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Q9QUS4 (HEY2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hairy/enhancer-of-split related with YRPW motif protein 2
Alternative name(s):
HES-related repressor protein 2
Hairy and enhancer of split-related protein 2
Short name=HESR-2
Hairy-related transcription factor 2
Short name=HRT-2
Short name=mHRT2
Protein gridlock homolog
Gene names
Name:Hey2
Synonyms:Chf1, Herp, Herp1, Hesr2, Hrt2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length339 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcriptional repressor which functions as a downstream effector of Notch signaling in cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY1 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3. Ref.3 Ref.10 Ref.11 Ref.12 Ref.13 Ref.14 Ref.16 Ref.17 Ref.18 Ref.19 Ref.20 Ref.21 Ref.22 Ref.23 Ref.24 Ref.25 Ref.26

Subunit structure

May self-associate By similarity. Interacts with ARNT By similarity. Interacts with GATA4, GATA6, HES1 and HEYL. Interacts with HDAC1, NCOR1 and SIN3A. Ref.12 Ref.21 Ref.23 Ref.25

Subcellular location

Nucleus Ref.15.

Tissue specificity

Highly expressed in the aorta, lower expression detected in the heart, brain, kidney, lung, muscle, ovary and testis. Ref.1 Ref.2 Ref.3 Ref.17

Developmental stage

Expressed in the developing somites and the ventricles of the heart. Expressed in the otic vesicles between E8.5 and E10.5. Expressed in the myocardium of the ventricles at E9.5 and in the atrioventricular cushions from E9.5 to E12.5. At E10.5, strongly expressed in the spinal nerves, the cranial ganglia and the telencephalon. At E11.5, expressed in the craniofacial region of the distal part of the maxillary arch, along the rostral mandibular arch and surrounding the lateral nasal processes. Expressed in the midbrain-hindbrain boundary and the posterior edge of the hand- and foot-paddle. Expressed in the mediodorsal region of the telencephalon and the ventricular zone of the ventral spinal cord at E12, then in the ventral region of the telencephalon and the cortical plate at E15. Expression in the heart is limited to the compact myocardial layer at E17.5. Also expressed in the developing retina up to P5, at which point expression decreases. Ref.1 Ref.2 Ref.3 Ref.8 Ref.11 Ref.17 Ref.23 Ref.24 Ref.25 Ref.26

Induction

By activation of the Notch signaling pathway. Ref.9 Ref.10 Ref.15

Disruption phenotype

Mice display a spectrum of cardiac malformations including ventricular septal defects, tetralogy of Fallot and tricuspid atresia. The penetrance of the cardiac malformation phenotype varies according to the strain, suggesting the presence of modifier genes. Ref.13 Ref.14 Ref.16 Ref.19 Ref.23 Ref.24 Ref.25

Sequence similarities

Belongs to the HEY family.

Contains 1 bHLH (basic helix-loop-helix) domain.

Contains 1 Orange domain.

Ontologies

Keywords
   Biological processNotch signaling pathway
Transcription
Transcription regulation
   Cellular componentNucleus
   LigandDNA-binding
   Molecular functionDevelopmental protein
Repressor
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processNotch signaling involved in heart development

Inferred by curator Ref.14. Source: BHF-UCL

Notch signaling pathway

Inferred from direct assay Ref.9. Source: UniProtKB

anterior/posterior axis specification

Inferred from genetic interaction Ref.22. Source: MGI

arterial endothelial cell differentiation

Inferred from genetic interaction Ref.20. Source: BHF-UCL

artery development

Inferred from genetic interaction Ref.22. Source: MGI

ascending aorta morphogenesis

Inferred from mutant phenotype Ref.14. Source: BHF-UCL

atrial septum morphogenesis

Inferred from mutant phenotype Ref.14. Source: BHF-UCL

atrioventricular valve development

Inferred from mutant phenotype Ref.19. Source: MGI

blood vessel development

Inferred from genetic interaction Ref.22. Source: MGI

cardiac epithelial to mesenchymal transition

Inferred from mutant phenotype Ref.25. Source: BHF-UCL

cardiac left ventricle morphogenesis

Inferred from mutant phenotype Ref.14. Source: BHF-UCL

cardiac muscle hypertrophy

Inferred from mutant phenotype PubMed 20382855. Source: MGI

cardiac muscle hypertrophy in response to stress

Inferred from direct assay PubMed 16603706. Source: MGI

cardiac right ventricle morphogenesis

Inferred from mutant phenotype Ref.14. Source: BHF-UCL

cardiac septum morphogenesis

Inferred from mutant phenotype Ref.26. Source: BHF-UCL

cardiac vascular smooth muscle cell development

Inferred from mutant phenotype PubMed 20619341. Source: MGI

cardiac ventricle morphogenesis

Inferred from mutant phenotype Ref.23. Source: UniProtKB

cell fate commitment

Inferred from mutant phenotype PubMed 19154718. Source: MGI

cochlea development

Inferred from mutant phenotype PubMed 18302773. Source: MGI

coronary vasculature morphogenesis

Inferred from mutant phenotype PubMed 20619341. Source: MGI

dorsal aorta morphogenesis

Inferred from genetic interaction Ref.20. Source: BHF-UCL

endocardial cushion to mesenchymal transition involved in heart valve formation

Inferred from genetic interaction Ref.22. Source: MGI

heart trabecula formation

Inferred from mutant phenotype Ref.26. Source: BHF-UCL

labyrinthine layer blood vessel development

Inferred from genetic interaction Ref.20. Source: BHF-UCL

mesenchymal cell development

Inferred from mutant phenotype Ref.25. Source: BHF-UCL

muscular septum morphogenesis

Inferred from mutant phenotype Ref.14. Source: BHF-UCL

negative regulation of Notch signaling pathway

Inferred from mutant phenotype Ref.10. Source: UniProtKB

negative regulation of cardiac muscle cell apoptotic process

Inferred from mutant phenotype PubMed 20382855. Source: MGI

negative regulation of gene expression

Inferred from mutant phenotype PubMed 16025100. Source: BHF-UCL

negative regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 21290414. Source: UniProtKB

negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation

Inferred from direct assay PubMed 18239137. Source: BHF-UCL

negative regulation of transcription initiation from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription regulatory region DNA binding

Inferred from direct assay PubMed 18239137. Source: BHF-UCL

negative regulation of transcription, DNA-templated

Inferred from direct assay Ref.21. Source: UniProtKB

outflow tract morphogenesis

Inferred from mutant phenotype Ref.14. Source: BHF-UCL

pattern specification process

Inferred from mutant phenotype PubMed 18302773. Source: MGI

positive regulation of cardiac muscle cell proliferation

Inferred from mutant phenotype Ref.24. Source: MGI

positive regulation of heart rate

Inferred from mutant phenotype Ref.19. Source: MGI

positive regulation of transcription from RNA polymerase II promoter

Inferred from mutant phenotype Ref.20Ref.25. Source: BHF-UCL

protein-DNA complex assembly

Inferred from direct assay Ref.3PubMed 16603706. Source: MGI

pulmonary artery morphogenesis

Inferred from mutant phenotype Ref.14. Source: BHF-UCL

pulmonary valve morphogenesis

Inferred from mutant phenotype Ref.14. Source: BHF-UCL

regulation of auditory receptor cell differentiation

Inferred from genetic interaction PubMed 19154718. Source: MGI

regulation of gene expression

Inferred from mutant phenotype PubMed 20619341. Source: MGI

regulation of transcription from RNA polymerase II promoter

Inferred from sequence or structural similarity Ref.1. Source: MGI

regulation of vasculogenesis

Inferred from genetic interaction Ref.20. Source: BHF-UCL

transcription from RNA polymerase II promoter

Inferred from direct assay Ref.23. Source: GOC

tricuspid valve formation

Inferred from mutant phenotype Ref.19. Source: MGI

tricuspid valve morphogenesis

Inferred from mutant phenotype Ref.14. Source: BHF-UCL

umbilical cord morphogenesis

Inferred from genetic interaction Ref.20. Source: BHF-UCL

vasculogenesis

Inferred from genetic interaction Ref.20. Source: MGI

ventricular cardiac muscle cell development

Inferred from mutant phenotype Ref.24. Source: BHF-UCL

ventricular septum morphogenesis

Inferred from mutant phenotype Ref.14. Source: BHF-UCL

ventricular trabecula myocardium morphogenesis

Inferred from genetic interaction Ref.22. Source: MGI

   Cellular_componentSin3 complex

Inferred from electronic annotation. Source: Ensembl

cytoplasm

Inferred from direct assay PubMed 21290414. Source: UniProtKB

nucleoplasm

Traceable author statement. Source: Reactome

nucleus

Inferred from direct assay Ref.10PubMed 21290414. Source: UniProtKB

transcription factor complex

Inferred from sequence or structural similarity Ref.1. Source: MGI

transcriptional repressor complex

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionDNA binding

Inferred from mutant phenotype Ref.10. Source: UniProtKB

RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity

Inferred from direct assay Ref.23. Source: UniProtKB

microsatellite binding

Inferred from direct assay PubMed 21290414. Source: UniProtKB

protein binding

Inferred from physical interaction Ref.21Ref.23PubMed 21259317. Source: UniProtKB

sequence-specific DNA binding

Inferred from direct assay PubMed 22615585. Source: MGI

sequence-specific DNA binding transcription factor activity

Inferred from direct assay Ref.21. Source: UniProtKB

transcription factor binding

Inferred from physical interaction PubMed 16603706. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 339339Hairy/enhancer-of-split related with YRPW motif protein 2
PRO_0000245516

Regions

Domain48 – 10356bHLH
Domain122 – 15736Orange
Region47 – 11670Transcriptional repression and interaction with NCOR1 and SIN3A
Motif329 – 3324YQPW motif
Compositional bias175 – 19117His-rich
Compositional bias262 – 30443Ala-rich

Experimental info

Mutagenesis33 – 375Missing: Abrogates interaction with GATA4 and repression of GATA4-mediated transcription. Ref.21
Mutagenesis49 – 6113RKKRR…EKRRR → LE: Abrogates DNA-binding and transcriptional repression. Ref.10
Sequence conflict71E → K in BAC27428. Ref.6
Sequence conflict2841G → E in BAE34310. Ref.6

Sequences

Sequence LengthMass (Da)Tools
Q9QUS4 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 105BEEA06DE50444

FASTA33935,873
        10         20         30         40         50         60 
MKRPCEETTS ESDLDETIDV GSENNYPGHA TSSVMRSNSP TTTSQIMARK KRRGIIEKRR 

        70         80         90        100        110        120 
RDRINNSLSE LRRLVPTAFE KQGSAKLEKA EILQMTVDHL KMLQATGGKG YFDAHALATD 

       130        140        150        160        170        180 
FMSIGFRECL TEVARYLSSV EGLDPSDPLR VRLVSHLSTC ASQREAAVMT SSMAHHHHPL 

       190        200        210        220        230        240 
HPHHWAAAFH HLPTALLQPN GLHTSESTPC RLSTSSEVPS AHGSALLTAT FAHADSALRM 

       250        260        270        280        290        300 
PSGGTVAPCV PPLSTSLLSL SATVHAAAAA ATAAAHSFPL SFAGAFPMLP SNAAAAAAVA 

       310        320        330 
AATAISPPLS VSAASSPQQT STGTNNKPYQ PWGTEVGAF 

« Hide

References

« Hide 'large scale' references
[1]"HRT1, HRT2 and HRT3: a new subclass of bHLH transcription factors marking specific cardiac, somitic and pharyngeal arch segments."
Nakagawa O., Nakagawa M., Richardson J.A., Olson E.N., Srivastava D.
Dev. Biol. 216:72-84(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
[2]"Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family."
Steidl C., Leimeister C., Klamt B., Maier M., Nanda I., Dixon M., Clarke R., Schmid M., Gessler M.
Genomics 66:195-203(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
[3]"Cardiovascular basic helix loop helix factor 1, a novel transcriptional repressor expressed preferentially in the developing and adult cardiovascular system."
Chin M.T., Maemura K., Fukumoto S., Jain M.K., Layne M.D., Watanabe M., Hsieh C.-M., Lee M.-E.
J. Biol. Chem. 275:6381-6387(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
[4]"HERP, a new primary target of Notch regulated by ligand binding."
Iso T., Sartorelli V., Chung G., Shichinohe T., Kedes L., Hamamori Y.
Mol. Cell. Biol. 21:6071-6079(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]"Cloning of hesr2 gene."
Kokubo H., Johnson R.L.
Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[6]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Inner ear and Testis.
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[8]"Hey genes: a novel subfamily of hairy- and enhancer of split related genes specifically expressed during mouse embryogenesis."
Leimeister C., Externbrinck A., Klamt B., Gessler M.
Mech. Dev. 85:173-177(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: DEVELOPMENTAL STAGE.
[9]"Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes."
Maier M.M., Gessler M.
Biochem. Biophys. Res. Commun. 275:652-660(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[10]"Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling."
Nakagawa O., McFadden D.G., Nakagawa M., Yanagisawa H., Hu T., Srivastava D., Olson E.N.
Proc. Natl. Acad. Sci. U.S.A. 97:13655-13660(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DNA-BINDING, INDUCTION, MUTAGENESIS OF 49-ARG--ARG-61.
[11]"The basic helix-loop-helix gene hesr2 promotes gliogenesis in mouse retina."
Satow T., Bae S.-K., Inoue T., Inoue C., Miyoshi G., Tomita K., Bessho Y., Hashimoto N., Kageyama R.
J. Neurosci. 21:1265-1273(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DEVELOPMENTAL STAGE.
[12]"HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling."
Iso T., Sartorelli V., Poizat C., Iezzi S., Wu H.-Y., Chung G., Kedes L., Hamamori Y.
Mol. Cell. Biol. 21:6080-6089(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DNA-BINDING, INTERACTION WITH HDAC1; HES1; NCOR1 AND SIN3A.
[13]"Mouse gridlock: no aortic coarctation or deficiency, but fatal cardiac defects in Hey2 -/- mice."
Gessler M., Knobeloch K.-P., Helisch A., Amann K., Schumacher N., Rohde E., Fischer A., Leimeister C.
Curr. Biol. 12:1601-1604(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DISRUPTION PHENOTYPE.
[14]"Tetralogy of fallot and other congenital heart defects in Hey2 mutant mice."
Donovan J., Kordylewska A., Jan Y.N., Utset M.F.
Curr. Biol. 12:1605-1610(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DISRUPTION PHENOTYPE.
[15]"HERP1 is a cell type-specific primary target of Notch."
Iso T., Chung G., Hamamori Y., Kedes L.
J. Biol. Chem. 277:6598-6607(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION, SUBCELLULAR LOCATION.
[16]"Ventricular septal defect and cardiomyopathy in mice lacking the transcription factor CHF1/Hey2."
Sakata Y., Kamei C.N., Nakagami H., Bronson R., Liao J.K., Chin M.T.
Proc. Natl. Acad. Sci. U.S.A. 99:16197-16202(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DISRUPTION PHENOTYPE.
[17]"The basic helix-loop-helix genes Hesr1/Hey1 and Hesr2/Hey2 regulate maintenance of neural precursor cells in the brain."
Sakamoto M., Hirata H., Ohtsuka T., Bessho Y., Kageyama R.
J. Biol. Chem. 278:44808-44815(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
[18]"Transcription factor CHF1/Hey2 regulates neointimal formation in vivo and vascular smooth muscle proliferation and migration in vitro."
Sakata Y., Xiang F., Chen Z., Kiriyama Y., Kamei C.N., Simon D.I., Chin M.T.
Arterioscler. Thromb. Vasc. Biol. 24:2069-2074(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[19]"Targeted disruption of hesr2 results in atrioventricular valve anomalies that lead to heart dysfunction."
Kokubo H., Miyagawa-Tomita S., Tomimatsu H., Nakashima Y., Nakazawa M., Saga Y., Johnson R.L.
Circ. Res. 95:540-547(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DISRUPTION PHENOTYPE.
[20]"The Notch target genes Hey1 and Hey2 are required for embryonic vascular development."
Fischer A., Schumacher N., Maier M., Sendtner M., Gessler M.
Genes Dev. 18:901-911(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[21]"Hairy-related transcription factors inhibit GATA-dependent cardiac gene expression through a signal-responsive mechanism."
Kathiriya I.S., King I.N., Murakami M., Nakagawa M., Astle J.M., Gardner K.A., Gerard R.D., Olson E.N., Srivastava D., Nakagawa O.
J. Biol. Chem. 279:54937-54943(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH GATA4, MUTAGENESIS OF 33-SER--SER-37.
[22]"Mouse hesr1 and hesr2 genes are redundantly required to mediate Notch signaling in the developing cardiovascular system."
Kokubo H., Miyagawa-Tomita S., Nakazawa M., Saga Y., Johnson R.L.
Dev. Biol. 278:301-309(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[23]"Hey basic helix-loop-helix transcription factors are repressors of GATA4 and GATA6 and restrict expression of the GATA target gene ANF in fetal hearts."
Fischer A., Klattig J., Kneitz B., Diez H., Maier M., Holtmann B., Englert C., Gessler M.
Mol. Cell. Biol. 25:8960-8970(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH GATA4 AND GATA6, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
[24]"CHF1/Hey2 plays a pivotal role in left ventricular maturation through suppression of ectopic atrial gene expression."
Koibuchi N., Chin M.T.
Circ. Res. 100:850-855(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
[25]"Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition."
Fischer A., Steidl C., Wagner T.U., Lang E., Jakob P.M., Friedl P., Knobeloch K.-P., Gessler M.
Circ. Res. 100:856-863(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH HEYL, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
[26]"Hesr1 and Hesr2 regulate atrioventricular boundary formation in the developing heart through the repression of Tbx2."
Kokubo H., Tomita-Miyagawa S., Hamada Y., Saga Y.
Development 134:747-755(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DEVELOPMENTAL STAGE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF172287 mRNA. Translation: AAF14546.1.
AJ271867 mRNA. Translation: CAB71346.1.
AF173902 mRNA. Translation: AAF20174.1.
AF232240 mRNA. Translation: AAF37298.1.
AB093589 mRNA. Translation: BAC55066.1.
AK031506 mRNA. Translation: BAC27428.1.
AK158000 mRNA. Translation: BAE34310.1.
BC103575 mRNA. Translation: AAI03576.1.
BC103576 mRNA. Translation: AAI03577.1.
CCDSCCDS23766.1.
RefSeqNP_038932.1. NM_013904.1.
UniGeneMm.103573.

