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Protein
Submitted name:

Pancreatic lipase

Gene

Pnlip

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei169 – 1691NucleophileUniRule annotation
Active sitei193 – 1931Charge relay systemUniRule annotation
Active sitei280 – 2801Charge relay systemUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Protein family/group databases

ESTHERiratno-1plip. Pancreatic_lipase.

Names & Taxonomyi

Protein namesi
Submitted name:
Pancreatic lipaseImported
Gene namesi
Name:PnlipImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi3360. Pnlip.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

SecretedSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024065.

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.UniRule annotation

Phylogenomic databases

HOVERGENiHBG003243.

Family and domain databases

Gene3Di2.60.60.20. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR016272. Lipase_LIPH.
IPR008976. Lipase_LipOase.
IPR013818. Lipase_N.
IPR002331. Lipase_panc.
IPR001024. PLAT/LH2_dom.
IPR000734. TAG_lipase.
[Graphical view]
PANTHERiPTHR11610. PTHR11610. 1 hit.
PfamiPF00151. Lipase. 1 hit.
PF01477. PLAT. 1 hit.
[Graphical view]
PIRSFiPIRSF000865. Lipoprotein_lipase_LIPH. 1 hit.
PRINTSiPR00823. PANCLIPASE.
PR00821. TAGLIPASE.
SMARTiSM00308. LH2. 1 hit.
[Graphical view]
SUPFAMiSSF49723. SSF49723. 1 hit.
SSF53474. SSF53474. 1 hit.
PROSITEiPS50095. PLAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9QUN4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLMLWTFAVL LGAVAGKEVC FDKLGCFSDD APWSGTIDRP LKALPWSPAQ
60 70 80 90 100
INTRFLLYTN ENQDNYQKIT SDASSIRNSN FKTNRKTRII IHGFIDKGEE
110 120 130 140 150
NWLSDMCKNM FKVESVNCIC VDWKGGSRAT YTQATQNVRV VGAEVALLVN
160 170 180 190 200
VLKSDLGYSP DNVHLIGHSL GSHVAGEAGK RTFGAIGRIT GLDAAEPYFQ
210 220 230 240 250
GTPEEVRLDP TDAQFVDAIH TDAAPIIPNL GFGMSQTVGH LDFFPNGGME
260 270 280 290 300
MPGCQKNILS QIVDIDGIWE GTRDFAACNH LRSYKYYTDS IVNPTGFSGF
310 320 330 340 350
SCSSYNVFSA NKCFPCGSEG CPQMGHYADK YPGKTKELYQ KFYLNTGDKS
360 370 380 390 400
NFARWRYQVT VTLSGQKVTG HILVSLFGNG GNSKQYEVFK GSLHPGDTHV
410 420 430 440 450
KEFDSDMDVG DLQKVKFIWY NNVINPTLPK VGASRISVER NDGRVFNFCS

Q
Length:451
Mass (Da):49,939
Last modified:May 1, 2000 - v1
Checksum:i65D19706B5D5B732
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei451 – 4511Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88534 mRNA. Translation: BAA13637.1.
D88535 mRNA. Translation: BAA13638.1.
UniGeneiRn.10130.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88534 mRNA. Translation: BAA13637.1.
D88535 mRNA. Translation: BAA13638.1.
UniGeneiRn.10130.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024065.

Protein family/group databases

ESTHERiratno-1plip. Pancreatic_lipase.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

RGDi3360. Pnlip.

Phylogenomic databases

HOVERGENiHBG003243.

Family and domain databases

Gene3Di2.60.60.20. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR016272. Lipase_LIPH.
IPR008976. Lipase_LipOase.
IPR013818. Lipase_N.
IPR002331. Lipase_panc.
IPR001024. PLAT/LH2_dom.
IPR000734. TAG_lipase.
[Graphical view]
PANTHERiPTHR11610. PTHR11610. 1 hit.
PfamiPF00151. Lipase. 1 hit.
PF01477. PLAT. 1 hit.
[Graphical view]
PIRSFiPIRSF000865. Lipoprotein_lipase_LIPH. 1 hit.
PRINTSiPR00823. PANCLIPASE.
PR00821. TAGLIPASE.
SMARTiSM00308. LH2. 1 hit.
[Graphical view]
SUPFAMiSSF49723. SSF49723. 1 hit.
SSF53474. SSF53474. 1 hit.
PROSITEiPS50095. PLAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Direct evidence that alkaline lipase from Rat brain is the same enzyme as pancreatic lipase from Rat Pancreas."
    Tsujita T., Sumida M., Sumiyoshi M., Kameda K., Okuda H.
    Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Wistar-KingImported.
    Tissue: PancreasImported.
  2. Sumida M.
    Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Wistar-KingImported.
  3. "Direct evidence that alkaline lipase from Rat brain is the same enzyme as pancreatic lipase from Rat Pancreas."
    Takahiro T.
    Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Wistar-KingImported.

Entry informationi

Entry nameiQ9QUN4_RAT
AccessioniPrimary (citable) accession number: Q9QUN4
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: June 24, 2015
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.