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Protein

Ammonium transporter Rh type A

Gene

Rhag

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane. Involved in ammonia transport across the erythrocyte membrane. Seems to act in monovalent cation transport.By similarity

GO - Molecular functioni

GO - Biological processi

  • ammonium transmembrane transport Source: UniProtKB
  • ammonium transport Source: UniProtKB
  • carbon dioxide transport Source: MGI
  • cellular ion homeostasis Source: UniProtKB
  • erythrocyte development Source: MGI
  • monovalent inorganic cation transport Source: UniProtKB
  • multicellular organismal iron ion homeostasis Source: MGI
  • nitrogen utilization Source: GO_Central
  • organic cation transport Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Ammonia transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-1237044. Erythrocytes take up carbon dioxide and release oxygen.
R-MMU-1247673. Erythrocytes take up oxygen and release carbon dioxide.
R-MMU-444411. Rhesus glycoproteins mediate ammonium transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Ammonium transporter Rh type A
Alternative name(s):
Erythrocyte membrane glycoprotein Rh50
Rhesus blood group family type A glycoprotein
Short name:
Rh family type A glycoprotein
Short name:
Rh type A glycoprotein
CD_antigen: CD241
Gene namesi
Name:Rhag
Synonyms:Rh50
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1202713. Rhag.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 4CytoplasmicSequence analysis4
Transmembranei5 – 25HelicalSequence analysisAdd BLAST21
Topological domaini26 – 61ExtracellularSequence analysisAdd BLAST36
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Topological domaini83 – 86CytoplasmicSequence analysis4
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Topological domaini108 – 121ExtracellularSequence analysisAdd BLAST14
Transmembranei122 – 142HelicalSequence analysisAdd BLAST21
Topological domaini143 – 148CytoplasmicSequence analysis6
Transmembranei149 – 169HelicalSequence analysisAdd BLAST21
Topological domaini170 – 178ExtracellularSequence analysis9
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21
Topological domaini200 – 218CytoplasmicSequence analysisAdd BLAST19
Transmembranei219 – 239HelicalSequence analysisAdd BLAST21
Topological domaini240 – 249ExtracellularSequence analysis10
Transmembranei250 – 270HelicalSequence analysisAdd BLAST21
Topological domaini271 – 278CytoplasmicSequence analysis8
Transmembranei279 – 296HelicalSequence analysisAdd BLAST18
Topological domaini297 – 300ExtracellularSequence analysis4
Transmembranei301 – 321HelicalSequence analysisAdd BLAST21
Topological domaini322 – 342CytoplasmicSequence analysisAdd BLAST21
Transmembranei343 – 363HelicalSequence analysisAdd BLAST21
Topological domaini364 – 372ExtracellularSequence analysis9
Transmembranei373 – 393HelicalSequence analysisAdd BLAST21
Topological domaini394 – 438CytoplasmicSequence analysisAdd BLAST45

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003801901 – 438Ammonium transporter Rh type AAdd BLAST438

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi31N-linked (GlcNAc...)Sequence analysis1
Glycosylationi36N-linked (GlcNAc...)Sequence analysis1
Glycosylationi41N-linked (GlcNAc...)Sequence analysis1
Glycosylationi47N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9QUT0.
PRIDEiQ9QUT0.

PTM databases

PhosphoSitePlusiQ9QUT0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000023926.
GenevisibleiQ9QUT0. MM.

Interactioni

Subunit structurei

Heterotetramer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9QUT0. 1 interactor.
MINTiMINT-4130470.
STRINGi10090.ENSMUSP00000024721.

Structurei

3D structure databases

ProteinModelPortaliQ9QUT0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3796. Eukaryota.
ENOG410XTF8. LUCA.
GeneTreeiENSGT00390000005787.
HOGENOMiHOG000007656.
InParanoidiQ9QUT0.
KOiK06580.
OMAiGHGDHSQ.
OrthoDBiEOG091G06KX.
PhylomeDBiQ9QUT0.
TreeFamiTF314450.

