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Q9QX01

- TRPC1_RAT

UniProt

Q9QX01 - TRPC1_RAT

Protein

Short transient receptor potential channel 1

Gene

Trpc1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.

    GO - Molecular functioni

    1. calcium channel activity Source: UniProtKB-KW

    GO - Biological processi

    1. cellular response to hypoxia Source: RGD

    Keywords - Molecular functioni

    Calcium channel, Ion channel

    Keywords - Biological processi

    Calcium transport, Ion transport, Transport

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Short transient receptor potential channel 1
    Short name:
    TrpC1
    Alternative name(s):
    Transient receptor protein 1
    Short name:
    TRP-1
    Gene namesi
    Name:Trpc1
    Synonyms:Trp1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi619783. Trpc1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 759759Short transient receptor potential channel 1PRO_0000215306Add
    BLAST

    Post-translational modificationi

    Activation of PRKCA induces phosphorylation of TRPC1 and subsequent Ca2+ entry into cells.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ9QX01.

    Expressioni

    Tissue specificityi

    Expressed in brain, hippocampus, amygdala, Purkinje cells and single neurons in the cortex and striatum.1 Publication

    Gene expression databases

    GenevestigatoriQ9QX01.

    Interactioni

    Subunit structurei

    Heteromer with TRPC4 and/or TRPC5. Interacts with TRPC3, TRPC4 and TRPC5 By similarity. Interacts with ITPR3 By similarity. Interacts with MX1 and RNF24 By similarity. Interacts with FKBP4 By similarity. Interacts with TRPC4AP By similarity.By similarity

    Protein-protein interaction databases

    BioGridi250144. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QX01.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 352352CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini374 – 3818ExtracellularSequence Analysis
    Topological domaini403 – 46159CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini483 – 50523ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini527 – 55226CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini574 – 5829ExtracellularSequence Analysis
    Topological domaini604 – 759156CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei353 – 37321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei382 – 40221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei462 – 48221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei506 – 52621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei553 – 57321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei583 – 60321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati46 – 7530ANK 1Add
    BLAST
    Repeati83 – 11230ANK 2Add
    BLAST
    Repeati124 – 15330ANK 3Add
    BLAST

    Sequence similaritiesi

    Contains 3 ANK repeats.Curated

    Keywords - Domaini

    ANK repeat, Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG245138.
    HOGENOMiHOG000020589.
    HOVERGENiHBG068337.
    KOiK04964.
    PhylomeDBiQ9QX01.

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR005821. Ion_trans_dom.
    IPR004729. TRP_channel.
    IPR013555. TRP_dom.
    IPR005457. TRPC1_channel.
    IPR002153. TRPC_channel.
    [Graphical view]
    PANTHERiPTHR10117. PTHR10117. 1 hit.
    PTHR10117:SF3. PTHR10117:SF3. 1 hit.
    PfamiPF12796. Ank_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    PF08344. TRP_2. 1 hit.
    [Graphical view]
    PRINTSiPR01097. TRNSRECEPTRP.
    PR01642. TRPCHANNEL1.
    SMARTiSM00248. ANK. 3 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    TIGRFAMsiTIGR00870. trp. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform Beta (identifier: Q9QX01-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MMAALYPSTD LSGVSSSSLP SSPSSSSPNE VMALKDVREV KEENTLNEKL    50
    FLLACDKGDY YMVKKILEEN SSGDLNINCV DVLGRNAVTI TIENESLDIL 100
    QLLLDYGCQK LMERIQNPEY STTMDVAPVI LAAHRNNYEI LTMLLKQDVA 150
    LPKPHAVGCE CTLCSAKNKK DSLRHSRFRL DIYRCLASPA LIMLTEEDPI 200
    LRAFELSADL KELSLVEVEF WNDYEELARQ CKMFAKDLLA QARNSRELEV 250
    ILNHTSSDEP LDKRGLLEER MNLSRLKLAI KYNQKEFVSQ SNCQQFLNTV 300
    WFGQMSGYRR KPTCKKIMTV LTVGIFWPVL SLCYLIAPKS QFGRIIHTPF 350
    MKFIIHGASY FTFLLLLNLY SLVYNEDKKN TMGPALERID YLLILWIIGM 400
    IWSDIKRLWY EGLEDFLEES RNQLSFVMNS LYLATFALKV VAHNKFHDFA 450
    DRKDWDAFHP TLVAEGLFAF ANVLSYLRLF FMYTTSSILG PLQISMGQML 500
    QDFGKFLGMF LLVLFSFTIG LTQLYDKGYT SKEQKDCVGI FCEQQSNDTF 550
    HSFIGTCFAL FWYIFSLAHV AIFVTRFSYG EELQSFVGAV IVGTYNVVVV 600
    IVLTKLLVAM LHKSFQLIAN HEDKEWKFAR AKLWLSYFDD KCTLPPPFNI 650
    IPSPKTICYM ISSLSKWVCS HTSKGKVRRQ NSLKEWRNLK QKRDENYQKV 700
    MCCLVHRYLT SMRQKMQSTD QATVENLNEL RQDLSKFRNE IRDLLGFRTS 750
    KYAMFYPKN 759
    Length:759
    Mass (Da):87,618
    Last modified:May 1, 2000 - v1
    Checksum:iCEBB27A1DF6420F4
    GO
    Isoform Alpha (identifier: Q9QX01-2)

