Myl7

Functionⁱ

Miscellaneous

This chain binds calcium.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Calcium bindingⁱ	45 – 56	Add BLAST		12

GO - Molecular functionⁱ

calcium ion binding Source: InterPro

Complete GO annotation...

Keywordsⁱ

Molecular function	Motor protein, Muscle protein, Myosin
Ligand	Calcium, Metal-binding

Enzyme and pathway databases

Reactomeⁱ	R-MMU-445355. Smooth Muscle Contraction.

Reactomeⁱ

R-MMU-445355. Smooth Muscle Contraction.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Myosin regulatory light chain 2, atrial isoform Short name: MLC-2a Short name: MLC2a Short name: Myosin light chain 2a Alternative name(s): Myosin regulatory light chain 7
Gene namesⁱ	Name:Myl7 Synonyms:Mylc2a
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 11

Organism-specific databases

MGIⁱ	MGI:107495. Myl7.

Subcellular locationⁱ

GO - Cellular componentⁱ

A band Source: MGI
dendritic spine
Source: MGI
Inferred from direct assayⁱ
- 15663482
myosin complex Source: UniProtKB-KW

Complete GO annotation...

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedBy similarity
ChainⁱPRO_0000198726	2 – 175	Myosin regulatory light chain 2, atrial isoformAdd BLAST		174

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineBy similarity	1
Modified residueⁱ	22	PhosphoserineCombined sources	1
Modified residueⁱ	23	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9QVP4.
PaxDbⁱ	Q9QVP4.
PRIDEⁱ	Q9QVP4.

PTM databases

iPTMnetⁱ	Q9QVP4.
PhosphoSitePlusⁱ	Q9QVP4.

Expressionⁱ

Tissue specificityⁱ

Predominantly expressed in adult atrial muscle.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000020469.
CleanExⁱ	MM_MYL7.
ExpressionAtlasⁱ	Q9QVP4. baseline and differential.
Genevisibleⁱ	Q9QVP4. MM.

Interactionⁱ

Subunit structureⁱ

Myosin is a hexamer of 2 heavy chains and 4 light chains.

Protein-protein interaction databases

IntActⁱ	Q9QVP4. 1 interactor.
Molecular INTeraction database More...MINTⁱ	MINT-4102168.
STRINGⁱ	10090.ENSMUSP00000099985.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9QVP4.
SMRⁱ	Q9QVP4.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	32 – 67	EF-hand 1PROSITE-ProRule annotationAdd BLAST	36
Domainⁱ	102 – 137	EF-hand 2PROSITE-ProRule annotationAdd BLAST	36
Domainⁱ	138 – 173	EF-hand 3PROSITE-ProRule annotationAdd BLAST	36

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG0031. Eukaryota. COG5126. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119196.
HOGENOMⁱ	HOG000233018.
HOVERGENⁱ	HBG012180.
InParanoidⁱ	Q9QVP4.
KEGG Orthology (KO) More...KOⁱ	K12754.
OMAⁱ	DGIICKS.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0QF6.
PhylomeDBⁱ	Q9QVP4.
TreeFamⁱ	TF314218.

Family and domain databases

InterProⁱ	View protein in InterPro IPR011992. EF-hand-dom_pair. IPR018247. EF_Hand_1_Ca_BS. IPR002048. EF_hand_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13499. EF-hand_7. 1 hit.
SMARTⁱ	View protein in SMART SM00054. EFh. 2 hits.
SUPFAMⁱ	SSF47473. SSF47473. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00018. EF_HAND_1. 1 hit. PS50222. EF_HAND_2. 3 hits.

