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Protein

Short transient receptor potential channel 1

Gene

Trpc1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Short transient receptor potential channel 1
Short name:
TrpC1
Alternative name(s):
Transient receptor protein 1
Short name:
TRP-1
Gene namesi
Name:Trpc1
Synonyms:Trp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi619783. Trpc1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 352CytoplasmicSequence analysisAdd BLAST352
Transmembranei353 – 373HelicalSequence analysisAdd BLAST21
Topological domaini374 – 381ExtracellularSequence analysis8
Transmembranei382 – 402HelicalSequence analysisAdd BLAST21
Topological domaini403 – 461CytoplasmicSequence analysisAdd BLAST59
Transmembranei462 – 482HelicalSequence analysisAdd BLAST21
Topological domaini483 – 505ExtracellularSequence analysisAdd BLAST23
Transmembranei506 – 526HelicalSequence analysisAdd BLAST21
Topological domaini527 – 552CytoplasmicSequence analysisAdd BLAST26
Transmembranei553 – 573HelicalSequence analysisAdd BLAST21
Topological domaini574 – 582ExtracellularSequence analysis9
Transmembranei583 – 603HelicalSequence analysisAdd BLAST21
Topological domaini604 – 759CytoplasmicSequence analysisAdd BLAST156

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002153061 – 759Short transient receptor potential channel 1Add BLAST759

Post-translational modificationi

Activation of PRKCA induces phosphorylation of TRPC1 and subsequent Ca2+ entry into cells.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9QX01.
PRIDEiQ9QX01.

Expressioni

Tissue specificityi

Expressed in brain, hippocampus, amygdala, Purkinje cells and single neurons in the cortex and striatum.1 Publication

Interactioni

Subunit structurei

Heteromer with TRPC4 and/or TRPC5. Interacts with TRPC3, TRPC4 and TRPC5 (By similarity). Interacts with ITPR3 (By similarity). Interacts with MX1 and RNF24 (By similarity). Interacts with FKBP4 (By similarity). Interacts with TRPC4AP (By similarity).By similarity

Protein-protein interaction databases

BioGridi250144. 2 interactors.
STRINGi10116.ENSRNOP00000013144.

Structurei

3D structure databases

ProteinModelPortaliQ9QX01.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati46 – 75ANK 1Add BLAST30
Repeati83 – 112ANK 2Add BLAST30
Repeati124 – 153ANK 3Add BLAST30

Sequence similaritiesi

Contains 3 ANK repeats.Curated

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3609. Eukaryota.
ENOG410XQ0Y. LUCA.
HOGENOMiHOG000020589.
HOVERGENiHBG068337.
InParanoidiQ9QX01.
KOiK04964.
PhylomeDBiQ9QX01.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR013555. TRP_dom.
IPR005457. TRPC1_channel.
IPR002153. TRPC_channel.
[Graphical view]
PANTHERiPTHR10117. PTHR10117. 1 hit.
PfamiPF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
[Graphical view]
PRINTSiPR01097. TRNSRECEPTRP.
PR01642. TRPCHANNEL1.
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
TIGRFAMsiTIGR00870. trp. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Beta (identifier: Q9QX01-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMAALYPSTD LSGVSSSSLP SSPSSSSPNE VMALKDVREV KEENTLNEKL
60 70 80 90 100
FLLACDKGDY YMVKKILEEN SSGDLNINCV DVLGRNAVTI TIENESLDIL
110 120 130 140 150
QLLLDYGCQK LMERIQNPEY STTMDVAPVI LAAHRNNYEI LTMLLKQDVA
160 170 180 190 200
LPKPHAVGCE CTLCSAKNKK DSLRHSRFRL DIYRCLASPA LIMLTEEDPI
210 220 230 240 250
LRAFELSADL KELSLVEVEF WNDYEELARQ CKMFAKDLLA QARNSRELEV
260 270 280 290 300
ILNHTSSDEP LDKRGLLEER MNLSRLKLAI KYNQKEFVSQ SNCQQFLNTV
310 320 330 340 350
WFGQMSGYRR KPTCKKIMTV LTVGIFWPVL SLCYLIAPKS QFGRIIHTPF
360 370 380 390 400
MKFIIHGASY FTFLLLLNLY SLVYNEDKKN TMGPALERID YLLILWIIGM
410 420 430 440 450
IWSDIKRLWY EGLEDFLEES RNQLSFVMNS LYLATFALKV VAHNKFHDFA
460 470 480 490 500
DRKDWDAFHP TLVAEGLFAF ANVLSYLRLF FMYTTSSILG PLQISMGQML
510 520 530 540 550
QDFGKFLGMF LLVLFSFTIG LTQLYDKGYT SKEQKDCVGI FCEQQSNDTF
560 570 580 590 600
HSFIGTCFAL FWYIFSLAHV AIFVTRFSYG EELQSFVGAV IVGTYNVVVV
610 620 630 640 650
IVLTKLLVAM LHKSFQLIAN HEDKEWKFAR AKLWLSYFDD KCTLPPPFNI
660 670 680 690 700
IPSPKTICYM ISSLSKWVCS HTSKGKVRRQ NSLKEWRNLK QKRDENYQKV
710 720 730 740 750
MCCLVHRYLT SMRQKMQSTD QATVENLNEL RQDLSKFRNE IRDLLGFRTS

KYAMFYPKN
Length:759
Mass (Da):87,618
Last modified:May 1, 2000 - v1
Checksum:iCEBB27A1DF6420F4
GO
Isoform Alpha (identifier: Q9QX01-2)
Sequence is not available
Length:
Mass (Da):

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061266 mRNA. Translation: AAC67387.1.
RefSeqiNP_446010.1. NM_053558.1. [Q9QX01-1]
UniGeneiRn.88592.

Genome annotation databases

GeneIDi89821.
KEGGirno:89821.
UCSCiRGD:619783. rat. [Q9QX01-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061266 mRNA. Translation: AAC67387.1.
RefSeqiNP_446010.1. NM_053558.1. [Q9QX01-1]
UniGeneiRn.88592.

3D structure databases

ProteinModelPortaliQ9QX01.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi250144. 2 interactors.
STRINGi10116.ENSRNOP00000013144.

Proteomic databases

PaxDbiQ9QX01.
PRIDEiQ9QX01.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi89821.
KEGGirno:89821.
UCSCiRGD:619783. rat. [Q9QX01-1]

Organism-specific databases

CTDi7220.
RGDi619783. Trpc1.

Phylogenomic databases

eggNOGiKOG3609. Eukaryota.
ENOG410XQ0Y. LUCA.
HOGENOMiHOG000020589.
HOVERGENiHBG068337.
InParanoidiQ9QX01.
KOiK04964.
PhylomeDBiQ9QX01.

Miscellaneous databases

PROiQ9QX01.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR013555. TRP_dom.
IPR005457. TRPC1_channel.
IPR002153. TRPC_channel.
[Graphical view]
PANTHERiPTHR10117. PTHR10117. 1 hit.
PfamiPF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
[Graphical view]
PRINTSiPR01097. TRNSRECEPTRP.
PR01642. TRPCHANNEL1.
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
TIGRFAMsiTIGR00870. trp. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTRPC1_RAT
AccessioniPrimary (citable) accession number: Q9QX01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 1, 2000
Last modified: July 6, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.