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Q9QWK5

- BIR1A_MOUSE

UniProt

Q9QWK5 - BIR1A_MOUSE

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Protein
Baculoviral IAP repeat-containing protein 1a
Gene
Naip1, Birc1a, Naip
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at 'Asp-315' and decreasing the rate of auto proteolysis at 'Asp-330'. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor-neuron apoptosis induced by a variety of signals By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi315 – 3151Zinc By similarity
Metal bindingi318 – 3181Zinc By similarity
Metal bindingi335 – 3351Zinc By similarity
Metal bindingi342 – 3421Zinc By similarity
Binding sitei476 – 4761ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB
  2. cysteine-type endopeptidase inhibitor activity involved in apoptotic process Source: UniProtKB
  3. metal ion binding Source: UniProtKB-KW
  4. nucleoside-triphosphatase activity Source: InterPro

GO - Biological processi

  1. cellular response to estrogen stimulus Source: MGI
  2. negative regulation of apoptotic process Source: UniProtKB
  3. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Thiol protease inhibitor

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Protein family/group databases

MEROPSiI32.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Baculoviral IAP repeat-containing protein 1a
Alternative name(s):
Neuronal apoptosis inhibitory protein 1
Gene namesi
Name:Naip1
Synonyms:Birc1a, Naip
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:1298223. Naip1.

Subcellular locationi

GO - Cellular componenti

  1. basolateral plasma membrane Source: UniProtKB
  2. cytoplasm Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14031403Baculoviral IAP repeat-containing protein 1a
PRO_0000122342Add
BLAST

Proteomic databases

MaxQBiQ9QWK5.
PRIDEiQ9QWK5.

PTM databases

PhosphoSiteiQ9QWK5.

Expressioni

Gene expression databases

ArrayExpressiQ9QWK5.
BgeeiQ9QWK5.
CleanExiMM_NAIP1.
GenevestigatoriQ9QWK5.

Interactioni

Subunit structurei

Interacts (via NACHT domain) with APAF1 (via CARD and NACHT domains) By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ9QWK5.
SMRiQ9QWK5. Positions 60-128, 140-244, 276-373, 403-811, 1051-1141, 1170-1242, 1291-1330.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati63 – 12866BIR 1
Add
BLAST
Repeati162 – 22867BIR 2
Add
BLAST
Repeati281 – 34666BIR 3
Add
BLAST
Domaini464 – 758295NACHT
Add
BLAST

Domaini

Both the BIR and NACHT domains are essential for effective inhibition of pro-CASP9 cleavage. BIR3 domain binds to procaspase-9 and the NACHT domain interacts with the NACHT domain of APAF1 forming a bridge between pro-CASP9 and APAF1 By similarity.

Sequence similaritiesi

Contains 3 BIR repeats.
Contains 1 NACHT domain.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG291696.
GeneTreeiENSGT00500000044782.
HOGENOMiHOG000236326.
HOVERGENiHBG050689.
InParanoidiA2RT89.
KOiK12807.
OMAiNFFSDFE.
OrthoDBiEOG73BVBV.
TreeFamiTF105356.

Family and domain databases

Gene3Di1.10.1170.10. 3 hits.
InterProiIPR003593. AAA+_ATPase.
IPR001370. BIR.
IPR007111. NACHT_NTPase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00653. BIR. 3 hits.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00238. BIR. 3 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS01282. BIR_REPEAT_1. 1 hit.
PS50143. BIR_REPEAT_2. 3 hits.
PS50837. NACHT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QWK5-1 [UniParc]FASTAAdd to Basket

