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Q9QWR5

- Q9QWR5_MOUSE

UniProt

Q9QWR5 - Q9QWR5_MOUSE

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Protein
Submitted name:

p21 protein

Gene

ras

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5- Protein predictedi

Functioni

GO - Molecular functioni

  1. GDP binding Source: Ensembl
  2. GMP binding Source: Ensembl
  3. GTP binding Source: UniProtKB-KW

GO - Biological processi

  1. apoptotic process Source: Ensembl
  2. cell cycle arrest Source: Ensembl
  3. cellular senescence Source: Ensembl
  4. cytokine-mediated signaling pathway Source: Ensembl
  5. GTP catabolic process Source: InterPro
  6. mitotic cell cycle checkpoint Source: Ensembl
  7. negative regulation of cell proliferation Source: Ensembl
  8. negative regulation of gene expression Source: Ensembl
  9. negative regulation of Rho GTPase activity Source: Ensembl
  10. positive regulation of actin cytoskeleton reorganization Source: Ensembl
  11. positive regulation of cell migration Source: Ensembl
  12. positive regulation of DNA replication Source: Ensembl
  13. positive regulation of epithelial cell proliferation Source: Ensembl
  14. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  15. positive regulation of JNK cascade Source: Ensembl
  16. positive regulation of MAP kinase activity Source: Ensembl
  17. positive regulation of miRNA metabolic process Source: Ensembl
  18. positive regulation of NF-kappaB transcription factor activity Source: Ensembl
  19. positive regulation of nitric-oxide synthase activity Source: Ensembl
  20. positive regulation of Rac GTPase activity Source: Ensembl
  21. positive regulation of Ras protein signal transduction Source: Ensembl
  22. positive regulation of ruffle assembly Source: Ensembl
  23. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  24. positive regulation of wound healing Source: Ensembl
  25. protein heterooligomerization Source: Ensembl
  26. Ras protein signal transduction Source: Ensembl
  27. response to glucocorticoid Source: Ensembl
  28. response to mineralocorticoid Source: Ensembl
  29. social behavior Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

GTP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_188185. DAP12 signaling.
REACT_188528. GRB2 events in ERBB2 signaling.
REACT_188530. FCERI mediated MAPK activation.
REACT_188574. SHC1 events in ERBB2 signaling.
REACT_188578. Signaling by SCF-KIT.
REACT_188580. SHC1 events in ERBB4 signaling.
REACT_196455. Signaling by FGFR mutants.
REACT_198350. EGFR Transactivation by Gastrin.
REACT_199122. Activation of RAS in B cells.
REACT_199123. Signaling by constitutively active EGFR.
REACT_207601. p38MAPK events.
REACT_211860. Tie2 Signaling.
REACT_230639. Downstream signal transduction.
REACT_234357. FRS2-mediated cascade.
REACT_237640. RAF activation.
REACT_237796. NCAM signaling for neurite out-growth.
REACT_239466. SHC-mediated signalling.
REACT_239722. Signalling to RAS.
REACT_241824. SOS-mediated signalling.
REACT_245086. VEGFR2 mediated cell proliferation.
REACT_245103. GRB2 events in EGFR signaling.
REACT_247566. MEK activation.
REACT_257146. RAF phosphorylates MEK.
REACT_260286. SHC1 events in EGFR signaling.
REACT_94437. SHC-mediated cascade.

Names & Taxonomyi

Protein namesi
Submitted name:
p21 proteinImported
Gene namesi
Name:rasImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. Golgi apparatus Source: Ensembl
  3. membrane raft Source: Ensembl
  4. mitochondrion Source: Ensembl
  5. plasma membrane Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ9QWR5.
ExpressionAtlasiQ9QWR5. baseline and differential.
GenevestigatoriQ9QWR5.

Structurei

3D structure databases

ProteinModelPortaliQ9QWR5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9QWR5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30 
QVVIDGETCL LDILDTAGQE EYSAMRDQYM RTGEGF
Length:36
Mass (Da):4,055
Last modified:May 1, 2000 - v1
Checksum:iC73AC89DFE3A2A51
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei36 – 361Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00836 Genomic DNA. Translation: BAA28218.1.
UniGeneiMm.400954.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00836 Genomic DNA. Translation: BAA28218.1 .
UniGenei Mm.400954.

3D structure databases

ProteinModelPortali Q9QWR5.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

Reactomei REACT_188185. DAP12 signaling.
REACT_188528. GRB2 events in ERBB2 signaling.
REACT_188530. FCERI mediated MAPK activation.
REACT_188574. SHC1 events in ERBB2 signaling.
REACT_188578. Signaling by SCF-KIT.
REACT_188580. SHC1 events in ERBB4 signaling.
REACT_196455. Signaling by FGFR mutants.
REACT_198350. EGFR Transactivation by Gastrin.
REACT_199122. Activation of RAS in B cells.
REACT_199123. Signaling by constitutively active EGFR.
REACT_207601. p38MAPK events.
REACT_211860. Tie2 Signaling.
REACT_230639. Downstream signal transduction.
REACT_234357. FRS2-mediated cascade.
REACT_237640. RAF activation.
REACT_237796. NCAM signaling for neurite out-growth.
REACT_239466. SHC-mediated signalling.
REACT_239722. Signalling to RAS.
REACT_241824. SOS-mediated signalling.
REACT_245086. VEGFR2 mediated cell proliferation.
REACT_245103. GRB2 events in EGFR signaling.
REACT_247566. MEK activation.
REACT_257146. RAF phosphorylates MEK.
REACT_260286. SHC1 events in EGFR signaling.
REACT_94437. SHC-mediated cascade.

Gene expression databases

Bgeei Q9QWR5.
ExpressionAtlasi Q9QWR5. baseline and differential.
Genevestigatori Q9QWR5.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view ]
PANTHERi PTHR24070. PTHR24070. 1 hit.
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS51421. RAS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Loss of the normal N-ras allele in a mouse thymic lymphoma induced by a chemical carcinogen."
    Guerrero I., Villasante A., Corces V., Pellicer A.
    Proc. Natl. Acad. Sci. U.S.A. 82:7810-7814(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/c nu/nuImported.
  2. "Alterations of mouse proto-oncogenes in sarcomas induced after transplantation of human tumors in athymic nude mice."
    Yuasa Y., Yamazaki H., Maruo K., Ueyama Y., Shibuya M., Tamaoki N.
    Jpn. J. Cancer Res. 81:333-339(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/c nu/nuImported.

Entry informationi

Entry nameiQ9QWR5_MOUSE
AccessioniPrimary (citable) accession number: Q9QWR5
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: November 26, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)