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Protein

Hyaluronan and proteoglycan link protein 1

Gene

Hapln1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Hyaluronic acid

Names & Taxonomyi

Protein namesi
Recommended name:
Hyaluronan and proteoglycan link protein 1
Alternative name(s):
Cartilage-linking protein 1
Short name:
Cartilage-link protein
Proteoglycan link protein
Gene namesi
Name:Hapln1
Synonyms:Crtl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1337006. Hapln1.

Subcellular locationi

GO - Cellular componenti

  • proteinaceous extracellular matrix Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 99By similarityPRO_0000013179
Chaini10 – 356347Hyaluronan and proteoglycan link protein 1PRO_0000013180Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi58 – 581N-linked (GlcNAc...)Sequence analysis
Disulfide bondi63 ↔ 141By similarity
Disulfide bondi183 ↔ 254By similarity
Disulfide bondi207 ↔ 228By similarity
Disulfide bondi281 ↔ 351By similarity
Disulfide bondi306 ↔ 327By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9QUP5.
PaxDbiQ9QUP5.
PeptideAtlasiQ9QUP5.
PRIDEiQ9QUP5.

PTM databases

iPTMnetiQ9QUP5.
PhosphoSiteiQ9QUP5.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiQ9QUP5.
CleanExiMM_HAPLN1.
GenevisibleiQ9QUP5. MM.

Interactioni

Protein-protein interaction databases

BioGridi198904. 1 interaction.
IntActiQ9QUP5. 2 interactions.
MINTiMINT-4097928.
STRINGi10090.ENSMUSP00000022108.

Structurei

3D structure databases

ProteinModelPortaliQ9QUP5.
SMRiQ9QUP5. Positions 44-148, 168-255, 271-355.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini40 – 154115Ig-like V-typeAdd
BLAST
Domaini161 – 25696Link 1PROSITE-ProRule annotationAdd
BLAST
Domaini261 – 35393Link 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the HAPLN family.Curated
Contains 2 Link domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat

Phylogenomic databases

eggNOGiENOG410IF28. Eukaryota.
ENOG410XRS8. LUCA.
GeneTreeiENSGT00760000119025.
HOGENOMiHOG000234353.
HOVERGENiHBG051922.
InParanoidiQ9QUP5.
KOiK06848.
OMAiWRSGLDW.
OrthoDBiEOG7ZWD1D.
PhylomeDBiQ9QUP5.
TreeFamiTF332134.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.100.10. 2 hits.
InterProiIPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR000538. Link_dom.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
PF00193. Xlink. 2 hits.
[Graphical view]
PRINTSiPR01265. LINKMODULE.
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
SM00445. LINK. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF56436. SSF56436. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS01241. LINK_1. 2 hits.
PS50963. LINK_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QUP5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSLLLLVLI SVCWADHHLS DSYTPPDQDR VIHIQAENGP RLLVEAEQAK
60 70 80 90 100
VFSHRGGNVT LPCKFYRDPT AFGSGIHKIR IKWTKLTSDY LREVDVFVSM
110 120 130 140 150
GYHKKTYGGY QGRVFLKGGS DNDASLVITD LTLEDYGRYK CEVIEGLEDD
160 170 180 190 200
TAVVALELQG VVFPYFPRLG RYNLNFHEAR QACLDQDAVI ASFDQLYDAW
210 220 230 240 250
RGGLDWCNAG WLSDGSVQYP ITKPREPCGG QNTVPGVRNY GFWDKDKSRY
260 270 280 290 300
DVFCFTSNFN GRFYYLIHPT KLTYDEAVQA CLNDGAQIAK VGQIFAAWKL
310 320 330 340 350
LGYDRCDAGW LADGSVRYPI SRPRRRCSPT EAAVRFVGFP DKKHKLYGVY

CFRAYN
Length:356
Mass (Da):40,478
Last modified:May 1, 2000 - v1
Checksum:i3FB4B8F30E28C9F2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti18 – 181Missing in AAD12253 (PubMed:12732630).Curated
Sequence conflicti35 – 351Q → H in AAH66853 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF137278
, AF137275, AF137276, AF137277 Genomic DNA. Translation: AAF24166.1.
AF139572 mRNA. Translation: AAF24977.1.
AF098460 mRNA. Translation: AAD12253.1.
AK032750 mRNA. Translation: BAC28007.1.
AK048107 mRNA. Translation: BAC33244.1.
BC066853 mRNA. Translation: AAH66853.1.
CCDSiCCDS26671.1.
RefSeqiNP_038528.3. NM_013500.4.
UniGeneiMm.266790.

