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Q9QWL7

- K1C17_MOUSE

UniProt

Q9QWL7 - K1C17_MOUSE

Protein

Keratin, type I cytoskeletal 17

Gene

Krt17

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation By similarity.By similarity

    GO - Molecular functioni

    1. MHC class II receptor activity Source: Ensembl
    2. protein binding Source: UniProtKB
    3. structural molecule activity Source: InterPro

    GO - Biological processi

    1. intermediate filament organization Source: MGI
    2. keratinization Source: MGI
    3. morphogenesis of an epithelium Source: MGI
    4. positive regulation of cell growth Source: UniProtKB
    5. positive regulation of hair follicle development Source: UniProtKB
    6. positive regulation of translation Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Keratin, type I cytoskeletal 17
    Alternative name(s):
    Cytokeratin-17
    Short name:
    CK-17
    Keratin-17
    Short name:
    K17
    Gene namesi
    Name:Krt17
    Synonyms:Krt1-17
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:96691. Krt17.

    Subcellular locationi

    Cytoplasm 2 Publications

    GO - Cellular componenti

    1. cell periphery Source: MGI
    2. cytoplasm Source: UniProtKB
    3. intermediate filament Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cytoplasm, Intermediate filament, Keratin

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi9 – 91T → A: Reduces binding to SNF. 1 Publication
    Mutagenesisi44 – 441S → A: Reduces binding to SNF. 1 Publication
    Mutagenesisi94 – 941R → P: Causes twisted hair shafts, broken hair follicles at sebaceous gland level and occasional rupture of the hair bulb or epidermal cyst-like changes. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 433433Keratin, type I cytoskeletal 17PRO_0000063665Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei13 – 131PhosphoserineBy similarity
    Modified residuei32 – 321PhosphoserineBy similarity
    Modified residuei39 – 391PhosphoserineBy similarity
    Modified residuei44 – 441Phosphoserine; by RPS6KA1By similarity

    Post-translational modificationi

    Phosphorylation at Ser-44 occurs in a growth- and stress-dependent fashion in skin keratinocytes, it has no effect on filament organization.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9QWL7.
    PaxDbiQ9QWL7.
    PRIDEiQ9QWL7.

    PTM databases

    PhosphoSiteiQ9QWL7.

    Expressioni

    Tissue specificityi

    Expressed strongly in outer root sheath and medulla region of hair follicle and in the early differentiating epithelial cells (trichocytes) within the hair bulb region. Weak expression in the matrix cells of hair bulb. Also present in the sweat gland within the skin, vibrissae follicle, salivary gland, tooth and thymus.3 Publications

    Developmental stagei

    Expression first occurs in a subset of epithelial cells within the single-layered, undifferentiated ectoderm of embryonic day 10.5 mouse fetuses. In the ensuing 48 hours, K17-expressing cells give rise to placodes, the precursors of ectoderm-derived appendages (hair, glands, and tooth), and to periderm.1 Publication

    Inductioni

    Induced in damaged or stressed epidermis and by interferon-gamma. Up-regulated by LEF1.2 Publications

    Gene expression databases

    BgeeiQ9QWL7.
    CleanExiMM_KRT17.
    GenevestigatoriQ9QWL7.

    Interactioni

    Subunit structurei

    Heterodimer of a type I and a type II keratin. KRT17 associates with KRT6 isomers By similarity. Interacts with TRADD and SFN.By similarity2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    SfnO704563EBI-309015,EBI-1544118

    Protein-protein interaction databases

    BioGridi201022. 3 interactions.
    DIPiDIP-38042N.
    IntActiQ9QWL7. 4 interactions.
    MINTiMINT-1859144.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QWL7.
    SMRiQ9QWL7. Positions 134-232, 248-390.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 8383HeadAdd
    BLAST
    Regioni84 – 392309RodAdd
    BLAST
    Regioni84 – 12037Coil 1AAdd
    BLAST
    Regioni121 – 13818Linker 1Add
    BLAST
    Regioni139 – 23092Coil 1BAdd
    BLAST
    Regioni231 – 25020Linker 12Add
    BLAST
    Regioni251 – 392142Coil 2Add
    BLAST
    Regioni393 – 43341TailAdd
    BLAST

    Sequence similaritiesi

    Belongs to the intermediate filament family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG148784.
    GeneTreeiENSGT00610000085921.
    HOGENOMiHOG000230975.
    HOVERGENiHBG013015.
    InParanoidiQ9QWL7.
    KOiK07604.
    OMAiGCYSFGS.
    OrthoDBiEOG7FV3Q8.
    PhylomeDBiQ9QWL7.
    TreeFamiTF332742.

    Family and domain databases

    InterProiIPR001664. IF.
    IPR018039. Intermediate_filament_CS.
    IPR002957. Keratin_I.
    IPR009053. Prefoldin.
    [Graphical view]
    PANTHERiPTHR23239. PTHR23239. 1 hit.
    PfamiPF00038. Filament. 1 hit.
    [Graphical view]
    PRINTSiPR01248. TYPE1KERATIN.
    SUPFAMiSSF46579. SSF46579. 1 hit.
    PROSITEiPS00226. IF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9QWL7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTTIRQFTS SSSIKGSSGL GGGSSRTSCR LSGSLGAGSC RLGSASGLGS    50
    ALGSNSYSSC YSFGTGSGYG GNFGGVDGLL AGGEKATMQN LNDRLASYLD 100
    KVRALEEANT ELEVKIRDWY QKQAPGPARD YSAYYHTIED LKNKILVATV 150
    DNASILLQID NARLAADDFR TKFETEQALR MSVEADINGL RRVLDELTLA 200
    RADLEMQIEN LKEELAYLKK NHEEEMNALR GQVGGEINVE MDAAPGVDLS 250
    RILSEMRDQY EKMAEKNRKD AEDWFFSKTE ELNREVATNS ELVQSGKSEI 300
    SELRRTMQAL EIELQSQLSM KASLEGSLAE TENRYCVQLS QIQGLIGSVE 350
    EQLAQLRCEM EQQNQEYKIL LDVKTRLEQE IATYRRLLEG EDAHLTQYKP 400
    KEPVTTRQVR TIVEEVQDGK VISSREQVHQ TTR 433
    Length:433
    Mass (Da):48,162
    Last modified:January 23, 2007 - v3
    Checksum:i279081DF2ECE105D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB013608 mRNA. Translation: BAA34229.1.
    AL590873 Genomic DNA. Translation: CAM17780.1.
    BC132454 mRNA. Translation: AAI32455.1.
    BC132456 mRNA. Translation: AAI32457.1.
    M13805 mRNA. Translation: AAA39394.1.
    CCDSiCCDS25415.1.
    PIRiC26135.
    RefSeqiNP_034793.1. NM_010663.2.
    UniGeneiMm.14046.

    Genome annotation databases

    EnsembliENSMUST00000080893; ENSMUSP00000079699; ENSMUSG00000035557.
    GeneIDi16667.
    KEGGimmu:16667.
    UCSCiuc007lks.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB013608 mRNA. Translation: BAA34229.1 .
    AL590873 Genomic DNA. Translation: CAM17780.1 .
    BC132454 mRNA. Translation: AAI32455.1 .
    BC132456 mRNA. Translation: AAI32457.1 .
    M13805 mRNA. Translation: AAA39394.1 .
    CCDSi CCDS25415.1.
    PIRi C26135.
    RefSeqi NP_034793.1. NM_010663.2.
    UniGenei Mm.14046.

    3D structure databases

    ProteinModelPortali Q9QWL7.
    SMRi Q9QWL7. Positions 134-232, 248-390.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 201022. 3 interactions.
    DIPi DIP-38042N.
    IntActi Q9QWL7. 4 interactions.
    MINTi MINT-1859144.

    PTM databases

    PhosphoSitei Q9QWL7.

    Proteomic databases

    MaxQBi Q9QWL7.
    PaxDbi Q9QWL7.
    PRIDEi Q9QWL7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000080893 ; ENSMUSP00000079699 ; ENSMUSG00000035557 .
    GeneIDi 16667.
    KEGGi mmu:16667.
    UCSCi uc007lks.1. mouse.

    Organism-specific databases

    CTDi 3872.
    MGIi MGI:96691. Krt17.

    Phylogenomic databases

    eggNOGi NOG148784.
    GeneTreei ENSGT00610000085921.
    HOGENOMi HOG000230975.
    HOVERGENi HBG013015.
    InParanoidi Q9QWL7.
    KOi K07604.
    OMAi GCYSFGS.
    OrthoDBi EOG7FV3Q8.
    PhylomeDBi Q9QWL7.
    TreeFami TF332742.

    Miscellaneous databases

    ChiTaRSi KRT17. mouse.
    NextBioi 290383.
    PROi Q9QWL7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9QWL7.
    CleanExi MM_KRT17.
    Genevestigatori Q9QWL7.

    Family and domain databases

    InterProi IPR001664. IF.
    IPR018039. Intermediate_filament_CS.
    IPR002957. Keratin_I.
    IPR009053. Prefoldin.
    [Graphical view ]
    PANTHERi PTHR23239. PTHR23239. 1 hit.
    Pfami PF00038. Filament. 1 hit.
    [Graphical view ]
    PRINTSi PR01248. TYPE1KERATIN.
    SUPFAMi SSF46579. SSF46579. 1 hit.
    PROSITEi PS00226. IF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Onset of keratin 17 expression coincides with the definition of major epithelial lineages during skin development."
      McGowan K.M., Coulombe P.A.
      J. Cell Biol. 143:469-486(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, DEVELOPMENTAL STAGE, INDUCTION.
      Strain: 129/SvJ.
    2. "The genomic organization of type I keratin genes in mice."
      Sato H., Koide T., Sagai T., Ishiguro S., Tamai M., Saitou N., Shiroishi T.
      Genomics 56:303-309(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/10J.
      Tissue: Skin.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    5. Lubec G., Sunyer B., Chen W.-Q.
      Submitted (JAN-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 95-101; 164-170; 285-297 AND 377-385, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: OF1.
      Tissue: Hippocampus.
    6. "Three cDNA sequences of mouse type I keratins: cellular localization of the mRNAs in normal and hyperproliferative tissues."
      Knapp B., Rentrop M., Schweizer J., Winter H.
      J. Biol. Chem. 262:938-945(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 229-433, TISSUE SPECIFICITY, INDUCTION.
      Tissue: Skin.
    7. "Keratin 17 expression in the hard epithelial context of the hair and nail, and its relevance for the pachyonychia congenita phenotype."
      McGowan K.M., Coulombe P.A.
      J. Invest. Dermatol. 114:1101-1107(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    8. "In vivo alteration of the keratin 17 gene in hair follicles by oligonucleotide-directed gene targeting."
      Fan W., Yoon K.
      Exp. Dermatol. 12:832-842(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, MUTAGENESIS OF ARG-94.
    9. "Keratin 17 modulates hair follicle cycling in a TNFalpha-dependent fashion."
      Tong X., Coulombe P.A.
      Genes Dev. 20:1353-1364(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH TRADD, SUBCELLULAR LOCATION.
    10. "A keratin cytoskeletal protein regulates protein synthesis and epithelial cell growth."
      Kim S., Wong P., Coulombe P.A.
      Nature 441:362-365(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH SFN, SUBCELLULAR LOCATION, MUTAGENESIS OF THR-9 AND SER-44.

    Entry informationi

    Entry nameiK1C17_MOUSE
    AccessioniPrimary (citable) accession number: Q9QWL7
    Secondary accession number(s): A2A4G6, Q61783
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2002
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 114 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3