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q9QVP4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MASRKAGTRG KAAATKQAQR GSSNVFSMFE QAQIQEFKEA FSCIDQNRDG 
        60         70         80         90        100
IICKSDLKET YSQLGRVSVP EEELDAMLQE GKGPINFTVF LTLFGEKLNG 
       110        120        130        140        150
TDPEEAILSA FRMFDPSGQG VVNKEEFKQL LMTQADKFSP AEVEQLFALT 
       160        170 
PMDLAGNIDY KSLCYIITHG DEKEE

Length:175

Mass (Da):19,450

Last modified:May 1, 2000 - v1

Checksum:ⁱ44C2D76C5D1D63CC

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	10 – 11	GK → Q in AAF76860 (PubMed:11124527).Curated	2
Sequence conflictⁱ	36 – 39	EFKE → DSRK in AAF76860 (PubMed:11124527).Curated	4
Sequence conflictⁱ	148	A → T in AAB31016 (PubMed:8207020).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF232920 Genomic DNA. Translation: AAF76860.1. BC061100 mRNA. Translation: AAH61100.1. S70785 mRNA. Translation: AAB31016.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS24408.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_075017.2. NM_022879.2.
UniGeneⁱ	Mm.46514.

Genome annotation databases

Ensemblⁱ	ENSMUST00000102921; ENSMUSP00000099985; ENSMUSG00000020469.
GeneIDⁱ	17898.
KEGGⁱ	mmu:17898.
UCSC genome browser More...UCSCⁱ	uc007hxl.1. mouse.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF232920 Genomic DNA. Translation: AAF76860.1. BC061100 mRNA. Translation: AAH61100.1. S70785 mRNA. Translation: AAB31016.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS24408.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_075017.2. NM_022879.2.
UniGeneⁱ	Mm.46514.

3D structure databases

ProteinModelPortalⁱ	Q9QVP4.
SMRⁱ	Q9QVP4.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q9QVP4. 1 interactor.
Molecular INTeraction database More...MINTⁱ	MINT-4102168.
STRINGⁱ	10090.ENSMUSP00000099985.

PTM databases

iPTMnetⁱ	Q9QVP4.
PhosphoSitePlusⁱ	Q9QVP4.

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9QVP4.
PaxDbⁱ	Q9QVP4.
PRIDEⁱ	Q9QVP4.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000102921; ENSMUSP00000099985; ENSMUSG00000020469.
GeneIDⁱ	17898.
KEGGⁱ	mmu:17898.
UCSC genome browser More...UCSCⁱ	uc007hxl.1. mouse.

Organism-specific databases

CTDⁱ	58498.
MGIⁱ	MGI:107495. Myl7.

Phylogenomic databases

eggNOGⁱ	KOG0031. Eukaryota. COG5126. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119196.
HOGENOMⁱ	HOG000233018.
HOVERGENⁱ	HBG012180.
InParanoidⁱ	Q9QVP4.
KEGG Orthology (KO) More...KOⁱ	K12754.
OMAⁱ	DGIICKS.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0QF6.
PhylomeDBⁱ	Q9QVP4.
TreeFamⁱ	TF314218.

Enzyme and pathway databases

Reactomeⁱ	R-MMU-445355. Smooth Muscle Contraction.

Reactomeⁱ

R-MMU-445355. Smooth Muscle Contraction.

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q9QVP4.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000020469.
CleanExⁱ	MM_MYL7.
ExpressionAtlasⁱ	Q9QVP4. baseline and differential.
Genevisibleⁱ	Q9QVP4. MM.

Family and domain databases

InterProⁱ	View protein in InterPro IPR011992. EF-hand-dom_pair. IPR018247. EF_Hand_1_Ca_BS. IPR002048. EF_hand_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13499. EF-hand_7. 1 hit.
SMARTⁱ	View protein in SMART SM00054. EFh. 2 hits.
SUPFAMⁱ	SSF47473. SSF47473. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00018. EF_HAND_1. 1 hit. PS50222. EF_HAND_2. 3 hits.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MLRA_MOUSE
Accessionⁱ	Q9QVP4Primary (citable) accession number: Q9QVP4 Secondary accession number(s): Q63977, Q9JIE8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 28, 2003
	Last sequence update:	May 1, 2000
	Last modified:	June 7, 2017
	This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9QVP4 (MLRA_MOUSE)

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Myosin regulatory light chain 2, atrial isoform

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