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Q9QWK5

- BIR1A_MOUSE

UniProt

Q9QWK5 - BIR1A_MOUSE

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Protein

Baculoviral IAP repeat-containing protein 1a

Gene

Naip1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at 'Asp-315' and decreasing the rate of auto proteolysis at 'Asp-330'. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor-neuron apoptosis induced by a variety of signals (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi315 – 3151ZincPROSITE-ProRule annotation
Metal bindingi318 – 3181ZincPROSITE-ProRule annotation
Metal bindingi335 – 3351ZincPROSITE-ProRule annotation
Metal bindingi342 – 3421ZincPROSITE-ProRule annotation
Binding sitei476 – 4761ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB
  2. cysteine-type endopeptidase inhibitor activity involved in apoptotic process Source: UniProtKB
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cellular response to estrogen stimulus Source: MGI
  2. negative regulation of apoptotic process Source: UniProtKB
  3. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Thiol protease inhibitor

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Protein family/group databases

MEROPSiI32.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Baculoviral IAP repeat-containing protein 1a
Alternative name(s):
Neuronal apoptosis inhibitory protein 1
Gene namesi
Name:Naip1
Synonyms:Birc1a, Naip
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:1298223. Naip1.

Subcellular locationi

GO - Cellular componenti

  1. basolateral plasma membrane Source: UniProtKB
  2. cytoplasm Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14031403Baculoviral IAP repeat-containing protein 1aPRO_0000122342Add
BLAST

Proteomic databases

MaxQBiQ9QWK5.
PRIDEiQ9QWK5.

PTM databases

PhosphoSiteiQ9QWK5.

Expressioni

Gene expression databases

BgeeiQ9QWK5.
CleanExiMM_NAIP1.
ExpressionAtlasiQ9QWK5. baseline and differential.
GenevestigatoriQ9QWK5.

Interactioni

Subunit structurei

Interacts (via NACHT domain) with APAF1 (via CARD and NACHT domains).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9QWK5.
SMRiQ9QWK5. Positions 60-128, 140-244, 276-373, 403-811.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati63 – 12866BIR 1Add
BLAST
Repeati162 – 22867BIR 2Add
BLAST
Repeati281 – 34666BIR 3Add
BLAST
Domaini464 – 758295NACHTPROSITE-ProRule annotationAdd
BLAST

Domaini

Both the BIR and NACHT domains are essential for effective inhibition of pro-CASP9 cleavage. BIR3 domain binds to procaspase-9 and the NACHT domain interacts with the NACHT domain of APAF1 forming a bridge between pro-CASP9 and APAF1 (By similarity).By similarity

Sequence similaritiesi

Contains 3 BIR repeats.PROSITE-ProRule annotation
Contains 1 NACHT domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG291696.
GeneTreeiENSGT00500000044782.
HOGENOMiHOG000236326.
HOVERGENiHBG050689.
InParanoidiQ9QWK5.
KOiK12807.
OMAiNFFSDFE.
OrthoDBiEOG73BVBV.
TreeFamiTF105356.

Family and domain databases

Gene3Di1.10.1170.10. 3 hits.
InterProiIPR003593. AAA+_ATPase.
IPR001370. BIR.
IPR007111. NACHT_NTPase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00653. BIR. 3 hits.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00238. BIR. 3 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS01282. BIR_REPEAT_1. 1 hit.
PS50143. BIR_REPEAT_2. 3 hits.
PS50837. NACHT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QWK5 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAEHGESSED RISEIDYEFL PELSALLGVD AVQLAKSQEE EEHKERMKMK
60 70 80 90 100
KGFNSQMRSE AKRLKTFETY DTFRSWTPQE MAAAGFYHTG VKLGVQCFCC
110 120 130 140 150
SLILFGNSLR KLPIERHKKL RPECEFLQGK DVGNIGKYDI RVKSPEKMLR
160 170 180 190 200
GGKARYHEEE ARLESFEDWP FYAHGTSPRV LSAAGFVFTG KRDTVQCFSC
210 220 230 240 250
GGSLGNWEEG DDPWKEHAKW FPKCEFLQSK KSSEEIAQYI QGYEGFVHVT
260 270 280 290 300
GEHFVNSWVR RELPMVSAYC NDSVFANEEL RMDTFKDWPH ESPVAVDALV
310 320 330 340 350
RAGLFYTGKK GIVQCFSCGG CMEKCTEGDD PIQEHNKFFP NCVFLQTPKS
360 370 380 390 400
SAEVIPALQS HCALPEAMET TSESNHDDPA AVHSTVVGLG RSEAQWFQEA
410 420 430 440 450
RSLSEQLRDN YTKATFRHMN LPEVCSSLGT DHLIGCDVSI ISKHISQPVQ
460 470 480 490 500
GALTIPEVFS NLSSVMCVEG ETGSGKTTFL KRIAFLWASG CCPLLYRFQL
510 520 530 540 550
VFYLSLSSIT PDQGLANIIC AQLLGAGGCI SEVCLSSIIQ QLQHQVLFLL
560 570 580 590 600
DDYSGLASLP QALHTLITKN YLSRTCLLIA VHTNRVRGIR SYLDTSLEIK
610 620 630 640 650
EFPLSNTVYI LKKFFSHNIK RLLEFMVYFG QNEDLQGIHK TPLFVAAVCT
660 670 680 690 700
DWFENPSDQP FQDMALFKSY MQYLSLKHKG AAKPLQATVS SCGQLALTGL
710 720 730 740 750
FSSCFEFNSD DLAEAGVDED EELTTCLMSK FTAQRLRPVY RFLGPLFQEF
760 770 780 790 800
LAAMRLTELL SSDRQEDQDL GLYYLRQINS PLKALTTYNN FLKYVFSHPS
810 820 830 840 850
SKAGPTVVSH LLHLVDETEL LENTYKNEDY VNHPPGTSRI MKGLKELWLL
860 870 880 890 900
SPEYYSSFVS EHLLRIALNF AYESNTVAEC SPFILQFLRG RTLALKVLNL
910 920 930 940 950
QYFRDHPESL LLVKSLEVSI NGNKVPKVVD YSVMEKSFET LQPPTIDQDY
960 970 980 990 1000
ASAFEQMKEH EKNLSENEET IKSIKNIFPL QPPKISSGYW KLSPKPCKIP
1010 1020 1030 1040 1050
RLEVGVTNMG PADQALLQVL MEVFSASQSI EFRLSDSSGF LESIRPALEL
1060 1070 1080 1090 1100
SKASVTKCSM SRLELSRAEQ ELLLTLPALQ SLEVSETNQL PDQLFHNLHK
1110 1120 1130 1140 1150
FLGLKELCVR LDGKPDVLSV LPGEFPNLLH MEKLSIRTSM ESDLSKLVKL
1160 1170 1180 1190 1200
IQNSPNLHVF HLKCDFLSNC DSLMAVLASC KKLREIEFSG RCFEAMPFVN
1210 1220 1230 1240 1250
ILPNFISLKI LNLISQQFPD KETSEKFAQA LGSLRNLEEL LVPTGDGIHQ
1260 1270 1280 1290 1300
VAKLIVRQCL QLPCLRVLAF HYILDNDSVI EIARVATSGG FQKLEKLDLS
1310 1320 1330 1340 1350
MNHKITEEGY RNFFQALDNL PNLQNLNICR HIPECIQVQA TTVKALGQCV
1360 1370 1380 1390 1400
SRLPSLTRLH MLSWLLDEED MKVINDVKER HPQSKRLIIF WKWIVPFSPV