Genome annotation databases

EnsembliENSMUST00000022108; ENSMUSP00000022108; ENSMUSG00000021613.
GeneIDi12950.
KEGGimmu:12950.
UCSCiuc007rjf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF137278
, AF137275, AF137276, AF137277 Genomic DNA. Translation: AAF24166.1.
AF139572 mRNA. Translation: AAF24977.1.
AF098460 mRNA. Translation: AAD12253.1.
AK032750 mRNA. Translation: BAC28007.1.
AK048107 mRNA. Translation: BAC33244.1.
BC066853 mRNA. Translation: AAH66853.1.
CCDSiCCDS26671.1.
RefSeqiNP_038528.3. NM_013500.4.
UniGeneiMm.266790.

3D structure databases

ProteinModelPortaliQ9QUP5.
SMRiQ9QUP5. Positions 44-148, 168-255, 271-355.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198904. 1 interaction.
IntActiQ9QUP5. 2 interactions.
MINTiMINT-4097928.
STRINGi10090.ENSMUSP00000022108.

PTM databases

iPTMnetiQ9QUP5.
PhosphoSiteiQ9QUP5.

Proteomic databases

MaxQBiQ9QUP5.
PaxDbiQ9QUP5.
PeptideAtlasiQ9QUP5.
PRIDEiQ9QUP5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022108; ENSMUSP00000022108; ENSMUSG00000021613.
GeneIDi12950.
KEGGimmu:12950.
UCSCiuc007rjf.2. mouse.

Organism-specific databases

CTDi1404.
MGIiMGI:1337006. Hapln1.

Phylogenomic databases

eggNOGiENOG410IF28. Eukaryota.
ENOG410XRS8. LUCA.
GeneTreeiENSGT00760000119025.
HOGENOMiHOG000234353.
HOVERGENiHBG051922.
InParanoidiQ9QUP5.
KOiK06848.
OMAiWRSGLDW.
OrthoDBiEOG7ZWD1D.
PhylomeDBiQ9QUP5.
TreeFamiTF332134.

Miscellaneous databases

PROiQ9QUP5.
SOURCEiSearch...

Gene expression databases

BgeeiQ9QUP5.
CleanExiMM_HAPLN1.
GenevisibleiQ9QUP5. MM.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.100.10. 2 hits.
InterProiIPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR000538. Link_dom.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
PF00193. Xlink. 2 hits.
[Graphical view]
PRINTSiPR01265. LINKMODULE.
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
SM00445. LINK. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF56436. SSF56436. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS01241. LINK_1. 2 hits.
PS50963. LINK_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization and chromosomal location of the mouse link protein gene (Crtl1)."
    Deak F., Mates L., Krysan K., Liu Z., Szabo P.E., Mann J.R., Beier D.R., Kiss I.
    Cytogenet. Cell Genet. 87:75-79(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: 129/Sv.
  2. "Genetic rescue of chondrodysplasia and the perinatal lethal effect of cartilage link protein deficiency."
    Czipri M., Otto J.M., Cs-Szabo G., Kamath R.V., Vermes C., Firneisz G., Kolman K.J., Watanabe H., Li Y., Roughley P.J., Yamada Y., Olsen B.R., Glant T.T.
    J. Biol. Chem. 278:39214-39223(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: BALB/cJ.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo and Embryonic head.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiHPLN1_MOUSE
AccessioniPrimary (citable) accession number: Q9QUP5
Secondary accession number(s): Q9D1G9, Q9Z1X7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: July 6, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.