Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9QUR8

- SEM7A_MOUSE

UniProt

Q9QUR8 - SEM7A_MOUSE

Protein

Semaphorin-7A

Gene

Sema7a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes.3 Publications

    GO - Molecular functioni

    1. integrin binding Source: UniProtKB
    2. receptor activity Source: InterPro

    GO - Biological processi

    1. axon extension Source: MGI
    2. inflammatory response Source: UniProtKB-KW
    3. integrin-mediated signaling pathway Source: UniProtKB
    4. neuron projection development Source: MGI
    5. olfactory lobe development Source: MGI
    6. positive regulation of axon extension Source: UniProtKB
    7. positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
    8. positive regulation of macrophage cytokine production Source: UniProtKB
    9. positive regulation of protein phosphorylation Source: MGI
    10. regulation of inflammatory response Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Inflammatory response, Neurogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Semaphorin-7A
    Alternative name(s):
    Semaphorin-K1
    Short name:
    Sema K1
    Semaphorin-L
    Short name:
    Sema L
    CD_antigen: CD108
    Gene namesi
    Name:Sema7a
    Synonyms:Cd108, Semal, Semk1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:1306826. Sema7a.

    Subcellular locationi

    Cell membrane 1 Publication; Lipid-anchorGPI-anchor 1 Publication; Extracellular side 1 Publication

    GO - Cellular componenti

    1. anchored component of membrane Source: UniProtKB-KW
    2. external side of plasma membrane Source: UniProtKB
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Disruption phenotypei

    No visible phenotype. Mice display normal levels of lymphocytes in spleen, and normal activation of T-cells by antigenic stimuli. In contrast, production of proinflammatory cytokines by macrophages is much reduced. The effect on contact hypersensitivity and experimental autoimmune encephalomyelitis is controversial. Reduced size of the lateral olfactory tract.3 Publications

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 4444Sequence AnalysisAdd
    BLAST
    Chaini45 – 646602Semaphorin-7APRO_0000032349Add
    BLAST
    Propeptidei647 – 66418Removed in mature formSequence AnalysisPRO_0000032350Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi117 ↔ 123By similarity
    Disulfide bondi140 ↔ 149By similarity
    Glycosylationi154 – 1541N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi256 – 2561N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi264 ↔ 364By similarity
    Disulfide bondi289 ↔ 333By similarity
    Glycosylationi328 – 3281N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi491 ↔ 509By similarity
    Disulfide bondi498 ↔ 539By similarity
    Disulfide bondi501 ↔ 516By similarity
    Disulfide bondi564 ↔ 611By similarity
    Disulfide bondi585 ↔ 594By similarity
    Glycosylationi600 – 6001N-linked (GlcNAc...)Sequence Analysis
    Lipidationi646 – 6461GPI-anchor amidated alanineSequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

    Proteomic databases

    PaxDbiQ9QUR8.
    PRIDEiQ9QUR8.

    PTM databases

    PhosphoSiteiQ9QUR8.

    Expressioni

    Tissue specificityi

    Highly expressed in activated T-cells (at protein level). Highest expression in brain. Lower in heart, thymus, spleen, testis and ovary. The expression increases in late embryonic and postnatal stages. Detected in T-cells.2 Publications

    Gene expression databases

    BgeeiQ9QUR8.
    GenevestigatoriQ9QUR8.

    Interactioni

    Subunit structurei

    Interacts with PLXNC1 By similarity. Interacts with ITGA1 and ITGB1.By similarity1 Publication

    Protein-protein interaction databases

    IntActiQ9QUR8. 1 interaction.
    MINTiMINT-4134084.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QUR8.
    SMRiQ9QUR8. Positions 46-631.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini53 – 488436SemaPROSITE-ProRule annotationAdd
    BLAST
    Domaini542 – 62786Ig-like C2-typeAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni265 – 2673Interaction with integrinsBy similarity

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi265 – 2673Cell attachment siteSequence Analysis

    Sequence similaritiesi

    Belongs to the semaphorin family.Curated
    Contains 1 PSI domain.Curated
    Contains 1 Sema domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Signal

    Phylogenomic databases

    eggNOGiNOG277924.
    GeneTreeiENSGT00690000101974.
    HOGENOMiHOG000154284.
    HOVERGENiHBG079171.
    InParanoidiQ9QUR8.
    KOiK06529.
    OMAiEPMGPLK.
    OrthoDBiEOG754HNX.
    PhylomeDBiQ9QUR8.
    TreeFamiTF333698.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    2.60.40.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR016201. Plexin-like_fold.
    IPR002165. Plexin_repeat.
    IPR001627. Semap_dom.
    IPR027231. Semaphorin.
    IPR015943. WD40/YVTN_repeat-like_dom.
    [Graphical view]
    PANTHERiPTHR11036. PTHR11036. 1 hit.
    PfamiPF01437. PSI. 1 hit.
    PF01403. Sema. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 1 hit.
    SM00423. PSI. 1 hit.
    SM00630. Sema. 1 hit.
    [Graphical view]
    SUPFAMiSSF101912. SSF101912. 1 hit.
    SSF103575. SSF103575. 1 hit.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS51004. SEMA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9QUR8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTPPPPGRAA PSAPRARVLS LPARFGLPLR LRLLLVFWVA AASAQGHSRS    50
    GPRISAVWKG QDHVDFSQPE PHTVLFHEPG SFSVWVGGRG KVYHFNFPEG 100
    KNASVRTVNI GSTKGSCQDK QDCGNYITLL ERRGNGLLVC GTNARKPSCW 150
    NLVNDSVVMS LGEMKGYAPF SPDENSLVLF EGDEVYSTIR KQEYNGKIPR 200
    FRRIRGESEL YTSDTVMQNP QFIKATIVHQ DQAYDDKIYY FFREDNPDKN 250
    PEAPLNVSRV AQLCRGDQGG ESSLSVSKWN TFLKAMLVCS DAATNRNFNR 300
    LQDVFLLPDP SGQWRDTRVY GVFSNPWNYS AVCVYSLGDI DRVFRTSSLK 350
    GYHMGLPNPR PGMCLPKKQP IPTETFQVAD SHPEVAQRVE PMGPLKTPLF 400
    HSKYHYQKVV VHRMQASNGE TFHVLYLTTD RGTIHKVVES GDQDHSFVFN 450
    IMEIQPFHRA AAIQAISLDA DRRKLYVTSQ WEVSQVPLDM CEVYSGGCHG 500
    CLMSRDPYCG WDQDRCVSIY SSQRSVLQSI NPAEPHRECP NPKPDEAPLQ 550
    KVSLARNSRY YLTCPMESRH ATYLWRHEEN VEQSCEPGHQ SPSCILFIEN 600
    LTARQYGHYR CEAQEGSYLR EAQHWELLPE DRALAEQLMG HARALAASFW 650
    LGVLPTLILG LLVH 664
    Length:664
    Mass (Da):74,994
    Last modified:May 1, 2000 - v1
    Checksum:i1804A31C3C55B715
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti357 – 3571P → S in AAC34262. (PubMed:9721204)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB017532 mRNA. Translation: BAA75665.1.
    AF030699 mRNA. Translation: AAC34262.1.
    AF176670 mRNA. Translation: AAD53118.1.
    BC057875 mRNA. Translation: AAH57875.1.
    CCDSiCCDS23235.1.
    RefSeqiNP_035482.1. NM_011352.2.
    UniGeneiMm.335187.

    Genome annotation databases

    EnsembliENSMUST00000043059; ENSMUSP00000042211; ENSMUSG00000038264.
    GeneIDi20361.
    KEGGimmu:20361.
    UCSCiuc009pvy.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB017532 mRNA. Translation: BAA75665.1 .
    AF030699 mRNA. Translation: AAC34262.1 .
    AF176670 mRNA. Translation: AAD53118.1 .
    BC057875 mRNA. Translation: AAH57875.1 .
    CCDSi CCDS23235.1.
    RefSeqi NP_035482.1. NM_011352.2.
    UniGenei Mm.335187.

