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Q9QX05

- TLR4_RAT

UniProt

Q9QX05 - TLR4_RAT

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Protein

Toll-like receptor 4

Gene
Tlr4
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response By similarity.

GO - Molecular functioni

  1. lipopolysaccharide binding Source: RGD
  2. lipopolysaccharide receptor activity Source: UniProtKB
  3. phosphatidylinositol 3-kinase binding Source: RGD
  4. protein binding Source: RGD
  5. receptor activity Source: RGD
  6. transmembrane signaling receptor activity Source: InterPro

GO - Biological processi

  1. cellular response to lipopolysaccharide Source: RGD
  2. cellular response to mechanical stimulus Source: RGD
  3. cellular response to retinoic acid Source: RGD
  4. defense response to Gram-negative bacterium Source: InterPro
  5. detection of lipopolysaccharide Source: UniProtKB
  6. immunoglobulin mediated immune response Source: RGD
  7. inflammatory response Source: RGD
  8. innate immune response Source: RGD
  9. innate immune response-activating signal transduction Source: RGD
  10. leukotriene metabolic process Source: RGD
  11. microglial cell activation Source: RGD
  12. MyD88-dependent toll-like receptor signaling pathway Source: InterPro
  13. positive regulation of apoptotic process Source: RGD
  14. positive regulation of DNA binding Source: RGD
  15. positive regulation of inflammatory response Source: RGD
  16. positive regulation of NF-kappaB transcription factor activity Source: RGD
  17. positive regulation of peptidyl-tyrosine phosphorylation Source: RGD
  18. positive regulation of sequence-specific DNA binding transcription factor activity Source: RGD
  19. regulation of cytokine secretion Source: InterPro
  20. regulation of sensory perception of pain Source: RGD
  21. response to activity Source: RGD
  22. response to ethanol Source: RGD
  23. response to fatty acid Source: RGD
  24. response to gold nanoparticle Source: RGD
  25. response to hypoxia Source: RGD
  26. response to insulin Source: RGD
  27. response to lipopolysaccharide Source: RGD
  28. response to morphine Source: RGD
  29. response to oxidative stress Source: RGD
  30. response to progesterone Source: RGD
  31. response to retinoic acid Source: RGD
  32. response to toxic substance Source: RGD
  33. skeletal muscle contraction Source: RGD
  34. toll-like receptor 4 signaling pathway Source: InterPro
  35. toll-like receptor signaling pathway Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Immunity, Inflammatory response, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Toll-like receptor 4
Short name:
Toll4
Alternative name(s):
CD_antigen: CD284
Gene namesi
Name:Tlr4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi3870. Tlr4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 638613Extracellular Reviewed predictionAdd
BLAST
Transmembranei639 – 65921Helical; Reviewed predictionAdd
BLAST
Topological domaini660 – 835176Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: RGD
  2. cytoplasm Source: RGD
  3. integral component of plasma membrane Source: RGD
  4. lipopolysaccharide receptor complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed predictionAdd
BLAST
Chaini26 – 835810Toll-like receptor 4PRO_0000034728Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi28 ↔ 39 By similarity
Glycosylationi34 – 341N-linked (GlcNAc...) Reviewed prediction
Glycosylationi43 – 431N-linked (GlcNAc...) Reviewed prediction
Glycosylationi75 – 751N-linked (GlcNAc...) Reviewed prediction
Glycosylationi172 – 1721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi204 – 2041N-linked (GlcNAc...) Reviewed prediction
Glycosylationi237 – 2371N-linked (GlcNAc...) Reviewed prediction
Glycosylationi248 – 2481N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi280 ↔ 304 By similarity
Glycosylationi281 – 2811N-linked (GlcNAc...) Reviewed prediction
Glycosylationi307 – 3071N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi388 ↔ 389 By similarity
Glycosylationi492 – 4921N-linked (GlcNAc...) Reviewed prediction
Glycosylationi495 – 4951N-linked (GlcNAc...) Reviewed prediction
Glycosylationi524 – 5241N-linked (GlcNAc...) Reviewed prediction
Glycosylationi572 – 5721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi575 – 5751N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi580 ↔ 606 By similarity
Disulfide bondi582 ↔ 625 By similarity
Glycosylationi622 – 6221N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ9QX05.

Expressioni

Gene expression databases

GenevestigatoriQ9QX05.

Interactioni

Subunit structurei

Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4. Binding to bacterial LPS leads to homodimerization. Interacts with LY96 via the extracellular domain. Interacts with MYD88 and TIRAP via their respective TIR domains. Interacts with NOX4 By similarity. Interacts with CNPY3 and HSP90B1; this interaction is required for proper folding in the endoplasmic reticulum. Interacts with MLK4; this interaction leads to negative regulation of TLR4 signaling By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ9QX05.
SMRiQ9QX05. Positions 27-625.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati54 – 7522LRR 1Add
BLAST
Repeati78 – 9922LRR 2Add
BLAST
Repeati102 – 12322LRR 3Add
BLAST
Repeati126 – 14722LRR 4Add
BLAST
Repeati150 – 17122LRR 5Add
BLAST
Repeati175 – 19824LRR 6Add
BLAST
Repeati204 – 22421LRR 7Add
BLAST
Repeati226 – 24722LRR 8Add
BLAST
Repeati372 – 38110LRR 9
Repeati398 – 42023LRR 10Add
BLAST
Repeati421 – 44222LRR 11Add
BLAST
Repeati446 – 46722LRR 12Add
BLAST
Repeati470 – 49122LRR 13Add
BLAST
Repeati495 – 51622LRR 14Add
BLAST
Repeati519 – 54022LRR 15Add
BLAST
Repeati543 – 56422LRR 16Add
BLAST
Domaini576 – 62752LRRCTAdd
BLAST
Domaini670 – 816147TIRAdd
BLAST

Domaini

The TIR domain mediates interaction with NOX4 By similarity.

Sequence similaritiesi

Contains 1 LRRCT domain.
Contains 1 TIR domain.

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG249751.
HOGENOMiHOG000037951.
HOVERGENiHBG018823.
InParanoidiQ9QX05.
KOiK10160.
PhylomeDBiQ9QX05.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR000157. TIR_dom.
IPR027168. TLR4.
IPR017241. Toll-like_receptor.
[Graphical view]
PANTHERiPTHR24365:SF230. PTHR24365:SF230. 1 hit.
PfamiPF13855. LRR_8. 3 hits.
PF01582. TIR. 1 hit.
[Graphical view]
PIRSFiPIRSF037595. Toll-like_receptor. 1 hit.
SMARTiSM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52200. SSF52200. 1 hit.
PROSITEiPS51450. LRR. 13 hits.
PS50104. TIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QX05-1 [UniParc]FASTAAdd to Basket

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MMPLLHLAGT LIMALFLSCL RPGSLNPCIE VLPNITYQCM DQNLSKIPHD    50
IPYSTKNLDL SFNPLKILRS YSFTNFSQLQ WLDLSRCEIE TIEDKAWHGL 100
NQLSTLVLTG NPIKSFSPGS FSGLTNLENL VAVETKMTSL EGFHIGQLIS 150
LKKLNVAHNL IHSFKLPEYF SNLTNLEHVD LSYNYIQTIS VKDLQFLREN 200
PQVNLSLDLS LNPIDSIQAQ AFQGIRLHEL TLRSNFNSSN VLKMCLQNMT 250
GLHVHRLILG EFKNERNLES FDRSVMEGLC NVSIDEFRLT YINHFSDDIY 300
NLNCLANISA MSFTGVHIKH IADVPRHFKW QSLSIIRCHL KPFPKLSLPF 350
LKSWTLTTNR EDISFGQLAL PSLRYLDLSR NAMSFRGCCS YSDFGTNNLK 400
YLDLSFNGVI LMSANFMGLE ELEYLDFQHS TLKKVTEFSV FLSLEKLLYL 450
DISYTNTKID FDGIFLGLIS LNTLKMAGNS FKDNTLSNVF TNTTNLTFLD 500
LSKCQLEQIS RGVFDTLYRL QLLNMSHNNL LFLDPSHYKQ LYSLRTLDCS 550
FNRIETSKGI LQHFPKSLAV FNLTNNSVAC ICEYQNFLQW VKDQKMFLVN 600
VEQMKCASPI DMKASLVLDF TNSTCYIYKT IISVSVVSVL VVATVAFLIY 650
HFYFHLILIA GCKKYSRGES IYDAFVIYSS QNEDWVRNEL VKNLEEGVPR 700
FQLCLHYRDF IPGVAIAANI IQEGFHKSRK VIVVVSRHFI QSRWCIFEYE 750
IAQTWQFLSS RSGIIFIVLE KVEKSLLRQQ VELYRLLSRN TYLEWEDNAL 800
GRHIFWRRLK KALLDGKALN PDETSEEEQE ATTLT 835
Length:835
Mass (Da):96,072
Last modified:May 1, 2000 - v1
Checksum:iDF5E16A30851E3A0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF057025 mRNA. Translation: AAC13313.1.
RefSeqiNP_062051.1. NM_019178.1.
UniGeneiRn.14534.

Genome annotation databases

GeneIDi29260.
KEGGirno:29260.
UCSCiRGD:3870. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF057025 mRNA. Translation: AAC13313.1 .
RefSeqi NP_062051.1. NM_019178.1.
UniGenei Rn.14534.

3D structure databases

ProteinModelPortali Q9QX05.
SMRi Q9QX05. Positions 27-625.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q9QX05.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 29260.
KEGGi rno:29260.
UCSCi RGD:3870. rat.

Organism-specific databases

CTDi 7099.
RGDi 3870. Tlr4.

Phylogenomic databases

eggNOGi NOG249751.
HOGENOMi HOG000037951.
HOVERGENi HBG018823.
InParanoidi Q9QX05.
KOi K10160.
PhylomeDBi Q9QX05.

Miscellaneous databases

NextBioi 608584.
PROi Q9QX05.

Gene expression databases

Genevestigatori Q9QX05.

Family and domain databases

Gene3Di 3.40.50.10140. 1 hit.
InterProi IPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR000157. TIR_dom.
IPR027168. TLR4.
IPR017241. Toll-like_receptor.
[Graphical view ]
PANTHERi PTHR24365:SF230. PTHR24365:SF230. 1 hit.
Pfami PF13855. LRR_8. 3 hits.
PF01582. TIR. 1 hit.
[Graphical view ]
PIRSFi PIRSF037595. Toll-like_receptor. 1 hit.
SMARTi SM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view ]
SUPFAMi SSF52200. SSF52200. 1 hit.
PROSITEi PS51450. LRR. 13 hits.
PS50104. TIR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Toll4 (TLR4) expression in cardiac myocytes in normal and failing myocardium."
    Frantz S., Kobzik L., Kim Y.-D., Fukazawa R., Medzhitov R., Lee R.T., Kelly R.A.
    J. Clin. Invest. 104:271-280(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Heart.

Entry informationi

Entry nameiTLR4_RAT
AccessioniPrimary (citable) accession number: Q9QX05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: May 1, 2000
Last modified: September 3, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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