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Q9QUR6 (PPCE_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Prolyl endopeptidase
Short name=PE
EC=3.4.21.26
Alternative name(s):
Post-proline cleaving enzyme
Gene names
Name:Prep
Synonyms:Pep
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length710 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long.

Catalytic activity

Hydrolysis of Pro-|-Xaa >> Ala-|-Xaa in oligopeptides.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the peptidase S9A family.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionHydrolase
Protease
Serine protease
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processproteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from direct assay Ref.1. Source: MGI

nucleus

Inferred from direct assay Ref.1. Source: MGI

   Molecular functionserine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

serine-type exopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 710710Prolyl endopeptidase
PRO_0000122402

Sites

Active site5541Charge relay system By similarity
Active site6411Charge relay system By similarity
Active site6801Charge relay system By similarity

Amino acid modifications

Modified residue1571N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9QUR6 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 1B010D5D6CA73C0E

FASTA71080,752
        10         20         30         40         50         60 
MLSFQYPDVY RDETSVQEYH GHKICDPYSW LEDPDSEQTK AFVEAQNKIT VPFLEQCPIR 

        70         80         90        100        110        120 
GLYKERMTEL YDYPKYSCHF KKGKRYFYFY NTGLQNQRVL YVQDSLEGEA RVFLDPNTLS 

       130        140        150        160        170        180 
DDGTVALRGY AFSEDGEYFA YGLSASGSDW VTIKFMKVDG AKELPDVLER VKFTCMAWTH 

       190        200        210        220        230        240 
DGKGMFYNSY PQQDGKSDGT ETSTNLHQKL CYHVLGTDQS EDILCAEFPD EPKWMGGAEL 

       250        260        270        280        290        300 
SDDGRYVLLS IWEGCDPVNR LWYCDLQQEP NGITGILKWV KLIDNFEGEY DYVTNEGTVF 

       310        320        330        340        350        360 
TFKTNRNSPN YRLINIDFTD PDESKWKVLV PEHEKDVLEW VACVRSNFLV LCYLHDVKNI 

       370        380        390        400        410        420 
LQLHDLTTGA LLKTFPLDVG SVVGYSGRKK DSEIFYQFTS FLSPGVIYHC DLTKEELEPM 

       430        440        450        460        470        480 
VFREVTVKGI DAADYQTIQI FYPSKDGTKI PMFIVHKKGI KLDGSHPAFL YGYGGFNISI 

       490        500        510        520        530        540 
TPNYSVSRLI FVRHMGGVLA VANIRGGGEY GETWHKGGIL ANKQNCFDDF QCAAEYLIKE 

       550        560        570        580        590        600 
GYTSPKRLTI NGGSNGGLLV AACANQRPDL FGCVIAQVGV MDMLKFHKFT IGHAWTTDYG 

       610        620        630        640        650        660 
CSDTKQHFEW LLKYSPLHNV KLPEADDIQY PSMLLLTADH DDRVVPLHSL KFIATLQYIV 

       670        680        690        700        710 
GRSRKQSNPL LIHVDTKAGH GAGKPTAKVI EEVSDMFAFI ARCLNIEWIQ

« Hide

References

« Hide 'large scale' references
[1]"cDNA cloning of mouse prolyl endopeptidase and its involvement in DNA synthesis by Swiss 3T3 cells."
Ishino T., Ohtsuki S., Homma K., Natori S.
J. Biochem. 123:540-545(1998) [PubMed: 9538240] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"Structure and localization of the mouse prolyl oligopeptidase gene."
Kimura A., Yoshida I., Takagi N., Takahashi T.
J. Biol. Chem. 274:24047-24053(1999) [PubMed: 10446174] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Limb and Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AB007631 mRNA. Translation: BAA88239.1.
AB022053 Genomic DNA. Translation: BAA83071.1.
BC012869 mRNA. Translation: AAH12869.1.
BC050830 mRNA. Translation: AAH50830.2.
IPIIPI00989777.
PIRJW0080.
RefSeqNP_035286.1. NM_011156.2.
UniGeneMm.37294.

3D structure databases

ProteinModelPortalQ9QUR6.
SMRQ9QUR6. Positions 1-709.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ9QUR6.

Protein family/group databases

MEROPSS09.001.

PTM databases

PhosphoSiteQ9QUR6.

Proteomic databases

PRIDEQ9QUR6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000099858; ENSMUSP00000097444; ENSMUSG00000019849.
GeneID19072.
KEGGmmu:19072.

Organism-specific databases

CTD5550.
MGIMGI:1270863. Prep.

Phylogenomic databases

GeneTreeENSGT00530000063426.
HOVERGENHBG007251.
InParanoidQ9QUR6.
OrthoDBEOG4548Z1.
PhylomeDBQ9QUR6.

Gene expression databases

ArrayExpressQ9QUR6.
BgeeQ9QUR6.
CleanExMM_PREP.
GenevestigatorQ9QUR6.
GermOnlineENSMUSG00000019849. Mus musculus.

Family and domain databases

InterProIPR002471. Pept_S9_AS.
IPR023302. Pept_S9A_oligopept_N.
IPR001375. Peptidase_S9.
IPR002470. Peptidase_S9A.
IPR004106. Peptidase_S9A_B_C_N.
[Graphical view]
Gene3DG3DSA:2.130.10.120. Pept_S9A_oligopept_N. 1 hit.
KOK01322.
PANTHERPTHR11757. Peptidase_S9A. 1 hit.
PfamPF00326. Peptidase_S9. 1 hit.
PF02897. Peptidase_S9_N. 1 hit.
[Graphical view]
PRINTSPR00862. PROLIGOPTASE.
SUPFAMSSF50993. Peptidase_S9A_N. 1 hit.
PROSITEPS00708. PRO_ENDOPEP_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio295594.
SOURCESearch...

Entry information

Entry namePPCE_MOUSE
AccessionPrimary (citable) accession number: Q9QUR6
Secondary accession number(s): Q80YS1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: November 16, 2011
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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