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Protein

Glucocorticoid modulatory element-binding protein 1

Gene

Gmeb1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi103ZincBy similarity1
Binding sitei129DNABy similarity1
Binding sitei133DNABy similarity1
Binding sitei136DNABy similarity1
Binding sitei147DNABy similarity1
Metal bindingi160ZincBy similarity1
Metal bindingi164ZincBy similarity1
Metal bindingi168ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Glucocorticoid modulatory element-binding protein 1
Short name:
GMEB-1
Gene namesi
Name:Gmeb1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1563208 Gmeb1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000740912 – 562Glucocorticoid modulatory element-binding protein 1Add BLAST561

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9QUZ8
PRIDEiQ9QUZ8

PTM databases

PhosphoSitePlusiQ9QUZ8

Expressioni

Gene expression databases

BgeeiENSRNOG00000010910
GenevisibleiQ9QUZ8 RN

Interactioni

Subunit structurei

Homodimer, and heterodimer of GMEB1 and GMEB2. Interacts with the glucocorticoid receptor (NR3C1) and NCOA2/TIF2. May interact with HSP27 and CREB-binding protein (CBP). Interacts with TRIM63 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014506

Structurei

3D structure databases

ProteinModelPortaliQ9QUZ8
SMRiQ9QUZ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini72 – 156SANDPROSITE-ProRule annotationAdd BLAST85

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili311 – 357Sequence analysisAdd BLAST47

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4333 Eukaryota
ENOG410ZMTP LUCA
GeneTreeiENSGT00410000025596
HOGENOMiHOG000231857
HOVERGENiHBG051742
InParanoidiQ9QUZ8
OMAiCPITCGD
OrthoDBiEOG091G07Q9
PhylomeDBiQ9QUZ8
TreeFamiTF317090

Family and domain databases

Gene3Di3.10.390.10, 1 hit
InterProiView protein in InterPro
IPR024830 GMEB1/2
IPR010919 SAND-like_dom_sf
IPR000770 SAND_dom
PANTHERiPTHR10417 PTHR10417, 1 hit
PfamiView protein in Pfam
PF01342 SAND, 1 hit
SMARTiView protein in SMART
SM00258 SAND, 1 hit
SUPFAMiSSF63763 SSF63763, 1 hit
PROSITEiView protein in PROSITE
PS50864 SAND, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QUZ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANAEVSVPV GDVVVVPTEG NEGENPEDTK TQVILQLQPV QQGIYEAGSE
60 70 80 90 100
NSAAVVAVET HTIHKIEEGI DASSIEANED MEIAYPITCG ESKAVLLWKK
110 120 130 140 150
FVCPGINVKC VKFNDQLISP KHFVHLAGKS TLKDWKRAIR LGGIMLRKMM
160 170 180 190 200
DSGQIDFYQH DKVCSNTCRS TKFDLLISSA RAPVPGQQTS VVQTPTSADG
210 220 230 240 250
NITQIAISEE SMEEAGLEWN SALTAAVTMA TEEGIKKESE EISEDTLMFW
260 270 280 290 300
KGIADVGLME EVVCNIQKEI EELLRGVQQR LIHAPFQVTD AAVLNNVANT
310 320 330 340 350
FGLMDTVKRV LDNRRKQVEH GEEQFLYTLA DLERQLEEQK KQAQDPRLKS
360 370 380 390 400
QTVQNVVLMP VSTPKPPKRP RLQRPASTTV LSPSPVQQPQ FTVISPITIT
410 420 430 440 450
PVGQSFSMGN IPVATLSQGT SPVTVHTLPS GPQLFRYATV VSSAKSNSPD
460 470 480 490 500
TVTIHPSSSL ALLSSTSMQD GSTLGNMATM VSPVELVAME SGLTSAIQAV
510 520 530 540 550
ESTSEDGQTI IEIDPAPDPE ADDPEGKAVI LETELRTEEK VVANMEERQH
560
QVHNVEIVVL ED
Length:562
Mass (Da):61,194
Last modified:September 2, 2008 - v3
Checksum:iB1A23491A5A76A38
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473968 Genomic DNA Translation: EDL80619.1
BC158640 mRNA Translation: AAI58641.1
RefSeqiNP_001102738.1, NM_001109268.2
XP_008762387.1, XM_008764165.1
XP_008762389.1, XM_008764167.2
XP_008762390.1, XM_008764168.1
UniGeneiRn.219045

Genome annotation databases

EnsembliENSRNOT00000014506; ENSRNOP00000014506; ENSRNOG00000010910
GeneIDi500558
KEGGirno:500558
UCSCiRGD:1563208 rat

Similar proteinsi

Entry informationi

Entry nameiGMEB1_RAT
AccessioniPrimary (citable) accession number: Q9QUZ8
Secondary accession number(s): B0BN09
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: September 2, 2008
Last modified: March 28, 2018
This is version 107 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health