Q9QUM5 (Q9QUM5_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Basic-helix-loop-helix protein (BHLH) EMBL CAB51321.1

Submitted name:
Brain cDNA, clone MNCb-2686, similar to Mus musculus hairy/enhancer-of-split related with YRPW motif1(Hey1), mRNA EMBL BAA95073.1
Submitted name:
Cardiovascular helix-loop-helix factor 2 EMBL AAD51750.1
Submitted name:
HES-related repressor protein 2 HERP2 EMBL AAF37299.1
Submitted name:
Hairy-related transcription factor 1 EMBL AAF14545.1
Submitted name:
Hairy/enhancer-of-split related with YRPW motif 1 EMBL AAH86635.1
Submitted name:
Hairy/enhancer-of-split related with YRPW motif 1, isoform CRA_a EMBL EDL05197.1
Submitted name:
Hairy/enhancer-of-split-related with YRPW motif protein 1 Ensembl ENSMUSP00000038014

Gene names

Name:	Hey1 MGI 1341800 EMBL CAB51321.1 Ensembl ENSMUSP00000038014
Synonyms:	Hrt1 EMBL AAF14545.1
ORF Names:	mCG_10136 EMBL EDL05197.1

Organism

Mus musculus (Mouse) [Reference proteome] EMBL CAB51321.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	299 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Nucleus By similarity SAAS SAAS003650.
Sequence similarities	Contains 1 basic helix-loop-helix (bHLH) domain. RuleBase RU000367 Contains Orange domain. SAAS SAAS003650 Contains bHLH (basic helix-loop-helix) domain. SAAS SAAS003650