« Hide

MAEHGESSED RISEIDYEFL PELSALLGVD AVQLAKSQEE EEHKERMKMK     50
KGFNSQMRSE AKRLKTFETY DTFRSWTPQE MAAAGFYHTG VKLGVQCFCC 100
SLILFGNSLR KLPIERHKKL RPECEFLQGK DVGNIGKYDI RVKSPEKMLR 150
GGKARYHEEE ARLESFEDWP FYAHGTSPRV LSAAGFVFTG KRDTVQCFSC 200
GGSLGNWEEG DDPWKEHAKW FPKCEFLQSK KSSEEIAQYI QGYEGFVHVT 250
GEHFVNSWVR RELPMVSAYC NDSVFANEEL RMDTFKDWPH ESPVAVDALV 300
RAGLFYTGKK GIVQCFSCGG CMEKCTEGDD PIQEHNKFFP NCVFLQTPKS 350
SAEVIPALQS HCALPEAMET TSESNHDDPA AVHSTVVGLG RSEAQWFQEA 400
RSLSEQLRDN YTKATFRHMN LPEVCSSLGT DHLIGCDVSI ISKHISQPVQ 450
GALTIPEVFS NLSSVMCVEG ETGSGKTTFL KRIAFLWASG CCPLLYRFQL 500
VFYLSLSSIT PDQGLANIIC AQLLGAGGCI SEVCLSSIIQ QLQHQVLFLL 550
DDYSGLASLP QALHTLITKN YLSRTCLLIA VHTNRVRGIR SYLDTSLEIK 600
EFPLSNTVYI LKKFFSHNIK RLLEFMVYFG QNEDLQGIHK TPLFVAAVCT 650
DWFENPSDQP FQDMALFKSY MQYLSLKHKG AAKPLQATVS SCGQLALTGL 700
FSSCFEFNSD DLAEAGVDED EELTTCLMSK FTAQRLRPVY RFLGPLFQEF 750
LAAMRLTELL SSDRQEDQDL GLYYLRQINS PLKALTTYNN FLKYVFSHPS 800
SKAGPTVVSH LLHLVDETEL LENTYKNEDY VNHPPGTSRI MKGLKELWLL 850
SPEYYSSFVS EHLLRIALNF AYESNTVAEC SPFILQFLRG RTLALKVLNL 900
QYFRDHPESL LLVKSLEVSI NGNKVPKVVD YSVMEKSFET LQPPTIDQDY 950
ASAFEQMKEH EKNLSENEET IKSIKNIFPL QPPKISSGYW KLSPKPCKIP 1000
RLEVGVTNMG PADQALLQVL MEVFSASQSI EFRLSDSSGF LESIRPALEL 1050
SKASVTKCSM SRLELSRAEQ ELLLTLPALQ SLEVSETNQL PDQLFHNLHK 1100
FLGLKELCVR LDGKPDVLSV LPGEFPNLLH MEKLSIRTSM ESDLSKLVKL 1150
IQNSPNLHVF HLKCDFLSNC DSLMAVLASC KKLREIEFSG RCFEAMPFVN 1200
ILPNFISLKI LNLISQQFPD KETSEKFAQA LGSLRNLEEL LVPTGDGIHQ 1250
VAKLIVRQCL QLPCLRVLAF HYILDNDSVI EIARVATSGG FQKLEKLDLS 1300
MNHKITEEGY RNFFQALDNL PNLQNLNICR HIPECIQVQA TTVKALGQCV 1350
SRLPSLTRLH MLSWLLDEED MKVINDVKER HPQSKRLIIF WKWIVPFSPV 1400
VLE 1403
Length:1,403
Mass (Da):158,724
Last modified:July 27, 2011 - v3
Checksum:i933E23BB1F1DA3E9
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti343 – 3431V → I in AAB69223. 1 Publication
Sequence conflicti343 – 3431V → I in AAF82752. 1 Publication
Sequence conflicti359 – 3591Q → L in AAB69223. 1 Publication
Sequence conflicti359 – 3591Q → L in AAF82752. 1 Publication
Sequence conflicti624 – 6241E → K in AAD56763. 1 Publication
Sequence conflicti1092 – 10921D → E in AAF82752. 1 Publication
Sequence conflicti1116 – 11161D → N in AAF82752. 1 Publication
Sequence conflicti1123 – 11231G → R in AAF82752. 1 Publication
Sequence conflicti1129 – 11291L → H in AAB69223. 1 Publication
Sequence conflicti1140 – 11401M → T in AAB69223. 1 Publication
Sequence conflicti1140 – 11401M → T in AAF82752. 1 Publication
Sequence conflicti1269 – 12691A → V in AAF82752. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF007769 mRNA. Translation: AAB69223.1.
AF135491 mRNA. Translation: AAD56763.1.
AF242432 Genomic DNA. Translation: AAF82752.1.
BC132413 mRNA. Translation: AAI32414.1.
CCDSiCCDS26729.1.
RefSeqiNP_032696.2. NM_008670.2.
XP_006517612.1. XM_006517549.1.
UniGeneiMm.6898.

Genome annotation databases

EnsembliENSMUST00000022142; ENSMUSP00000022142; ENSMUSG00000021640.
GeneIDi17940.
KEGGimmu:17940.
UCSCiuc007rqr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF007769 mRNA. Translation: AAB69223.1 .
AF135491 mRNA. Translation: AAD56763.1 .
AF242432 Genomic DNA. Translation: AAF82752.1 .
BC132413 mRNA. Translation: AAI32414.1 .
CCDSi CCDS26729.1.
RefSeqi NP_032696.2. NM_008670.2.
XP_006517612.1. XM_006517549.1.
UniGenei Mm.6898.

3D structure databases

ProteinModelPortali Q9QWK5.
SMRi Q9QWK5. Positions 60-128, 140-244, 276-373, 403-811, 1051-1141, 1170-1242, 1291-1330.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi I32.001.

PTM databases

PhosphoSitei Q9QWK5.

Proteomic databases

MaxQBi Q9QWK5.
PRIDEi Q9QWK5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000022142 ; ENSMUSP00000022142 ; ENSMUSG00000021640 .
GeneIDi 17940.
KEGGi mmu:17940.
UCSCi uc007rqr.1. mouse.

Organism-specific databases

CTDi 17940.
MGIi MGI:1298223. Naip1.

Phylogenomic databases

eggNOGi NOG291696.
GeneTreei ENSGT00500000044782.
HOGENOMi HOG000236326.
HOVERGENi HBG050689.
InParanoidi A2RT89.
KOi K12807.
OMAi NFFSDFE.
OrthoDBi EOG73BVBV.
TreeFami TF105356.

Miscellaneous databases

NextBioi 292849.
PROi Q9QWK5.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9QWK5.
Bgeei Q9QWK5.
CleanExi MM_NAIP1.
Genevestigatori Q9QWK5.

Family and domain databases

Gene3Di 1.10.1170.10. 3 hits.
InterProi IPR003593. AAA+_ATPase.
IPR001370. BIR.
IPR007111. NACHT_NTPase.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00653. BIR. 3 hits.
[Graphical view ]
SMARTi SM00382. AAA. 1 hit.
SM00238. BIR. 3 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS01282. BIR_REPEAT_1. 1 hit.
PS50143. BIR_REPEAT_2. 3 hits.
PS50837. NACHT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of the multiple murine homologues of NAIP (neuronal apoptosis inhibitory protein)."
    Yaraghi Z., Korneluk R.G., MacKenzie A.E.
    Genomics 51:107-113(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The mouse Naip gene cluster on chromosome 13 encodes several distinct functional transcripts."
    Huang S., Scharf J.M., Growney J.D., Endrizzi M.G., Dietrich W.F.
    Mamm. Genome 10:1032-1035(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiBIR1A_MOUSE
AccessioniPrimary (citable) accession number: Q9QWK5
Secondary accession number(s): A2RT89, Q9JIB5, Q9R017
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 113 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi