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Protein

Neuropilin-1

Gene

Nrp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. Regulates VEGFA-induced angiogenesis (By similarity). Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi195CalciumBy similarity1
Metal bindingi209CalciumBy similarity1
Metal bindingi250CalciumBy similarity1

GO - Molecular functioni

  • GTPase activator activity Source: Ensembl
  • heparin binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • protein kinase binding Source: Ensembl
  • semaphorin receptor activity Source: RGD
  • vascular endothelial growth factor-activated receptor activity Source: RGD
  • vascular endothelial growth factor binding Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Heparin-binding, Receptor
Biological processAngiogenesis, Differentiation, Neurogenesis
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-RNO-194306 Neurophilin interactions with VEGF and VEGFR
R-RNO-399954 Sema3A PAK dependent Axon repulsion
R-RNO-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
R-RNO-399956 CRMPs in Sema3A signaling
R-RNO-445144 Signal transduction by L1

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropilin-1
Alternative name(s):
Vascular endothelial cell growth factor 165 receptor
CD_antigen: CD304
Gene namesi
Name:Nrp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi621588 Nrp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 855ExtracellularSequence analysisAdd BLAST834
Transmembranei856 – 880HelicalSequence analysisAdd BLAST25
Topological domaini881 – 922CytoplasmicSequence analysisAdd BLAST42

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3309098

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000002186122 – 922Neuropilin-1Add BLAST901

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi27 ↔ 541 Publication
Disulfide bondi82 ↔ 1041 Publication
Disulfide bondi147 ↔ 173By similarity
Glycosylationi150N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi206 ↔ 228By similarity
Glycosylationi261N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi275 ↔ 4241 Publication
Glycosylationi300N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi431 ↔ 5831 Publication
Glycosylationi522N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi612O-linked (Xyl...) (chondroitin sulfate) serine; alternateBy similarity1
Glycosylationi612O-linked (Xyl...) (heparan sulfate) serine; alternateBy similarity1
Glycosylationi841N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei893PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Heparan sulfate, Phosphoprotein, Proteoglycan

Proteomic databases

PaxDbiQ9QWJ9
PRIDEiQ9QWJ9

PTM databases

iPTMnetiQ9QWJ9
PhosphoSitePlusiQ9QWJ9
SwissPalmiQ9QWJ9

Expressioni

Tissue specificityi

Found in the embryonic nervous system.

Gene expression databases

BgeeiENSRNOG00000010744
GenevisibleiQ9QWJ9 RN

Interactioni

Subunit structurei

Homodimer, and heterodimer with NRP2. Binds PLXNB1. Interacts with FER (By similarity). Interacts with VEGFA (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi251596, 1 interactor
DIPiDIP-44935N
IntActiQ9QWJ9, 2 interactors
STRINGi10116.ENSRNOP00000014492

Chemistry databases

BindingDBiQ9QWJ9

Structurei

Secondary structure

1922
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni281 – 283Combined sources3
Helixi288 – 290Combined sources3
Beta strandi291 – 294Combined sources4
Helixi299 – 301Combined sources3
Helixi303 – 305Combined sources3
Beta strandi326 – 342Combined sources17
Turni347 – 349Combined sources3
Beta strandi352 – 368Combined sources17
Beta strandi385 – 389Combined sources5
Beta strandi391 – 414Combined sources24
Beta strandi417 – 424Combined sources8
Helixi426 – 428Combined sources3
Beta strandi429 – 431Combined sources3
Beta strandi432 – 434Combined sources3
Turni437 – 439Combined sources3
Helixi442 – 444Combined sources3
Beta strandi445 – 449Combined sources5
Helixi459 – 462Combined sources4
Turni464 – 466Combined sources3
Beta strandi467 – 469Combined sources3
Beta strandi471 – 473Combined sources3
Beta strandi485 – 501Combined sources17
Beta strandi503 – 505Combined sources3
Beta strandi508 – 510Combined sources3
Beta strandi512 – 525Combined sources14
Beta strandi534 – 537Combined sources4
Beta strandi544 – 547Combined sources4
Beta strandi550 – 570Combined sources21
Beta strandi573 – 583Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ORXX-ray2.40A273-586[»]
2ORZX-ray2.15A273-586[»]
ProteinModelPortaliQ9QWJ9
SMRiQ9QWJ9
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9QWJ9

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 141CUB 1PROSITE-ProRule annotationAdd BLAST115
Domaini147 – 265CUB 2PROSITE-ProRule annotationAdd BLAST119
Domaini275 – 424F5/8 type C 1PROSITE-ProRule annotationAdd BLAST150
Domaini431 – 583F5/8 type C 2PROSITE-ProRule annotationAdd BLAST153
Domaini645 – 811MAMPROSITE-ProRule annotationAdd BLAST167

Domaini

The tandem CUB domains mediate binding to semaphorin, while the tandem F5/8 domains are responsible for heparin and VEGF binding.By similarity

Sequence similaritiesi

Belongs to the neuropilin family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE8T Eukaryota
ENOG410YRBE LUCA
GeneTreeiENSGT00910000143988
HOGENOMiHOG000039978
HOVERGENiHBG000502
InParanoidiQ9QWJ9
KOiK06724
OMAiLYCACWH
PhylomeDBiQ9QWJ9
TreeFamiTF316506

Family and domain databases

CDDicd00041 CUB, 2 hits
cd06263 MAM, 1 hit
Gene3Di2.60.120.260, 2 hits
2.60.120.290, 2 hits
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000859 CUB_dom
IPR000421 FA58C
IPR008979 Galactose-bd-like_sf
IPR000998 MAM_dom
IPR014648 Neuropilin
IPR022579 Neuropilin_C
IPR027146 NRP1
IPR035914 Sperma_CUB_dom_sf
PANTHERiPTHR44185 PTHR44185, 1 hit
PTHR44185:SF1 PTHR44185:SF1, 1 hit
PfamiView protein in Pfam
PF00431 CUB, 2 hits
PF11980 DUF3481, 1 hit
PF00754 F5_F8_type_C, 2 hits
PF00629 MAM, 1 hit
PIRSFiPIRSF036960 Neuropilin, 1 hit
PRINTSiPR00020 MAMDOMAIN
SMARTiView protein in SMART
SM00042 CUB, 2 hits
SM00231 FA58C, 2 hits
SM00137 MAM, 1 hit
SUPFAMiSSF49785 SSF49785, 2 hits
SSF49854 SSF49854, 2 hits
SSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS01180 CUB, 2 hits
PS01285 FA58C_1, 2 hits
PS01286 FA58C_2, 2 hits
PS50022 FA58C_3, 2 hits
PS00740 MAM_1, 1 hit
PS50060 MAM_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QWJ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERGLPLLCA TLALALALAG AFRSDKCGGT IKIENPGYLT SPGYPHSYHP
60 70 80 90 100
SEKCEWLIQA PEPYQRIMIN FNPHFDLEDR DCKYDYVEVI DGENEGGRLW
110 120 130 140 150
GKFCGKIAPS PVVSSGPFLF IKFVSDYETH GAGFSIRYEI FKRGPECSQN
160 170 180 190 200
YTAPTGVIKS PGFPEKYPNS LECTYIIFAP KMSEIILEFE SFDLEQDSNP
210 220 230 240 250
PGGVFCRYDR LEIWDGFPEV GPHIGRYCGQ KTPGRIRSSS GILSMVFYTD
260 270 280 290 300
SAIAKEGFSA NYSVLQSSIS EDFKCMEALG MESGEIHSDQ ITASSQYGTN
310 320 330 340 350
WSVERSRLNY PENGWTPGED SYREWIQVDL GLLRFVTAVG TQGAISKETK
360 370 380 390 400
KKYYVKTYRV DISSNGEDWI TLKEGNKAII FQGNTNPTDV VFGVFPKPLI
410 420 430 440 450
TRFVRIKPAS WETGISMRFE VYGCKITDYP CSGMLGMVSG LISDSQITAS
460 470 480 490 500
NQGDRNWMPE NIRLVTSRTG WALPPSPHPY INEWLQVDLG DEKIVRGVII
510 520 530 540 550
QGGKHRENKV FMRKFKIAYS NNGSDWKMIM DDSKRKAKSF EGNNNYDTPE
560 570 580 590 600
LRAFTPLSTR FIRIYPERAT HSGLGLRMEL LGCEVEVPTA GPTTPNGNPV
610 620 630 640 650
DECDDDQANC HSGTGDDFQL TGGTTVLATE KPTIIDSTIQ SEFPTYGFNC
660 670 680 690 700
EFGWGSHKTF CHWEHDSHAQ LRWRVLTSKT GPIQDHTGDG NFIYSQADEN
710 720 730 740 750
QKGKVARLVS PVVYSQSSAH CMTFWYHMSG SHVGTLRVKL HYQKPEEYDQ
760 770 780 790 800
LVWMVVGHQG DHWKEGRVLL HKSLKLYQVI FEGEIGKGNL GGIAVDDISI
810 820 830 840 850
NNHIPQEDCA KPTDLDKKNT EIKIDETGST PGYEEGKGDK NISRKPGNVL
860 870 880 890 900
KTLDPILITI IAMSALGVLL GAVCGVVLYC ACWHNGMSER NLSALENYNF
910 920
ELVDGVKLKK DKLNPQSNYS EA
Length:922
Mass (Da):103,082
Last modified:May 1, 2000 - v1
Checksum:iCC6F82AD098B0F2E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016296 mRNA Translation: AAC53337.1
BC085689 mRNA Translation: AAH85689.1
RefSeqiNP_659566.1, NM_145098.2
XP_006255887.1, XM_006255825.3
UniGeneiRn.10815
Rn.165344

Genome annotation databases

EnsembliENSRNOT00000014492; ENSRNOP00000014492; ENSRNOG00000010744
ENSRNOT00000080465; ENSRNOP00000075034; ENSRNOG00000010744
GeneIDi246331
KEGGirno:246331
UCSCiRGD:621588 rat

Similar proteinsi

Entry informationi

Entry nameiNRP1_RAT
AccessioniPrimary (citable) accession number: Q9QWJ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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