Reviewed,
UniProtKB/Swiss-Prot Q9QUR6 (PPCE_MOUSE)
Last modified
February 10, 2009.
Version 70.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Prolyl endopeptidase Short name=PE EC=3.4.21.26 Alternative name(s): Post-proline cleaving enzyme | ||||
| Gene names |
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| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 710 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. |
| Catalytic activity | Hydrolysis of Pro-|-Xaa >> Ala-|-Xaa in oligopeptides. |
| Subcellular location | |
| Sequence similarities | Belongs to the peptidase S9A family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Molecular function | Hydrolase Protease Serine protease |
| Gene Ontology (GO) | |
| Biological process | proteolysis Inferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Ref.1 Inferred from direct assay. Source: MGI nucleus Ref.1Inferred from direct assay. Source: MGI |
| Molecular function | serine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "cDNA cloning of mouse prolyl endopeptidase and its involvement in DNA synthesis by Swiss 3T3 cells." Ishino T., Ohtsuki S., Homma K., Natori S. J. Biochem. 123:540-545(1998) [PubMed: 9538240] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain. |
| [2] | "Structure and localization of the mouse prolyl oligopeptidase gene." Kimura A., Yoshida I., Takagi N., Takahashi T. J. Biol. Chem. 274:24047-24053(1999) [PubMed: 10446174] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Limb and Mammary gland. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AB007631 mRNA. Translation: BAA88239.1. AB022053 Genomic DNA. Translation: BAA83071.1. BC012869 mRNA. Translation: AAH12869.1. BC050830 mRNA. Translation: AAH50830.2. | |
| IPI | IPI00132089. |
| PIR | JW0080. |
| RefSeq | NP_035286.1. |
| UniGene | Mm.37294 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1O6G based on UniProtKB P23687. |
| SMR | Q9QUR6. Positions 1-709. |
| ModBase | Search... |
Protein family/group databases | |
| MEROPS | S09.001. |
PTM databases | |
| PhosphoSite | Q9QUR6. |
Proteomic databases | |
| PRIDE | Q9QUR6. |
Genome annotation databases | |
| Ensembl | ENSMUSG00000019849. Mus musculus. [Contig view] |
| GeneID | 19072. |
| KEGG | mmu:19072. |
Organism-specific databases | |
| MGI | MGI:1270863. Prep. |
Phylogenomic databases | |
| HOVERGEN | Q9QUR6. |
Enzyme and pathway databases | |
| BRENDA | 3.4.21.26. 244. |
Gene expression databases | |
| ArrayExpress | Q9QUR6. |
| Bgee | Q9QUR6. |
| CleanEx | MM_PREP. |
| GermOnline | ENSMUSG00000019849. Mus musculus. |
Family and domain databases | |
| InterPro | IPR002471. Pept_S9_AS. IPR001375. Peptidase_S9. IPR002470. Peptidase_S9A. IPR004106. Peptidase_S9A_N. [Graphical view] |
| PANTHER | PTHR11757. Peptidase_S9A. 1 hit. |
| Pfam | PF00326. Peptidase_S9. 1 hit. PF02897. Peptidase_S9_N. 1 hit. [Graphical view] |
| PRINTS | PR00862. PROLIGOPTASE. |
| PROSITE | PS00708. PRO_ENDOPEP_SER. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 295594. |
| SOURCE | Search... |
Entry information
| Entry name | PPCE_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q9QUR6 Secondary accession number(s): Q80YS1 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| Peptidase families Classification of peptidase families and list of entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with


