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Protein
Submitted name:

p21 protein

Gene

ras

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_275935. RAF phosphorylates MEK.
REACT_276076. SHC1 events in ERBB4 signaling.
REACT_278498. Downstream signal transduction.
REACT_285497. GRB2 events in EGFR signaling.
REACT_286571. SHC1 events in EGFR signaling.
REACT_288801. SOS-mediated signalling.
REACT_293097. Activation of RAS in B cells.
REACT_296095. p38MAPK events.
REACT_299722. VEGFR2 mediated cell proliferation.
REACT_301936. DAP12 signaling.
REACT_309034. MEK activation.
REACT_309710. RAF activation.
REACT_314186. FCERI mediated MAPK activation.
REACT_320246. Signalling to RAS.
REACT_321592. SHC1 events in ERBB2 signaling.
REACT_325060. EGFR Transactivation by Gastrin.
REACT_327089. GRB2 events in ERBB2 signaling.
REACT_327841. Signaling by SCF-KIT.
REACT_333309. SHC-mediated signalling.
REACT_339798. NCAM signaling for neurite out-growth.
REACT_341964. Tie2 Signaling.
REACT_357671. FRS-mediated FGFR1 signaling.
REACT_358810. FRS-mediated FGFR3 signaling.
REACT_358906. SHC-mediated cascade:FGFR4.
REACT_359700. FRS-mediated FGFR2 signaling.
REACT_360524. CD209 (DC-SIGN) signaling.
REACT_361588. SHC-mediated cascade:FGFR2.
REACT_361658. FRS2-mediated FGFR4 signaling.
REACT_361860. SHC-mediated cascade:FGFR1.
REACT_361987. SHC-mediated cascade:FGFR3.

Names & Taxonomyi

Protein namesi
Submitted name:
p21 proteinImported
Gene namesi
Name:rasImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ9QWR5.
ExpressionAtlasiQ9QWR5. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032399.

Structurei

3D structure databases

ProteinModelPortaliQ9QWR5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9QWR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
QVVIDGETCL LDILDTAGQE EYSAMRDQYM RTGEGF
Length:36
Mass (Da):4,055
Last modified:May 1, 2000 - v1
Checksum:iC73AC89DFE3A2A51
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei36 – 361Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00836 Genomic DNA. Translation: BAA28218.1.
UniGeneiMm.400954.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00836 Genomic DNA. Translation: BAA28218.1.
UniGeneiMm.400954.

3D structure databases

ProteinModelPortaliQ9QWR5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032399.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

ReactomeiREACT_275935. RAF phosphorylates MEK.
REACT_276076. SHC1 events in ERBB4 signaling.
REACT_278498. Downstream signal transduction.
REACT_285497. GRB2 events in EGFR signaling.
REACT_286571. SHC1 events in EGFR signaling.
REACT_288801. SOS-mediated signalling.
REACT_293097. Activation of RAS in B cells.
REACT_296095. p38MAPK events.
REACT_299722. VEGFR2 mediated cell proliferation.
REACT_301936. DAP12 signaling.
REACT_309034. MEK activation.
REACT_309710. RAF activation.
REACT_314186. FCERI mediated MAPK activation.
REACT_320246. Signalling to RAS.
REACT_321592. SHC1 events in ERBB2 signaling.
REACT_325060. EGFR Transactivation by Gastrin.
REACT_327089. GRB2 events in ERBB2 signaling.
REACT_327841. Signaling by SCF-KIT.
REACT_333309. SHC-mediated signalling.
REACT_339798. NCAM signaling for neurite out-growth.
REACT_341964. Tie2 Signaling.
REACT_357671. FRS-mediated FGFR1 signaling.
REACT_358810. FRS-mediated FGFR3 signaling.
REACT_358906. SHC-mediated cascade:FGFR4.
REACT_359700. FRS-mediated FGFR2 signaling.
REACT_360524. CD209 (DC-SIGN) signaling.
REACT_361588. SHC-mediated cascade:FGFR2.
REACT_361658. FRS2-mediated FGFR4 signaling.
REACT_361860. SHC-mediated cascade:FGFR1.
REACT_361987. SHC-mediated cascade:FGFR3.

Gene expression databases

BgeeiQ9QWR5.
ExpressionAtlasiQ9QWR5. baseline and differential.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Loss of the normal N-ras allele in a mouse thymic lymphoma induced by a chemical carcinogen."
    Guerrero I., Villasante A., Corces V., Pellicer A.
    Proc. Natl. Acad. Sci. U.S.A. 82:7810-7814(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/c nu/nuImported.
  2. "Alterations of mouse proto-oncogenes in sarcomas induced after transplantation of human tumors in athymic nude mice."
    Yuasa Y., Yamazaki H., Maruo K., Ueyama Y., Shibuya M., Tamaoki N.
    Jpn. J. Cancer Res. 81:333-339(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/c nu/nuImported.

Entry informationi

Entry nameiQ9QWR5_MOUSE
AccessioniPrimary (citable) accession number: Q9QWR5
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: July 22, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.