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Protein

Glucocorticoid modulatory element-binding protein 1

Gene

Gmeb1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi103 – 1031ZincBy similarity
Binding sitei129 – 1291DNABy similarity
Binding sitei133 – 1331DNABy similarity
Binding sitei136 – 1361DNABy similarity
Binding sitei147 – 1471DNABy similarity
Metal bindingi160 – 1601ZincBy similarity
Metal bindingi164 – 1641ZincBy similarity
Metal bindingi168 – 1681ZincBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Glucocorticoid modulatory element-binding protein 1
Short name:
GMEB-1
Gene namesi
Name:Gmeb1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1563208. Gmeb1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 562561Glucocorticoid modulatory element-binding protein 1PRO_0000074091Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9QUZ8.

PTM databases

PhosphoSiteiQ9QUZ8.

Expressioni

Gene expression databases

BgeeiENSRNOG00000010910.
GenevisibleiQ9QUZ8. RN.

Interactioni

Subunit structurei

Homodimer, and heterodimer of GMEB1 and GMEB2. Interacts with the glucocorticoid receptor (NR3C1) and NCOA2/TIF2. May interact with HSP27 and CREB-binding protein (CBP). Interacts with TRIM63 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014506.

Structurei

3D structure databases

ProteinModelPortaliQ9QUZ8.
SMRiQ9QUZ8. Positions 80-169.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini72 – 15685SANDPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili311 – 35747Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 SAND domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4333. Eukaryota.
ENOG410ZMTP. LUCA.
GeneTreeiENSGT00410000025596.
HOGENOMiHOG000231857.
HOVERGENiHBG051742.
InParanoidiQ9QUZ8.
OMAiAAMQDGG.
OrthoDBiEOG091G07Q9.
PhylomeDBiQ9QUZ8.
TreeFamiTF317090.

Family and domain databases

Gene3Di3.10.390.10. 1 hit.
InterProiIPR024830. GMEB1/2.
IPR000770. SAND_dom.
IPR010919. SAND_dom-like.
[Graphical view]
PANTHERiPTHR10417. PTHR10417. 1 hit.
PfamiPF01342. SAND. 1 hit.
[Graphical view]
SMARTiSM00258. SAND. 1 hit.
[Graphical view]
SUPFAMiSSF63763. SSF63763. 1 hit.
PROSITEiPS50864. SAND. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QUZ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANAEVSVPV GDVVVVPTEG NEGENPEDTK TQVILQLQPV QQGIYEAGSE
60 70 80 90 100
NSAAVVAVET HTIHKIEEGI DASSIEANED MEIAYPITCG ESKAVLLWKK
110 120 130 140 150
FVCPGINVKC VKFNDQLISP KHFVHLAGKS TLKDWKRAIR LGGIMLRKMM
160 170 180 190 200
DSGQIDFYQH DKVCSNTCRS TKFDLLISSA RAPVPGQQTS VVQTPTSADG
210 220 230 240 250
NITQIAISEE SMEEAGLEWN SALTAAVTMA TEEGIKKESE EISEDTLMFW
260 270 280 290 300
KGIADVGLME EVVCNIQKEI EELLRGVQQR LIHAPFQVTD AAVLNNVANT
310 320 330 340 350
FGLMDTVKRV LDNRRKQVEH GEEQFLYTLA DLERQLEEQK KQAQDPRLKS
360 370 380 390 400
QTVQNVVLMP VSTPKPPKRP RLQRPASTTV LSPSPVQQPQ FTVISPITIT
410 420 430 440 450
PVGQSFSMGN IPVATLSQGT SPVTVHTLPS GPQLFRYATV VSSAKSNSPD
460 470 480 490 500
TVTIHPSSSL ALLSSTSMQD GSTLGNMATM VSPVELVAME SGLTSAIQAV
510 520 530 540 550
ESTSEDGQTI IEIDPAPDPE ADDPEGKAVI LETELRTEEK VVANMEERQH
560
QVHNVEIVVL ED
Length:562
Mass (Da):61,194
Last modified:September 2, 2008 - v3
Checksum:iB1A23491A5A76A38
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473968 Genomic DNA. Translation: EDL80619.1.
BC158640 mRNA. Translation: AAI58641.1.
RefSeqiNP_001102738.1. NM_001109268.2.
XP_008762387.1. XM_008764165.1.
XP_008762388.1. XM_008764166.1.
XP_008762389.1. XM_008764167.1.
XP_008762390.1. XM_008764168.1.
XP_008762391.1. XM_008764169.1.
UniGeneiRn.219045.

Genome annotation databases

EnsembliENSRNOT00000014506; ENSRNOP00000014506; ENSRNOG00000010910.
GeneIDi500558.
KEGGirno:500558.
UCSCiRGD:1563208. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473968 Genomic DNA. Translation: EDL80619.1.
BC158640 mRNA. Translation: AAI58641.1.
RefSeqiNP_001102738.1. NM_001109268.2.
XP_008762387.1. XM_008764165.1.
XP_008762388.1. XM_008764166.1.
XP_008762389.1. XM_008764167.1.
XP_008762390.1. XM_008764168.1.
XP_008762391.1. XM_008764169.1.
UniGeneiRn.219045.

3D structure databases

ProteinModelPortaliQ9QUZ8.
SMRiQ9QUZ8. Positions 80-169.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014506.

PTM databases

PhosphoSiteiQ9QUZ8.

Proteomic databases

PaxDbiQ9QUZ8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000014506; ENSRNOP00000014506; ENSRNOG00000010910.
GeneIDi500558.
KEGGirno:500558.
UCSCiRGD:1563208. rat.

Organism-specific databases

CTDi10691.
RGDi1563208. Gmeb1.

Phylogenomic databases

eggNOGiKOG4333. Eukaryota.
ENOG410ZMTP. LUCA.
GeneTreeiENSGT00410000025596.
HOGENOMiHOG000231857.
HOVERGENiHBG051742.
InParanoidiQ9QUZ8.
OMAiAAMQDGG.
OrthoDBiEOG091G07Q9.
PhylomeDBiQ9QUZ8.
TreeFamiTF317090.

Miscellaneous databases

PROiQ9QUZ8.

Gene expression databases

BgeeiENSRNOG00000010910.
GenevisibleiQ9QUZ8. RN.

Family and domain databases

Gene3Di3.10.390.10. 1 hit.
InterProiIPR024830. GMEB1/2.
IPR000770. SAND_dom.
IPR010919. SAND_dom-like.
[Graphical view]
PANTHERiPTHR10417. PTHR10417. 1 hit.
PfamiPF01342. SAND. 1 hit.
[Graphical view]
SMARTiSM00258. SAND. 1 hit.
[Graphical view]
SUPFAMiSSF63763. SSF63763. 1 hit.
PROSITEiPS50864. SAND. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGMEB1_RAT
AccessioniPrimary (citable) accession number: Q9QUZ8
Secondary accession number(s): B0BN09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: September 2, 2008
Last modified: September 7, 2016
This is version 96 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.