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Q9QUR6

- PPCE_MOUSE

UniProt

Q9QUR6 - PPCE_MOUSE

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Protein
Prolyl endopeptidase
Gene
Prep, Pep
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long.

Catalytic activityi

Hydrolysis of Pro-|-Xaa >> Ala-|-Xaa in oligopeptides.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei554 – 5541Charge relay system By similarity
Active sitei641 – 6411Charge relay system By similarity
Active sitei680 – 6801Charge relay system By similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
  2. serine-type exopeptidase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. protein metabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS09.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Prolyl endopeptidase (EC:3.4.21.26)
Short name:
PE
Alternative name(s):
Post-proline cleaving enzyme
Gene namesi
Name:Prep
Synonyms:Pep
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:1270863. Prep.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 710710Prolyl endopeptidase
PRO_0000122402Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine By similarity
Modified residuei157 – 1571N6-acetyllysine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9QUR6.
PaxDbiQ9QUR6.
PRIDEiQ9QUR6.

PTM databases

PhosphoSiteiQ9QUR6.

Expressioni

Gene expression databases

ArrayExpressiQ9QUR6.
BgeeiQ9QUR6.
CleanExiMM_PREP.
GenevestigatoriQ9QUR6.

Interactioni

Protein-protein interaction databases

IntActiQ9QUR6. 1 interaction.
MINTiMINT-1854903.

Structurei

3D structure databases

ProteinModelPortaliQ9QUR6.
SMRiQ9QUR6. Positions 1-709.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9A family.

Phylogenomic databases

eggNOGiCOG1505.
GeneTreeiENSGT00530000063426.
HOVERGENiHBG007251.
InParanoidiQ9QUR6.
KOiK01322.
OMAiDYQTIQI.
OrthoDBiEOG78PV88.
PhylomeDBiQ9QUR6.
TreeFamiTF300655.

Family and domain databases

Gene3Di2.130.10.120. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002471. Pept_S9_AS.
IPR023302. Pept_S9A_N.
IPR001375. Peptidase_S9.
IPR002470. Peptidase_S9A.
[Graphical view]
PANTHERiPTHR11757. PTHR11757. 1 hit.
PfamiPF00326. Peptidase_S9. 1 hit.
PF02897. Peptidase_S9_N. 1 hit.
[Graphical view]
PRINTSiPR00862. PROLIGOPTASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00708. PRO_ENDOPEP_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QUR6-1 [UniParc]FASTAAdd to Basket

« Hide

MLSFQYPDVY RDETSVQEYH GHKICDPYSW LEDPDSEQTK AFVEAQNKIT    50
VPFLEQCPIR GLYKERMTEL YDYPKYSCHF KKGKRYFYFY NTGLQNQRVL 100
YVQDSLEGEA RVFLDPNTLS DDGTVALRGY AFSEDGEYFA YGLSASGSDW 150
VTIKFMKVDG AKELPDVLER VKFTCMAWTH DGKGMFYNSY PQQDGKSDGT 200
ETSTNLHQKL CYHVLGTDQS EDILCAEFPD EPKWMGGAEL SDDGRYVLLS 250
IWEGCDPVNR LWYCDLQQEP NGITGILKWV KLIDNFEGEY DYVTNEGTVF 300
TFKTNRNSPN YRLINIDFTD PDESKWKVLV PEHEKDVLEW VACVRSNFLV 350
LCYLHDVKNI LQLHDLTTGA LLKTFPLDVG SVVGYSGRKK DSEIFYQFTS 400
FLSPGVIYHC DLTKEELEPM VFREVTVKGI DAADYQTIQI FYPSKDGTKI 450
PMFIVHKKGI KLDGSHPAFL YGYGGFNISI TPNYSVSRLI FVRHMGGVLA 500
VANIRGGGEY GETWHKGGIL ANKQNCFDDF QCAAEYLIKE GYTSPKRLTI 550
NGGSNGGLLV AACANQRPDL FGCVIAQVGV MDMLKFHKFT IGHAWTTDYG 600
CSDTKQHFEW LLKYSPLHNV KLPEADDIQY PSMLLLTADH DDRVVPLHSL 650
KFIATLQYIV GRSRKQSNPL LIHVDTKAGH GAGKPTAKVI EEVSDMFAFI 700
ARCLNIEWIQ 710
Length:710
Mass (Da):80,752
Last modified:May 1, 2000 - v1
Checksum:i1B010D5D6CA73C0E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB007631 mRNA. Translation: BAA88239.1.
AB022053 Genomic DNA. Translation: BAA83071.1.
BC012869 mRNA. Translation: AAH12869.1.
BC050830 mRNA. Translation: AAH50830.2.
CCDSiCCDS23826.1.
PIRiJW0080.
RefSeqiNP_035286.1. NM_011156.2.
UniGeneiMm.37294.

Genome annotation databases

EnsembliENSMUST00000099858; ENSMUSP00000097444; ENSMUSG00000019849.
GeneIDi19072.
KEGGimmu:19072.
UCSCiuc007ezx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB007631 mRNA. Translation: BAA88239.1 .
AB022053 Genomic DNA. Translation: BAA83071.1 .
BC012869 mRNA. Translation: AAH12869.1 .
BC050830 mRNA. Translation: AAH50830.2 .
CCDSi CCDS23826.1.
PIRi JW0080.
RefSeqi NP_035286.1. NM_011156.2.
UniGenei Mm.37294.

3D structure databases

ProteinModelPortali Q9QUR6.
SMRi Q9QUR6. Positions 1-709.
ModBasei Search...

Protein-protein interaction databases

IntActi Q9QUR6. 1 interaction.
MINTi MINT-1854903.

Chemistry

BindingDBi Q9QUR6.
ChEMBLi CHEMBL4935.

Protein family/group databases

MEROPSi S09.001.

PTM databases

PhosphoSitei Q9QUR6.

Proteomic databases

MaxQBi Q9QUR6.
PaxDbi Q9QUR6.
PRIDEi Q9QUR6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000099858 ; ENSMUSP00000097444 ; ENSMUSG00000019849 .
GeneIDi 19072.
KEGGi mmu:19072.
UCSCi uc007ezx.1. mouse.

Organism-specific databases

CTDi 5550.
MGIi MGI:1270863. Prep.

Phylogenomic databases

eggNOGi COG1505.
GeneTreei ENSGT00530000063426.
HOVERGENi HBG007251.
InParanoidi Q9QUR6.
KOi K01322.
OMAi DYQTIQI.
OrthoDBi EOG78PV88.
PhylomeDBi Q9QUR6.
TreeFami TF300655.

Miscellaneous databases

ChiTaRSi PREP. mouse.
NextBioi 295594.
PROi Q9QUR6.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9QUR6.
Bgeei Q9QUR6.
CleanExi MM_PREP.
Genevestigatori Q9QUR6.

Family and domain databases

Gene3Di 2.130.10.120. 1 hit.
3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR002471. Pept_S9_AS.
IPR023302. Pept_S9A_N.
IPR001375. Peptidase_S9.
IPR002470. Peptidase_S9A.
[Graphical view ]
PANTHERi PTHR11757. PTHR11757. 1 hit.
Pfami PF00326. Peptidase_S9. 1 hit.
PF02897. Peptidase_S9_N. 1 hit.
[Graphical view ]
PRINTSi PR00862. PROLIGOPTASE.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00708. PRO_ENDOPEP_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning of mouse prolyl endopeptidase and its involvement in DNA synthesis by Swiss 3T3 cells."
    Ishino T., Ohtsuki S., Homma K., Natori S.
    J. Biochem. 123:540-545(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Structure and localization of the mouse prolyl oligopeptidase gene."
    Kimura A., Yoshida I., Takagi N., Takahashi T.
    J. Biol. Chem. 274:24047-24053(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Limb and Mammary gland.

Entry informationi

Entry nameiPPCE_MOUSE
AccessioniPrimary (citable) accession number: Q9QUR6
Secondary accession number(s): Q80YS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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