Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9QWK5

- BIR1A_MOUSE

UniProt

Q9QWK5 - BIR1A_MOUSE

Protein

Baculoviral IAP repeat-containing protein 1a

Gene

Naip1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 3 (27 Jul 2011)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at 'Asp-315' and decreasing the rate of auto proteolysis at 'Asp-330'. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor-neuron apoptosis induced by a variety of signals By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi315 – 3151ZincPROSITE-ProRule annotation
    Metal bindingi318 – 3181ZincPROSITE-ProRule annotation
    Metal bindingi335 – 3351ZincPROSITE-ProRule annotation
    Metal bindingi342 – 3421ZincPROSITE-ProRule annotation
    Binding sitei476 – 4761ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB
    2. cysteine-type endopeptidase inhibitor activity involved in apoptotic process Source: UniProtKB
    3. metal ion binding Source: UniProtKB-KW
    4. nucleoside-triphosphatase activity Source: InterPro

    GO - Biological processi

    1. cellular response to estrogen stimulus Source: MGI
    2. negative regulation of apoptotic process Source: UniProtKB
    3. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB

    Keywords - Molecular functioni

    Protease inhibitor, Thiol protease inhibitor

    Keywords - Biological processi

    Apoptosis

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Protein family/group databases

    MEROPSiI32.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Baculoviral IAP repeat-containing protein 1a
    Alternative name(s):
    Neuronal apoptosis inhibitory protein 1
    Gene namesi
    Name:Naip1
    Synonyms:Birc1a, Naip
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:1298223. Naip1.

    Subcellular locationi

    GO - Cellular componenti

    1. basolateral plasma membrane Source: UniProtKB
    2. cytoplasm Source: UniProtKB

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14031403Baculoviral IAP repeat-containing protein 1aPRO_0000122342Add
    BLAST

    Proteomic databases

    MaxQBiQ9QWK5.
    PRIDEiQ9QWK5.

    PTM databases

    PhosphoSiteiQ9QWK5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9QWK5.
    BgeeiQ9QWK5.
    CleanExiMM_NAIP1.
    GenevestigatoriQ9QWK5.

    Interactioni

    Subunit structurei

    Interacts (via NACHT domain) with APAF1 (via CARD and NACHT domains).By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QWK5.
    SMRiQ9QWK5. Positions 60-128, 140-244, 276-373, 403-811, 1051-1141, 1170-1242, 1291-1330.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati63 – 12866BIR 1Add
    BLAST
    Repeati162 – 22867BIR 2Add
    BLAST
    Repeati281 – 34666BIR 3Add
    BLAST
    Domaini464 – 758295NACHTPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    Both the BIR and NACHT domains are essential for effective inhibition of pro-CASP9 cleavage. BIR3 domain binds to procaspase-9 and the NACHT domain interacts with the NACHT domain of APAF1 forming a bridge between pro-CASP9 and APAF1 By similarity.By similarity

    Sequence similaritiesi

    Contains 3 BIR repeats.PROSITE-ProRule annotation
    Contains 1 NACHT domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG291696.
    GeneTreeiENSGT00500000044782.
    HOGENOMiHOG000236326.
    HOVERGENiHBG050689.
    InParanoidiA2RT89.
    KOiK12807.
    OMAiNFFSDFE.
    OrthoDBiEOG73BVBV.
    TreeFamiTF105356.

