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Q9QW08

- PHOS_MOUSE

UniProt

Q9QW08 - PHOS_MOUSE

Protein

Phosducin

Gene

Pdc

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Inhibits the transcriptional activation activity of the cone-rod homeobox CRX By similarity. May participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism.By similarity

    GO - Biological processi

    1. response to stimulus Source: UniProtKB-KW
    2. visual perception Source: UniProtKB-KW

    Keywords - Biological processi

    Sensory transduction, Vision

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosducin
    Short name:
    PHD
    Alternative name(s):
    33 kDa phototransducing protein
    Rod photoreceptor 1
    Short name:
    RPR-1
    Gene namesi
    Name:Pdc
    Synonyms:Rpr1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:98090. Pdc.

    Subcellular locationi

    Cytoplasmcytosol. Cell projectionciliumphotoreceptor outer segment. Photoreceptor inner segment. Nucleus By similarity
    Note: Outer and inner segments of the rod cells.

    GO - Cellular componenti

    1. actin cytoskeleton Source: Ensembl
    2. cytosol Source: MGI
    3. nucleus Source: UniProtKB-SubCell
    4. photoreceptor inner segment Source: UniProtKB-SubCell
    5. photoreceptor outer segment Source: MGI

    Keywords - Cellular componenti

    Cell projection, Cilium, Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 244244PhosducinPRO_0000163753Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei71 – 711Phosphoserine; by PKABy similarity

    Post-translational modificationi

    Light-induced changes in cyclic nucleotide levels modulate the phosphorylation of this protein by cAMP kinase.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9QW08.
    PRIDEiQ9QW08.

    PTM databases

    PhosphoSiteiQ9QW08.

    Expressioni

    Gene expression databases

    BgeeiQ9QW08.
    CleanExiMM_PDC.
    GenevestigatoriQ9QW08.

    Interactioni

    Subunit structurei

    Interacts with CRX By similarity. Forms a complex with the beta and gamma subunits of the GTP-binding protein, transducin.By similarity

    Protein-protein interaction databases

    BioGridi203000. 2 interactions.
    STRINGi10090.ENSMUSP00000006164.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QW08.
    SMRiQ9QW08. Positions 14-228.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni109 – 244136Thioredoxin foldBy similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the phosducin family.Curated

    Phylogenomic databases

    eggNOGiNOG262340.
    GeneTreeiENSGT00530000062970.
    HOGENOMiHOG000232010.
    HOVERGENiHBG003456.
    InParanoidiQ9QW08.
    KOiK08327.
    OMAiCMQDMHQ.
    OrthoDBiEOG7H4DVC.
    PhylomeDBiQ9QW08.
    TreeFamiTF315179.

    Family and domain databases

    Gene3Di1.10.168.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR001200. Phosducin.
    IPR023196. Phosducin_N_dom.
    IPR024253. Phosducin_thioredoxin-like_dom.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF02114. Phosducin. 1 hit.
    [Graphical view]
    PRINTSiPR00677. PHOSDUCIN.
    SUPFAMiSSF52833. SSF52833. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9QW08-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEEAASQSLE EDFEGQATHT GPKGVINDWR KFKLESEDGD SIPPSKKEIL    50
    RQMSSPQSRD DSKERMSRKM SIQEYELIHQ DKEDESCLRK YRRQCMQDMH 100
    QKLSFGPRYG FVYELETGEQ FLETIEKEQK VTTIVVNIYE DGVRGCDALN 150
    SSLACLAVEY PMVKFCKIKA SNTGAGDRFS TDVLPTLLVY KGGELISNFI 200
    SVAEQFAEEF FAVDVESFLN EYGLLPEREI HDLEQTNMED EDIE 244
    Length:244
    Mass (Da):28,016
    Last modified:May 1, 2000 - v1
    Checksum:iF42361EA25F0F254
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L08075 mRNA. Translation: AAK13559.1.
    BC012507 mRNA. Translation: AAH12507.1.
    BC021920 mRNA. Translation: AAH21920.1.
    CCDSiCCDS15354.1.
    PIRiJC2018.
    RefSeqiNP_001153202.1. NM_001159730.1.
    NP_077778.1. NM_024458.2.
    UniGeneiMm.440883.

    Genome annotation databases

    EnsembliENSMUST00000165062; ENSMUSP00000131631; ENSMUSG00000006007.
    GeneIDi20028.
    KEGGimmu:20028.
    UCSCiuc007cxw.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L08075 mRNA. Translation: AAK13559.1 .
    BC012507 mRNA. Translation: AAH12507.1 .
    BC021920 mRNA. Translation: AAH21920.1 .
    CCDSi CCDS15354.1.
    PIRi JC2018.
    RefSeqi NP_001153202.1. NM_001159730.1.
    NP_077778.1. NM_024458.2.
    UniGenei Mm.440883.

    3D structure databases

    ProteinModelPortali Q9QW08.
    SMRi Q9QW08. Positions 14-228.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 203000. 2 interactions.
    STRINGi 10090.ENSMUSP00000006164.

    PTM databases

    PhosphoSitei Q9QW08.

    Proteomic databases

    MaxQBi Q9QW08.
    PRIDEi Q9QW08.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000165062 ; ENSMUSP00000131631 ; ENSMUSG00000006007 .
    GeneIDi 20028.
    KEGGi mmu:20028.
    UCSCi uc007cxw.1. mouse.

    Organism-specific databases

    CTDi 5132.
    MGIi MGI:98090. Pdc.

    Phylogenomic databases

    eggNOGi NOG262340.
    GeneTreei ENSGT00530000062970.
    HOGENOMi HOG000232010.
    HOVERGENi HBG003456.
    InParanoidi Q9QW08.
    KOi K08327.
    OMAi CMQDMHQ.
    OrthoDBi EOG7H4DVC.
    PhylomeDBi Q9QW08.
    TreeFami TF315179.

    Miscellaneous databases

    NextBioi 297551.
    PROi Q9QW08.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9QW08.
    CleanExi MM_PDC.
    Genevestigatori Q9QW08.

    Family and domain databases

    Gene3Di 1.10.168.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR001200. Phosducin.
    IPR023196. Phosducin_N_dom.
    IPR024253. Phosducin_thioredoxin-like_dom.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF02114. Phosducin. 1 hit.
    [Graphical view ]
    PRINTSi PR00677. PHOSDUCIN.
    SUPFAMi SSF52833. SSF52833. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of a cDNA for mouse retinal phosducin."
      Groshan K.R., Norton J.C., Craft C.M., Travis G.H.
      Exp. Eye Res. 57:253-255(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Retina.
    2. "The sequence of the mouse phosducin-encoding gene and its 5'-flanking region."
      Abe T., Kikuchi T., Chang T., Shinohara T.
      Gene 133:179-186(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.

    Entry informationi

    Entry nameiPHOS_MOUSE
    AccessioniPrimary (citable) accession number: Q9QW08
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3