3D structure databases

ProteinModelPortalQ9QUS4.
SMRQ9QUS4. Positions 40-104, 110-164.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid200283. 1 interaction.
IntActQ9QUS4. 2 interactions.

PTM databases

PhosphoSiteQ9QUS4.

Proteomic databases

PRIDEQ9QUS4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000019924; ENSMUSP00000019924; ENSMUSG00000019789.
GeneID15214.
KEGGmmu:15214.
UCSCuc007etp.1. mouse.

Organism-specific databases

CTD23493.
MGIMGI:1341884. Hey2.

Phylogenomic databases

eggNOGNOG324798.
GeneTreeENSGT00700000104130.
HOGENOMHOG000286035.
HOVERGENHBG003275.
InParanoidQ9QUS4.
KOK09091.
OMASTCASQR.
OrthoDBEOG76MK98.
PhylomeDBQ9QUS4.
TreeFamTF323617.

Enzyme and pathway databases

ReactomeREACT_188257. Signal Transduction.
REACT_189085. Disease.

Gene expression databases

ArrayExpressQ9QUS4.
BgeeQ9QUS4.
CleanExMM_HEY2.
GenevestigatorQ9QUS4.

Family and domain databases

Gene3D4.10.280.10. 1 hit.
InterProIPR011598. bHLH_dom.
IPR003650. Orange.
IPR018352. Orange_subgr.
[Graphical view]
PfamPF07527. Hairy_orange. 1 hit.
PF00010. HLH. 1 hit.
[Graphical view]
SMARTSM00353. HLH. 1 hit.
SM00511. ORANGE. 1 hit.
[Graphical view]
SUPFAMSSF47459. SSF47459. 1 hit.
PROSITEPS50888. BHLH. 1 hit.
PS51054. ORANGE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio287789.
PROQ9QUS4.
SOURCESearch...

Entry information

Entry nameHEY2_MOUSE
AccessionPrimary (citable) accession number: Q9QUS4
Secondary accession number(s): Q3TZ99, Q8CD44
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot