Q9QWI0 (Q9QWI0_RAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Peroxisome proliferator activated receptor delta EMBL AAC65985.1

Gene names

Name:

Ppard RGD 3370

Organism

Rattus norvegicus (Rat) EMBL AAC65985.1

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	440 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the nuclear hormone receptor family. RuleBase RU000377 Contains 1 nuclear receptor DNA-binding domain. SAAS SAAS008946

Ontologies

Keywords
Biological process	Transcription Transcription regulation RuleBase RU004334 SAAS SAAS008946
Cellular component	Nucleus RuleBase RU004334 SAAS SAAS008946
Domain	Zinc-finger RuleBase RU004334 SAAS SAAS008946
Ligand	DNA-binding RuleBase RU004334 SAAS SAAS008946 Metal-binding Zinc
Molecular function	Receptor RuleBase RU004334 EMBL AAC65985.1
Gene Ontology (GO)
Biological process	decidualization Inferred from expression pattern. Source: RGD embryo implantation Inferred from expression pattern. Source: RGD fatty acid oxidation Inferred from direct assay. Source: RGD heart development Inferred from expression pattern. Source: RGD mRNA transcription Inferred from direct assay. Source: RGD negative regulation of apoptotic process Inferred from direct assay. Source: RGD negative regulation of cell growth Inferred from direct assay. Source: RGD negative regulation of collagen biosynthetic process Inferred from mutant phenotype. Source: RGD negative regulation of inflammatory response Inferred from direct assay. Source: RGD negative regulation of smooth muscle cell migration Inferred from direct assay. Source: RGD negative regulation of smooth muscle cell proliferation Inferred from direct assay. Source: RGD phospholipid biosynthetic process Inferred from direct assay. Source: RGD positive regulation of epidermis development Inferred from direct assay. Source: RGD positive regulation of insulin secretion Inferred from direct assay. Source: RGD positive regulation of vasodilation Inferred from direct assay. Source: RGD proteoglycan metabolic process Inferred from direct assay. Source: RGD response to activity Inferred from expression pattern. Source: RGD response to glucose stimulus Inferred from expression pattern. Source: RGD response to vitamin A Inferred from expression pattern. Source: RGD vitamin A metabolic process Inferred from mutant phenotype. Source: RGD
Cellular component	nucleus Inferred from direct assay. Source: RGD
Molecular function	NF-kappaB binding Inferred from physical interaction. Source: RGD fatty acid binding Inferred from direct assay. Source: RGD sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Traceable author statement. Source: RGD steroid hormone receptor activity Inferred from electronic annotation. Source: InterPro transcription coactivator activity Inferred from direct assay. Source: RGD zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9QWI0 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 7F050F795586A13C	FASTA	440	49,719
	10 20 30 40 50 60 MEQPQEETPE AREEEKEEVA TGDGAPELNG GPEHTLPSSS CTDLSQNSSP SSLLDQLQMG 70 80 90 100 110 120 CDGASGGSLN MECRVCGDKA SGFHYGVHAC EGCKGFFRRT IRMKLKYEKC DRICKIQKKN 130 140 150 160 170 180 RNKCQYCRFQ KCLALGMSHN AIRFGRMPEA EKRKLVAGLT ASEGCQQNPQ LADLKAFSKH 190 200 210 220 230 240 IYNAYLKNFN MTKKKARSIL TGKSSHNAPF IIHDIETLWQ AEKGLVWKQL VNGPRPYNEI 250 260 270 280 290 300 SVHVFYRCQS TTVDTVRELT EFAKNIPNFS SLFLNDQVTL LKYGVHQAIF AMLASIVNKD 310 320 330 340 350 360 GLLVANGSGF VTHEFLRSIR KPFSDIIEPK FEFAVKFNAL ELDDSDLALF IAAIILCGDR 370 380 390 400 410 420 PGLMNVPQVE AIQDTILQAL EFHLQVNHPD SQYLFPKLLQ KMADLRQLVT EHAQMMQWLK 430 440 KTESETLLHP LLQEIYKDMY

References

[1]

"A systematic analysis of 40 random genes in cultured vascular smooth muscle subtypes reveals a heterogeneity of gene expression and identifies the tight junction gene zonula occludens 2 as a marker of epithelioid 'pup' smooth muscle cells and a participant in carotid neointimal formation." Adams L.D., Lemire J.M., Schwartz S.M. Arterioscler. Thromb. Vasc. Biol. 19:2600-2608(1999) [PubMed: 10559001] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Wistar-Kyoto EMBL AAC65985.1.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U75918 mRNA. Translation: AAC65985.1.
IPI	IPI00325169.
UniGene	Rn.96181.
3D structure databases
HSSP	HSSP built from PDB template 3GWX based on UniProtKB Q03181.
ProteinModelPortal	Q9QWI0.
SMR	Q9QWI0. Positions 64-150, 170-440.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9QWI0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
RGD	3370. Ppard.
Phylogenomic databases
GeneTree	ENSGT00590000082832.
HOVERGEN	HBG106004.
InParanoid	Q9QWI0.
Gene expression databases
ArrayExpress	Q9QWI0.
Genevestigator	Q9QWI0.
Family and domain databases
InterPro	IPR003074. 1Cnucl_rcpt. IPR003075. 1Cnucl_rcpt_B. IPR008946. Nucl_hormone_rcpt_ligand-bd. IPR000536. Nucl_hrmn_rcpt_lig-bd_core. IPR001723. Str_hrmn_rcpt. IPR001628. Znf_hrmn_rcpt. IPR013088. Znf_NHR/GATA. [Graphical view]
Gene3D	G3DSA:1.10.565.10. Nucl_hrmn_rcpt_lig_bd. 2 hits. G3DSA:3.30.50.10. Znf_NHR/GATA. 1 hit.
Pfam	PF00104. Hormone_recep. 1 hit. PF00105. zf-C4. 1 hit. [Graphical view]
PRINTS	PR01288. PROXISOMEPAR. PR01290. PROXISOMPABR. PR00398. STRDHORMONER. PR00047. STROIDFINGER.
SMART	SM00430. HOLI. 1 hit. SM00399. ZnF_C4. 1 hit. [Graphical view]
SUPFAM	SSF48508. Str_ncl_receptor. 1 hit.
PROSITE	PS00031. NUCLEAR_REC_DBD_1. 1 hit. PS51030. NUCLEAR_REC_DBD_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q9QWI0_RAT

Accession

Primary (citable) accession number: Q9QWI0

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2000
Last sequence update:	May 1, 2000
Last modified:	July 27, 2011
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)