Ontologies

Keywords
Biological process	Transcription Transcription regulation SAAS SAAS003650
Cellular component	Nucleus SAAS SAAS003650
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Notch signaling pathway Inferred from electronic annotation. Source: Ensembl angiogenesis Inferred from electronic annotation. Source: Ensembl anterior/posterior axis specification Inferred from genetic interaction PubMed 15680351. Source: MGI artery development Inferred from genetic interaction PubMed 15680351. Source: MGI cellular response to glucocorticoid stimulus Inferred from electronic annotation. Source: Ensembl endocardial cushion to mesenchymal transition involved in heart valve formation Inferred from genetic interaction PubMed 15680351. Source: MGI epithelial to mesenchymal transition involved in endocardial cushion formation Inferred from genetic interaction PubMed 17303760. Source: MGI negative regulation of Notch signaling pathway Inferred from electronic annotation. Source: Ensembl negative regulation of gene expression Inferred from mutant phenotype PubMed 22615585. Source: MGI negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation Inferred from electronic annotation. Source: Ensembl negative regulation of transcription regulatory region DNA binding Inferred from electronic annotation. Source: Ensembl osteoblast development Inferred from genetic interaction PubMed 18986983. Source: MGI positive regulation of osteoblast differentiation Inferred from genetic interaction PubMed 18986983. Source: MGI transcription, DNA-templated Inferred from electronic annotation. Source: UniProtKB-KW vasculogenesis Inferred from genetic interaction PubMed 15107403. Source: MGI ventricular trabecula myocardium morphogenesis Inferred from genetic interaction PubMed 15680351. Source: MGI
Cellular_component	nucleus Inferred from direct assay Ref.8. Source: MGI
Molecular_function	microsatellite binding Inferred from electronic annotation. Source: Ensembl protein binding transcription factor activity Inferred from electronic annotation. Source: Ensembl sequence-specific DNA binding Inferred from direct assay PubMed 22615585. Source: MGI sequence-specific DNA binding transcription factor activity Inferred from sequence or structural similarity PubMed 10860664. Source: MGI
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9QUM5 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 77110233BC98A1AE	FASTA	299	32,106
	10 20 30 40 50 60 MKRAHPDYSS SDSELDETIE VEKESADENG NLSSALCSMS PTTSSQVLAR KRRRGIIEKR 70 80 90 100 110 120 RRDRINNSLS ELRRLVPSAF EKQGSAKLEK AEILQMTVDH LKMLHTAGGK GYFDAHALAM 130 140 150 160 170 180 DYRSLGFREC LAEVARYLSI IEGLDASDPL RVRLVSHLNN YASQREAASG AHGGLGHIPW 190 200 210 220 230 240 GSAFGHHPHI AHPLLLPQNG HGNAGTAASP TEPHHQGRLA SAHPEAPALR APPSGGLGPV 250 260 270 280 290 LPVVTSASKL SPPLLSSVAS LSAFPFSFSS FHLLSPSTPT QAANLGKPYR PWGTEIGAF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"HRT1, HRT2 and HRT3: a new subclass of bHLH transcription factors marking specific cardiac, somitic and pharyngeal arch segments." Nakagawa O., Nakagawa M., Richardson J.A., Olson E.N., Srivastava D. Dev. Biol. 216:72-84(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Hey genes: a novel subfamily of hairy- and enhancer of split related genes specifically expressed during mouse embryogenesis." Leimeister C., Externbrinck A., Klamt B., Gessler M. Mech. Dev. 85:173-177(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[3]	"High-efficiency full-length cDNA cloning." Carninci P., Hayashizaki Y. Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE24283.1. Tissue: Corpora quadrigemina EMBL BAE24283.1.
[4]	"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes." Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y. Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE24283.1. Tissue: Corpora quadrigemina EMBL BAE24283.1.
[5]	"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer." Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y. Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE24283.1. Tissue: Corpora quadrigemina EMBL BAE24283.1.
[6]	"Cardiovascular basic helix loop helix factor 1, a novel transcriptional repressor expressed preferentially in the developing and adult cardiovascular system." Chin M.T., Maemura K., Fukumoto S., Jain M.K., Layne M.D., Watanabe M., Hsieh C.-M., Lee M.-E. J. Biol. Chem. 275:6381-6387(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[7]	"isolation of full-length cDNA clones from mouse brain cDNA library made by oligo-capping method." Osada N., Kusuda J., Tanuma R., Ito A., Hirata M., Sugano S., Hashimoto K. Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL EMBL BAA95073.1.
[8]	"HERP, a new primary target of Notch regulated by ligand binding." Iso T., Sartorelli V., Chung G., Shichinohe T., Kedes L., Hamamori Y. Mol. Cell. Biol. 21:6071-6079(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[9]	"Functional annotation of a full-length mouse cDNA collection." The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium Nature 409:685-690(2001) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE24283.1. Tissue: Corpora quadrigemina EMBL BAE24283.1.
[10]	"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs." The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team Nature 420:563-573(2002) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE24283.1. Tissue: Corpora quadrigemina EMBL BAE24283.1.
[11]	"A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome." Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W. , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D. Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Mixed EMBL EDL05197.1.
[12]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J. Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6 EMBL AAH86635.1. Tissue: Brain EMBL AAH86635.1.
[13]	Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H. , Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y. Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE24283.1. Tissue: Corpora quadrigemina EMBL BAE24283.1.
[14]	"The Transcriptional Landscape of the Mammalian Genome." The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) Science 309:1559-1563(2005) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE24283.1. Tissue: Corpora quadrigemina EMBL BAE24283.1.
[15]	"Antisense Transcription in the Mammalian Transcriptome." RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE24283.1. Tissue: Corpora quadrigemina EMBL BAE24283.1.
[16]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Mixed EMBL EDL05197.1.
[17]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J Ensembl ENSMUSP00000038014.
[18]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION. Strain: C57BL/6J Ensembl ENSMUSP00000038014.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC132225 Genomic DNA. No translation available. AF176423 mRNA. Translation: AAD51750.1. AF172286 mRNA. Translation: AAF14545.1. AF232241 mRNA. Translation: AAF37299.1. BC086635 mRNA. Translation: AAH86635.1. AB041590 mRNA. Translation: BAA95073.1. AK140212 mRNA. Translation: BAE24283.1. AJ243895 mRNA. Translation: CAB51321.1. CH466577 Genomic DNA. Translation: EDL05197.1.
RefSeq	NP_034553.2. NM_010423.2.
UniGene	Mm.29581.
3D structure databases
ModBase	Search...
MobiDB	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000038014.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000042412; ENSMUSP00000038014; ENSMUSG00000040289.
GeneID	15213.
KEGG	mmu:15213.
UCSC	uc008oop.1. mouse.
Organism-specific databases
CTD	23462.
MGI	MGI:1341800. Hey1.
Phylogenomic databases
GeneTree	ENSGT00700000104130.
HOVERGEN	HBG003275.
InParanoid	Q9QUM5.
KO	K09091.
OMA	ADENGNM.
OrthoDB	EOG76MK98.
TreeFam	TF323617.
Gene expression databases
Genevestigator	Q9QUM5.
Family and domain databases
Gene3D	4.10.280.10. 1 hit.
InterPro	IPR011598. bHLH_dom. IPR003650. Orange. IPR018352. Orange_subgr. [Graphical view]
Pfam	PF07527. Hairy_orange. 1 hit. PF00010. HLH. 1 hit. [Graphical view]
SMART	SM00353. HLH. 1 hit. SM00511. ORANGE. 1 hit. [Graphical view]
SUPFAM	SSF47459. SSF47459. 1 hit.
PROSITE	PS50888. BHLH. 1 hit. PS51054. ORANGE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	287785.
SOURCE	Search...

Entry information

Entry name

Q9QUM5_MOUSE

Accession

Primary (citable) accession number: Q9QUM5

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2000
Last sequence update:	May 1, 2000
Last modified:	February 19, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)