Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9QWL7 (K1C17_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Keratin, type I cytoskeletal 17
Alternative name(s):
Cytokeratin-17
Short name=CK-17
Keratin-17
Short name=K17
Gene names
Name:Krt17
Synonyms:Krt1-17
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length433 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation By similarity. Ref.1 Ref.8 Ref.9 Ref.10

Subunit structure

Heterodimer of a type I and a type II keratin. KRT17 associates with KRT6 isomers By similarity. Interacts with TRADD and SFN. Ref.9 Ref.10

Subcellular location

Cytoplasm Ref.9 Ref.10.

Tissue specificity

Expressed strongly in outer root sheath and medulla region of hair follicle and in the early differentiating epithelial cells (trichocytes) within the hair bulb region. Weak expression in the matrix cells of hair bulb. Also present in the sweat gland within the skin, vibrissae follicle, salivary gland, tooth and thymus. Ref.6 Ref.7 Ref.8

Developmental stage

Expression first occurs in a subset of epithelial cells within the single-layered, undifferentiated ectoderm of embryonic day 10.5 mouse fetuses. In the ensuing 48 hours, K17-expressing cells give rise to placodes, the precursors of ectoderm-derived appendages (hair, glands, and tooth), and to periderm. Ref.1

Induction

Induced in damaged or stressed epidermis and by interferon-gamma. Up-regulated by LEF1. Ref.1 Ref.6

Post-translational modification

Phosphorylation at Ser-44 occurs in a growth- and stress-dependent fashion in skin keratinocytes, it has no effect on filament organization By similarity.

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Sequence similarities

Belongs to the intermediate filament family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

SfnO704563EBI-309015,EBI-1544118

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 433433Keratin, type I cytoskeletal 17
PRO_0000063665

Regions

Region1 – 8383Head
Region84 – 392309Rod
Region84 – 12037Coil 1A
Region121 – 13818Linker 1
Region139 – 23092Coil 1B
Region231 – 25020Linker 12
Region251 – 392142Coil 2
Region393 – 43341Tail

Amino acid modifications

Modified residue131Phosphoserine By similarity
Modified residue321Phosphoserine By similarity
Modified residue391Phosphoserine By similarity
Modified residue441Phosphoserine; by RPS6KA1 By similarity

Experimental info

Mutagenesis91T → A: Reduces binding to SNF. Ref.10
Mutagenesis441S → A: Reduces binding to SNF. Ref.10
Mutagenesis941R → P: Causes twisted hair shafts, broken hair follicles at sebaceous gland level and occasional rupture of the hair bulb or epidermal cyst-like changes. Ref.8

Sequences

Sequence LengthMass (Da)Tools
Q9QWL7 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 279081DF2ECE105D

FASTA43348,162
        10         20         30         40         50         60 
MTTTIRQFTS SSSIKGSSGL GGGSSRTSCR LSGSLGAGSC RLGSASGLGS ALGSNSYSSC 

        70         80         90        100        110        120 
YSFGTGSGYG GNFGGVDGLL AGGEKATMQN LNDRLASYLD KVRALEEANT ELEVKIRDWY 

       130        140        150        160        170        180 
QKQAPGPARD YSAYYHTIED LKNKILVATV DNASILLQID NARLAADDFR TKFETEQALR 

       190        200        210        220        230        240 
MSVEADINGL RRVLDELTLA RADLEMQIEN LKEELAYLKK NHEEEMNALR GQVGGEINVE 

       250        260        270        280        290        300 
MDAAPGVDLS RILSEMRDQY EKMAEKNRKD AEDWFFSKTE ELNREVATNS ELVQSGKSEI 

       310        320        330        340        350        360 
SELRRTMQAL EIELQSQLSM KASLEGSLAE TENRYCVQLS QIQGLIGSVE EQLAQLRCEM 

       370        380        390        400        410        420 
EQQNQEYKIL LDVKTRLEQE IATYRRLLEG EDAHLTQYKP KEPVTTRQVR TIVEEVQDGK 

       430 
VISSREQVHQ TTR 

« Hide

References

« Hide 'large scale' references
[1]"Onset of keratin 17 expression coincides with the definition of major epithelial lineages during skin development."
McGowan K.M., Coulombe P.A.
J. Cell Biol. 143:469-486(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, DEVELOPMENTAL STAGE, INDUCTION.
Strain: 129/SvJ.
[2]"The genomic organization of type I keratin genes in mice."
Sato H., Koide T., Sagai T., Ishiguro S., Tamai M., Saitou N., Shiroishi T.
Genomics 56:303-309(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/10J.
Tissue: Skin.
[3]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[5]Lubec G., Sunyer B., Chen W.-Q.
Submitted (JAN-2009) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 95-101; 164-170; 285-297 AND 377-385, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: OF1.
Tissue: Hippocampus.
[6]"Three cDNA sequences of mouse type I keratins: cellular localization of the mRNAs in normal and hyperproliferative tissues."
Knapp B., Rentrop M., Schweizer J., Winter H.
J. Biol. Chem. 262:938-945(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 229-433, TISSUE SPECIFICITY, INDUCTION.
Tissue: Skin.
[7]"Keratin 17 expression in the hard epithelial context of the hair and nail, and its relevance for the pachyonychia congenita phenotype."
McGowan K.M., Coulombe P.A.
J. Invest. Dermatol. 114:1101-1107(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[8]"In vivo alteration of the keratin 17 gene in hair follicles by oligonucleotide-directed gene targeting."
Fan W., Yoon K.
Exp. Dermatol. 12:832-842(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY, MUTAGENESIS OF ARG-94.
[9]"Keratin 17 modulates hair follicle cycling in a TNFalpha-dependent fashion."
Tong X., Coulombe P.A.
Genes Dev. 20:1353-1364(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH TRADD, SUBCELLULAR LOCATION.
[10]"A keratin cytoskeletal protein regulates protein synthesis and epithelial cell growth."
Kim S., Wong P., Coulombe P.A.
Nature 441:362-365(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH SFN, SUBCELLULAR LOCATION, MUTAGENESIS OF THR-9 AND SER-44.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB013608 mRNA. Translation: BAA34229.1.
AL590873 Genomic DNA. Translation: CAM17780.1.
BC132454 mRNA. Translation: AAI32455.1.
BC132456 mRNA. Translation: AAI32457.1.
M13805 mRNA. Translation: AAA39394.1.
PIRC26135.
RefSeqNP_034793.1. NM_010663.2.
UniGeneMm.14046.

3D structure databases

ProteinModelPortalQ9QWL7.
SMRQ9QWL7. Positions 82-232, 248-390.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid201022. 3 interactions.
DIPDIP-38042N.
IntActQ9QWL7. 4 interactions.
MINTMINT-1859144.

PTM databases

PhosphoSiteQ9QWL7.

Proteomic databases

PaxDbQ9QWL7.
PRIDEQ9QWL7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000080893; ENSMUSP00000079699; ENSMUSG00000035557.
GeneID16667.
KEGGmmu:16667.
UCSCuc007lks.1. mouse.

Organism-specific databases

CTD3872.
MGIMGI:96691. Krt17.

Phylogenomic databases

eggNOGNOG148784.
GeneTreeENSGT00610000085921.
HOGENOMHOG000230975.
HOVERGENHBG013015.
InParanoidQ9QWL7.
KOK07604.
OMAGCYSFGS.
OrthoDBEOG7FV3Q8.
PhylomeDBQ9QWL7.
TreeFamTF332742.

Gene expression databases

BgeeQ9QWL7.
CleanExMM_KRT17.
GenevestigatorQ9QWL7.

Family and domain databases

InterProIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
IPR009053. Prefoldin.
[Graphical view]
PANTHERPTHR23239. PTHR23239. 1 hit.
PfamPF00038. Filament. 1 hit.
[Graphical view]
PRINTSPR01248. TYPE1KERATIN.
SUPFAMSSF46579. SSF46579. 1 hit.
PROSITEPS00226. IF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSKRT17. mouse.
NextBio290383.
PROQ9QWL7.
SOURCESearch...

Entry information

Entry nameK1C17_MOUSE
AccessionPrimary (citable) accession number: Q9QWL7
Secondary accession number(s): A2A4G6, Q61783
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 110 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot