Hey1

Functionⁱ

GO - Molecular functionⁱ

microsatellite binding Source: Ensembl
protein dimerization activity Source: InterPro
transcription factor activity, protein binding Source: Ensembl
transcription factor activity, sequence-specific DNA binding Source: Ensembl

Complete GO annotation...

GO - Biological processⁱ

angiogenesis Source: Ensembl
cellular response to glucocorticoid stimulus Source: Ensembl
negative regulation of Notch signaling pathway Source: Ensembl
negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation Source: Ensembl
negative regulation of transcription regulatory region DNA binding Source: Ensembl
Notch signaling pathway Source: Ensembl
transcription, DNA-templated Source: UniProtKB-UniRule

Complete GO annotation...

Keywordsⁱ

Biological process	Transcription, Transcription regulationPROSITE-ProRule annotationSAAS annotation

Biological process

Transcription, Transcription regulationPROSITE-ProRule annotationSAAS annotation

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Basic-helix-loop-helix protein (BHLH)Imported Submitted name: Brain cDNA, clone MNCb-2686, similar to Mus musculus hairy/enhancer-of-split related with YRPW motif1(Hey1), mRNAImported Submitted name: Cardiovascular helix-loop-helix factor 2Imported Submitted name: HES-related repressor protein 2 HERP2Imported Submitted name: Hairy-related transcription factor 1Imported Submitted name: Hairy/enhancer-of-split related with YRPW motif 1Imported Submitted name: Hairy/enhancer-of-split related with YRPW motif 1, isoform CRA_aImported Submitted name: Hairy/enhancer-of-split-related with YRPW motif protein 1Imported
Gene namesⁱ	Name:Hey1Imported Synonyms:Hrt1Imported ORF Names:mCG_10136Imported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 3

Organism-specific databases

MGIⁱ	MGI:1341800. Hey1.

Subcellular locationⁱ

Nucleus
PROSITE-ProRule annotation
Automatic assertion according to rulesⁱ
- PROSITE-ProRule:PRU00380
SAAS annotation
Automatic assertion according to rulesⁱ
- SAAS:SAAS00812946

GO - Cellular componentⁱ

nucleus Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

NucleusPROSITE-ProRule annotationSAAS annotation

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000040289.

Bgeeⁱ

ENSMUSG00000040289.

Interactionⁱ

GO - Molecular functionⁱ

protein dimerization activity Source: InterPro

Complete GO annotation...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	49 – 104	BHLH (basic helix-loop-helix)InterPro annotationAdd BLAST		56
Domainⁱ	122 – 158	OrangeInterPro annotationAdd BLAST		37

Phylogenomic databases

eggNOGⁱ	KOG4304. Eukaryota. ENOG4111F0X. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00700000104130.
HOVERGENⁱ	HBG003275.
KEGG Orthology (KO) More...KOⁱ	K09091.
OMAⁱ	HPHVAHP.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0HWC.
TreeFamⁱ	TF323617.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083. HLH. 1 hit.
Gene3Dⁱ	4.10.280.10. 1 hit.
InterProⁱ	View protein in InterPro IPR011598. bHLH_dom. IPR003650. Orange_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07527. Hairy_orange. 1 hit. PF00010. HLH. 1 hit.
SMARTⁱ	View protein in SMART SM00353. HLH. 1 hit. SM00511. ORANGE. 1 hit.
SUPFAMⁱ	SSF47459. SSF47459. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50888. BHLH. 1 hit. PS51054. ORANGE. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9QUM5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKRAHPDYSS SDSELDETIE VEKESADENG NLSSALCSMS PTTSSQVLAR 
        60         70         80         90        100
KRRRGIIEKR RRDRINNSLS ELRRLVPSAF EKQGSAKLEK AEILQMTVDH 
       110        120        130        140        150
LKMLHTAGGK GYFDAHALAM DYRSLGFREC LAEVARYLSI IEGLDASDPL 
       160        170        180        190        200
RVRLVSHLNN YASQREAASG AHGGLGHIPW GSAFGHHPHI AHPLLLPQNG 
       210        220        230        240        250
HGNAGTAASP TEPHHQGRLA SAHPEAPALR APPSGGLGPV LPVVTSASKL 
       260        270        280        290 
SPPLLSSVAS LSAFPFSFSS FHLLSPSTPT QAANLGKPYR PWGTEIGAF

Length:299

Mass (Da):32,106

Last modified:May 1, 2000 - v1

Checksum:ⁱ77110233BC98A1AE

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC132225 Genomic DNA. No translation available. AF176423 mRNA. Translation: AAD51750.1. AF172286 mRNA. Translation: AAF14545.1. AF232241 mRNA. Translation: AAF37299.1. BC086635 mRNA. Translation: AAH86635.1. AB041590 mRNA. Translation: BAA95073.1. AK140212 mRNA. Translation: BAE24283.1. AJ243895 mRNA. Translation: CAB51321.1. CH466577 Genomic DNA. Translation: EDL05197.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_034553.2. NM_010423.2.
UniGeneⁱ	Mm.29581.

Genome annotation databases

Ensemblⁱ	ENSMUST00000042412; ENSMUSP00000038014; ENSMUSG00000040289.
GeneIDⁱ	15213.
KEGGⁱ	mmu:15213.
UCSC genome browser More...UCSCⁱ	uc008oop.1. mouse.

Similar proteinsⁱ

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q9QUM5	Q2KIN4 F6PYF0 H9F179 D2HYE8 G3R3A1 H2QWB8 Q9Y5J3-2 A0A1U7TWS4 L8IGV6 G5BAJ7 +126	Bos taurus (Bovine) Callithrix jacchus (White-tufted-ear marmoset) Macaca mulatta (Rhesus macaque) Ailuropoda melanoleuca (Giant panda) Gorilla gorilla gorilla (Western lowland gorilla) Pan troglodytes (Chimpanzee) Tarsius syrichta (Philippine tarsier) Bos mutus (wild yak) Heterocephalus glaber (Naked mole rat) Sus scrofa (Pig) And more	304	UniRef90_Q2KIN4	Cluster: Hairy/enhancer-of-split related with YRPW motif protein 1	137

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q9QUM5	Q9QUS4 Q0VGJ1 A0A1A6HD66 UPI000787B3D2 UPI00046BD572 F7FUU4 G3WVG0 UPI000A2833F4 UPI000A28ACAD UPI000B4EA07D +294	Mus musculus (Mouse) Neotoma lepida (Desert woodrat) Rousettus aegyptiacus (Egyptian rousette) (Egyptian fruit bat) Eptesicus fuscus (Big brown bat) (Vespertilio fuscus) Monodelphis domestica (Gray short-tailed opossum) Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius) Phascolarctos cinereus (Koala) Meriones unguiculatus (Mongolian jird) (Mongolian gerbil) Mus pahari (Gairdner's shrew-mouse) (Coelomys pahari) Sorex araneus (Eurasian common shrew) (European shrew) And more	339	UniRef50_Q9QUS4	Cluster: Hairy/enhancer-of-split related with YRPW motif protein 2	305

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC132225 Genomic DNA. No translation available. AF176423 mRNA. Translation: AAD51750.1. AF172286 mRNA. Translation: AAF14545.1. AF232241 mRNA. Translation: AAF37299.1. BC086635 mRNA. Translation: AAH86635.1. AB041590 mRNA. Translation: BAA95073.1. AK140212 mRNA. Translation: BAE24283.1. AJ243895 mRNA. Translation: CAB51321.1. CH466577 Genomic DNA. Translation: EDL05197.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_034553.2. NM_010423.2.
UniGeneⁱ	Mm.29581.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000042412; ENSMUSP00000038014; ENSMUSG00000040289.
GeneIDⁱ	15213.
KEGGⁱ	mmu:15213.
UCSC genome browser More...UCSCⁱ	uc008oop.1. mouse.

Organism-specific databases

CTDⁱ	23462.
MGIⁱ	MGI:1341800. Hey1.

Phylogenomic databases

eggNOGⁱ	KOG4304. Eukaryota. ENOG4111F0X. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00700000104130.
HOVERGENⁱ	HBG003275.
KEGG Orthology (KO) More...KOⁱ	K09091.
OMAⁱ	HPHVAHP.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0HWC.
TreeFamⁱ	TF323617.

Miscellaneous databases

SOURCEⁱ	Search...

SOURCEⁱ

Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000040289.

Bgeeⁱ

ENSMUSG00000040289.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083. HLH. 1 hit.
Gene3Dⁱ	4.10.280.10. 1 hit.
InterProⁱ	View protein in InterPro IPR011598. bHLH_dom. IPR003650. Orange_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07527. Hairy_orange. 1 hit. PF00010. HLH. 1 hit.
SMARTⁱ	View protein in SMART SM00353. HLH. 1 hit. SM00511. ORANGE. 1 hit.
SUPFAMⁱ	SSF47459. SSF47459. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50888. BHLH. 1 hit. PS51054. ORANGE. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q9QUM5_MOUSE
Accessionⁱ	Q9QUM5Primary (citable) accession number: Q9QUM5
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	May 1, 2000
	Last sequence update:	May 1, 2000
	Last modified:	August 30, 2017
	This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB - Q9QUM5 (Q9QUM5_MOUSE)

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Basic-helix-loop-helix protein (BHLH)

Select a section on the left to see content.

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Organism-specific databases

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

Expressionⁱ

Gene expression databases

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9QUM5 (Q9QUM5_MOUSE)

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Basic-helix-loop-helix protein (BHLH)

Hey1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