UniProtKB - Q9QUM5 (Q9QUM5_MOUSE)
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Protein
Submitted name:
Basic-helix-loop-helix protein (BHLH)
Gene
Hey1
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- DNA binding transcription factor activity Source: Ensembl
- microsatellite binding Source: Ensembl
- protein dimerization activity Source: InterPro
- transcription factor activity, transcription factor binding Source: Ensembl
GO - Biological processi
- angiogenesis Source: Ensembl
- negative regulation of Notch signaling pathway Source: Ensembl
- negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation Source: Ensembl
- negative regulation of transcription regulatory region DNA binding Source: Ensembl
- Notch signaling pathway Source: Ensembl
- transcription, DNA-templated Source: UniProtKB-UniRule
Keywordsi
Biological process | Transcription, Transcription regulationPROSITE-ProRule annotationSAAS annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Basic-helix-loop-helix protein (BHLH)ImportedSubmitted name: Brain cDNA, clone MNCb-2686, similar to Mus musculus hairy/enhancer-of-split related with YRPW motif1(Hey1), mRNAImportedSubmitted name: Cardiovascular helix-loop-helix factor 2ImportedSubmitted name: HES-related repressor protein 2 HERP2ImportedSubmitted name: Hairy-related transcription factor 1ImportedSubmitted name: Hairy/enhancer-of-split related with YRPW motif 1ImportedSubmitted name: Hairy/enhancer-of-split related with YRPW motif 1, isoform CRA_aImportedSubmitted name: Hairy/enhancer-of-split-related with YRPW motif protein 1Imported |
Gene namesi | ORF Names:mCG_10136Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1341800. Hey1. |
Subcellular locationi
Keywords - Cellular componenti
NucleusPROSITE-ProRule annotationSAAS annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 49 – 104 | BHLHInterPro annotationAdd BLAST | 56 | |
Domaini | 122 – 158 | OrangeInterPro annotationAdd BLAST | 37 |
Phylogenomic databases
eggNOGi | KOG4304. Eukaryota. ENOG4111F0X. LUCA. |
GeneTreei | ENSGT00700000104130. |
HOVERGENi | HBG003275. |
KOi | K09091. |
OMAi | HPHVAHP. |
OrthoDBi | EOG091G0HWC. |
TreeFami | TF323617. |
Family and domain databases
CDDi | cd00083. HLH. 1 hit. |
Gene3Di | 4.10.280.10. 1 hit. |
InterProi | View protein in InterPro IPR011598. bHLH_dom. IPR036638. HLH_DNA-bd_sf. IPR003650. Orange_dom. |
Pfami | View protein in Pfam PF07527. Hairy_orange. 1 hit. PF00010. HLH. 1 hit. |
SMARTi | View protein in SMART SM00353. HLH. 1 hit. SM00511. ORANGE. 1 hit. |
SUPFAMi | SSF47459. SSF47459. 1 hit. |
PROSITEi | View protein in PROSITE PS50888. BHLH. 1 hit. PS51054. ORANGE. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q9QUM5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKRAHPDYSS SDSELDETIE VEKESADENG NLSSALCSMS PTTSSQVLAR
60 70 80 90 100
KRRRGIIEKR RRDRINNSLS ELRRLVPSAF EKQGSAKLEK AEILQMTVDH
110 120 130 140 150
LKMLHTAGGK GYFDAHALAM DYRSLGFREC LAEVARYLSI IEGLDASDPL
160 170 180 190 200
RVRLVSHLNN YASQREAASG AHGGLGHIPW GSAFGHHPHI AHPLLLPQNG
210 220 230 240 250
HGNAGTAASP TEPHHQGRLA SAHPEAPALR APPSGGLGPV LPVVTSASKL
260 270 280 290
SPPLLSSVAS LSAFPFSFSS FHLLSPSTPT QAANLGKPYR PWGTEIGAF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC132225 Genomic DNA. No translation available. AF176423 mRNA. Translation: AAD51750.1. AF172286 mRNA. Translation: AAF14545.1. AF232241 mRNA. Translation: AAF37299.1. BC086635 mRNA. Translation: AAH86635.1. AB041590 mRNA. Translation: BAA95073.1. AK140212 mRNA. Translation: BAE24283.1. AJ243895 mRNA. Translation: CAB51321.1. CH466577 Genomic DNA. Translation: EDL05197.1. |
RefSeqi | NP_034553.2. NM_010423.2. |
UniGenei | Mm.29581. |
Genome annotation databases
Ensembli | ENSMUST00000042412; ENSMUSP00000038014; ENSMUSG00000040289. |
GeneIDi | 15213. |
KEGGi | mmu:15213. |
UCSCi | uc008oop.1. mouse. |
Similar proteinsi
Entry informationi
Entry namei | Q9QUM5_MOUSE | |
Accessioni | Q9QUM5Primary (citable) accession number: Q9QUM5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 1, 2000 |
Last sequence update: | May 1, 2000 | |
Last modified: | March 28, 2018 | |
This is version 144 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |