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Q9QWK5 (BIR1A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Baculoviral IAP repeat-containing protein 1a
Alternative name(s):
Neuronal apoptosis inhibitory protein 1
Gene names
Name:Naip1
Synonyms:Birc1a, Naip
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1403 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at 'Asp-315' and decreasing the rate of auto proteolysis at 'Asp-330'. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor-neuron apoptosis induced by a variety of signals By similarity.

Subunit structure

Interacts (via NACHT domain) with APAF1 (via CARD and NACHT domains) By similarity.

Domain

Both the BIR and NACHT domains are essential for effective inhibition of pro-CASP9 cleavage. BIR3 domain binds to procaspase-9 and the NACHT domain interacts with the NACHT domain of APAF1 forming a bridge between pro-CASP9 and APAF1 By similarity.

Sequence similarities

Contains 3 BIR repeats.

Contains 1 NACHT domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 14031403Baculoviral IAP repeat-containing protein 1a
PRO_0000122342

Regions

Repeat63 – 12866BIR 1
Repeat162 – 22867BIR 2
Repeat281 – 34666BIR 3
Domain464 – 758295NACHT

Sites

Metal binding3151Zinc By similarity
Metal binding3181Zinc By similarity
Metal binding3351Zinc By similarity
Metal binding3421Zinc By similarity
Binding site4761ATP By similarity

Experimental info

Sequence conflict3431V → I in AAB69223. Ref.1
Sequence conflict3431V → I in AAF82752. Ref.3
Sequence conflict3591Q → L in AAB69223. Ref.1
Sequence conflict3591Q → L in AAF82752. Ref.3
Sequence conflict6241E → K in AAD56763. Ref.2
Sequence conflict10921D → E in AAF82752. Ref.3
Sequence conflict11161D → N in AAF82752. Ref.3
Sequence conflict11231G → R in AAF82752. Ref.3
Sequence conflict11291L → H in AAB69223. Ref.1
Sequence conflict11401M → T in AAB69223. Ref.1
Sequence conflict11401M → T in AAF82752. Ref.3
Sequence conflict12691A → V in AAF82752. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q9QWK5 [UniParc].

Last modified July 27, 2011. Version 3.
Checksum: 933E23BB1F1DA3E9

FASTA1,403158,724
        10         20         30         40         50         60 
MAEHGESSED RISEIDYEFL PELSALLGVD AVQLAKSQEE EEHKERMKMK KGFNSQMRSE 

        70         80         90        100        110        120 
AKRLKTFETY DTFRSWTPQE MAAAGFYHTG VKLGVQCFCC SLILFGNSLR KLPIERHKKL 

       130        140        150        160        170        180 
RPECEFLQGK DVGNIGKYDI RVKSPEKMLR GGKARYHEEE ARLESFEDWP FYAHGTSPRV 

       190        200        210        220        230        240 
LSAAGFVFTG KRDTVQCFSC GGSLGNWEEG DDPWKEHAKW FPKCEFLQSK KSSEEIAQYI 

       250        260        270        280        290        300 
QGYEGFVHVT GEHFVNSWVR RELPMVSAYC NDSVFANEEL RMDTFKDWPH ESPVAVDALV 

       310        320        330        340        350        360 
RAGLFYTGKK GIVQCFSCGG CMEKCTEGDD PIQEHNKFFP NCVFLQTPKS SAEVIPALQS 

       370        380        390        400        410        420 
HCALPEAMET TSESNHDDPA AVHSTVVGLG RSEAQWFQEA RSLSEQLRDN YTKATFRHMN 

       430        440        450        460        470        480 
LPEVCSSLGT DHLIGCDVSI ISKHISQPVQ GALTIPEVFS NLSSVMCVEG ETGSGKTTFL 

       490        500        510        520        530        540 
KRIAFLWASG CCPLLYRFQL VFYLSLSSIT PDQGLANIIC AQLLGAGGCI SEVCLSSIIQ 

       550        560        570        580        590        600 
QLQHQVLFLL DDYSGLASLP QALHTLITKN YLSRTCLLIA VHTNRVRGIR SYLDTSLEIK 

       610        620        630        640        650        660 
EFPLSNTVYI LKKFFSHNIK RLLEFMVYFG QNEDLQGIHK TPLFVAAVCT DWFENPSDQP 

       670        680        690        700        710        720 
FQDMALFKSY MQYLSLKHKG AAKPLQATVS SCGQLALTGL FSSCFEFNSD DLAEAGVDED 

       730        740        750        760        770        780 
EELTTCLMSK FTAQRLRPVY RFLGPLFQEF LAAMRLTELL SSDRQEDQDL GLYYLRQINS 

       790        800        810        820        830        840 
PLKALTTYNN FLKYVFSHPS SKAGPTVVSH LLHLVDETEL LENTYKNEDY VNHPPGTSRI 

       850        860        870        880        890        900 
MKGLKELWLL SPEYYSSFVS EHLLRIALNF AYESNTVAEC SPFILQFLRG RTLALKVLNL 

       910        920        930        940        950        960 
QYFRDHPESL LLVKSLEVSI NGNKVPKVVD YSVMEKSFET LQPPTIDQDY ASAFEQMKEH 

       970        980        990       1000       1010       1020 
EKNLSENEET IKSIKNIFPL QPPKISSGYW KLSPKPCKIP RLEVGVTNMG PADQALLQVL 

      1030       1040       1050       1060       1070       1080 
MEVFSASQSI EFRLSDSSGF LESIRPALEL SKASVTKCSM SRLELSRAEQ ELLLTLPALQ 

      1090       1100       1110       1120       1130       1140 
SLEVSETNQL PDQLFHNLHK FLGLKELCVR LDGKPDVLSV LPGEFPNLLH MEKLSIRTSM 

      1150       1160       1170       1180       1190       1200 
ESDLSKLVKL IQNSPNLHVF HLKCDFLSNC DSLMAVLASC KKLREIEFSG RCFEAMPFVN 

      1210       1220       1230       1240       1250       1260 
ILPNFISLKI LNLISQQFPD KETSEKFAQA LGSLRNLEEL LVPTGDGIHQ VAKLIVRQCL 

      1270       1280       1290       1300       1310       1320 
QLPCLRVLAF HYILDNDSVI EIARVATSGG FQKLEKLDLS MNHKITEEGY RNFFQALDNL 

      1330       1340       1350       1360       1370       1380 
PNLQNLNICR HIPECIQVQA TTVKALGQCV SRLPSLTRLH MLSWLLDEED MKVINDVKER 

      1390       1400 
HPQSKRLIIF WKWIVPFSPV VLE 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of the multiple murine homologues of NAIP (neuronal apoptosis inhibitory protein)."
Yaraghi Z., Korneluk R.G., MacKenzie A.E.
Genomics 51:107-113(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The mouse Naip gene cluster on chromosome 13 encodes several distinct functional transcripts."
Huang S., Scharf J.M., Growney J.D., Endrizzi M.G., Dietrich W.F.
Mamm. Genome 10:1032-1035(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Genomic sequence analysis of the mouse Naip gene array."
Endrizzi M.G., Hadinoto V., Growney J.D., Miller W., Dietrich W.F.
Genome Res. 10:1095-1102(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF007769 mRNA. Translation: AAB69223.1.
AF135491 mRNA. Translation: AAD56763.1.
AF242432 Genomic DNA. Translation: AAF82752.1.
BC132413 mRNA. Translation: AAI32414.1.
RefSeqNP_032696.2. NM_008670.2.
XP_006517612.1. XM_006517549.1.
UniGeneMm.6898.

3D structure databases

ProteinModelPortalQ9QWK5.
SMRQ9QWK5. Positions 60-374, 403-811, 1054-1245.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSI32.001.

PTM databases

PhosphoSiteQ9QWK5.

Proteomic databases

PRIDEQ9QWK5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000022142; ENSMUSP00000022142; ENSMUSG00000021640.
GeneID17940.
KEGGmmu:17940.
UCSCuc007rqr.1. mouse.

Organism-specific databases

CTD17940.
MGIMGI:1298223. Naip1.

Phylogenomic databases

eggNOGNOG291696.
GeneTreeENSGT00500000044782.
HOGENOMHOG000236326.
HOVERGENHBG050689.
InParanoidA2RT89.
KOK12807.
OMANFFSDFE.
OrthoDBEOG73BVBV.
TreeFamTF105356.

Gene expression databases

ArrayExpressQ9QWK5.
BgeeQ9QWK5.
CleanExMM_NAIP1.
GenevestigatorQ9QWK5.

Family and domain databases

Gene3D1.10.1170.10. 3 hits.
InterProIPR003593. AAA+_ATPase.
IPR001370. BIR.
IPR007111. NACHT_NTPase.
IPR028789. Naip.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERPTHR10044:SF5. PTHR10044:SF5. 1 hit.
PfamPF00653. BIR. 3 hits.
[Graphical view]
SMARTSM00382. AAA. 1 hit.
SM00238. BIR. 3 hits.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS01282. BIR_REPEAT_1. 1 hit.
PS50143. BIR_REPEAT_2. 3 hits.
PS50837. NACHT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio292849.
PROQ9QWK5.
SOURCESearch...

Entry information

Entry nameBIR1A_MOUSE
AccessionPrimary (citable) accession number: Q9QWK5
Secondary accession number(s): A2RT89, Q9JIB5, Q9R017
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: July 27, 2011
Last modified: April 16, 2014
This is version 110 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot