Hey1

Functionⁱ

GO - Molecular functionⁱ

DNA binding transcription factor activity Source: Ensembl
microsatellite binding Source: Ensembl
protein dimerization activity Source: InterPro
transcription factor activity, transcription factor binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

angiogenesis Source: Ensembl
cellular response to glucocorticoid stimulus Source: Ensembl
negative regulation of Notch signaling pathway Source: Ensembl
negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation Source: Ensembl
negative regulation of transcription regulatory region DNA binding Source: Ensembl
Notch signaling pathway Source: Ensembl
transcription, DNA-templated Source: UniProtKB-UniRule

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Transcription, Transcription regulationPROSITE-ProRule annotationSAAS annotation

Biological process

Transcription, Transcription regulationPROSITE-ProRule annotationSAAS annotation

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Basic-helix-loop-helix protein (BHLH)Imported Submitted name: Brain cDNA, clone MNCb-2686, similar to Mus musculus hairy/enhancer-of-split related with YRPW motif1(Hey1), mRNAImported Submitted name: Cardiovascular helix-loop-helix factor 2Imported Submitted name: HES-related repressor protein 2 HERP2Imported Submitted name: Hairy-related transcription factor 1Imported Submitted name: Hairy/enhancer-of-split related with YRPW motif 1, isoform CRA_aImported Submitted name: Hairy/enhancer-of-split-related with YRPW motif protein 1Imported
Gene namesⁱ	Name:Hey1Imported Synonyms:Hrt1Imported ORF Names:mCG_10136Imported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 3

Organism-specific databases

MGIⁱ	MGI:1341800 Hey1

Keywords - Cellular componentⁱ

NucleusPROSITE-ProRule annotationSAAS annotation

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000040289

Bgeeⁱ

ENSMUSG00000040289

Interactionⁱ

GO - Molecular functionⁱ

protein dimerization activity Source: InterPro

View the complete GO annotation on QuickGO ...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	49 – 104	BHLHInterPro annotationAdd BLAST		56
Domainⁱ	122 – 158	OrangeInterPro annotationAdd BLAST		37

Phylogenomic databases

eggNOGⁱ	KOG4304 Eukaryota ENOG4111F0X LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00700000104130
HOVERGENⁱ	HBG003275
KEGG Orthology (KO) More...KOⁱ	K09091
OMAⁱ	HPHVAHP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0HWC
TreeFamⁱ	TF323617

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR003650 Orange_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07527 Hairy_orange, 1 hit PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit SM00511 ORANGE, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit PS51054 ORANGE, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9QUM5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKRAHPDYSS SDSELDETIE VEKESADENG NLSSALCSMS PTTSSQVLAR 
        60         70         80         90        100
KRRRGIIEKR RRDRINNSLS ELRRLVPSAF EKQGSAKLEK AEILQMTVDH 
       110        120        130        140        150
LKMLHTAGGK GYFDAHALAM DYRSLGFREC LAEVARYLSI IEGLDASDPL 
       160        170        180        190        200
RVRLVSHLNN YASQREAASG AHGGLGHIPW GSAFGHHPHI AHPLLLPQNG 
       210        220        230        240        250
HGNAGTAASP TEPHHQGRLA SAHPEAPALR APPSGGLGPV LPVVTSASKL 
       260        270        280        290 
SPPLLSSVAS LSAFPFSFSS FHLLSPSTPT QAANLGKPYR PWGTEIGAF

Length:299

Mass (Da):32,106

Last modified:May 1, 2000 - v1

Checksum:ⁱ77110233BC98A1AE

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC132225 Genomic DNA No translation available. AF176423 mRNA Translation: AAD51750.1 AF172286 mRNA Translation: AAF14545.1 AF232241 mRNA Translation: AAF37299.1 BC086635 mRNA Translation: AAH86635.1 AB041590 mRNA Translation: BAA95073.1 AK140212 mRNA Translation: BAE24283.1 AJ243895 mRNA Translation: CAB51321.1 CH466577 Genomic DNA Translation: EDL05197.1
NCBI Reference Sequences More...RefSeqⁱ	NP_034553.2, NM_010423.2
UniGeneⁱ	Mm.29581

Genome annotation databases

Ensemblⁱ	ENSMUST00000042412; ENSMUSP00000038014; ENSMUSG00000040289
GeneIDⁱ	15213
KEGGⁱ	mmu:15213
UCSC genome browser More...UCSCⁱ	uc008oop.1 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q9QUM5	Hairy/enhancer-of-split related with YRPW motif protein 1		MOUSE		299
Hairy/enhancer-of-split related with YRPW motif protein 2		CRIGR		299
Uncharacterized protein		NEOLE		299
UPI00029D76BB		SHEEP		299
UPI00038BFEE1		MICOH		299
+32

Protein	Similar proteins		Species	Score	Length
Q9QUM5	Hairy/enhancer-of-split related with YRPW motif protein 2		MOUSE		339
Uncharacterized protein		NEOLE		368
UPI000787B3D2		ROUAE		347
UPI00046BD572		EPTFU		343
Hes related family bHLH transcription factor with YRPW motif 2		MONDO		341
+223

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC132225 Genomic DNA No translation available. AF176423 mRNA Translation: AAD51750.1 AF172286 mRNA Translation: AAF14545.1 AF232241 mRNA Translation: AAF37299.1 BC086635 mRNA Translation: AAH86635.1 AB041590 mRNA Translation: BAA95073.1 AK140212 mRNA Translation: BAE24283.1 AJ243895 mRNA Translation: CAB51321.1 CH466577 Genomic DNA Translation: EDL05197.1
NCBI Reference Sequences More...RefSeqⁱ	NP_034553.2, NM_010423.2
UniGeneⁱ	Mm.29581

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000042412; ENSMUSP00000038014; ENSMUSG00000040289
GeneIDⁱ	15213
KEGGⁱ	mmu:15213
UCSC genome browser More...UCSCⁱ	uc008oop.1 mouse

Organism-specific databases

CTDⁱ	23462
MGIⁱ	MGI:1341800 Hey1

Phylogenomic databases

eggNOGⁱ	KOG4304 Eukaryota ENOG4111F0X LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00700000104130
HOVERGENⁱ	HBG003275
KEGG Orthology (KO) More...KOⁱ	K09091
OMAⁱ	HPHVAHP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0HWC
TreeFamⁱ	TF323617

Miscellaneous databases

SOURCEⁱ	Search...

SOURCEⁱ

Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000040289

Bgeeⁱ

ENSMUSG00000040289

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR003650 Orange_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07527 Hairy_orange, 1 hit PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit SM00511 ORANGE, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit PS51054 ORANGE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q9QUM5_MOUSE
Accessionⁱ	Q9QUM5Primary (citable) accession number: Q9QUM5
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	May 1, 2000
	Last sequence update:	May 1, 2000
	Last modified:	June 20, 2018
	This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9QUM5 (Q9QUM5_MOUSE)

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Basic-helix-loop-helix protein (BHLH)

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