Family and domain databases

Gene3Di1.10.3430.10. 1 hit.
InterProiIPR029020. Ammonium/urea_transptr.
IPR001905. Ammonium_transpt.
IPR024041. NH4_transpt_AmtB-like_dom.
IPR002229. RhesusRHD.
[Graphical view]
PANTHERiPTHR11730. PTHR11730. 1 hit.
PfamiPF00909. Ammonium_transp. 1 hit.
[Graphical view]
PRINTSiPR00342. RHESUSRHD.
SUPFAMiSSF111352. SSF111352. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9QUT0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFKFPLMAI SLEVAMIVLF GLFVEYETPQ NASQKNASHQ NASQQGNTSS
60 70 80 90 100
SAKKDQFFQL YPLFQDVHVM IFVGFGFLMT FLKKYGFSGV GFNLFLAALG
110 120 130 140 150
LQWGTIMQGL LHSHGKEFHF GIYNMINADF STATVLISFG AVLGKTSPIQ
160 170 180 190 200
MLIMTILEIA VFAGNEYLVT ELFEASDTGA SMTIHAFGAY FGLAVAGVLY
210 220 230 240 250
RPGLRCEHPN DESVYHSDLF AMIGTLFLWI FWPSFNSAIA DPGDHQYRAI
260 270 280 290 300
VNTYMSLAAC VITAYALSSL VERRGRLDMV HIQNATLAGG VAVGTCADME
310 320 330 340 350
IPLYAAMTIG SIAGIISVLG YKFFSPLLAN KLMIHDTCGV HNLHGLPGVF
360 370 380 390 400
GGLASIVAIS WGMSTASMAM QAAALGSSIG SAIVGGLLTG LILKLPIWNQ
410 420 430
PPDEYCYDDS VSWKVPKFRE LDNRFFQHAN HNHVEHEV
Length:438
Mass (Da):47,837
Last modified:May 1, 2000 - v1
Checksum:i077935143287FF9B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti180A → P in BAE25570 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015192 mRNA. Translation: BAA32441.1.
AF065395 mRNA. Translation: AAD13387.1.
AF057526 mRNA. Translation: AAC25155.1.
AK143851 mRNA. Translation: BAE25570.1.
AK157847 mRNA. Translation: BAE34227.1.
CH466559 Genomic DNA. Translation: EDL23386.1.
BC101941 mRNA. Translation: AAI01942.1.
BC101942 mRNA. Translation: AAI01943.1.
BC103512 mRNA. Translation: AAI03513.1.
BC103662 mRNA. Translation: AAI03663.1.
CCDSiCCDS28787.1.
RefSeqiNP_035399.1. NM_011269.2.
UniGeneiMm.12961.

Genome annotation databases

EnsembliENSMUST00000024721; ENSMUSP00000024721; ENSMUSG00000023926.
GeneIDi19743.
KEGGimmu:19743.
UCSCiuc008col.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015192 mRNA. Translation: BAA32441.1.
AF065395 mRNA. Translation: AAD13387.1.
AF057526 mRNA. Translation: AAC25155.1.
AK143851 mRNA. Translation: BAE25570.1.
AK157847 mRNA. Translation: BAE34227.1.
CH466559 Genomic DNA. Translation: EDL23386.1.
BC101941 mRNA. Translation: AAI01942.1.
BC101942 mRNA. Translation: AAI01943.1.
BC103512 mRNA. Translation: AAI03513.1.
BC103662 mRNA. Translation: AAI03663.1.
CCDSiCCDS28787.1.
RefSeqiNP_035399.1. NM_011269.2.
UniGeneiMm.12961.

3D structure databases

ProteinModelPortaliQ9QUT0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9QUT0. 1 interactor.
MINTiMINT-4130470.
STRINGi10090.ENSMUSP00000024721.

PTM databases

PhosphoSitePlusiQ9QUT0.

Proteomic databases

PaxDbiQ9QUT0.
PRIDEiQ9QUT0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024721; ENSMUSP00000024721; ENSMUSG00000023926.
GeneIDi19743.
KEGGimmu:19743.
UCSCiuc008col.1. mouse.

Organism-specific databases

CTDi6005.
MGIiMGI:1202713. Rhag.

Phylogenomic databases

eggNOGiKOG3796. Eukaryota.
ENOG410XTF8. LUCA.
GeneTreeiENSGT00390000005787.
HOGENOMiHOG000007656.
InParanoidiQ9QUT0.
KOiK06580.
OMAiGHGDHSQ.
OrthoDBiEOG091G06KX.
PhylomeDBiQ9QUT0.
TreeFamiTF314450.

Enzyme and pathway databases

ReactomeiR-MMU-1237044. Erythrocytes take up carbon dioxide and release oxygen.
R-MMU-1247673. Erythrocytes take up oxygen and release carbon dioxide.
R-MMU-444411. Rhesus glycoproteins mediate ammonium transport.

Miscellaneous databases

PROiQ9QUT0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000023926.
GenevisibleiQ9QUT0. MM.

Family and domain databases

Gene3Di1.10.3430.10. 1 hit.
InterProiIPR029020. Ammonium/urea_transptr.
IPR001905. Ammonium_transpt.
IPR024041. NH4_transpt_AmtB-like_dom.
IPR002229. RhesusRHD.
[Graphical view]
PANTHERiPTHR11730. PTHR11730. 1 hit.
PfamiPF00909. Ammonium_transp. 1 hit.
[Graphical view]
PRINTSiPR00342. RHESUSRHD.
SUPFAMiSSF111352. SSF111352. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRHAG_MOUSE
AccessioniPrimary (citable) accession number: Q9QUT0
Secondary accession number(s): Q3UP27, Q794G1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.