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Q9QW08

- PHOS_MOUSE

UniProt

Q9QW08 - PHOS_MOUSE

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Protein

Phosducin

Gene

Pdc

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Inhibits the transcriptional activation activity of the cone-rod homeobox CRX (By similarity). May participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism.By similarity

GO - Biological processi

  1. response to stimulus Source: UniProtKB-KW
  2. visual perception Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Sensory transduction, Vision

Names & Taxonomyi

Protein namesi
Recommended name:
Phosducin
Short name:
PHD
Alternative name(s):
33 kDa phototransducing protein
Rod photoreceptor 1
Short name:
RPR-1
Gene namesi
Name:Pdc
Synonyms:Rpr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:98090. Pdc.

Subcellular locationi

Cytoplasmcytosol. Cell projectionciliumphotoreceptor outer segment. Photoreceptor inner segment. Nucleus By similarity
Note: Outer and inner segments of the rod cells.

GO - Cellular componenti

  1. cytosol Source: MGI
  2. nucleus Source: UniProtKB-KW
  3. photoreceptor outer segment Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 244244PhosducinPRO_0000163753Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei71 – 711Phosphoserine; by PKABy similarity

Post-translational modificationi

Light-induced changes in cyclic nucleotide levels modulate the phosphorylation of this protein by cAMP kinase.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9QW08.
PRIDEiQ9QW08.

PTM databases

PhosphoSiteiQ9QW08.

Expressioni

Gene expression databases

BgeeiQ9QW08.
CleanExiMM_PDC.
GenevestigatoriQ9QW08.

Interactioni

Subunit structurei

Interacts with CRX (By similarity). Forms a complex with the beta and gamma subunits of the GTP-binding protein, transducin.By similarity

Protein-protein interaction databases

BioGridi203000. 2 interactions.
STRINGi10090.ENSMUSP00000006164.

Structurei

3D structure databases

ProteinModelPortaliQ9QW08.
SMRiQ9QW08. Positions 14-228.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni109 – 244136Thioredoxin foldBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the phosducin family.Curated

Phylogenomic databases

eggNOGiNOG262340.
GeneTreeiENSGT00530000062970.
HOGENOMiHOG000232010.
HOVERGENiHBG003456.
InParanoidiQ9QW08.
KOiK08327.
OMAiCMQDMHQ.
OrthoDBiEOG7H4DVC.
PhylomeDBiQ9QW08.
TreeFamiTF315179.

Family and domain databases

Gene3Di1.10.168.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR001200. Phosducin.
IPR023196. Phosducin_N_dom.
IPR024253. Phosducin_thioredoxin-like_dom.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF02114. Phosducin. 1 hit.
[Graphical view]
PRINTSiPR00677. PHOSDUCIN.
SUPFAMiSSF52833. SSF52833. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9QW08-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEEAASQSLE EDFEGQATHT GPKGVINDWR KFKLESEDGD SIPPSKKEIL
60 70 80 90 100
RQMSSPQSRD DSKERMSRKM SIQEYELIHQ DKEDESCLRK YRRQCMQDMH
110 120 130 140 150
QKLSFGPRYG FVYELETGEQ FLETIEKEQK VTTIVVNIYE DGVRGCDALN
160 170 180 190 200
SSLACLAVEY PMVKFCKIKA SNTGAGDRFS TDVLPTLLVY KGGELISNFI
210 220 230 240
SVAEQFAEEF FAVDVESFLN EYGLLPEREI HDLEQTNMED EDIE
Length:244
Mass (Da):28,016
Last modified:May 1, 2000 - v1
Checksum:iF42361EA25F0F254
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08075 mRNA. Translation: AAK13559.1.
BC012507 mRNA. Translation: AAH12507.1.
BC021920 mRNA. Translation: AAH21920.1.
CCDSiCCDS15354.1.
PIRiJC2018.
RefSeqiNP_001153202.1. NM_001159730.1.
NP_077778.1. NM_024458.2.
UniGeneiMm.440883.

Genome annotation databases

EnsembliENSMUST00000165062; ENSMUSP00000131631; ENSMUSG00000006007.
ENSMUST00000191228; ENSMUSP00000141136; ENSMUSG00000006007.
GeneIDi20028.
KEGGimmu:20028.
UCSCiuc007cxw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08075 mRNA. Translation: AAK13559.1 .
BC012507 mRNA. Translation: AAH12507.1 .
BC021920 mRNA. Translation: AAH21920.1 .
CCDSi CCDS15354.1.
PIRi JC2018.
RefSeqi NP_001153202.1. NM_001159730.1.
NP_077778.1. NM_024458.2.
UniGenei Mm.440883.

3D structure databases

ProteinModelPortali Q9QW08.
SMRi Q9QW08. Positions 14-228.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 203000. 2 interactions.
STRINGi 10090.ENSMUSP00000006164.

PTM databases

PhosphoSitei Q9QW08.

Proteomic databases

MaxQBi Q9QW08.
PRIDEi Q9QW08.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000165062 ; ENSMUSP00000131631 ; ENSMUSG00000006007 .
ENSMUST00000191228 ; ENSMUSP00000141136 ; ENSMUSG00000006007 .
GeneIDi 20028.
KEGGi mmu:20028.
UCSCi uc007cxw.1. mouse.

Organism-specific databases

CTDi 5132.
MGIi MGI:98090. Pdc.

Phylogenomic databases

eggNOGi NOG262340.
GeneTreei ENSGT00530000062970.
HOGENOMi HOG000232010.
HOVERGENi HBG003456.
InParanoidi Q9QW08.
KOi K08327.
OMAi CMQDMHQ.
OrthoDBi EOG7H4DVC.
PhylomeDBi Q9QW08.
TreeFami TF315179.

Miscellaneous databases

NextBioi 297551.
PROi Q9QW08.
SOURCEi Search...

Gene expression databases

Bgeei Q9QW08.
CleanExi MM_PDC.
Genevestigatori Q9QW08.

Family and domain databases

Gene3Di 1.10.168.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR001200. Phosducin.
IPR023196. Phosducin_N_dom.
IPR024253. Phosducin_thioredoxin-like_dom.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF02114. Phosducin. 1 hit.
[Graphical view ]
PRINTSi PR00677. PHOSDUCIN.
SUPFAMi SSF52833. SSF52833. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of a cDNA for mouse retinal phosducin."
    Groshan K.R., Norton J.C., Craft C.M., Travis G.H.
    Exp. Eye Res. 57:253-255(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Retina.
  2. "The sequence of the mouse phosducin-encoding gene and its 5'-flanking region."
    Abe T., Kikuchi T., Chang T., Shinohara T.
    Gene 133:179-186(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.

Entry informationi

Entry nameiPHOS_MOUSE
AccessioniPrimary (citable) accession number: Q9QW08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3