    3D structure databases

    ProteinModelPortali Q9QUR8.
    SMRi Q9QUR8. Positions 46-631.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9QUR8. 1 interaction.
    MINTi MINT-4134084.

    PTM databases

    PhosphoSitei Q9QUR8.

    Proteomic databases

    PaxDbi Q9QUR8.
    PRIDEi Q9QUR8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000043059 ; ENSMUSP00000042211 ; ENSMUSG00000038264 .
    GeneIDi 20361.
    KEGGi mmu:20361.
    UCSCi uc009pvy.1. mouse.

    Organism-specific databases

    CTDi 8482.
    MGIi MGI:1306826. Sema7a.

    Phylogenomic databases

    eggNOGi NOG277924.
    GeneTreei ENSGT00690000101974.
    HOGENOMi HOG000154284.
    HOVERGENi HBG079171.
    InParanoidi Q9QUR8.
    KOi K06529.
    OMAi EPMGPLK.
    OrthoDBi EOG754HNX.
    PhylomeDBi Q9QUR8.
    TreeFami TF333698.

    Miscellaneous databases

    NextBioi 298249.
    PROi Q9QUR8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9QUR8.
    Genevestigatori Q9QUR8.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    2.60.40.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR016201. Plexin-like_fold.
    IPR002165. Plexin_repeat.
    IPR001627. Semap_dom.
    IPR027231. Semaphorin.
    IPR015943. WD40/YVTN_repeat-like_dom.
    [Graphical view ]
    PANTHERi PTHR11036. PTHR11036. 1 hit.
    Pfami PF01437. PSI. 1 hit.
    PF01403. Sema. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 1 hit.
    SM00423. PSI. 1 hit.
    SM00630. Sema. 1 hit.
    [Graphical view ]
    SUPFAMi SSF101912. SSF101912. 1 hit.
    SSF103575. SSF103575. 1 hit.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS51004. SEMA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and expression of murine homologue of semaphorin K1 gene."
      Sato Y., Takahashi H.
      Biochim. Biophys. Acta 1443:419-422(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "New eukaryotic semaphorins with close homology to semaphorins of DNA viruses."
      Lange C., Liehr T., Goen M., Gebhart E., Fleckenstein B., Ensser A.
      Genomics 51:340-350(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Testis.
    3. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: 129.
      Tissue: Mammary gland.
    5. "Semaphorin 7A promotes axon outgrowth through integrins and MAPKs."
      Pasterkamp R.J., Peschon J.J., Spriggs M.K., Kolodkin A.L.
      Nature 424:398-405(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE, FUNCTION.
    6. "Semaphorin 7A is a negative regulator of T cell responses."
      Czopik A.K., Bynoe M.S., Palm N., Raine C.S., Medzhitov R.
      Immunity 24:591-600(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE, FUNCTION, TISSUE SPECIFICITY.
    7. "Semaphorin 7A initiates T-cell-mediated inflammatory responses through alpha1beta1 integrin."
      Suzuki K., Okuno T., Yamamoto M., Pasterkamp R.J., Takegahara N., Takamatsu H., Kitao T., Takagi J., Rennert P.D., Kolodkin A.L., Kumanogoh A., Kikutani H.
      Nature 446:680-684(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE, SUBCELLULAR LOCATION, INTERACTION WITH ITGA1 AND ITGB1, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiSEM7A_MOUSE
    AccessioniPrimary (citable) accession number: Q9QUR8
    Secondary accession number(s): O88371
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 122 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    The exact role in regulating T-cell function is under debate. According to (PubMed:16713976), SEMA7A-deficient mice are highly susceptible to contact hypersensitivity and experimental autoimmune encephalomyelitis. According to (PubMed:17377534) mice do not develop contact hypersensitivity, and are highly resistant to experimental autoimmune encephalomyelitis.2 Publications

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3