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Protein

Keratin, type I cytoskeletal 17

Gene

Krt17

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (PubMed:14714564, PubMed:16702408). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (PubMed:16702408). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (PubMed:16710422). Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (PubMed:20871598). May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.5 Publications

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

GO - Molecular functioni

GO - Biological processi

  • hair follicle morphogenesis Source: UniProtKB
  • intermediate filament organization Source: MGI
  • keratinization Source: MGI
  • morphogenesis of an epithelium Source: MGI
  • positive regulation of cell growth Source: UniProtKB
  • positive regulation of hair follicle development Source: UniProtKB
  • positive regulation of translation Source: UniProtKB
  • signal transduction Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-6805567 Keratinization
R-MMU-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 17
Alternative name(s):
Cytokeratin-17
Short name:
CK-17
Keratin-17
Short name:
K17
Gene namesi
Name:Krt17
Synonyms:Krt1-17
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:96691 Krt17

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Intermediate filament, Keratin

Pathology & Biotechi

Disruption phenotypei

Severe alopecia during the first week postbirth, correlating with hair fragility, alterations in follicular histology, and apoptosis in matrix cells.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi9T → A: Reduces binding to SNF. 1 Publication1
Mutagenesisi44S → A: Reduces binding to SNF. 1 Publication1
Mutagenesisi94R → P: Causes twisted hair shafts, broken hair follicles at sebaceous gland level and occasional rupture of the hair bulb or epidermal cyst-like changes. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000636651 – 433Keratin, type I cytoskeletal 17Add BLAST433

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12PhosphoserineBy similarity1
Modified residuei13PhosphoserineBy similarity1
Cross-linki15Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki15Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei25PhosphoserineBy similarity1
Modified residuei32PhosphoserineCombined sources1
Modified residuei34PhosphoserineBy similarity1
Modified residuei39PhosphoserineCombined sources1
Modified residuei44Phosphoserine; by RPS6KA1By similarity1
Modified residuei110PhosphothreonineBy similarity1
Cross-linki278Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei279PhosphothreonineBy similarity1
Modified residuei323PhosphoserineBy similarity1
Cross-linki399Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki399Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Cross-linki401Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki401Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Cross-linki420Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki420Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity

Post-translational modificationi

Phosphorylation at Ser-44 occurs in a growth- and stress-dependent fashion in skin keratinocytes, it has no effect on filament organization.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ9QWL7
PeptideAtlasiQ9QWL7
PRIDEiQ9QWL7

PTM databases

iPTMnetiQ9QWL7
PhosphoSitePlusiQ9QWL7

Expressioni

Tissue specificityi

Expressed strongly in outer root sheath and medulla region of hair follicle and in the early differentiating epithelial cells (trichocytes) within the hair bulb region. Weak expression in the matrix cells of hair bulb. Also present in the sweat gland within the skin, vibrissae follicle, salivary gland, tooth and thymus.3 Publications

Developmental stagei

Expression first occurs in a subset of epithelial cells within the single-layered, undifferentiated ectoderm of embryonic day 10.5 mouse fetuses. In the ensuing 48 hours, K17-expressing cells give rise to placodes, the precursors of ectoderm-derived appendages (hair, glands, and tooth), and to periderm.1 Publication

Inductioni

Induced in damaged or stressed epidermis and by interferon-gamma. Up-regulated by LEF1.2 Publications

Gene expression databases

BgeeiENSMUSG00000035557
CleanExiMM_KRT17
GenevisibleiQ9QWL7 MM

Interactioni

Subunit structurei

Heterodimer of a type I and a type II keratin. KRT17 associates with KRT6 isomers (KRT6A or KRT6B) (By similarity). Interacts with TRADD and SFN.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SfnO704563EBI-309015,EBI-1544118

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201022, 3 interactors
DIPiDIP-38042N
IntActiQ9QWL7, 7 interactors
MINTiQ9QWL7
STRINGi10090.ENSMUSP00000079699

Structurei

3D structure databases

ProteinModelPortaliQ9QWL7
SMRiQ9QWL7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini84 – 395IF rodPROSITE-ProRule annotationAdd BLAST312

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 83HeadAdd BLAST83
Regioni84 – 120Coil 1AAdd BLAST37
Regioni121 – 138Linker 1Add BLAST18
Regioni139 – 230Coil 1BAdd BLAST92
Regioni231 – 250Linker 12Add BLAST20
Regioni251 – 392Coil 2Add BLAST142
Regioni393 – 433TailAdd BLAST41

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFTF Eukaryota
ENOG410Y9IV LUCA
GeneTreeiENSGT00900000140820
HOGENOMiHOG000230975
HOVERGENiHBG013015
InParanoidiQ9QWL7
KOiK07604
OMAiQYHRTIE
OrthoDBiEOG091G087I
PhylomeDBiQ9QWL7
TreeFamiTF332742

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR002957 Keratin_I
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PRINTSiPR01248 TYPE1KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9QWL7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTTIRQFTS SSSIKGSSGL GGGSSRTSCR LSGSLGAGSC RLGSASGLGS
60 70 80 90 100
ALGSNSYSSC YSFGTGSGYG GNFGGVDGLL AGGEKATMQN LNDRLASYLD
110 120 130 140 150
KVRALEEANT ELEVKIRDWY QKQAPGPARD YSAYYHTIED LKNKILVATV
160 170 180 190 200
DNASILLQID NARLAADDFR TKFETEQALR MSVEADINGL RRVLDELTLA
210 220 230 240 250
RADLEMQIEN LKEELAYLKK NHEEEMNALR GQVGGEINVE MDAAPGVDLS
260 270 280 290 300
RILSEMRDQY EKMAEKNRKD AEDWFFSKTE ELNREVATNS ELVQSGKSEI
310 320 330 340 350
SELRRTMQAL EIELQSQLSM KASLEGSLAE TENRYCVQLS QIQGLIGSVE
360 370 380 390 400
EQLAQLRCEM EQQNQEYKIL LDVKTRLEQE IATYRRLLEG EDAHLTQYKP
410 420 430
KEPVTTRQVR TIVEEVQDGK VISSREQVHQ TTR
Length:433
Mass (Da):48,162
Last modified:January 23, 2007 - v3
Checksum:i279081DF2ECE105D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013608 mRNA Translation: BAA34229.1
AL590873 Genomic DNA No translation available.
BC132454 mRNA Translation: AAI32455.1
BC132456 mRNA Translation: AAI32457.1
M13805 mRNA Translation: AAA39394.1
CCDSiCCDS25415.1
PIRiC26135
RefSeqiNP_034793.1, NM_010663.3
UniGeneiMm.14046

Genome annotation databases

EnsembliENSMUST00000080893; ENSMUSP00000079699; ENSMUSG00000035557
GeneIDi16667
KEGGimmu:16667
UCSCiuc007lks.1 mouse

Similar proteinsi

Entry informationi

Entry nameiK1C17_MOUSE
AccessioniPrimary (citable) accession number: Q9QWL7
Secondary accession number(s): A2A4G6, Q61783
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 141 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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