    Family and domain databases

    Gene3Di1.10.1170.10. 3 hits.
    InterProiIPR003593. AAA+_ATPase.
    IPR001370. BIR.
    IPR007111. NACHT_NTPase.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00653. BIR. 3 hits.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    SM00238. BIR. 3 hits.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS01282. BIR_REPEAT_1. 1 hit.
    PS50143. BIR_REPEAT_2. 3 hits.
    PS50837. NACHT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9QWK5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEHGESSED RISEIDYEFL PELSALLGVD AVQLAKSQEE EEHKERMKMK     50
    KGFNSQMRSE AKRLKTFETY DTFRSWTPQE MAAAGFYHTG VKLGVQCFCC 100
    SLILFGNSLR KLPIERHKKL RPECEFLQGK DVGNIGKYDI RVKSPEKMLR 150
    GGKARYHEEE ARLESFEDWP FYAHGTSPRV LSAAGFVFTG KRDTVQCFSC 200
    GGSLGNWEEG DDPWKEHAKW FPKCEFLQSK KSSEEIAQYI QGYEGFVHVT 250
    GEHFVNSWVR RELPMVSAYC NDSVFANEEL RMDTFKDWPH ESPVAVDALV 300
    RAGLFYTGKK GIVQCFSCGG CMEKCTEGDD PIQEHNKFFP NCVFLQTPKS 350
    SAEVIPALQS HCALPEAMET TSESNHDDPA AVHSTVVGLG RSEAQWFQEA 400
    RSLSEQLRDN YTKATFRHMN LPEVCSSLGT DHLIGCDVSI ISKHISQPVQ 450
    GALTIPEVFS NLSSVMCVEG ETGSGKTTFL KRIAFLWASG CCPLLYRFQL 500
    VFYLSLSSIT PDQGLANIIC AQLLGAGGCI SEVCLSSIIQ QLQHQVLFLL 550
    DDYSGLASLP QALHTLITKN YLSRTCLLIA VHTNRVRGIR SYLDTSLEIK 600
    EFPLSNTVYI LKKFFSHNIK RLLEFMVYFG QNEDLQGIHK TPLFVAAVCT 650
    DWFENPSDQP FQDMALFKSY MQYLSLKHKG AAKPLQATVS SCGQLALTGL 700
    FSSCFEFNSD DLAEAGVDED EELTTCLMSK FTAQRLRPVY RFLGPLFQEF 750
    LAAMRLTELL SSDRQEDQDL GLYYLRQINS PLKALTTYNN FLKYVFSHPS 800
    SKAGPTVVSH LLHLVDETEL LENTYKNEDY VNHPPGTSRI MKGLKELWLL 850
    SPEYYSSFVS EHLLRIALNF AYESNTVAEC SPFILQFLRG RTLALKVLNL 900
    QYFRDHPESL LLVKSLEVSI NGNKVPKVVD YSVMEKSFET LQPPTIDQDY 950
    ASAFEQMKEH EKNLSENEET IKSIKNIFPL QPPKISSGYW KLSPKPCKIP 1000
    RLEVGVTNMG PADQALLQVL MEVFSASQSI EFRLSDSSGF LESIRPALEL 1050
    SKASVTKCSM SRLELSRAEQ ELLLTLPALQ SLEVSETNQL PDQLFHNLHK 1100
    FLGLKELCVR LDGKPDVLSV LPGEFPNLLH MEKLSIRTSM ESDLSKLVKL 1150
    IQNSPNLHVF HLKCDFLSNC DSLMAVLASC KKLREIEFSG RCFEAMPFVN 1200
    ILPNFISLKI LNLISQQFPD KETSEKFAQA LGSLRNLEEL LVPTGDGIHQ 1250
    VAKLIVRQCL QLPCLRVLAF HYILDNDSVI EIARVATSGG FQKLEKLDLS 1300
    MNHKITEEGY RNFFQALDNL PNLQNLNICR HIPECIQVQA TTVKALGQCV 1350
    SRLPSLTRLH MLSWLLDEED MKVINDVKER HPQSKRLIIF WKWIVPFSPV 1400
    VLE 1403
    Length:1,403
    Mass (Da):158,724
    Last modified:July 27, 2011 - v3
    Checksum:i933E23BB1F1DA3E9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti343 – 3431V → I in AAB69223. (PubMed:9693038)Curated
    Sequence conflicti343 – 3431V → I in AAF82752. (PubMed:10958627)Curated
    Sequence conflicti359 – 3591Q → L in AAB69223. (PubMed:9693038)Curated
    Sequence conflicti359 – 3591Q → L in AAF82752. (PubMed:10958627)Curated
    Sequence conflicti624 – 6241E → K in AAD56763. (PubMed:10501978)Curated
    Sequence conflicti1092 – 10921D → E in AAF82752. (PubMed:10958627)Curated
    Sequence conflicti1116 – 11161D → N in AAF82752. (PubMed:10958627)Curated
    Sequence conflicti1123 – 11231G → R in AAF82752. (PubMed:10958627)Curated
    Sequence conflicti1129 – 11291L → H in AAB69223. (PubMed:9693038)Curated
    Sequence conflicti1140 – 11401M → T in AAB69223. (PubMed:9693038)Curated
    Sequence conflicti1140 – 11401M → T in AAF82752. (PubMed:10958627)Curated
    Sequence conflicti1269 – 12691A → V in AAF82752. (PubMed:10958627)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF007769 mRNA. Translation: AAB69223.1.
    AF135491 mRNA. Translation: AAD56763.1.
    AF242432 Genomic DNA. Translation: AAF82752.1.
    BC132413 mRNA. Translation: AAI32414.1.
    CCDSiCCDS26729.1.
    RefSeqiNP_032696.2. NM_008670.2.
    XP_006517612.1. XM_006517549.1.
    UniGeneiMm.6898.

