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Q9QX01

- TRPC1_RAT

UniProt

Q9QX01 - TRPC1_RAT

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Protein

Short transient receptor potential channel 1

Gene

Trpc1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.

GO - Molecular functioni

  1. calcium channel activity Source: UniProtKB-KW

GO - Biological processi

  1. cellular response to hypoxia Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Short transient receptor potential channel 1
Short name:
TrpC1
Alternative name(s):
Transient receptor protein 1
Short name:
TRP-1
Gene namesi
Name:Trpc1
Synonyms:Trp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi619783. Trpc1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 352352CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei353 – 37321HelicalSequence AnalysisAdd
BLAST
Topological domaini374 – 3818ExtracellularSequence Analysis
Transmembranei382 – 40221HelicalSequence AnalysisAdd
BLAST
Topological domaini403 – 46159CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei462 – 48221HelicalSequence AnalysisAdd
BLAST
Topological domaini483 – 50523ExtracellularSequence AnalysisAdd
BLAST
Transmembranei506 – 52621HelicalSequence AnalysisAdd
BLAST
Topological domaini527 – 55226CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei553 – 57321HelicalSequence AnalysisAdd
BLAST
Topological domaini574 – 5829ExtracellularSequence Analysis
Transmembranei583 – 60321HelicalSequence AnalysisAdd
BLAST
Topological domaini604 – 759156CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 759759Short transient receptor potential channel 1PRO_0000215306Add
BLAST

Post-translational modificationi

Activation of PRKCA induces phosphorylation of TRPC1 and subsequent Ca2+ entry into cells.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ9QX01.

Expressioni

Tissue specificityi

Expressed in brain, hippocampus, amygdala, Purkinje cells and single neurons in the cortex and striatum.1 Publication

Gene expression databases

GenevestigatoriQ9QX01.

Interactioni

Subunit structurei

Heteromer with TRPC4 and/or TRPC5. Interacts with TRPC3, TRPC4 and TRPC5 (By similarity). Interacts with ITPR3 (By similarity). Interacts with MX1 and RNF24 (By similarity). Interacts with FKBP4 (By similarity). Interacts with TRPC4AP (By similarity).By similarity

Protein-protein interaction databases

BioGridi250144. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9QX01.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati46 – 7530ANK 1Add
BLAST
Repeati83 – 11230ANK 2Add
BLAST
Repeati124 – 15330ANK 3Add
BLAST

Sequence similaritiesi

Contains 3 ANK repeats.Curated

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG245138.
HOGENOMiHOG000020589.
HOVERGENiHBG068337.
InParanoidiQ9QX01.
KOiK04964.
PhylomeDBiQ9QX01.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR013555. TRP_dom.
IPR005457. TRPC1_channel.
IPR002153. TRPC_channel.
[Graphical view]
PANTHERiPTHR10117. PTHR10117. 1 hit.
PTHR10117:SF3. PTHR10117:SF3. 1 hit.
PfamiPF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
[Graphical view]
PRINTSiPR01097. TRNSRECEPTRP.
PR01642. TRPCHANNEL1.
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
TIGRFAMsiTIGR00870. trp. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform Beta (identifier: Q9QX01-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMAALYPSTD LSGVSSSSLP SSPSSSSPNE VMALKDVREV KEENTLNEKL
60 70 80 90 100
FLLACDKGDY YMVKKILEEN SSGDLNINCV DVLGRNAVTI TIENESLDIL
110 120 130 140 150
QLLLDYGCQK LMERIQNPEY STTMDVAPVI LAAHRNNYEI LTMLLKQDVA
160 170 180 190 200
LPKPHAVGCE CTLCSAKNKK DSLRHSRFRL DIYRCLASPA LIMLTEEDPI
210 220 230 240 250
LRAFELSADL KELSLVEVEF WNDYEELARQ CKMFAKDLLA QARNSRELEV
260 270 280 290 300
ILNHTSSDEP LDKRGLLEER MNLSRLKLAI KYNQKEFVSQ SNCQQFLNTV
310 320 330 340 350
WFGQMSGYRR KPTCKKIMTV LTVGIFWPVL SLCYLIAPKS QFGRIIHTPF
360 370 380 390 400
MKFIIHGASY FTFLLLLNLY SLVYNEDKKN TMGPALERID YLLILWIIGM
410 420 430 440 450
IWSDIKRLWY EGLEDFLEES RNQLSFVMNS LYLATFALKV VAHNKFHDFA
460 470 480 490 500
DRKDWDAFHP TLVAEGLFAF ANVLSYLRLF FMYTTSSILG PLQISMGQML
510 520 530 540 550
QDFGKFLGMF LLVLFSFTIG LTQLYDKGYT SKEQKDCVGI FCEQQSNDTF
560 570 580 590 600
HSFIGTCFAL FWYIFSLAHV AIFVTRFSYG EELQSFVGAV IVGTYNVVVV
610 620 630 640 650
IVLTKLLVAM LHKSFQLIAN HEDKEWKFAR AKLWLSYFDD KCTLPPPFNI
660 670 680 690 700
IPSPKTICYM ISSLSKWVCS HTSKGKVRRQ NSLKEWRNLK QKRDENYQKV
710 720 730 740 750
MCCLVHRYLT SMRQKMQSTD QATVENLNEL RQDLSKFRNE IRDLLGFRTS

KYAMFYPKN
Length:759
Mass (Da):87,618
Last modified:May 1, 2000 - v1
Checksum:iCEBB27A1DF6420F4
GO
Isoform Alpha (identifier: Q9QX01-2)

Sequence is not available
Length:
Mass (Da):

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061266 mRNA. Translation: AAC67387.1.
RefSeqiNP_446010.1. NM_053558.1. [Q9QX01-1]
UniGeneiRn.88592.

Genome annotation databases

GeneIDi89821.
KEGGirno:89821.
UCSCiRGD:619783. rat. [Q9QX01-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061266 mRNA. Translation: AAC67387.1 .
RefSeqi NP_446010.1. NM_053558.1. [Q9QX01-1 ]
UniGenei Rn.88592.

3D structure databases

ProteinModelPortali Q9QX01.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 250144. 2 interactions.

Proteomic databases

PRIDEi Q9QX01.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 89821.
KEGGi rno:89821.
UCSCi RGD:619783. rat. [Q9QX01-1 ]

Organism-specific databases

CTDi 7220.
RGDi 619783. Trpc1.

Phylogenomic databases

eggNOGi NOG245138.
HOGENOMi HOG000020589.
HOVERGENi HBG068337.
InParanoidi Q9QX01.
KOi K04964.
PhylomeDBi Q9QX01.

Miscellaneous databases

NextBioi 617724.
PROi Q9QX01.

Gene expression databases

Genevestigatori Q9QX01.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR013555. TRP_dom.
IPR005457. TRPC1_channel.
IPR002153. TRPC_channel.
[Graphical view ]
PANTHERi PTHR10117. PTHR10117. 1 hit.
PTHR10117:SF3. PTHR10117:SF3. 1 hit.
Pfami PF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
[Graphical view ]
PRINTSi PR01097. TRNSRECEPTRP.
PR01642. TRPCHANNEL1.
SMARTi SM00248. ANK. 3 hits.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
TIGRFAMsi TIGR00870. trp. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Cloning of Trp1beta isoform from rat brain: immunodetection and localization of the endogenous Trp1 protein."
    Wang W., O'Connell B., Dykeman R., Sakai T., Delporte C., Swaim W., Zhu X., Birnbaumer L., Ambudkar I.S.
    Am. J. Physiol. 276:C969-C979(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Brain.
  2. "TRPC1 and TRPC5 form a novel cation channel in mammalian brain."
    Strubing C., Krapivinsky G., Krapivinsky L., Clapham D.E.
    Neuron 29:645-655(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, INTERACTION WITH TRPC4 AND TRPC5.

Entry informationi

Entry nameiTRPC1_RAT
AccessioniPrimary (citable) accession number: Q9QX01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3