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Protein
Submitted name:

p21 protein

Gene

ras

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. GDP binding Source: Ensembl
  2. GMP binding Source: Ensembl
  3. GTP binding Source: UniProtKB-KW

GO - Biological processi

  1. apoptotic process Source: Ensembl
  2. cell cycle arrest Source: Ensembl
  3. cellular senescence Source: Ensembl
  4. cytokine-mediated signaling pathway Source: Ensembl
  5. mitotic cell cycle checkpoint Source: Ensembl
  6. negative regulation of cell proliferation Source: Ensembl
  7. negative regulation of gene expression Source: Ensembl
  8. negative regulation of Rho GTPase activity Source: Ensembl
  9. positive regulation of actin cytoskeleton reorganization Source: Ensembl
  10. positive regulation of cell migration Source: Ensembl
  11. positive regulation of DNA replication Source: Ensembl
  12. positive regulation of epithelial cell proliferation Source: Ensembl
  13. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  14. positive regulation of JNK cascade Source: Ensembl
  15. positive regulation of MAP kinase activity Source: Ensembl
  16. positive regulation of miRNA metabolic process Source: Ensembl
  17. positive regulation of NF-kappaB transcription factor activity Source: Ensembl
  18. positive regulation of nitric-oxide synthase activity Source: Ensembl
  19. positive regulation of Rac GTPase activity Source: Ensembl
  20. positive regulation of Ras protein signal transduction Source: Ensembl
  21. positive regulation of ruffle assembly Source: Ensembl
  22. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  23. positive regulation of wound healing Source: Ensembl
  24. protein heterooligomerization Source: Ensembl
  25. Ras protein signal transduction Source: Ensembl
  26. response to glucocorticoid Source: Ensembl
  27. response to mineralocorticoid Source: Ensembl
  28. social behavior Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

GTP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_275935. RAF phosphorylates MEK.
REACT_276076. SHC1 events in ERBB4 signaling.
REACT_278498. Downstream signal transduction.
REACT_285497. GRB2 events in EGFR signaling.
REACT_286571. SHC1 events in EGFR signaling.
REACT_288801. SOS-mediated signalling.
REACT_293097. Activation of RAS in B cells.
REACT_296095. p38MAPK events.
REACT_299722. VEGFR2 mediated cell proliferation.
REACT_301936. DAP12 signaling.
REACT_309034. MEK activation.
REACT_309710. RAF activation.
REACT_314186. FCERI mediated MAPK activation.
REACT_317270. Constitutive Signaling by EGFRvIII.
REACT_320246. Signalling to RAS.
REACT_321421. SHC-mediated cascade.
REACT_321592. SHC1 events in ERBB2 signaling.
REACT_325060. EGFR Transactivation by Gastrin.
REACT_326306. Signaling by FGFR mutants.
REACT_327089. GRB2 events in ERBB2 signaling.
REACT_327841. Signaling by SCF-KIT.
REACT_332809. FRS2-mediated cascade.
REACT_333309. SHC-mediated signalling.
REACT_339798. NCAM signaling for neurite out-growth.
REACT_341964. Tie2 Signaling.
REACT_344438. Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants.

Names & Taxonomyi

Protein namesi
Submitted name:
p21 proteinImported
Gene namesi
Name:rasImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. focal adhesion Source: Ensembl
  3. Golgi apparatus Source: Ensembl
  4. membrane raft Source: Ensembl
  5. mitochondrion Source: Ensembl
  6. plasma membrane Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ9QWR5.
ExpressionAtlasiQ9QWR5. baseline and differential.
GenevestigatoriQ9QWR5.

Structurei

3D structure databases

ProteinModelPortaliQ9QWR5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9QWR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
QVVIDGETCL LDILDTAGQE EYSAMRDQYM RTGEGF
Length:36
Mass (Da):4,055
Last modified:April 30, 2000 - v1
Checksum:iC73AC89DFE3A2A51
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei36 – 361Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00836 Genomic DNA. Translation: BAA28218.1.
UniGeneiMm.400954.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00836 Genomic DNA. Translation: BAA28218.1.
UniGeneiMm.400954.

3D structure databases

ProteinModelPortaliQ9QWR5.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

ReactomeiREACT_275935. RAF phosphorylates MEK.
REACT_276076. SHC1 events in ERBB4 signaling.
REACT_278498. Downstream signal transduction.
REACT_285497. GRB2 events in EGFR signaling.
REACT_286571. SHC1 events in EGFR signaling.
REACT_288801. SOS-mediated signalling.
REACT_293097. Activation of RAS in B cells.
REACT_296095. p38MAPK events.
REACT_299722. VEGFR2 mediated cell proliferation.
REACT_301936. DAP12 signaling.
REACT_309034. MEK activation.
REACT_309710. RAF activation.
REACT_314186. FCERI mediated MAPK activation.
REACT_317270. Constitutive Signaling by EGFRvIII.
REACT_320246. Signalling to RAS.
REACT_321421. SHC-mediated cascade.
REACT_321592. SHC1 events in ERBB2 signaling.
REACT_325060. EGFR Transactivation by Gastrin.
REACT_326306. Signaling by FGFR mutants.
REACT_327089. GRB2 events in ERBB2 signaling.
REACT_327841. Signaling by SCF-KIT.
REACT_332809. FRS2-mediated cascade.
REACT_333309. SHC-mediated signalling.
REACT_339798. NCAM signaling for neurite out-growth.
REACT_341964. Tie2 Signaling.
REACT_344438. Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants.

Gene expression databases

BgeeiQ9QWR5.
ExpressionAtlasiQ9QWR5. baseline and differential.
GenevestigatoriQ9QWR5.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Loss of the normal N-ras allele in a mouse thymic lymphoma induced by a chemical carcinogen."
    Guerrero I., Villasante A., Corces V., Pellicer A.
    Proc. Natl. Acad. Sci. U.S.A. 82:7810-7814(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/c nu/nuImported.
  2. "Alterations of mouse proto-oncogenes in sarcomas induced after transplantation of human tumors in athymic nude mice."
    Yuasa Y., Yamazaki H., Maruo K., Ueyama Y., Shibuya M., Tamaoki N.
    Jpn. J. Cancer Res. 81:333-339(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/c nu/nuImported.

Entry informationi

Entry nameiQ9QWR5_MOUSE
AccessioniPrimary (citable) accession number: Q9QWR5
Entry historyi
Integrated into UniProtKB/TrEMBL: April 30, 2000
Last sequence update: April 30, 2000
Last modified: March 31, 2015
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.