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Q9QX01 (TRPC1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Short transient receptor potential channel 1

Short name=TrpC1
Alternative name(s):
Transient receptor protein 1
Short name=TRP-1
Gene names
Name:Trpc1
Synonyms:Trp1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length759 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.

Subunit structure

Heteromer with TRPC4 and/or TRPC5. Interacts with TRPC3, TRPC4 and TRPC5 By similarity. Interacts with ITPR3 By similarity. Interacts with MX1 and RNF24 By similarity. Interacts with FKBP4 By similarity. Interacts with TRPC4AP By similarity. Ref.2

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in brain, hippocampus, amygdala, Purkinje cells and single neurons in the cortex and striatum. Ref.2

Post-translational modification

Activation of PRKCA induces phosphorylation of TRPC1 and subsequent Ca2+ entry into cells By similarity.

Sequence similarities

Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily. [View classification]

Contains 3 ANK repeats.

Ontologies

Keywords
   Biological processCalcium transport
Ion transport
Transport
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainANK repeat
Repeat
Transmembrane
Transmembrane helix
   LigandCalcium
   Molecular functionCalcium channel
Ion channel
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcellular response to hypoxia

Inferred from expression pattern PubMed 19889962. Source: RGD

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functioncalcium channel activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Select]
Isoform Beta (identifier: Q9QX01-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Alpha (identifier: Q9QX01-2)

The sequence of this isoform is not available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 759759Short transient receptor potential channel 1
PRO_0000215306

Regions

Topological domain1 – 352352Cytoplasmic Potential
Transmembrane353 – 37321Helical; Potential
Topological domain374 – 3818Extracellular Potential
Transmembrane382 – 40221Helical; Potential
Topological domain403 – 46159Cytoplasmic Potential
Transmembrane462 – 48221Helical; Potential
Topological domain483 – 50523Extracellular Potential
Transmembrane506 – 52621Helical; Potential
Topological domain527 – 55226Cytoplasmic Potential
Transmembrane553 – 57321Helical; Potential
Topological domain574 – 5829Extracellular Potential
Transmembrane583 – 60321Helical; Potential
Topological domain604 – 759156Cytoplasmic Potential
Repeat46 – 7530ANK 1
Repeat83 – 11230ANK 2
Repeat124 – 15330ANK 3

Sequences

Sequence LengthMass (Da)Tools
Isoform Beta [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: CEBB27A1DF6420F4

FASTA75987,618
        10         20         30         40         50         60 
MMAALYPSTD LSGVSSSSLP SSPSSSSPNE VMALKDVREV KEENTLNEKL FLLACDKGDY 

        70         80         90        100        110        120 
YMVKKILEEN SSGDLNINCV DVLGRNAVTI TIENESLDIL QLLLDYGCQK LMERIQNPEY 

       130        140        150        160        170        180 
STTMDVAPVI LAAHRNNYEI LTMLLKQDVA LPKPHAVGCE CTLCSAKNKK DSLRHSRFRL 

       190        200        210        220        230        240 
DIYRCLASPA LIMLTEEDPI LRAFELSADL KELSLVEVEF WNDYEELARQ CKMFAKDLLA 

       250        260        270        280        290        300 
QARNSRELEV ILNHTSSDEP LDKRGLLEER MNLSRLKLAI KYNQKEFVSQ SNCQQFLNTV 

       310        320        330        340        350        360 
WFGQMSGYRR KPTCKKIMTV LTVGIFWPVL SLCYLIAPKS QFGRIIHTPF MKFIIHGASY 

       370        380        390        400        410        420 
FTFLLLLNLY SLVYNEDKKN TMGPALERID YLLILWIIGM IWSDIKRLWY EGLEDFLEES 

       430        440        450        460        470        480 
RNQLSFVMNS LYLATFALKV VAHNKFHDFA DRKDWDAFHP TLVAEGLFAF ANVLSYLRLF 

       490        500        510        520        530        540 
FMYTTSSILG PLQISMGQML QDFGKFLGMF LLVLFSFTIG LTQLYDKGYT SKEQKDCVGI 

       550        560        570        580        590        600 
FCEQQSNDTF HSFIGTCFAL FWYIFSLAHV AIFVTRFSYG EELQSFVGAV IVGTYNVVVV 

       610        620        630        640        650        660 
IVLTKLLVAM LHKSFQLIAN HEDKEWKFAR AKLWLSYFDD KCTLPPPFNI IPSPKTICYM 

       670        680        690        700        710        720 
ISSLSKWVCS HTSKGKVRRQ NSLKEWRNLK QKRDENYQKV MCCLVHRYLT SMRQKMQSTD 

       730        740        750 
QATVENLNEL RQDLSKFRNE IRDLLGFRTS KYAMFYPKN 

« Hide

Isoform Alpha (Sequence not available).

References

[1]"Cloning of Trp1beta isoform from rat brain: immunodetection and localization of the endogenous Trp1 protein."
Wang W., O'Connell B., Dykeman R., Sakai T., Delporte C., Swaim W., Zhu X., Birnbaumer L., Ambudkar I.S.
Am. J. Physiol. 276:C969-C979(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Brain.
[2]"TRPC1 and TRPC5 form a novel cation channel in mammalian brain."
Strubing C., Krapivinsky G., Krapivinsky L., Clapham D.E.
Neuron 29:645-655(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, INTERACTION WITH TRPC4 AND TRPC5.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF061266 mRNA. Translation: AAC67387.1.
RefSeqNP_446010.1. NM_053558.1. [Q9QX01-1]
UniGeneRn.88592.

3D structure databases

ProteinModelPortalQ9QX01.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid250144. 2 interactions.

Proteomic databases

PRIDEQ9QX01.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID89821.
KEGGrno:89821.
UCSCRGD:619783. rat. [Q9QX01-1]

Organism-specific databases

CTD7220.
RGD619783. Trpc1.

Phylogenomic databases

eggNOGNOG245138.
HOGENOMHOG000020589.
HOVERGENHBG068337.
KOK04964.
PhylomeDBQ9QX01.

Gene expression databases

GenevestigatorQ9QX01.

Family and domain databases

Gene3D1.25.40.20. 1 hit.
InterProIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR013555. TRP_dom.
IPR005457. TRPC1_channel.
IPR002153. TRPC_channel.
[Graphical view]
PANTHERPTHR10117. PTHR10117. 1 hit.
PTHR10117:SF3. PTHR10117:SF3. 1 hit.
PfamPF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
[Graphical view]
PRINTSPR01097. TRNSRECEPTRP.
PR01642. TRPCHANNEL1.
SMARTSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMSSF48403. SSF48403. 1 hit.
TIGRFAMsTIGR00870. trp. 1 hit.
ProtoNetSearch...

Other

NextBio617724.
PROQ9QX01.

Entry information

Entry nameTRPC1_RAT
AccessionPrimary (citable) accession number: Q9QX01
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 1, 2000
Last modified: May 14, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families