Baculoviral IAP repeat-containing protein 1a

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Q9QWK5 (BIR1A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 102. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Baculoviral IAP repeat-containing protein 1a

Alternative name(s):
Neuronal apoptosis inhibitory protein 1

Gene names

Name:	Naip1
Synonyms:	Birc1a, Naip

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1403 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at 'Asp-315' and decreasing the rate of auto proteolysis at 'Asp-330'. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor-neuron apoptosis induced by a variety of signals By similarity.
Subunit structure	Interacts (via NACHT domain) with APAF1 (via CARD and NACHT domains) By similarity.
Domain	Both the BIR and NACHT domains are essential for effective inhibition of pro-CASP9 cleavage. BIR3 domain binds to procaspase-9 and the NACHT domain interacts with the NACHT domain of APAF1 forming a bridge between pro-CASP9 and APAF1 By similarity.
Sequence similarities	Contains 3 BIR repeats. Contains 1 NACHT domain.

Ontologies

Keywords
Biological process	Apoptosis
Domain	Repeat
Ligand	ATP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Protease inhibitor Thiol protease inhibitor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular response to estrogen stimulus Inferred from mutant phenotype PubMed 17901126. Source: MGI negative regulation of apoptotic process Inferred from mutant phenotype PubMed 16735463. Source: UniProtKB
Cellular_component	basolateral plasma membrane Inferred from direct assay PubMed 16735463. Source: UniProtKB cytoplasm Inferred from direct assay PubMed 16735463. Source: UniProtKB
Molecular_function	ATP binding Inferred from sequence or structural similarity. Source: UniProtKB cysteine-type endopeptidase inhibitor activity involved in apoptotic process Inferred from mutant phenotype PubMed 16735463. Source: UniProtKB metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1403

1403

Baculoviral IAP repeat-containing protein 1a

PRO_0000122342

Regions

Repeat

63 – 128

BIR 1

Repeat

162 – 228

BIR 2

Repeat

281 – 346

BIR 3

Domain

464 – 758

295

NACHT

Sites

Metal binding

315

Zinc By similarity

Metal binding

318

Zinc By similarity

Metal binding

335

Zinc By similarity

Metal binding

342

Zinc By similarity

Binding site

476

ATP By similarity

Experimental info

Sequence conflict

343

V → I in AAB69223. Ref.1

Sequence conflict

343

V → I in AAF82752. Ref.3

Sequence conflict

359

Q → L in AAB69223. Ref.1

Sequence conflict

359

Q → L in AAF82752. Ref.3

Sequence conflict

624

E → K in AAD56763. Ref.2

Sequence conflict

1092

D → E in AAF82752. Ref.3

Sequence conflict

1116

D → N in AAF82752. Ref.3

Sequence conflict

1123

G → R in AAF82752. Ref.3

Sequence conflict

1129

L → H in AAB69223. Ref.1

Sequence conflict

1140

M → T in AAB69223. Ref.1

Sequence conflict

1140

M → T in AAF82752. Ref.3

Sequence conflict

1269

A → V in AAF82752. Ref.3

Sequences

Sequence

Length

Mass (Da)

Tools

Q9QWK5 [UniParc].

Last modified July 27, 2011. Version 3.
Checksum: 933E23BB1F1DA3E9
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FASTA

1,403

158,724

        10         20         30         40         50         60 
MAEHGESSED RISEIDYEFL PELSALLGVD AVQLAKSQEE EEHKERMKMK KGFNSQMRSE 

        70         80         90        100        110        120 
AKRLKTFETY DTFRSWTPQE MAAAGFYHTG VKLGVQCFCC SLILFGNSLR KLPIERHKKL 

       130        140        150        160        170        180 
RPECEFLQGK DVGNIGKYDI RVKSPEKMLR GGKARYHEEE ARLESFEDWP FYAHGTSPRV 

       190        200        210        220        230        240 
LSAAGFVFTG KRDTVQCFSC GGSLGNWEEG DDPWKEHAKW FPKCEFLQSK KSSEEIAQYI 

       250        260        270        280        290        300 
QGYEGFVHVT GEHFVNSWVR RELPMVSAYC NDSVFANEEL RMDTFKDWPH ESPVAVDALV 

       310        320        330        340        350        360 
RAGLFYTGKK GIVQCFSCGG CMEKCTEGDD PIQEHNKFFP NCVFLQTPKS SAEVIPALQS 

       370        380        390        400        410        420 
HCALPEAMET TSESNHDDPA AVHSTVVGLG RSEAQWFQEA RSLSEQLRDN YTKATFRHMN 

       430        440        450        460        470        480 
LPEVCSSLGT DHLIGCDVSI ISKHISQPVQ GALTIPEVFS NLSSVMCVEG ETGSGKTTFL 

       490        500        510        520        530        540 
KRIAFLWASG CCPLLYRFQL VFYLSLSSIT PDQGLANIIC AQLLGAGGCI SEVCLSSIIQ 

       550        560        570        580        590        600 
QLQHQVLFLL DDYSGLASLP QALHTLITKN YLSRTCLLIA VHTNRVRGIR SYLDTSLEIK 

       610        620        630        640        650        660 
EFPLSNTVYI LKKFFSHNIK RLLEFMVYFG QNEDLQGIHK TPLFVAAVCT DWFENPSDQP 

       670        680        690        700        710        720 
FQDMALFKSY MQYLSLKHKG AAKPLQATVS SCGQLALTGL FSSCFEFNSD DLAEAGVDED 

       730        740        750        760        770        780 
EELTTCLMSK FTAQRLRPVY RFLGPLFQEF LAAMRLTELL SSDRQEDQDL GLYYLRQINS 

       790        800        810        820        830        840 
PLKALTTYNN FLKYVFSHPS SKAGPTVVSH LLHLVDETEL LENTYKNEDY VNHPPGTSRI 

       850        860        870        880        890        900 
MKGLKELWLL SPEYYSSFVS EHLLRIALNF AYESNTVAEC SPFILQFLRG RTLALKVLNL 

       910        920        930        940        950        960 
QYFRDHPESL LLVKSLEVSI NGNKVPKVVD YSVMEKSFET LQPPTIDQDY ASAFEQMKEH 

       970        980        990       1000       1010       1020 
EKNLSENEET IKSIKNIFPL QPPKISSGYW KLSPKPCKIP RLEVGVTNMG PADQALLQVL 

      1030       1040       1050       1060       1070       1080 
MEVFSASQSI EFRLSDSSGF LESIRPALEL SKASVTKCSM SRLELSRAEQ ELLLTLPALQ 

      1090       1100       1110       1120       1130       1140 
SLEVSETNQL PDQLFHNLHK FLGLKELCVR LDGKPDVLSV LPGEFPNLLH MEKLSIRTSM 

      1150       1160       1170       1180       1190       1200 
ESDLSKLVKL IQNSPNLHVF HLKCDFLSNC DSLMAVLASC KKLREIEFSG RCFEAMPFVN 

      1210       1220       1230       1240       1250       1260 
ILPNFISLKI LNLISQQFPD KETSEKFAQA LGSLRNLEEL LVPTGDGIHQ VAKLIVRQCL 

      1270       1280       1290       1300       1310       1320 
QLPCLRVLAF HYILDNDSVI EIARVATSGG FQKLEKLDLS MNHKITEEGY RNFFQALDNL 

      1330       1340       1350       1360       1370       1380 
PNLQNLNICR HIPECIQVQA TTVKALGQCV SRLPSLTRLH MLSWLLDEED MKVINDVKER 

      1390       1400 
HPQSKRLIIF WKWIVPFSPV VLE

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of the multiple murine homologues of NAIP (neuronal apoptosis inhibitory protein)." Yaraghi Z., Korneluk R.G., MacKenzie A.E. Genomics 51:107-113(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The mouse Naip gene cluster on chromosome 13 encodes several distinct functional transcripts." Huang S., Scharf J.M., Growney J.D., Endrizzi M.G., Dietrich W.F. Mamm. Genome 10:1032-1035(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Genomic sequence analysis of the mouse Naip gene array." Endrizzi M.G., Hadinoto V., Growney J.D., Miller W., Dietrich W.F. Genome Res. 10:1095-1102(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF007769 mRNA. Translation: AAB69223.1. AF135491 mRNA. Translation: AAD56763.1. AF242432 Genomic DNA. Translation: AAF82752.1. BC132413 mRNA. Translation: AAI32414.1.
IPI	IPI00316047.
RefSeq	NP_032696.2. NM_008670.2.
UniGene	Mm.6898.
3D structure databases
ProteinModelPortal	Q9QWK5.
SMR	Q9QWK5. Positions 60-128, 140-244, 276-373, 1054-1139.
ModBase	Search...
Protein family/group databases
MEROPS	I32.001.
PTM databases
PhosphoSite	Q9QWK5.
Proteomic databases
PRIDE	Q9QWK5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000022142; ENSMUSP00000022142; ENSMUSG00000021640.
GeneID	17940.
KEGG	mmu:17940.
UCSC	uc007rqr.1. mouse.
Organism-specific databases
CTD	17940.
MGI	MGI:1298223. Naip1.
Phylogenomic databases
eggNOG	NOG291696.
GeneTree	ENSGT00530000064142.
HOGENOM	HOG000236326.
HOVERGEN	HBG050689.
InParanoid	A2RT89.
KO	K12807.
OMA	WILPFSP.
OrthoDB	EOG4XGZZ7.
Gene expression databases
ArrayExpress	Q9QWK5.
Bgee	Q9QWK5.
CleanEx	MM_NAIP1.
Genevestigator	Q9QWK5.
GermOnline	ENSMUSG00000021640. Mus musculus.
Family and domain databases
Gene3D	1.10.1170.10. 3 hits.
InterPro	IPR003593. AAA+_ATPase. IPR001370. BIR. IPR007111. NACHT_NTPase. IPR027417. P-loop_NTPase. [Graphical view]
Pfam	PF00653. BIR. 3 hits. [Graphical view]
SMART	SM00382. AAA. 1 hit. SM00238. BIR. 3 hits. [Graphical view]
SUPFAM	SSF52540. SSF52540. 1 hit.
PROSITE	PS01282. BIR_REPEAT_1. 1 hit. PS50143. BIR_REPEAT_2. 3 hits. PS50837. NACHT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	292849.
SOURCE	Search...

Entry information

Entry name

BIR1A_MOUSE

Accession

Primary (citable) accession number: Q9QWK5
Secondary accession number(s): A2RT89, Q9JIB5, Q9R017

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 24, 2001
Last sequence update:	July 27, 2011
Last modified:	May 29, 2013
This is version 102 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents