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Protein

MutS protein homolog 5

Gene

Msh5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in DNA mismatch repair and meiotic recombination processes. Facilitates crossovers between homologs during meiosis (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi591 – 598ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

  • chiasma assembly Source: GO_Central
  • female gamete generation Source: MGI
  • meiosis I Source: MGI
  • mismatch repair Source: GO_Central
  • synapsis Source: MGI

Keywordsi

Molecular functionDNA-binding
Biological processDNA damage, DNA repair, Meiosis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-912497. Meiotic Recombination.

Names & Taxonomyi

Protein namesi
Recommended name:
MutS protein homolog 5
Gene namesi
Name:Msh5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1329021. Msh5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi486D → Y: Mice carrying this mutation show atrophic ovaries without oocytes, but no other visible phenotype. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001152031 – 833MutS protein homolog 5Add BLAST833

Proteomic databases

PaxDbiQ9QUM7.
PRIDEiQ9QUM7.

PTM databases

iPTMnetiQ9QUM7.
PhosphoSitePlusiQ9QUM7.

Expressioni

Gene expression databases

CleanExiMM_MSH5.

Interactioni

Subunit structurei

Heterooligomer of MSH4 and MSH5. Interacts with HJURP (By similarity).By similarity

Protein-protein interaction databases

BioGridi201527. 1 interactor.
IntActiQ9QUM7. 1 interactor.
MINTiMINT-4621768.
STRINGi10090.ENSMUSP00000007250.

Structurei

3D structure databases

ProteinModelPortaliQ9QUM7.
SMRiQ9QUM7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA mismatch repair MutS family.Curated

Phylogenomic databases

eggNOGiKOG0221. Eukaryota.
COG0249. LUCA.
HOGENOMiHOG000006649.
HOVERGENiHBG001449.
InParanoidiQ9QUM7.
KOiK08741.
PhylomeDBiQ9QUM7.
TreeFamiTF314549.

Family and domain databases

Gene3Di3.30.420.110. 1 hit.
InterProiView protein in InterPro
IPR011184. DNA_mismatch_repair_Msh2.
IPR000432. DNA_mismatch_repair_MutS_C.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR036187. DNA_mismatch_repair_MutS_sf.
IPR036678. MutS_con_dom_sf.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
PF00488. MutS_V. 1 hit.
PIRSFiPIRSF005813. MSH2. 1 hit.
SMARTiView protein in SMART
SM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
SUPFAMiSSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00486. DNA_MISMATCH_REPAIR_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9QUM7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFRATPGRT PPGPGPRSGI PSASFPSPQP PMAGPGGIEE EDEEEPAEIH
60 70 80 90 100
LCVLWSSGYL GIAYYDTSDS TIHFMPDAPD HESLKLLQRV LDEINPQSVV
110 120 130 140 150
TSAKQDEAMT RFLGKLASEE HREPKGPEII LLPSVDFGPE ISKQRLLSGN
160 170 180 190 200
YSFISDSMTA TEKILFLSSI IPFDCVLTVR ALGGLLKFLS RRRIGVELED
210 220 230 240 250
YDVGVPILGF KKFVLTHLVS IDQDTYSVLQ IFKSESHPSV YKVASGLKEG
260 270 280 290 300
LSLFGILNRC RCKWGQKLLR LWFTRPTREL RELNSRLDVI QFFLMPQNLD
310 320 330 340 350
MAQMLHRLLS HIKNVPLILK RMKLSHTKVS DWQVLYKTVY SALGLRDACR
360 370 380 390 400
SLPQSIQLFQ DIAQEFSDDL HHIASLIGKV VDFEESLAEN RFTVLPNIDP
410 420 430 440 450
DIDAKKRRLI GLPSFLTEVA QKELENLDSR IPSCSVIYIP LIGFLLSIPR
460 470 480 490 500
LPFMVEASDF EIEGLDFMFL SEDKLHYRSA RTKELDTLLG DLHCEIRDQE
510 520 530 540 550
TLLMYQLQCQ VLARASVLTR VLDLASRLDV LLALASAARD YGYSRPHYSP
560 570 580 590 600
CIHGVRIRNG RHPLMELCAR TFVPNSTDCG GDQGRVKVIT GPNSSGKSIY
610 620 630 640 650
LKQVGLITFM ALVGSFVPAE EAEIGVIDAI FTRIHSCESI SLGLSTFMID
660 670 680 690 700
LNQVAKAVNN ATEHSLVLID EFGKGTNSVD GLALLAAVLR HWLALGPSCP
710 720 730 740 750
HVFVATNFLS LVQLQLLPQG PLVQYLTMET CEDGEDLVFF YQLCQGVASA
760 770 780 790 800
SHASHTAAQA GLPDPLIARG KEVSDLIRSG KPIKATNELL RRNQMENCQA
810 820 830
LVDKFLKLDL EDPTLDLDIF ISQEVLPAAP TIL
Length:833
Mass (Da):92,602
Last modified:May 1, 2000 - v1
Checksum:i73C6634698D991E2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti804K → T (PubMed:11797099).Curated1
Sequence conflicti804K → T (PubMed:14656967).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF146227 mRNA. Translation: AAF07881.1.
AF107352 mRNA. Translation: AAD52102.1.
AF109905 Genomic DNA. Translation: AAC84154.1.
AF397035 Genomic DNA. Translation: AAL14454.1.
AF397036 Genomic DNA. Translation: AAL14462.1.
CCDSiCCDS28674.1.
RefSeqiNP_001139687.1. NM_001146215.2.
NP_038628.2. NM_013600.3.
UniGeneiMm.24192.

Genome annotation databases

GeneIDi17687.
KEGGimmu:17687.
UCSCiuc008cfc.3. mouse.

Similar proteinsi

Entry informationi

Entry nameiMSH5_MOUSE
AccessioniPrimary (citable) accession number: Q9QUM7
Secondary accession number(s): Q9Z1Q6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: May 1, 2000
Last modified: November 22, 2017
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families