYLLTTKKKW KDCKIRVFIG 1050
GKINRIDHDR RAMATLLSKF RIDFSDIMVL GDINTKPKKE NIVAFDDMIE 1100
PYRLHEDDKE QDIADKMKED EPWRITDNEL ELYKTKTYRQ IRLNELLKEH 1150
SSTANIIVMS LPVARKGAVS SALYMAWLEA LSKDLPPILL VRGNHQSVLT 1200
FYS 1203
Length:1,203
Mass (Da):130,352
Last modified:May 1, 2000 - v1
Checksum:iF59E4959A7E760FC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF051561 mRNA. Translation: AAC27557.1.
RefSeqiNP_113986.1. NM_031798.1.
UniGeneiRn.11523.

Genome annotation databases

GeneIDi83629.
KEGGirno:83629.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF051561 mRNA. Translation: AAC27557.1 .
RefSeqi NP_113986.1. NM_031798.1.
UniGenei Rn.11523.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000021921.

PTM databases

PhosphoSitei Q9QX10.

Proteomic databases

PRIDEi Q9QX10.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 83629.
KEGGi rno:83629.

Organism-specific databases

CTDi 6558.
RGDi 620809. Slc12a2.

Phylogenomic databases

HOGENOMi HOG000062855.
HOVERGENi HBG052851.
InParanoidi Q9QX10.
KOi K10951.

Miscellaneous databases

NextBioi 616211.

Gene expression databases

Genevestigatori Q9QX10.

Family and domain databases

InterProi IPR004841. AA-permease/SLC12A_dom.
IPR013612. AA_permease_N.
IPR002443. Na/K/Cl_cotranspt.
IPR002444. Na/K/Cl_cotranspt1.
IPR004842. Na/K/Cl_cotransptS.
[Graphical view ]
Pfami PF00324. AA_permease. 1 hit.
PF08403. AA_permease_N. 1 hit.
[Graphical view ]
PRINTSi PR01207. NAKCLTRNSPRT.
PR01208. NAKCLTRSPRT1.
TIGRFAMsi TIGR00930. 2a30. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Molecular and topological characterization of the rat parotid Na+-K+-2Cl- cotransporter1."
    Moore-Hoon M.L., Turner R.J.
    Biochim. Biophys. Acta 1373:261-269(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: WistarImported.
    Tissue: Parotid salivary glandImported.

Entry informationi

Entry nameiQ9QX10_RAT
AccessioniPrimary (citable) accession number: Q9QX10
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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