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Q9QW08 (PHOS_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosducin

Short name=PHD
Alternative name(s):
33 kDa phototransducing protein
Rod photoreceptor 1
Short name=RPR-1
Gene names
Name:Pdc
Synonyms:Rpr1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length244 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Inhibits the transcriptional activation activity of the cone-rod homeobox CRX By similarity. May participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism.

Subunit structure

Interacts with CRX By similarity. Forms a complex with the beta and gamma subunits of the GTP-binding protein, transducin.

Subcellular location

Cytoplasmcytosol. Cell projectionciliumphotoreceptor outer segment. Photoreceptor inner segment. Nucleus By similarity. Note: Outer and inner segments of the rod cells.

Post-translational modification

Light-induced changes in cyclic nucleotide levels modulate the phosphorylation of this protein by cAMP kinase By similarity.

Sequence similarities

Belongs to the phosducin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 244244Phosducin
PRO_0000163753

Regions

Region109 – 244136Thioredoxin fold By similarity

Amino acid modifications

Modified residue711Phosphoserine; by PKA By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9QW08 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: F42361EA25F0F254

FASTA24428,016
        10         20         30         40         50         60 
MEEAASQSLE EDFEGQATHT GPKGVINDWR KFKLESEDGD SIPPSKKEIL RQMSSPQSRD 

        70         80         90        100        110        120 
DSKERMSRKM SIQEYELIHQ DKEDESCLRK YRRQCMQDMH QKLSFGPRYG FVYELETGEQ 

       130        140        150        160        170        180 
FLETIEKEQK VTTIVVNIYE DGVRGCDALN SSLACLAVEY PMVKFCKIKA SNTGAGDRFS 

       190        200        210        220        230        240 
TDVLPTLLVY KGGELISNFI SVAEQFAEEF FAVDVESFLN EYGLLPEREI HDLEQTNMED 


EDIE 

« Hide

References

« Hide 'large scale' references
[1]"Isolation and characterization of a cDNA for mouse retinal phosducin."
Groshan K.R., Norton J.C., Craft C.M., Travis G.H.
Exp. Eye Res. 57:253-255(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Retina.
[2]"The sequence of the mouse phosducin-encoding gene and its 5'-flanking region."
Abe T., Kikuchi T., Chang T., Shinohara T.
Gene 133:179-186(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L08075 mRNA. Translation: AAK13559.1.
BC012507 mRNA. Translation: AAH12507.1.
BC021920 mRNA. Translation: AAH21920.1.
CCDSCCDS15354.1.
PIRJC2018.
RefSeqNP_001153202.1. NM_001159730.1.
NP_077778.1. NM_024458.2.
UniGeneMm.440883.

3D structure databases

ProteinModelPortalQ9QW08.
SMRQ9QW08. Positions 14-228.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid203000. 2 interactions.
STRING10090.ENSMUSP00000006164.

PTM databases

PhosphoSiteQ9QW08.

Proteomic databases

MaxQBQ9QW08.
PRIDEQ9QW08.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000165062; ENSMUSP00000131631; ENSMUSG00000006007.
GeneID20028.
KEGGmmu:20028.
UCSCuc007cxw.1. mouse.

Organism-specific databases

CTD5132.
MGIMGI:98090. Pdc.

Phylogenomic databases

eggNOGNOG262340.
GeneTreeENSGT00530000062970.
HOGENOMHOG000232010.
HOVERGENHBG003456.
InParanoidQ9QW08.
KOK08327.
OMACMQDMHQ.
OrthoDBEOG7H4DVC.
PhylomeDBQ9QW08.
TreeFamTF315179.

Gene expression databases

BgeeQ9QW08.
CleanExMM_PDC.
GenevestigatorQ9QW08.

Family and domain databases

Gene3D1.10.168.10. 1 hit.
3.40.30.10. 1 hit.
InterProIPR001200. Phosducin.
IPR023196. Phosducin_N_dom.
IPR024253. Phosducin_thioredoxin-like_dom.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF02114. Phosducin. 1 hit.
[Graphical view]
PRINTSPR00677. PHOSDUCIN.
SUPFAMSSF52833. SSF52833. 1 hit.
ProtoNetSearch...

Other

NextBio297551.
PROQ9QW08.
SOURCESearch...

Entry information

Entry namePHOS_MOUSE
AccessionPrimary (citable) accession number: Q9QW08
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot