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Protein

Nuclear receptor subfamily 5 group A member 2

Gene

Nr5a2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to promoters containing the sequence element 5'-AACGACCGACCTTGAG-3'. Plays a role in the regulation of gene expression in liver and pancreas. May play a role in embryonic development (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei535 – 5351Lipid headgroupBy similarity
Binding sitei539 – 5391Lipid headgroupBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi104 – 17976Nuclear receptorPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri107 – 12721NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri143 – 16220NR C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Lipid-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-383280. Nuclear Receptor transcription pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor subfamily 5 group A member 2
Alternative name(s):
FTZ-F1 beta
Liver receptor homolog 1
Short name:
LRH-1
Gene namesi
Name:Nr5a2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi68353. Nr5a2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 560560Nuclear receptor subfamily 5 group A member 2PRO_0000232606Add
BLAST

PTM databases

PhosphoSiteiQ9QWM1.

Expressioni

Gene expression databases

ExpressionAtlasiQ9QWM1. baseline and differential.
GenevisibleiQ9QWM1. RN.

Interactioni

Subunit structurei

Binds DNA as a monomer. Interacts with GRIP1, NCOA2 and NR0B2 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9QWM1.
SMRiQ9QWM1. Positions 105-199, 318-560.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni361 – 40949Ligand-bindingBy similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi176 – 20530FTZ-F1 boxBy similarityAdd
BLAST

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri107 – 12721NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri143 – 16220NR C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00760000118887.
HOGENOMiHOG000063718.
HOVERGENiHBG106677.
InParanoidiQ9QWM1.
KOiK08027.
PhylomeDBiQ9QWM1.
TreeFamiTF350737.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR016355. NR5_fam.
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PANTHERiPTHR24086. PTHR24086. 1 hit.
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PIRSFiPIRSF002530. Nuc_orph_FTZ-F1. 1 hit.
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 2 hits.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9QWM1-1) [UniParc]FASTAAdd to basket

Also known as: FTZ-F1 beta1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSASSITGDF QDFLKHGLPA IAPAPGSETP HSPKLEEKHR EKRAGLPDRH
60 70 80 90 100
RRPIPARSRL VMLPKVETEA SGLVRSHGEQ GQMPENMQVS QFKMVNYSYD
110 120 130 140 150
EDLEELCPVC GDKVSGYHYG LLTCESCKGF FKRTVQNQKR YTCIENQNCQ
160 170 180 190 200
IDKTQRKRCP YCRFKKCIDV GMKLEAVRAD RMRGGRNKFG PMYKRDRALK
210 220 230 240 250
QQKKALIRAN GLKLEAMSQV IQAMPSDLTS AIQNIHSASK GLPLSHVALP
260 270 280 290 300
PTDYDRSPFV TSPISMTMPP HGSLHGYQPY GHFPNRAIKS EYPDPYSSSP
310 320 330 340 350
ESMMGYSYMD GYQTSSPASI PHLILELLKC EPDEPQVQAK IMAYLQQEQN
360 370 380 390 400
NRNRQEKLSA FGLLCKMADQ TLFSIVEWAR SSIFFRELKV DDQMKLLQNC
410 420 430 440 450
WSELLILDHI YRQVAHGKEG TIFLVTGEHV DYSSIISNTE VAFNNLLSLA
460 470 480 490 500
QELVVRLRSL QFDQREFVCL KFLVLFSSDV KNLENFQLVE GVQEQVNAAL
510 520 530 540 550
LDYTLCNYPQ QTEKFGQLLL RLPEIRAISK QAEDYLYYKH VNGDVPYNNL
560
LIEMLHAKRA
Length:560
Mass (Da):63,904
Last modified:May 1, 2000 - v1
Checksum:iF738B943B443CCE2
GO
Isoform 2 (identifier: Q9QWM1-2) [UniParc]FASTAAdd to basket

Also known as: FTZ-F1 beta2

The sequence of this isoform differs from the canonical sequence as follows:
     22-43: APAPGSETPHSPKLEEKHREKR → G

Show »
Length:539
Mass (Da):61,498
Checksum:i3F4E4217B94E7A60
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei22 – 4322APAPG…HREKR → G in isoform 2. 1 PublicationVSP_017915Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012960 mRNA. Translation: BAA36339.1.
AB012961 mRNA. Translation: BAA36340.1.
RefSeqiNP_068510.1. NM_021742.1. [Q9QWM1-1]
XP_006249990.1. XM_006249928.2. [Q9QWM1-2]
UniGeneiRn.42941.

Genome annotation databases

EnsembliENSRNOT00000000812; ENSRNOP00000000812; ENSRNOG00000000653. [Q9QWM1-1]
GeneIDi60349.
KEGGirno:60349.
UCSCiRGD:68353. rat. [Q9QWM1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012960 mRNA. Translation: BAA36339.1.
AB012961 mRNA. Translation: BAA36340.1.
RefSeqiNP_068510.1. NM_021742.1. [Q9QWM1-1]
XP_006249990.1. XM_006249928.2. [Q9QWM1-2]
UniGeneiRn.42941.

3D structure databases

ProteinModelPortaliQ9QWM1.
SMRiQ9QWM1. Positions 105-199, 318-560.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ9QWM1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000000812; ENSRNOP00000000812; ENSRNOG00000000653. [Q9QWM1-1]
GeneIDi60349.
KEGGirno:60349.
UCSCiRGD:68353. rat. [Q9QWM1-1]

Organism-specific databases

CTDi2494.
RGDi68353. Nr5a2.

Phylogenomic databases

GeneTreeiENSGT00760000118887.
HOGENOMiHOG000063718.
HOVERGENiHBG106677.
InParanoidiQ9QWM1.
KOiK08027.
PhylomeDBiQ9QWM1.
TreeFamiTF350737.

Enzyme and pathway databases

ReactomeiR-RNO-383280. Nuclear Receptor transcription pathway.

Miscellaneous databases

PROiQ9QWM1.

Gene expression databases

ExpressionAtlasiQ9QWM1. baseline and differential.
GenevisibleiQ9QWM1. RN.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR016355. NR5_fam.
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PANTHERiPTHR24086. PTHR24086. 1 hit.
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PIRSFiPIRSF002530. Nuc_orph_FTZ-F1. 1 hit.
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 2 hits.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Rat FTZ-F1beta1 (rat homologue 1 of mLRH-1)."
    Yanase T., Ichino I., Oba K.
    Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Tissue: Liver.

Entry informationi

Entry nameiNR5A2_RAT
AccessioniPrimary (citable) accession number: Q9QWM1
Secondary accession number(s): Q9QWM0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: May 1, 2000
Last modified: June 8, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.