VLE
Length:1,403
Mass (Da):158,724
Last modified:July 27, 2011 - v3
Checksum:i933E23BB1F1DA3E9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti343 – 3431V → I in AAB69223. (PubMed:9693038)Curated
Sequence conflicti343 – 3431V → I in AAF82752. (PubMed:10958627)Curated
Sequence conflicti359 – 3591Q → L in AAB69223. (PubMed:9693038)Curated
Sequence conflicti359 – 3591Q → L in AAF82752. (PubMed:10958627)Curated
Sequence conflicti624 – 6241E → K in AAD56763. (PubMed:10501978)Curated
Sequence conflicti1092 – 10921D → E in AAF82752. (PubMed:10958627)Curated
Sequence conflicti1116 – 11161D → N in AAF82752. (PubMed:10958627)Curated
Sequence conflicti1123 – 11231G → R in AAF82752. (PubMed:10958627)Curated
Sequence conflicti1129 – 11291L → H in AAB69223. (PubMed:9693038)Curated
Sequence conflicti1140 – 11401M → T in AAB69223. (PubMed:9693038)Curated
Sequence conflicti1140 – 11401M → T in AAF82752. (PubMed:10958627)Curated
Sequence conflicti1269 – 12691A → V in AAF82752. (PubMed:10958627)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF007769 mRNA. Translation: AAB69223.1.
AF135491 mRNA. Translation: AAD56763.1.
AF242432 Genomic DNA. Translation: AAF82752.1.
BC132413 mRNA. Translation: AAI32414.1.
CCDSiCCDS26729.1.
RefSeqiNP_032696.2. NM_008670.2.
XP_006517612.1. XM_006517549.1.
UniGeneiMm.6898.

Genome annotation databases

EnsembliENSMUST00000022142; ENSMUSP00000022142; ENSMUSG00000021640.
GeneIDi17940.
KEGGimmu:17940.
UCSCiuc007rqr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF007769 mRNA. Translation: AAB69223.1 .
AF135491 mRNA. Translation: AAD56763.1 .
AF242432 Genomic DNA. Translation: AAF82752.1 .
BC132413 mRNA. Translation: AAI32414.1 .
CCDSi CCDS26729.1.
RefSeqi NP_032696.2. NM_008670.2.
XP_006517612.1. XM_006517549.1.
UniGenei Mm.6898.

3D structure databases

ProteinModelPortali Q9QWK5.
SMRi Q9QWK5. Positions 60-128, 140-244, 276-373, 403-811.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi I32.001.

PTM databases

PhosphoSitei Q9QWK5.

Proteomic databases

MaxQBi Q9QWK5.
PRIDEi Q9QWK5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000022142 ; ENSMUSP00000022142 ; ENSMUSG00000021640 .
GeneIDi 17940.
KEGGi mmu:17940.
UCSCi uc007rqr.1. mouse.

Organism-specific databases

CTDi 17940.
MGIi MGI:1298223. Naip1.

Phylogenomic databases

eggNOGi NOG291696.
GeneTreei ENSGT00500000044782.
HOGENOMi HOG000236326.
HOVERGENi HBG050689.
InParanoidi Q9QWK5.
KOi K12807.
OMAi NFFSDFE.
OrthoDBi EOG73BVBV.
TreeFami TF105356.

Miscellaneous databases

NextBioi 292849.
PROi Q9QWK5.
SOURCEi Search...

Gene expression databases

Bgeei Q9QWK5.
CleanExi MM_NAIP1.
ExpressionAtlasi Q9QWK5. baseline and differential.
Genevestigatori Q9QWK5.

Family and domain databases

Gene3Di 1.10.1170.10. 3 hits.
InterProi IPR003593. AAA+_ATPase.
IPR001370. BIR.
IPR007111. NACHT_NTPase.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00653. BIR. 3 hits.
[Graphical view ]
SMARTi SM00382. AAA. 1 hit.
SM00238. BIR. 3 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS01282. BIR_REPEAT_1. 1 hit.
PS50143. BIR_REPEAT_2. 3 hits.
PS50837. NACHT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of the multiple murine homologues of NAIP (neuronal apoptosis inhibitory protein)."
    Yaraghi Z., Korneluk R.G., MacKenzie A.E.
    Genomics 51:107-113(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The mouse Naip gene cluster on chromosome 13 encodes several distinct functional transcripts."
    Huang S., Scharf J.M., Growney J.D., Endrizzi M.G., Dietrich W.F.
    Mamm. Genome 10:1032-1035(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiBIR1A_MOUSE
AccessioniPrimary (citable) accession number: Q9QWK5
Secondary accession number(s): A2RT89, Q9JIB5, Q9R017
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 115 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3