Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

MutS protein homolog 5

Gene

Msh5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in meiotic recombination. Facilitate crossovers between homologs during meiosis (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi591 – 5988ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

  • female gamete generation Source: MGI
  • meiosis I Source: MGI
  • mismatch repair Source: InterPro
  • synapsis Source: MGI
Complete GO annotation...

Keywords - Biological processi

Meiosis

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-912497. Meiotic Recombination.

Names & Taxonomyi

Protein namesi
Recommended name:
MutS protein homolog 5
Gene namesi
Name:Msh5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1329021. Msh5.

Subcellular locationi

GO - Cellular componenti

  • nucleoplasm Source: Reactome
  • synaptonemal complex Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 833833MutS protein homolog 5PRO_0000115203Add
BLAST

Proteomic databases

PaxDbiQ9QUM7.
PRIDEiQ9QUM7.

PTM databases

PhosphoSiteiQ9QUM7.

Expressioni

Gene expression databases

BgeeiQ9QUM7.
CleanExiMM_MSH5.

Interactioni

Subunit structurei

Heterooligomer of MSH4 and MSH5. Interacts with HJURP (By similarity).By similarity

Protein-protein interaction databases

BioGridi201527. 1 interaction.
IntActiQ9QUM7. 1 interaction.
MINTiMINT-4621768.
STRINGi10090.ENSMUSP00000007250.

Structurei

3D structure databases

ProteinModelPortaliQ9QUM7.
SMRiQ9QUM7. Positions 180-771.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA mismatch repair MutS family.Curated

Phylogenomic databases

eggNOGiKOG0221. Eukaryota.
COG0249. LUCA.
HOGENOMiHOG000006649.
HOVERGENiHBG001449.
InParanoidiQ9QUM7.
KOiK08741.
OrthoDBiEOG74XS60.
PhylomeDBiQ9QUM7.
TreeFamiTF314549.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR011184. DNA_mismatch_repair_MutS.
IPR000432. DNA_mismatch_repair_MutS_C.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
PF00488. MutS_V. 1 hit.
[Graphical view]
PIRSFiPIRSF005813. MSH2. 1 hit.
SMARTiSM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view]
SUPFAMiSSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QUM7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFRATPGRT PPGPGPRSGI PSASFPSPQP PMAGPGGIEE EDEEEPAEIH
60 70 80 90 100
LCVLWSSGYL GIAYYDTSDS TIHFMPDAPD HESLKLLQRV LDEINPQSVV
110 120 130 140 150
TSAKQDEAMT RFLGKLASEE HREPKGPEII LLPSVDFGPE ISKQRLLSGN
160 170 180 190 200
YSFISDSMTA TEKILFLSSI IPFDCVLTVR ALGGLLKFLS RRRIGVELED
210 220 230 240 250
YDVGVPILGF KKFVLTHLVS IDQDTYSVLQ IFKSESHPSV YKVASGLKEG
260 270 280 290 300
LSLFGILNRC RCKWGQKLLR LWFTRPTREL RELNSRLDVI QFFLMPQNLD
310 320 330 340 350
MAQMLHRLLS HIKNVPLILK RMKLSHTKVS DWQVLYKTVY SALGLRDACR
360 370 380 390 400
SLPQSIQLFQ DIAQEFSDDL HHIASLIGKV VDFEESLAEN RFTVLPNIDP
410 420 430 440 450
DIDAKKRRLI GLPSFLTEVA QKELENLDSR IPSCSVIYIP LIGFLLSIPR
460 470 480 490 500
LPFMVEASDF EIEGLDFMFL SEDKLHYRSA RTKELDTLLG DLHCEIRDQE
510 520 530 540 550
TLLMYQLQCQ VLARASVLTR VLDLASRLDV LLALASAARD YGYSRPHYSP
560 570 580 590 600
CIHGVRIRNG RHPLMELCAR TFVPNSTDCG GDQGRVKVIT GPNSSGKSIY
610 620 630 640 650
LKQVGLITFM ALVGSFVPAE EAEIGVIDAI FTRIHSCESI SLGLSTFMID
660 670 680 690 700
LNQVAKAVNN ATEHSLVLID EFGKGTNSVD GLALLAAVLR HWLALGPSCP
710 720 730 740 750
HVFVATNFLS LVQLQLLPQG PLVQYLTMET CEDGEDLVFF YQLCQGVASA
760 770 780 790 800
SHASHTAAQA GLPDPLIARG KEVSDLIRSG KPIKATNELL RRNQMENCQA
810 820 830
LVDKFLKLDL EDPTLDLDIF ISQEVLPAAP TIL
Length:833
Mass (Da):92,602
Last modified:May 1, 2000 - v1
Checksum:i73C6634698D991E2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti804 – 8041K → T (PubMed:11797099).Curated
Sequence conflicti804 – 8041K → T (PubMed:14656967).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF146227 mRNA. Translation: AAF07881.1.
AF107352 mRNA. Translation: AAD52102.1.
AF109905 Genomic DNA. Translation: AAC84154.1.
AF397035 Genomic DNA. Translation: AAL14454.1.
AF397036 Genomic DNA. Translation: AAL14462.1.
CCDSiCCDS28674.1.
RefSeqiNP_001139687.1. NM_001146215.2.
NP_038628.2. NM_013600.3.
UniGeneiMm.24192.

Genome annotation databases

GeneIDi17687.
KEGGimmu:17687.
UCSCiuc008cfc.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF146227 mRNA. Translation: AAF07881.1.
AF107352 mRNA. Translation: AAD52102.1.
AF109905 Genomic DNA. Translation: AAC84154.1.
AF397035 Genomic DNA. Translation: AAL14454.1.
AF397036 Genomic DNA. Translation: AAL14462.1.
CCDSiCCDS28674.1.
RefSeqiNP_001139687.1. NM_001146215.2.
NP_038628.2. NM_013600.3.
UniGeneiMm.24192.

3D structure databases

ProteinModelPortaliQ9QUM7.
SMRiQ9QUM7. Positions 180-771.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201527. 1 interaction.
IntActiQ9QUM7. 1 interaction.
MINTiMINT-4621768.
STRINGi10090.ENSMUSP00000007250.

PTM databases

PhosphoSiteiQ9QUM7.

Proteomic databases

PaxDbiQ9QUM7.
PRIDEiQ9QUM7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi17687.
KEGGimmu:17687.
UCSCiuc008cfc.3. mouse.

Organism-specific databases

CTDi4439.
MGIiMGI:1329021. Msh5.

Phylogenomic databases

eggNOGiKOG0221. Eukaryota.
COG0249. LUCA.
HOGENOMiHOG000006649.
HOVERGENiHBG001449.
InParanoidiQ9QUM7.
KOiK08741.
OrthoDBiEOG74XS60.
PhylomeDBiQ9QUM7.
TreeFamiTF314549.

Enzyme and pathway databases

ReactomeiR-MMU-912497. Meiotic Recombination.

Miscellaneous databases

NextBioi292260.
PROiQ9QUM7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9QUM7.
CleanExiMM_MSH5.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR011184. DNA_mismatch_repair_MutS.
IPR000432. DNA_mismatch_repair_MutS_C.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
PF00488. MutS_V. 1 hit.
[Graphical view]
PIRSFiPIRSF005813. MSH2. 1 hit.
SMARTiSM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view]
SUPFAMiSSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of the mouse MutS homolog 5: Msh5."
    Her C., Wu X., Wan W., Doggett N.A.
    Mamm. Genome 10:1054-1061(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cJ.
    Tissue: Testis.
  2. "Mammalian MutS homologue 5 is required for chromosome pairing in meiosis."
    Edelmann W., Cohen P.E., Kneitz B., Winand N., Lia M., Heyer J., Kolodner R., Pollard J.W., Kucherlapati R.
    Nat. Genet. 21:123-127(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 129/Ola.
  3. "Genotype versus phenotype: conflicting results in mapping a lung tumor susceptibility locus to the G7c recombination interval in the mouse MHC class III region."
    van Kooij M., de Groot K., van Vugt H., Aten J., Snoek M.
    Immunogenetics 53:656-661(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: B10.A.
  4. "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
    Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
    Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 129.

Entry informationi

Entry nameiMSH5_MOUSE
AccessioniPrimary (citable) accession number: Q9QUM7
Secondary accession number(s): Q9Z1Q6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: May 1, 2000
Last modified: May 11, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.