Unreviewed, UniProtKB/TrEMBL Q9QWI0 (Q9QWI0_RAT)

Names and origin

Protein names

Submitted name:
    Peroxisome proliferator activated receptor delta EMBL AAC65985.1

Gene names

Name:

Ppard RGD 3370

Organism

Rattus norvegicus (Rat) EMBL AAC65985.1

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	440 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Belongs to the nuclear hormone receptor family. RuleBase RU000377V1 Contains 1 nuclear receptor DNA-binding domain. Spearmint SPM001723

Ontologies

Keywords
Biological process	Transcription Transcription regulation RuleBase RU004334V0 Spearmint SPM001723
Cellular component	Nucleus RuleBase RU004334V0 Spearmint SPM001723
Domain	Zinc-finger RuleBase RU004334V0
Ligand	DNA-binding RuleBase RU004334V0 Spearmint SPM001723 Metal-binding Zinc
Molecular function	Receptor RuleBase RU004334V0 EMBL AAC65985.1
Gene Ontology (GO)
Biological process	anagen Inferred from electronic annotation. Source: Compara axon ensheathment Inferred from electronic annotation. Source: Compara cell differentiation Inferred from electronic annotation. Source: Compara cell-substrate adhesion Inferred from electronic annotation. Source: Compara fatty acid beta-oxidation Inferred from electronic annotation. Source: Compara fatty acid transport Inferred from electronic annotation. Source: Compara keratinocyte migration Inferred from electronic annotation. Source: Compara keratinocyte proliferation Inferred from electronic annotation. Source: Compara negative regulation of epithelial cell proliferation Inferred from electronic annotation. Source: Compara negative regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara placenta development Inferred from electronic annotation. Source: Compara positive regulation of cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of phosphoinositide 3-kinase cascade Inferred from electronic annotation. Source: Compara regulation of fat cell differentiation Inferred from electronic annotation. Source: Compara transcription Inferred from electronic annotation. Source: UniProtKB-KW vitamin A metabolic process Inferred from mutant phenotype. Source: RGD wound healing Inferred from electronic annotation. Source: Compara
Cellular component	nucleus Non-traceable author statement. Source: RGD
Molecular function	NF-kappaB binding Inferred from physical interaction. Source: RGD fatty acid binding Inferred from direct assay. Source: RGD sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro steroid hormone receptor activity Inferred from electronic annotation. Source: InterPro transcription factor activity Traceable author statement. Source: RGD transcription repressor activity Inferred from electronic annotation. Source: Compara zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9QWI0-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 7F050F795586A13C	FASTA	440	49,719
	10 20 30 40 50 60 MEQPQEETPE AREEEKEEVA TGDGAPELNG GPEHTLPSSS CTDLSQNSSP SSLLDQLQMG 70 80 90 100 110 120 CDGASGGSLN MECRVCGDKA SGFHYGVHAC EGCKGFFRRT IRMKLKYEKC DRICKIQKKN 130 140 150 160 170 180 RNKCQYCRFQ KCLALGMSHN AIRFGRMPEA EKRKLVAGLT ASEGCQQNPQ LADLKAFSKH 190 200 210 220 230 240 IYNAYLKNFN MTKKKARSIL TGKSSHNAPF IIHDIETLWQ AEKGLVWKQL VNGPRPYNEI 250 260 270 280 290 300 SVHVFYRCQS TTVDTVRELT EFAKNIPNFS SLFLNDQVTL LKYGVHQAIF AMLASIVNKD 310 320 330 340 350 360 GLLVANGSGF VTHEFLRSIR KPFSDIIEPK FEFAVKFNAL ELDDSDLALF IAAIILCGDR 370 380 390 400 410 420 PGLMNVPQVE AIQDTILQAL EFHLQVNHPD SQYLFPKLLQ KMADLRQLVT EHAQMMQWLK 430 440 KTESETLLHP LLQEIYKDMY

References

[1]

"A systematic analysis of 40 random genes in cultured vascular smooth muscle subtypes reveals a heterogeneity of gene expression and identifies the tight junction gene zonula occludens 2 as a marker of epithelioid 'pup' smooth muscle cells and a participant in carotid neointimal formation." Adams L.D., Lemire J.M., Schwartz S.M. Arterioscler. Thromb. Vasc. Biol. 19:2600-2608(1999) [PubMed: 10559001] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Wistar-Kyoto EMBL AAC65985.1.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U75918 mRNA. Translation: AAC65985.1.
IPI	IPI00325169.
UniGene	Rn.96181
3D structure databases
HSSP	HSSP built from PDB template 3GWX based on UniProtKB Q03181.
SMR	Q9QWI0. Positions 170-440.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9QWI0.
Genome annotation databases
Ensembl	ENSRNOT00000042539; ENSRNOP00000045974; ENSRNOG00000000503; Rattus norvegicus. [Genome view]
Phylogenomic databases
HOVERGEN	Q9QWI0.
Gene expression databases
ArrayExpress	Q9QWI0.
Genevestigator	Q9QWI0.
Family and domain databases
InterPro	IPR003074. 1Cnucl_rcpt. IPR003075. 1Cnucl_rcpt_B. IPR008946. Nucl_hormone_rcpt_ligand-bd. IPR000536. Nucl_hrmn_rcpt_lig-bd_core. IPR001723. Str_hrmn_rcpt. IPR001628. Znf_hrmn_rcpt. IPR013088. Znf_NHR/GATA. [Graphical view]
Gene3D	G3DSA:1.10.565.10. Nucl_hrmn_rcpt_lig_bd. 1 hit. G3DSA:3.30.50.10. Znf_NHR/GATA. 1 hit.
Pfam	PF00104. Hormone_recep. 1 hit. PF00105. zf-C4. 1 hit. [Graphical view]
PRINTS	PR01288. PROXISOMEPAR. PR01290. PROXISOMPABR. PR00398. STRDHORMONER. PR00047. STROIDFINGER.
ProDom	PD000035. Znf_C4steroid. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00430. HOLI. 1 hit. SM00399. ZnF_C4. 1 hit. [Graphical view]
PROSITE	PS00031. NUCLEAR_REC_DBD_1. 1 hit. PS51030. NUCLEAR_REC_DBD_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q9QWI0_RAT

Accession

Primary (citable) accession number: Q9QWI0

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2000
Last sequence update:	May 1, 2000
Last modified:	November 3, 2009
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)