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Protein

Homer protein homolog 2

Gene

Homer2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2 (By similarity). Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses (By similarity) Required for normal hearing (PubMed:25816005).By similarity1 Publication

GO - Molecular functioni

  • actin binding Source: MGI
  • GKAP/Homer scaffold activity Source: MGI
  • G-protein coupled glutamate receptor binding Source: GO_Central

GO - Biological processi

  • behavioral response to cocaine Source: MGI
  • calcium-mediated signaling using intracellular calcium source Source: MGI
  • chemical homeostasis within a tissue Source: MGI
  • G-protein coupled glutamate receptor signaling pathway Source: MGI
  • regulation of G-protein coupled receptor protein signaling pathway Source: MGI
  • sensory perception of sound Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Hearing

Names & Taxonomyi

Protein namesi
Recommended name:
Homer protein homolog 2
Short name:
Homer-2
Alternative name(s):
Cupidin
VASP/Ena-related gene up-regulated during seizure and LTP 2
Short name:
Vesl-2
Gene namesi
Name:Homer2
Synonyms:Vesl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1347354. Homer2.

Subcellular locationi

GO - Cellular componenti

  • apical part of cell Source: MGI
  • cell junction Source: MGI
  • cytoplasm Source: MGI
  • nucleolus Source: MGI
  • nucleus Source: MGI
  • plasma membrane Source: MGI
  • postsynaptic density Source: UniProtKB-SubCell
  • postsynaptic membrane Source: UniProtKB-KW
  • stereocilium tip Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Disruption phenotypei

Homozygous knockout mice exhibit early onset progressive hearing loss.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 354354Homer protein homolog 2PRO_0000191009Add
BLAST

Proteomic databases

MaxQBiQ9QWW1.
PaxDbiQ9QWW1.
PeptideAtlasiQ9QWW1.
PRIDEiQ9QWW1.

PTM databases

iPTMnetiQ9QWW1.
PhosphoSiteiQ9QWW1.

Expressioni

Tissue specificityi

Expressed in olfactory bulb, hippocampus, thalamus and heart (PubMed:9808459). Expressed in the cochlea, organ of Corti. Expression is particularly enriched in the tips of stereocilia of both inner and outer hair cells (PubMed:25816005).2 Publications

Gene expression databases

BgeeiENSMUSG00000025813.
CleanExiMM_HOMER2.
ExpressionAtlasiQ9QWW1. baseline and differential.
GenevisibleiQ9QWW1. MM.

Interactioni

Subunit structurei

Forms coiled-coil structures coiled-coil structures that mediate homo- and heteromultimerization.

GO - Molecular functioni

  • actin binding Source: MGI
  • GKAP/Homer scaffold activity Source: MGI
  • G-protein coupled glutamate receptor binding Source: GO_Central

Protein-protein interaction databases

BioGridi205015. 11 interactions.
STRINGi10090.ENSMUSP00000026922.

Structurei

Secondary structure

1
354
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi6 – 1510Combined sources
Beta strandi32 – 398Combined sources
Turni40 – 434Combined sources
Beta strandi44 – 518Combined sources
Beta strandi54 – 618Combined sources
Beta strandi67 – 7913Combined sources
Turni80 – 834Combined sources
Beta strandi84 – 896Combined sources
Helixi93 – 11018Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1I7AX-ray2.24A/B/C/D1-111[»]
ProteinModelPortaliQ9QWW1.
SMRiQ9QWW1. Positions 3-111.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9QWW1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 110110WH1PROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili160 – 329170Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the Homer family.Curated
Contains 1 WH1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGRQ. Eukaryota.
ENOG410XQWT. LUCA.
GeneTreeiENSGT00390000017850.
HOGENOMiHOG000006979.
HOVERGENiHBG051918.
InParanoidiQ9QWW1.
KOiK15010.
OMAiMAECESI.
OrthoDBiEOG091G0CQ0.
PhylomeDBiQ9QWW1.
TreeFamiTF325627.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR000697. WH1/EVH1_dom.
[Graphical view]
PfamiPF00568. WH1. 1 hit.
[Graphical view]
SMARTiSM00461. WH1. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50229. WH1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9QWW1-1) [UniParc]FASTAAdd to basket
Also known as: 2b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGEQPIFTTR AHVFQIDPST KKNWVPASKQ AVTVSYFYDV TRNSYRIISV
60 70 80 90 100
DGAKVIINST ITPNMTFTKT SQKFGQWADS RANTVFGLGF SSELQLTKFA
110 120 130 140 150
EKFQEVREAA RLARDKSQEK TETSSNHSQE SGCETPSSTQ ASSVNGTDDE
160 170 180 190 200
KASHASPADT HLKSENDKLK IALTQSAANV KKWEMELQTL RESNARLTTA
210 220 230 240 250
LQESAASVEQ WKRQFSICRD ENDRLRSKIE ELEEQCSEIN REKEKNTQLK
260 270 280 290 300
RRIEELESEV RDKEMELKDL RKQSEIIPQL MSECEYVSEK LEAAERDNQN
310 320 330 340 350
LEDKVRSLKT DIEESKYRQR HLKGELKSFL EVLDGKIDDL HDFRRGLSKL

GTDN
Length:354
Mass (Da):40,570
Last modified:May 1, 2000 - v1
Checksum:i18AF2F22EA8E1D06
GO
Isoform 2 (identifier: Q9QWW1-2) [UniParc]FASTAAdd to basket
Also known as: 2a

The sequence of this isoform differs from the canonical sequence as follows:
     130-140: Missing.

Show »
Length:343
Mass (Da):39,463
Checksum:i417769609B7D655E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti191 – 1922RE → VP in CAA09909 (Ref. 3) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei130 – 14011Missing in isoform 2. 2 PublicationsVSP_009071Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF093259 mRNA. Translation: AAC71023.1.
AF093260 mRNA. Translation: AAC71024.1.
AB017136 mRNA. Translation: BAA37088.1.
AJ012076 mRNA. Translation: CAA09909.1.
CCDSiCCDS40009.1. [Q9QWW1-1]
RefSeqiNP_001157558.1. NM_001164086.1. [Q9QWW1-2]
NP_001157559.1. NM_001164087.1.
NP_036113.1. NM_011983.2. [Q9QWW1-1]
UniGeneiMm.228.

Genome annotation databases

EnsembliENSMUST00000026922; ENSMUSP00000026922; ENSMUSG00000025813. [Q9QWW1-2]
ENSMUST00000207983; ENSMUSP00000146787; ENSMUSG00000025813. [Q9QWW1-1]
GeneIDi26557.
KEGGimmu:26557.
UCSCiuc009ich.2. mouse. [Q9QWW1-1]
uc009ici.2. mouse. [Q9QWW1-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF093259 mRNA. Translation: AAC71023.1.
AF093260 mRNA. Translation: AAC71024.1.
AB017136 mRNA. Translation: BAA37088.1.
AJ012076 mRNA. Translation: CAA09909.1.
CCDSiCCDS40009.1. [Q9QWW1-1]
RefSeqiNP_001157558.1. NM_001164086.1. [Q9QWW1-2]
NP_001157559.1. NM_001164087.1.
NP_036113.1. NM_011983.2. [Q9QWW1-1]
UniGeneiMm.228.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1I7AX-ray2.24A/B/C/D1-111[»]
ProteinModelPortaliQ9QWW1.
SMRiQ9QWW1. Positions 3-111.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205015. 11 interactions.
STRINGi10090.ENSMUSP00000026922.

PTM databases

iPTMnetiQ9QWW1.
PhosphoSiteiQ9QWW1.

Proteomic databases

MaxQBiQ9QWW1.
PaxDbiQ9QWW1.
PeptideAtlasiQ9QWW1.
PRIDEiQ9QWW1.

Protocols and materials databases

DNASUi26557.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026922; ENSMUSP00000026922; ENSMUSG00000025813. [Q9QWW1-2]
ENSMUST00000207983; ENSMUSP00000146787; ENSMUSG00000025813. [Q9QWW1-1]
GeneIDi26557.
KEGGimmu:26557.
UCSCiuc009ich.2. mouse. [Q9QWW1-1]
uc009ici.2. mouse. [Q9QWW1-2]

Organism-specific databases

CTDi9455.
MGIiMGI:1347354. Homer2.

Phylogenomic databases

eggNOGiENOG410IGRQ. Eukaryota.
ENOG410XQWT. LUCA.
GeneTreeiENSGT00390000017850.
HOGENOMiHOG000006979.
HOVERGENiHBG051918.
InParanoidiQ9QWW1.
KOiK15010.
OMAiMAECESI.
OrthoDBiEOG091G0CQ0.
PhylomeDBiQ9QWW1.
TreeFamiTF325627.

Miscellaneous databases

ChiTaRSiHomer2. mouse.
EvolutionaryTraceiQ9QWW1.
PROiQ9QWW1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025813.
CleanExiMM_HOMER2.
ExpressionAtlasiQ9QWW1. baseline and differential.
GenevisibleiQ9QWW1. MM.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR000697. WH1/EVH1_dom.
[Graphical view]
PfamiPF00568. WH1. 1 hit.
[Graphical view]
SMARTiSM00461. WH1. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50229. WH1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHOME2_MOUSE
AccessioniPrimary (citable) accession number: Q9QWW1
Secondary accession number(s): O89025, Q9Z0E4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.