    Sequence is not available
    Length:
    Mass (Da):

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF061266 mRNA. Translation: AAC67387.1.
    RefSeqiNP_446010.1. NM_053558.1. [Q9QX01-1]
    UniGeneiRn.88592.

    Genome annotation databases

    GeneIDi89821.
    KEGGirno:89821.
    UCSCiRGD:619783. rat. [Q9QX01-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF061266 mRNA. Translation: AAC67387.1 .
    RefSeqi NP_446010.1. NM_053558.1. [Q9QX01-1 ]
    UniGenei Rn.88592.

    3D structure databases

    ProteinModelPortali Q9QX01.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 250144. 2 interactions.

    Proteomic databases

    PRIDEi Q9QX01.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 89821.
    KEGGi rno:89821.
    UCSCi RGD:619783. rat. [Q9QX01-1 ]

    Organism-specific databases

    CTDi 7220.
    RGDi 619783. Trpc1.

    Phylogenomic databases

    eggNOGi NOG245138.
    HOGENOMi HOG000020589.
    HOVERGENi HBG068337.
    KOi K04964.
    PhylomeDBi Q9QX01.

    Miscellaneous databases

    NextBioi 617724.
    PROi Q9QX01.

    Gene expression databases

    Genevestigatori Q9QX01.

    Family and domain databases

    Gene3Di 1.25.40.20. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR005821. Ion_trans_dom.
    IPR004729. TRP_channel.
    IPR013555. TRP_dom.
    IPR005457. TRPC1_channel.
    IPR002153. TRPC_channel.
    [Graphical view ]
    PANTHERi PTHR10117. PTHR10117. 1 hit.
    PTHR10117:SF3. PTHR10117:SF3. 1 hit.
    Pfami PF12796. Ank_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    PF08344. TRP_2. 1 hit.
    [Graphical view ]
    PRINTSi PR01097. TRNSRECEPTRP.
    PR01642. TRPCHANNEL1.
    SMARTi SM00248. ANK. 3 hits.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    TIGRFAMsi TIGR00870. trp. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of Trp1beta isoform from rat brain: immunodetection and localization of the endogenous Trp1 protein."
      Wang W., O'Connell B., Dykeman R., Sakai T., Delporte C., Swaim W., Zhu X., Birnbaumer L., Ambudkar I.S.
      Am. J. Physiol. 276:C969-C979(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Brain.
    2. "TRPC1 and TRPC5 form a novel cation channel in mammalian brain."
      Strubing C., Krapivinsky G., Krapivinsky L., Clapham D.E.
      Neuron 29:645-655(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, INTERACTION WITH TRPC4 AND TRPC5.

    Entry informationi

    Entry nameiTRPC1_RAT
    AccessioniPrimary (citable) accession number: Q9QX01
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3