Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Keratin, type I cytoskeletal 17

Gene

Krt17

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (PubMed:14714564, PubMed:16702408). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (PubMed:16702408). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (PubMed:16710422). Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (PubMed:20871598). May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.5 Publications

GO - Molecular functioni

GO - Biological processi

  • hair follicle morphogenesis Source: UniProtKB
  • intermediate filament organization Source: MGI
  • keratinization Source: MGI
  • morphogenesis of an epithelium Source: MGI
  • positive regulation of cell growth Source: UniProtKB
  • positive regulation of hair follicle development Source: UniProtKB
  • positive regulation of translation Source: UniProtKB
  • signal transduction Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 17
Alternative name(s):
Cytokeratin-17
Short name:
CK-17
Keratin-17
Short name:
K17
Gene namesi
Name:Krt17
Synonyms:Krt1-17
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:96691. Krt17.

Subcellular locationi

GO - Cellular componenti

  • cell periphery Source: MGI
  • cytoplasm Source: UniProtKB
  • extracellular exosome Source: MGI
  • intermediate filament Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Intermediate filament, Keratin

Pathology & Biotechi

Disruption phenotypei

Severe alopecia during the first week postbirth, correlating with hair fragility, alterations in follicular histology, and apoptosis in matrix cells.1 Publication

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi9 – 91T → A: Reduces binding to SNF. 1 Publication
Mutagenesisi44 – 441S → A: Reduces binding to SNF. 1 Publication
Mutagenesisi94 – 941R → P: Causes twisted hair shafts, broken hair follicles at sebaceous gland level and occasional rupture of the hair bulb or epidermal cyst-like changes. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 433433Keratin, type I cytoskeletal 17PRO_0000063665Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei13 – 131PhosphoserineBy similarity
Modified residuei32 – 321PhosphoserineBy similarity
Modified residuei39 – 391PhosphoserineBy similarity
Modified residuei44 – 441Phosphoserine; by RPS6KA1By similarity

Post-translational modificationi

Phosphorylation at Ser-44 occurs in a growth- and stress-dependent fashion in skin keratinocytes, it has no effect on filament organization.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9QWL7.
PaxDbiQ9QWL7.
PRIDEiQ9QWL7.

PTM databases

PhosphoSiteiQ9QWL7.

Expressioni

Tissue specificityi

Expressed strongly in outer root sheath and medulla region of hair follicle and in the early differentiating epithelial cells (trichocytes) within the hair bulb region. Weak expression in the matrix cells of hair bulb. Also present in the sweat gland within the skin, vibrissae follicle, salivary gland, tooth and thymus.3 Publications

Developmental stagei

Expression first occurs in a subset of epithelial cells within the single-layered, undifferentiated ectoderm of embryonic day 10.5 mouse fetuses. In the ensuing 48 hours, K17-expressing cells give rise to placodes, the precursors of ectoderm-derived appendages (hair, glands, and tooth), and to periderm.1 Publication

Inductioni

Induced in damaged or stressed epidermis and by interferon-gamma. Up-regulated by LEF1.2 Publications

Gene expression databases

BgeeiQ9QWL7.
CleanExiMM_KRT17.
GenevisibleiQ9QWL7. MM.

Interactioni

Subunit structurei

Heterodimer of a type I and a type II keratin. KRT17 associates with KRT6 isomers (KRT6A or KRT6B) (By similarity). Interacts with TRADD and SFN.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SfnO704563EBI-309015,EBI-1544118

Protein-protein interaction databases

BioGridi201022. 3 interactions.
DIPiDIP-38042N.
IntActiQ9QWL7. 4 interactions.
MINTiMINT-1859144.
STRINGi10090.ENSMUSP00000079699.

Structurei

3D structure databases

ProteinModelPortaliQ9QWL7.
SMRiQ9QWL7. Positions 134-232, 248-390.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 8383HeadAdd
BLAST
Regioni84 – 392309RodAdd
BLAST
Regioni84 – 12037Coil 1AAdd
BLAST
Regioni121 – 13818Linker 1Add
BLAST
Regioni139 – 23092Coil 1BAdd
BLAST
Regioni231 – 25020Linker 12Add
BLAST
Regioni251 – 392142Coil 2Add
BLAST
Regioni393 – 43341TailAdd
BLAST

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG148784.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ9QWL7.
KOiK07604.
OMAiGCYSFGS.
OrthoDBiEOG7FV3Q8.
PhylomeDBiQ9QWL7.
TreeFamiTF332742.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
IPR009053. Prefoldin.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SUPFAMiSSF46579. SSF46579. 1 hit.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QWL7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTTIRQFTS SSSIKGSSGL GGGSSRTSCR LSGSLGAGSC RLGSASGLGS
60 70 80 90 100
ALGSNSYSSC YSFGTGSGYG GNFGGVDGLL AGGEKATMQN LNDRLASYLD
110 120 130 140 150
KVRALEEANT ELEVKIRDWY QKQAPGPARD YSAYYHTIED LKNKILVATV
160 170 180 190 200
DNASILLQID NARLAADDFR TKFETEQALR MSVEADINGL RRVLDELTLA
210 220 230 240 250
RADLEMQIEN LKEELAYLKK NHEEEMNALR GQVGGEINVE MDAAPGVDLS
260 270 280 290 300
RILSEMRDQY EKMAEKNRKD AEDWFFSKTE ELNREVATNS ELVQSGKSEI
310 320 330 340 350
SELRRTMQAL EIELQSQLSM KASLEGSLAE TENRYCVQLS QIQGLIGSVE
360 370 380 390 400
EQLAQLRCEM EQQNQEYKIL LDVKTRLEQE IATYRRLLEG EDAHLTQYKP
410 420 430
KEPVTTRQVR TIVEEVQDGK VISSREQVHQ TTR
Length:433
Mass (Da):48,162
Last modified:January 23, 2007 - v3
Checksum:i279081DF2ECE105D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013608 mRNA. Translation: BAA34229.1.
AL590873 Genomic DNA. Translation: CAM17780.1.
BC132454 mRNA. Translation: AAI32455.1.
BC132456 mRNA. Translation: AAI32457.1.
M13805 mRNA. Translation: AAA39394.1.
CCDSiCCDS25415.1.
PIRiC26135.
RefSeqiNP_034793.1. NM_010663.2.
UniGeneiMm.14046.

Genome annotation databases

EnsembliENSMUST00000080893; ENSMUSP00000079699; ENSMUSG00000035557.
GeneIDi16667.
KEGGimmu:16667.
UCSCiuc007lks.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013608 mRNA. Translation: BAA34229.1.
AL590873 Genomic DNA. Translation: CAM17780.1.
BC132454 mRNA. Translation: AAI32455.1.
BC132456 mRNA. Translation: AAI32457.1.
M13805 mRNA. Translation: AAA39394.1.
CCDSiCCDS25415.1.
PIRiC26135.
RefSeqiNP_034793.1. NM_010663.2.
UniGeneiMm.14046.

3D structure databases

ProteinModelPortaliQ9QWL7.
SMRiQ9QWL7. Positions 134-232, 248-390.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201022. 3 interactions.
DIPiDIP-38042N.
IntActiQ9QWL7. 4 interactions.
MINTiMINT-1859144.
STRINGi10090.ENSMUSP00000079699.

PTM databases

PhosphoSiteiQ9QWL7.

Proteomic databases

MaxQBiQ9QWL7.
PaxDbiQ9QWL7.
PRIDEiQ9QWL7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000080893; ENSMUSP00000079699; ENSMUSG00000035557.
GeneIDi16667.
KEGGimmu:16667.
UCSCiuc007lks.1. mouse.

Organism-specific databases

CTDi3872.
MGIiMGI:96691. Krt17.

Phylogenomic databases

eggNOGiNOG148784.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ9QWL7.
KOiK07604.
OMAiGCYSFGS.
OrthoDBiEOG7FV3Q8.
PhylomeDBiQ9QWL7.
TreeFamiTF332742.

Miscellaneous databases

ChiTaRSiKrt17. mouse.
NextBioi290383.
PROiQ9QWL7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9QWL7.
CleanExiMM_KRT17.
GenevisibleiQ9QWL7. MM.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
IPR009053. Prefoldin.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SUPFAMiSSF46579. SSF46579. 1 hit.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Onset of keratin 17 expression coincides with the definition of major epithelial lineages during skin development."
    McGowan K.M., Coulombe P.A.
    J. Cell Biol. 143:469-486(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, DEVELOPMENTAL STAGE, INDUCTION.
    Strain: 129/SvJ.
  2. "The genomic organization of type I keratin genes in mice."
    Sato H., Koide T., Sagai T., Ishiguro S., Tamai M., Saitou N., Shiroishi T.
    Genomics 56:303-309(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/10J.
    Tissue: Skin.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  5. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 95-101; 164-170; 285-297 AND 377-385, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.
  6. "Three cDNA sequences of mouse type I keratins: cellular localization of the mRNAs in normal and hyperproliferative tissues."
    Knapp B., Rentrop M., Schweizer J., Winter H.
    J. Biol. Chem. 262:938-945(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 229-433, TISSUE SPECIFICITY, INDUCTION.
    Tissue: Skin.
  7. "Keratin 17 expression in the hard epithelial context of the hair and nail, and its relevance for the pachyonychia congenita phenotype."
    McGowan K.M., Coulombe P.A.
    J. Invest. Dermatol. 114:1101-1107(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  8. "Keratin 17 null mice exhibit age- and strain-dependent alopecia."
    McGowan K.M., Tong X., Colucci-Guyon E., Langa F., Babinet C., Coulombe P.A.
    Genes Dev. 16:1412-1422(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
  9. "In vivo alteration of the keratin 17 gene in hair follicles by oligonucleotide-directed gene targeting."
    Fan W., Yoon K.
    Exp. Dermatol. 12:832-842(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, MUTAGENESIS OF ARG-94.
  10. "Keratin 17 modulates hair follicle cycling in a TNFalpha-dependent fashion."
    Tong X., Coulombe P.A.
    Genes Dev. 20:1353-1364(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH TRADD, SUBCELLULAR LOCATION.
  11. "A keratin cytoskeletal protein regulates protein synthesis and epithelial cell growth."
    Kim S., Wong P., Coulombe P.A.
    Nature 441:362-365(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH SFN, SUBCELLULAR LOCATION, MUTAGENESIS OF THR-9 AND SER-44.
  12. "Keratin 17 promotes epithelial proliferation and tumor growth by polarizing the immune response in skin."
    Depianto D., Kerns M.L., Dlugosz A.A., Coulombe P.A.
    Nat. Genet. 42:910-914(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiK1C17_MOUSE
AccessioniPrimary (citable) accession number: Q9QWL7
Secondary accession number(s): A2A4G6, Q61783
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: January 23, 2007
Last modified: June 24, 2015
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.