Q9QX01 (TRPC1_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Short transient receptor potential channel 1
Short name=TrpC1

Alternative name(s):
Transient receptor protein 1
Short name=TRP-1

Gene names

Name:	Trpc1
Synonyms:	Trp1

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	759 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.
Subunit structure	Heteromer with TRPC4 and/or TRPC5. Interacts with TRPC3, TRPC4 and TRPC5 By similarity. Interacts with ITPR3 By similarity. Interacts with MX1 and RNF24 By similarity. Interacts with FKBP4 By similarity. Interacts with TRPC4AP By similarity. Ref.2
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in brain, hippocampus, amygdala, Purkinje cells and single neurons in the cortex and striatum. Ref.2
Sequence similarities	Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily. [View classification] Contains 3 ANK repeats.

Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	ANK repeat Repeat Transmembrane Transmembrane helix
Ligand	Calcium
Molecular function	Calcium channel Ion channel
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	calcium channel activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Select]

Isoform Beta (identifier: Q9QX01-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform Alpha (identifier: Q9QX01-2)

The sequence of this isoform is not available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 759	759	Short transient receptor potential channel 1		PRO_0000215306
Regions
	Topological domain	1 – 352	352	Cytoplasmic Potential
	Transmembrane	353 – 373	21	Helical; Potential
	Topological domain	374 – 381	8	Extracellular Potential
	Transmembrane	382 – 402	21	Helical; Potential
	Topological domain	403 – 461	59	Cytoplasmic Potential
	Transmembrane	462 – 482	21	Helical; Potential
	Topological domain	483 – 505	23	Extracellular Potential
	Transmembrane	506 – 526	21	Helical; Potential
	Topological domain	527 – 552	26	Cytoplasmic Potential
	Transmembrane	553 – 573	21	Helical; Potential
	Topological domain	574 – 582	9	Extracellular Potential
	Transmembrane	583 – 603	21	Helical; Potential
	Topological domain	604 – 759	156	Cytoplasmic Potential
	Repeat	46 – 75	30	ANK 1
	Repeat	83 – 112	30	ANK 2
	Repeat	124 – 153	30	ANK 3

Sequences

	Sequence		Length	Mass (Da)
	Isoform Beta [UniParc]. Last modified May 1, 2000. Version 1. Checksum: CEBB27A1DF6420F4	FASTA	759	87,618
	10 20 30 40 50 60 MMAALYPSTD LSGVSSSSLP SSPSSSSPNE VMALKDVREV KEENTLNEKL FLLACDKGDY 70 80 90 100 110 120 YMVKKILEEN SSGDLNINCV DVLGRNAVTI TIENESLDIL QLLLDYGCQK LMERIQNPEY 130 140 150 160 170 180 STTMDVAPVI LAAHRNNYEI LTMLLKQDVA LPKPHAVGCE CTLCSAKNKK DSLRHSRFRL 190 200 210 220 230 240 DIYRCLASPA LIMLTEEDPI LRAFELSADL KELSLVEVEF WNDYEELARQ CKMFAKDLLA 250 260 270 280 290 300 QARNSRELEV ILNHTSSDEP LDKRGLLEER MNLSRLKLAI KYNQKEFVSQ SNCQQFLNTV 310 320 330 340 350 360 WFGQMSGYRR KPTCKKIMTV LTVGIFWPVL SLCYLIAPKS QFGRIIHTPF MKFIIHGASY 370 380 390 400 410 420 FTFLLLLNLY SLVYNEDKKN TMGPALERID YLLILWIIGM IWSDIKRLWY EGLEDFLEES 430 440 450 460 470 480 RNQLSFVMNS LYLATFALKV VAHNKFHDFA DRKDWDAFHP TLVAEGLFAF ANVLSYLRLF 490 500 510 520 530 540 FMYTTSSILG PLQISMGQML QDFGKFLGMF LLVLFSFTIG LTQLYDKGYT SKEQKDCVGI 550 560 570 580 590 600 FCEQQSNDTF HSFIGTCFAL FWYIFSLAHV AIFVTRFSYG EELQSFVGAV IVGTYNVVVV 610 620 630 640 650 660 IVLTKLLVAM LHKSFQLIAN HEDKEWKFAR AKLWLSYFDD KCTLPPPFNI IPSPKTICYM 670 680 690 700 710 720 ISSLSKWVCS HTSKGKVRRQ NSLKEWRNLK QKRDENYQKV MCCLVHRYLT SMRQKMQSTD 730 740 750 QATVENLNEL RQDLSKFRNE IRDLLGFRTS KYAMFYPKN
	Isoform Alpha (Sequence not available).		–	–

References

[1]	"Cloning of Trp1beta isoform from rat brain: immunodetection and localization of the endogenous Trp1 protein." Wang W., O'Connell B., Dykeman R., Sakai T., Delporte C., Swaim W., Zhu X., Birnbaumer L., Ambudkar I.S. Am. J. Physiol. 276:C969-C979(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley. Tissue: Brain.
[2]	"TRPC1 and TRPC5 form a novel cation channel in mammalian brain." Strubing C., Krapivinsky G., Krapivinsky L., Clapham D.E. Neuron 29:645-655(2001) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, INTERACTION WITH TRPC4 AND TRPC5.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF061266 mRNA. Translation: AAC67387.1.
IPI	IPI00561339.
RefSeq	NP_446010.1. NM_053558.1.
UniGene	Rn.88592.
3D structure databases
ProteinModelPortal	Q9QX01.
ModBase	Search...
Proteomic databases
PRIDE	Q9QX01.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	89821.
KEGG	rno:89821.
UCSC	RGD:619783. rat.
Organism-specific databases
CTD	7220.
RGD	619783. Trpc1.
Phylogenomic databases
eggNOG	NOG245138.
HOGENOM	HOG000020589.
HOVERGEN	HBG068337.
KO	K04964.
Gene expression databases
ArrayExpress	Q9QX01.
Genevestigator	Q9QX01.
GermOnline	ENSRNOG00000009601. Rattus norvegicus.
Family and domain databases
Gene3D	1.25.40.20. 1 hit.
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR005821. Ion_trans_dom. IPR004729. TRP_channel. IPR013555. TRP_dom. IPR005457. TRPC1_channel. IPR002153. TRPC_channel. [Graphical view]
PANTHER	PTHR10117. PTHR10117. 1 hit. PTHR10117:SF3. PTHR10117:SF3. 1 hit.
Pfam	PF12796. Ank_2. 1 hit. PF00520. Ion_trans. 1 hit. PF08344. TRP_2. 1 hit. [Graphical view]
PRINTS	PR01097. TRNSRECEPTRP. PR01642. TRPCHANNEL1.
SMART	SM00248. ANK. 3 hits. [Graphical view]
SUPFAM	SSF48403. ANK. 1 hit.
TIGRFAMs	TIGR00870. trp. 1 hit.
PROSITE	PS50297. ANK_REP_REGION. False negative. PS50088. ANK_REPEAT. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	617724.

Entry information

Entry name

TRPC1_RAT

Accession

Primary (citable) accession number: Q9QX01

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	May 1, 2000
Last modified:	April 3, 2013
This is version 93 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program