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Q9QX01

- TRPC1_RAT

UniProt

Q9QX01 - TRPC1_RAT

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Protein
Short transient receptor potential channel 1
Gene
Trpc1, Trp1
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.

GO - Molecular functioni

  1. calcium channel activity Source: UniProtKB-KW

GO - Biological processi

  1. cellular response to hypoxia Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Short transient receptor potential channel 1
Short name:
TrpC1
Alternative name(s):
Transient receptor protein 1
Short name:
TRP-1
Gene namesi
Name:Trpc1
Synonyms:Trp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi619783. Trpc1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 352352Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei353 – 37321Helical; Reviewed prediction
Add
BLAST
Topological domaini374 – 3818Extracellular Reviewed prediction
Transmembranei382 – 40221Helical; Reviewed prediction
Add
BLAST
Topological domaini403 – 46159Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei462 – 48221Helical; Reviewed prediction
Add
BLAST
Topological domaini483 – 50523Extracellular Reviewed prediction
Add
BLAST
Transmembranei506 – 52621Helical; Reviewed prediction
Add
BLAST
Topological domaini527 – 55226Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei553 – 57321Helical; Reviewed prediction
Add
BLAST
Topological domaini574 – 5829Extracellular Reviewed prediction
Transmembranei583 – 60321Helical; Reviewed prediction
Add
BLAST
Topological domaini604 – 759156Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 759759Short transient receptor potential channel 1
PRO_0000215306Add
BLAST

Post-translational modificationi

Activation of PRKCA induces phosphorylation of TRPC1 and subsequent Ca2+ entry into cells By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ9QX01.

Expressioni

Tissue specificityi

Expressed in brain, hippocampus, amygdala, Purkinje cells and single neurons in the cortex and striatum.1 Publication

Gene expression databases

GenevestigatoriQ9QX01.

Interactioni

Subunit structurei

Heteromer with TRPC4 and/or TRPC5. Interacts with TRPC3, TRPC4 and TRPC5 By similarity. Interacts with ITPR3 By similarity. Interacts with MX1 and RNF24 By similarity. Interacts with FKBP4 By similarity. Interacts with TRPC4AP By similarity.1 Publication

Protein-protein interaction databases

BioGridi250144. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9QX01.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati46 – 7530ANK 1
Add
BLAST
Repeati83 – 11230ANK 2
Add
BLAST
Repeati124 – 15330ANK 3
Add
BLAST

Sequence similaritiesi

Contains 3 ANK repeats.

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG245138.
HOGENOMiHOG000020589.
HOVERGENiHBG068337.
KOiK04964.
PhylomeDBiQ9QX01.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR013555. TRP_dom.
IPR005457. TRPC1_channel.
IPR002153. TRPC_channel.
[Graphical view]
PANTHERiPTHR10117. PTHR10117. 1 hit.
PTHR10117:SF3. PTHR10117:SF3. 1 hit.
PfamiPF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
[Graphical view]
PRINTSiPR01097. TRNSRECEPTRP.
PR01642. TRPCHANNEL1.
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
TIGRFAMsiTIGR00870. trp. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform Beta (identifier: Q9QX01-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MMAALYPSTD LSGVSSSSLP SSPSSSSPNE VMALKDVREV KEENTLNEKL    50
FLLACDKGDY YMVKKILEEN SSGDLNINCV DVLGRNAVTI TIENESLDIL 100
QLLLDYGCQK LMERIQNPEY STTMDVAPVI LAAHRNNYEI LTMLLKQDVA 150
LPKPHAVGCE CTLCSAKNKK DSLRHSRFRL DIYRCLASPA LIMLTEEDPI 200
LRAFELSADL KELSLVEVEF WNDYEELARQ CKMFAKDLLA QARNSRELEV 250
ILNHTSSDEP LDKRGLLEER MNLSRLKLAI KYNQKEFVSQ SNCQQFLNTV 300
WFGQMSGYRR KPTCKKIMTV LTVGIFWPVL SLCYLIAPKS QFGRIIHTPF 350
MKFIIHGASY FTFLLLLNLY SLVYNEDKKN TMGPALERID YLLILWIIGM 400
IWSDIKRLWY EGLEDFLEES RNQLSFVMNS LYLATFALKV VAHNKFHDFA 450
DRKDWDAFHP TLVAEGLFAF ANVLSYLRLF FMYTTSSILG PLQISMGQML 500
QDFGKFLGMF LLVLFSFTIG LTQLYDKGYT SKEQKDCVGI FCEQQSNDTF 550
HSFIGTCFAL FWYIFSLAHV AIFVTRFSYG EELQSFVGAV IVGTYNVVVV 600
IVLTKLLVAM LHKSFQLIAN HEDKEWKFAR AKLWLSYFDD KCTLPPPFNI 650
IPSPKTICYM ISSLSKWVCS HTSKGKVRRQ NSLKEWRNLK QKRDENYQKV 700
MCCLVHRYLT SMRQKMQSTD QATVENLNEL RQDLSKFRNE IRDLLGFRTS 750
KYAMFYPKN 759
Length:759
Mass (Da):87,618
Last modified:May 1, 2000 - v1
Checksum:iCEBB27A1DF6420F4
GO
Isoform Alpha (identifier: Q9QX01-2)

Sequence is not available
Length:
Mass (Da):

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF061266 mRNA. Translation: AAC67387.1.
RefSeqiNP_446010.1. NM_053558.1. [Q9QX01-1]
UniGeneiRn.88592.

Genome annotation databases

GeneIDi89821.
KEGGirno:89821.
UCSCiRGD:619783. rat. [Q9QX01-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF061266 mRNA. Translation: AAC67387.1 .
RefSeqi NP_446010.1. NM_053558.1. [Q9QX01-1 ]
UniGenei Rn.88592.

3D structure databases

ProteinModelPortali Q9QX01.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 250144. 2 interactions.

Proteomic databases

PRIDEi Q9QX01.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 89821.
KEGGi rno:89821.
UCSCi RGD:619783. rat. [Q9QX01-1 ]

Organism-specific databases

CTDi 7220.
RGDi 619783. Trpc1.

Phylogenomic databases

eggNOGi NOG245138.
HOGENOMi HOG000020589.
HOVERGENi HBG068337.
KOi K04964.
PhylomeDBi Q9QX01.

Miscellaneous databases

NextBioi 617724.
PROi Q9QX01.

Gene expression databases

Genevestigatori Q9QX01.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR013555. TRP_dom.
IPR005457. TRPC1_channel.
IPR002153. TRPC_channel.
[Graphical view ]
PANTHERi PTHR10117. PTHR10117. 1 hit.
PTHR10117:SF3. PTHR10117:SF3. 1 hit.
Pfami PF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
[Graphical view ]
PRINTSi PR01097. TRNSRECEPTRP.
PR01642. TRPCHANNEL1.
SMARTi SM00248. ANK. 3 hits.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
TIGRFAMsi TIGR00870. trp. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Cloning of Trp1beta isoform from rat brain: immunodetection and localization of the endogenous Trp1 protein."
    Wang W., O'Connell B., Dykeman R., Sakai T., Delporte C., Swaim W., Zhu X., Birnbaumer L., Ambudkar I.S.
    Am. J. Physiol. 276:C969-C979(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Brain.
  2. "TRPC1 and TRPC5 form a novel cation channel in mammalian brain."
    Strubing C., Krapivinsky G., Krapivinsky L., Clapham D.E.
    Neuron 29:645-655(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, INTERACTION WITH TRPC4 AND TRPC5.

Entry informationi

Entry nameiTRPC1_RAT
AccessioniPrimary (citable) accession number: Q9QX01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 1, 2000
Last modified: May 14, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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