    Genome annotation databases

    EnsembliENSMUST00000022142; ENSMUSP00000022142; ENSMUSG00000021640.
    GeneIDi17940.
    KEGGimmu:17940.
    UCSCiuc007rqr.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF007769 mRNA. Translation: AAB69223.1 .
    AF135491 mRNA. Translation: AAD56763.1 .
    AF242432 Genomic DNA. Translation: AAF82752.1 .
    BC132413 mRNA. Translation: AAI32414.1 .
    CCDSi CCDS26729.1.
    RefSeqi NP_032696.2. NM_008670.2.
    XP_006517612.1. XM_006517549.1.
    UniGenei Mm.6898.

    3D structure databases

    ProteinModelPortali Q9QWK5.
    SMRi Q9QWK5. Positions 60-128, 140-244, 276-373, 403-811, 1051-1141, 1170-1242, 1291-1330.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi I32.001.

    PTM databases

    PhosphoSitei Q9QWK5.

    Proteomic databases

    MaxQBi Q9QWK5.
    PRIDEi Q9QWK5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000022142 ; ENSMUSP00000022142 ; ENSMUSG00000021640 .
    GeneIDi 17940.
    KEGGi mmu:17940.
    UCSCi uc007rqr.1. mouse.

    Organism-specific databases

    CTDi 17940.
    MGIi MGI:1298223. Naip1.

    Phylogenomic databases

    eggNOGi NOG291696.
    GeneTreei ENSGT00500000044782.
    HOGENOMi HOG000236326.
    HOVERGENi HBG050689.
    InParanoidi A2RT89.
    KOi K12807.
    OMAi NFFSDFE.
    OrthoDBi EOG73BVBV.
    TreeFami TF105356.

    Miscellaneous databases

    NextBioi 292849.
    PROi Q9QWK5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9QWK5.
    Bgeei Q9QWK5.
    CleanExi MM_NAIP1.
    Genevestigatori Q9QWK5.

    Family and domain databases

    Gene3Di 1.10.1170.10. 3 hits.
    InterProi IPR003593. AAA+_ATPase.
    IPR001370. BIR.
    IPR007111. NACHT_NTPase.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00653. BIR. 3 hits.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    SM00238. BIR. 3 hits.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS01282. BIR_REPEAT_1. 1 hit.
    PS50143. BIR_REPEAT_2. 3 hits.
    PS50837. NACHT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of the multiple murine homologues of NAIP (neuronal apoptosis inhibitory protein)."
      Yaraghi Z., Korneluk R.G., MacKenzie A.E.
      Genomics 51:107-113(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The mouse Naip gene cluster on chromosome 13 encodes several distinct functional transcripts."
      Huang S., Scharf J.M., Growney J.D., Endrizzi M.G., Dietrich W.F.
      Mamm. Genome 10:1032-1035(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiBIR1A_MOUSE
    AccessioniPrimary (citable) accession number: Q9QWK5
    Secondary accession number(s): A2RT89, Q9JIB5, Q9R017
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2001
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 114 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3