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Protein

Dickkopf-related protein 3

Gene

Dkk3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Dickkopf-related protein 3
Short name:
Dickkopf-3
Short name:
Dkk-3
Short name:
mDkk-3
Gene namesi
Name:Dkk3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1354952. Dkk3.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: MGI
  • extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22By similarityAdd BLAST22
ChainiPRO_000000722323 – 349Dickkopf-related protein 3Add BLAST327

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi96N-linked (GlcNAc...)Sequence analysis1
Glycosylationi106N-linked (GlcNAc...)Sequence analysis1
Glycosylationi121N-linked (GlcNAc...)Sequence analysis1
Glycosylationi204N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi208 ↔ 220By similarity
Disulfide bondi214 ↔ 231By similarity
Disulfide bondi219 ↔ 265By similarity
Disulfide bondi241 ↔ 273By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9QUN9.
PaxDbiQ9QUN9.
PeptideAtlasiQ9QUN9.
PRIDEiQ9QUN9.

PTM databases

iPTMnetiQ9QUN9.
PhosphoSitePlusiQ9QUN9.

Expressioni

Tissue specificityi

Highest expression in brain, eye and heart.

Gene expression databases

BgeeiENSMUSG00000030772.
CleanExiMM_DKK3.
GenevisibleiQ9QUN9. MM.

Interactioni

Subunit structurei

Interacts with LRP5 and LRP6.By similarity

Protein-protein interaction databases

IntActiQ9QUN9. 1 interactor.
STRINGi10090.ENSMUSP00000033036.

Structurei

3D structure databases

ProteinModelPortaliQ9QUN9.
SMRiQ9QUN9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni147 – 195DKK-type Cys-1Add BLAST49
Regioni208 – 284DKK-type Cys-2Add BLAST77

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili39 – 84Sequence analysisAdd BLAST46

Domaini

The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6.By similarity

Sequence similaritiesi

Belongs to the dickkopf family.Curated

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiKOG1218. Eukaryota.
ENOG410XQWV. LUCA.
GeneTreeiENSGT00390000000221.
HOGENOMiHOG000234342.
HOVERGENiHBG004476.
InParanoidiQ9QUN9.
OMAiSHECIID.
OrthoDBiEOG091G0BUI.
PhylomeDBiQ9QUN9.
TreeFamiTF337340.

Family and domain databases

InterProiIPR006796. Dickkopf_N.
[Graphical view]
PfamiPF04706. Dickkopf_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QUN9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRLGGILLC TLLAAAVPTA PAPSPTVTWT PAEPGPALNY PQEEATLNEM
60 70 80 90 100
FREVEELMED TQHKLRSAVE EMEAEEAAAK TSSEVNLASL PPNYHNETST
110 120 130 140 150
ETRVGNNTVH VHQEVHKITN NQSGQVVFSE TVITSVGDEE GKRSHECIID
160 170 180 190 200
EDCGPTRYCQ FSSFKYTCQP CRDQQMLCTR DSECCGDQLC AWGHCTQKAT
210 220 230 240 250
KGGNGTICDN QRDCQPGLCC AFQRGLLFPV CTPLPVEGEL CHDPTSQLLD
260 270 280 290 300
LITWELEPEG ALDRCPCASG LLCQPHSHSL VYMCKPAFVG SHDHSEESQL
310 320 330 340
PREAPDEYED VGFIGEVRQE LEDLERSLAQ EMAFEGPAPV ESLGGEEEI
Length:349
Mass (Da):38,388
Last modified:May 1, 2000 - v1
Checksum:i564CB3C4FB2EAB88
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243964 mRNA. Translation: CAB60111.1.
AF177400 mRNA. Translation: AAF02680.1.
AK004853 mRNA. Translation: BAB23617.1.
BC046304 mRNA. Translation: AAH46304.1.
BC050934 mRNA. Translation: AAH50934.1.
CCDSiCCDS21752.1.
RefSeqiNP_056629.1. NM_015814.2.
XP_006508076.1. XM_006508013.1.
UniGeneiMm.55143.

Genome annotation databases

EnsembliENSMUST00000033036; ENSMUSP00000033036; ENSMUSG00000030772.
GeneIDi50781.
KEGGimmu:50781.
UCSCiuc009jgi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243964 mRNA. Translation: CAB60111.1.
AF177400 mRNA. Translation: AAF02680.1.
AK004853 mRNA. Translation: BAB23617.1.
BC046304 mRNA. Translation: AAH46304.1.
BC050934 mRNA. Translation: AAH50934.1.
CCDSiCCDS21752.1.
RefSeqiNP_056629.1. NM_015814.2.
XP_006508076.1. XM_006508013.1.
UniGeneiMm.55143.

3D structure databases

ProteinModelPortaliQ9QUN9.
SMRiQ9QUN9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9QUN9. 1 interactor.
STRINGi10090.ENSMUSP00000033036.

PTM databases

iPTMnetiQ9QUN9.
PhosphoSitePlusiQ9QUN9.

Proteomic databases

MaxQBiQ9QUN9.
PaxDbiQ9QUN9.
PeptideAtlasiQ9QUN9.
PRIDEiQ9QUN9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033036; ENSMUSP00000033036; ENSMUSG00000030772.
GeneIDi50781.
KEGGimmu:50781.
UCSCiuc009jgi.1. mouse.

Organism-specific databases

CTDi27122.
MGIiMGI:1354952. Dkk3.

Phylogenomic databases

eggNOGiKOG1218. Eukaryota.
ENOG410XQWV. LUCA.
GeneTreeiENSGT00390000000221.
HOGENOMiHOG000234342.
HOVERGENiHBG004476.
InParanoidiQ9QUN9.
OMAiSHECIID.
OrthoDBiEOG091G0BUI.
PhylomeDBiQ9QUN9.
TreeFamiTF337340.

Miscellaneous databases

PROiQ9QUN9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030772.
CleanExiMM_DKK3.
GenevisibleiQ9QUN9. MM.

Family and domain databases

InterProiIPR006796. Dickkopf_N.
[Graphical view]
PfamiPF04706. Dickkopf_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDKK3_MOUSE
AccessioniPrimary (citable) accession number: Q9QUN9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.