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Protein

Nuclear receptor subfamily 1 group I member 3

Gene

Nr1i3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi18 – 9376Nuclear receptorPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri21 – 4121NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri57 – 8125NR C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • osteoblast differentiation Source: RGD
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-383280. Nuclear Receptor transcription pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor subfamily 1 group I member 3
Alternative name(s):
Constitutive androstane receptor
Short name:
CAR
Gene namesi
Name:Nr1i3
Synonyms:Car
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621400. Nr1i3.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation
  • Cytoplasm By similarity
  • Cytoplasmcytoskeleton By similarity

  • Note: Recruited to the cytoplasm by DNAJC7.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL3509594.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 358358Nuclear receptor subfamily 1 group I member 3PRO_0000053556Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei48 – 481Phosphothreonine; by PKCBy similarity

Post-translational modificationi

Phosphorylated at Thr-48 by PKC, dephosphorylation of Thr-48 is required for nuclear translocation and activation.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9QUS1.
PRIDEiQ9QUS1.

PTM databases

PhosphoSiteiQ9QUS1.

Expressioni

Gene expression databases

GenevisibleiQ9QUS1. RN.

Interactioni

Subunit structurei

Heterodimer of NR1I3 and RXR. Interacts with PSMC4. Interacts with ECT2. Directly interacts with DNAJC7; this complex may also include HSP90 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000048836.

Structurei

3D structure databases

ProteinModelPortaliQ9QUS1.
SMRiQ9QUS1. Positions 117-358.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Composed by a short N-terminal domain followed by the DNA binding, hinge, and ligand binding/dimerization domains.

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri21 – 4121NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri57 – 8125NR C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
HOGENOMiHOG000220844.
HOVERGENiHBG108655.
InParanoidiQ9QUS1.
KOiK08541.
OMAiDEPRNCA.
OrthoDBiEOG7SXW4K.
PhylomeDBiQ9QUS1.
TreeFamiTF316304.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001728. ThyrH_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
PR00546. THYROIDHORMR.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QUS1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTATLTLETM TSEEEYGPRN CVVCGDRATG YHFHALTCEG CKGFFRRTVS
60 70 80 90 100
KTIGPICPFA GRCEVSKAQR RHCPACRLQK CLNVGMRKDM ILSAEALALR
110 120 130 140 150
RARQARRRAQ KASLQLSQQQ KELIQTLLGA HTRHVGPMFD QFVQFRPPAY
160 170 180 190 200
LFSHHRPFQP LAPVLPLLTH FADINTFMVQ QIIKFTKDLP LFRSLTMEDQ
210 220 230 240 250
ISLLKGAAVE ILHISLNTTF CLQTQNFFCG PLCYKMEDAV HVGFQYEFLE
260 270 280 290 300
LIIHFHKTLK RLQLQEPEYA LMAAMALFSP DRPGVTQREE IDQLQEEVAL
310 320 330 340 350
ILNNHIMEQQ SRLQSRFLYA KLMGLLAELR SINSAYSYEI HRIQGLSAMM

PLLGEICS
Length:358
Mass (Da):40,923
Last modified:May 1, 2000 - v1
Checksum:i13691F49CAD8F1ED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF133095 mRNA. Translation: AAF22567.1.
AF133094 mRNA. Translation: AAF22566.1.
AB104736 mRNA. Translation: BAC82431.1.
AB105071 Genomic DNA. Translation: BAC84955.1.
RefSeqiNP_075230.1. NM_022941.4.
UniGeneiRn.163229.

Genome annotation databases

GeneIDi65035.
KEGGirno:65035.
UCSCiRGD:621400. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF133095 mRNA. Translation: AAF22567.1.
AF133094 mRNA. Translation: AAF22566.1.
AB104736 mRNA. Translation: BAC82431.1.
AB105071 Genomic DNA. Translation: BAC84955.1.
RefSeqiNP_075230.1. NM_022941.4.
UniGeneiRn.163229.

3D structure databases

ProteinModelPortaliQ9QUS1.
SMRiQ9QUS1. Positions 117-358.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000048836.

Chemistry

ChEMBLiCHEMBL3509594.

PTM databases

PhosphoSiteiQ9QUS1.

Proteomic databases

PaxDbiQ9QUS1.
PRIDEiQ9QUS1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi65035.
KEGGirno:65035.
UCSCiRGD:621400. rat.

Organism-specific databases

CTDi9970.
RGDi621400. Nr1i3.

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
HOGENOMiHOG000220844.
HOVERGENiHBG108655.
InParanoidiQ9QUS1.
KOiK08541.
OMAiDEPRNCA.
OrthoDBiEOG7SXW4K.
PhylomeDBiQ9QUS1.
TreeFamiTF316304.

Enzyme and pathway databases

ReactomeiR-RNO-383280. Nuclear Receptor transcription pathway.

Miscellaneous databases

NextBioi613836.
PROiQ9QUS1.

Gene expression databases

GenevisibleiQ9QUS1. RN.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001728. ThyrH_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
PR00546. THYROIDHORMR.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Nuclear receptor CAR as a regulatory factor for the sexually dimorphic induction of CYB2B1 gene by phenobarbital in rat livers."
    Yoshinari K., Sueyoshi T., Moore R., Negishi M.
    Mol. Pharmacol. 59:278-284(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Fischer and Wistar Kyoto.
    Tissue: Liver.
  2. "Role of the defective splicing of mRNA in the lack of pulmonary expression of constitutively active receptor in rat."
    Kanno Y., Aoki S., Nakahama T., Inouye Y.
    J. Health Sci. 49:541-546(2003)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: Wistar.
    Tissue: Liver.

Entry informationi

Entry nameiNR1I3_RAT
AccessioniPrimary (citable) accession number: Q9QUS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: May 11, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.