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Protein

Integrin alpha-IIb

Gene

Itga2b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi273 – 281Sequence analysis9
Calcium bindingi327 – 335Sequence analysis9
Calcium bindingi395 – 403Sequence analysis9
Calcium bindingi456 – 464Sequence analysis9

GO - Molecular functioni

  • extracellular matrix binding Source: MGI
  • identical protein binding Source: MGI
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • cell-matrix adhesion Source: MGI
  • integrin-mediated signaling pathway Source: MGI
  • platelet aggregation Source: Ensembl
  • positive regulation of leukocyte migration Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Integrin, Receptor

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-114608. Platelet degranulation.
R-MMU-216083. Integrin cell surface interactions.
R-MMU-3000178. ECM proteoglycans.
R-MMU-354192. Integrin alphaIIb beta3 signaling.
R-MMU-354194. GRB2:SOS provides linkage to MAPK signaling for Integrins.
R-MMU-372708. p130Cas linkage to MAPK signaling for integrins.
R-MMU-445144. Signal transduction by L1.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-IIb
Alternative name(s):
GPalpha IIb
Short name:
GPIIb
Platelet membrane glycoprotein IIb
CD_antigen: CD41
Cleaved into the following 2 chains:
Gene namesi
Name:Itga2b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:96601. Itga2b.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini32 – 988ExtracellularSequence analysisAdd BLAST957
Transmembranei989 – 1014HelicalSequence analysisAdd BLAST26
Topological domaini1015 – 1033CytoplasmicSequence analysisAdd BLAST19

GO - Cellular componenti

  • blood microparticle Source: MGI
  • cell surface Source: MGI
  • external side of plasma membrane Source: MGI
  • extracellular exosome Source: MGI
  • focal adhesion Source: MGI
  • integrin complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000016280? – 1033Integrin alpha-IIb light chainBy similarity
Signal peptidei1 – 31By similarityAdd BLAST31
ChainiPRO_000001627832 – 1033Integrin alpha-IIbAdd BLAST1002
ChainiPRO_000001627932 – ?Integrin alpha-IIb heavy chainBy similarity

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi46N-linked (GlcNAc...)Sequence analysis1
Glycosylationi75N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi87 ↔ 96By similarity
Disulfide bondi138 ↔ 161By similarity
Disulfide bondi177 ↔ 197By similarity
Disulfide bondi503 ↔ 514By similarity
Disulfide bondi520 ↔ 575By similarity
Glycosylationi600N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi632 ↔ 638By similarity
Disulfide bondi704 ↔ 717By similarity
Glycosylationi710N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi856 ↔ 905Interchain (between heavy and light chains)By similarity
Disulfide bondi911 ↔ 916By similarity
Glycosylationi957N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9QUM0.
PaxDbiQ9QUM0.
PRIDEiQ9QUM0.

PTM databases

iPTMnetiQ9QUM0.
PhosphoSitePlusiQ9QUM0.
SwissPalmiQ9QUM0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000034664.
CleanExiMM_ITGA2B.
GenevisibleiQ9QUM0. MM.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-IIb associates with beta-3. Directly interacts with RNF181. Interacts (via C-terminus cytoplasmic tail region) with CIB1; the interaction is direct and calcium-dependent. Interacts (via C-terminus cytoplasmic tail region) with CIB2, CIB3 and CIB4; the interactions are stabilized/increased in a calcium and magnesium-dependent manner (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9QUM0. 1 interactor.
MINTiMINT-4098793.
STRINGi10090.ENSMUSP00000099375.

Structurei

3D structure databases

ProteinModelPortaliQ9QUM0.
SMRiQ9QUM0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati35 – 96FG-GAP 1PROSITE-ProRule annotationAdd BLAST62
Repeati109 – 173FG-GAP 2PROSITE-ProRule annotationAdd BLAST65
Repeati184 – 237FG-GAP 3PROSITE-ProRule annotationAdd BLAST54
Repeati252 – 304FG-GAP 4PROSITE-ProRule annotationAdd BLAST53
Repeati305 – 370FG-GAP 5PROSITE-ProRule annotationAdd BLAST66
Repeati372 – 431FG-GAP 6PROSITE-ProRule annotationAdd BLAST60
Repeati434 – 495FG-GAP 7PROSITE-ProRule annotationAdd BLAST62

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1017 – 1021GFFKR motif5

Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated
Contains 7 FG-GAP repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3637. Eukaryota.
ENOG410XPVZ. LUCA.
GeneTreeiENSGT00760000118782.
HOGENOMiHOG000231603.
HOVERGENiHBG006186.
InParanoidiQ9QUM0.
KOiK06476.
OMAiLWLLEWV.
OrthoDBiEOG091G05Z4.
TreeFamiTF105391.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR032695. Integrin_dom.
[Graphical view]
PfamiPF01839. FG-GAP. 2 hits.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
[Graphical view]
SUPFAMiSSF69179. SSF69179. 3 hits.
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QUM0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARASCAWHS LWLLQWTPLF LGPSAVPPVW ALNLDSEKFS VYAGPNGSHF
60 70 80 90 100
GFSVDFHKDK HGSVSIVVGA PRALNASQEE TGAVFLCPWK ANGGKCNPLL
110 120 130 140 150
FDLRDETRNL GFQIFQTFKT GQGLGASVVS WNDVIVACAP WQHWNVLEKR
160 170 180 190 200
DEAEKTPVGG CFLAQLQSGG RAEYSPCRAN TMSSVYAESF RGDKRYCEAG
210 220 230 240 250
FSLAVTQAGE LVLGAPGGYF FLGLLARVPI ENIISSYRPG TLLWHVSNQR
260 270 280 290 300
FTYDNSNPVF FDGYRGYSVA VGEFDGDPST TEYVSGAPTW SWTLGAVEIL
310 320 330 340 350
DSYYQPLHRL HGEQMASYFG HSVAVTDVNG DGRHDLLVGA PLYMESRADR
360 370 380 390 400
KLAEVGRVYL FLQPKGPQAL STPTLLLTGT QLYGRFGSAI APLGDLNRDG
410 420 430 440 450
YNDIAVAAPY GGPSGQGQVL IFLGQSEGLS PRPSQVLDSP FPTGSGFGFS
460 470 480 490 500
LRGAVDIDDN GYPDLIVGAY GASKVAVYRA QPVVMATVQL MVQDSLNPTL
510 520 530 540 550
KNCVLDQTKT PVSCFNIQMC VGATGHNIPQ KLHLKAELQL DLQKPRQGRR
560 570 580 590 600
VLLLASQQAS LTLSLDLGGR DKPICHTTGA FLRDEADFRD KLSPIVLSLN
610 620 630 640 650
VSLPPEETGG APAVVLHGET HVQEQTRIIL DCGEDDLCVP QLRLTATAGD
660 670 680 690 700
SPLLIGADNV LELKIEAAND GEGAYEAELA VHLPPGAHYM RALSNIEGFE
710 720 730 740 750
RLVCTQKKEN ESRVALCELG NPMKKDTRIG ITMLVSVENL EEAGESVSFQ
760 770 780 790 800
LQVRSKNSQN PNSKVVMLPV AIQAEATVEL RGNSFPASLV VAAEEGDREQ
810 820 830 840 850
EDLDRWVSRL EHTYELHNIG PGTVNGLRLL IHIPGQSQPS DLLYILDVQP
860 870 880 890 900
QGGLLCSTQP SPKVDWKLST PSPSSIRPVH HQRERRQAFL QGPKPGQQDP
910 920 930 940 950
VLVSCDGSAS CTVVECELRE MVRGQRAMVT VQVMLGLSSL RQRPQEQFVL
960 970 980 990 1000
QSHAWFNVSS LPYSVPVVSL PSGQARVQTQ LLRALEERAI PVWWVLVGVL
1010 1020 1030
GGLLLLTLLV LAMWKAGFFK RNRPPLEEDE EEE
Length:1,033
Mass (Da):112,678
Last modified:July 27, 2011 - v2
Checksum:i7B4826E32B9130B1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti236S → T in AAF06996 (PubMed:10572112).Curated1
Sequence conflicti236S → T in AAD56216 (PubMed:10572112).Curated1
Sequence conflicti270A → S in AAF06996 (PubMed:10572112).Curated1
Sequence conflicti270A → S in AAD56216 (PubMed:10572112).Curated1
Sequence conflicti464D → G in AAF43997 (PubMed:10713093).Curated1
Sequence conflicti471G → W in AAF06996 (PubMed:10572112).Curated1
Sequence conflicti471G → W in AAD56216 (PubMed:10572112).Curated1
Sequence conflicti483V → G in AAF06996 (PubMed:10572112).Curated1
Sequence conflicti483V → G in AAD56216 (PubMed:10572112).Curated1
Sequence conflicti805R → S in AAF06996 (PubMed:10572112).Curated1
Sequence conflicti805R → S in AAD56216 (PubMed:10572112).Curated1
Sequence conflicti834P → H in AAD02339 (Ref. 6) Curated1
Sequence conflicti848 – 849VQ → LR in AAD02339 (Ref. 6) Curated2
Sequence conflicti865D → E in AAB23054 (PubMed:1512266).Curated1
Sequence conflicti933V → A in AAF06996 (PubMed:10572112).Curated1
Sequence conflicti933V → A in AAD56216 (PubMed:10572112).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF169829 Genomic DNA. Translation: AAF06996.1.
AF170316 mRNA. Translation: AAD56216.1.
AK142289 mRNA. Translation: BAE25013.1.
AK154619 mRNA. Translation: BAE32718.1.
AL596258 Genomic DNA. Translation: CAM18010.1.
BC120493 mRNA. Translation: AAI20494.1.
S43388 mRNA. Translation: AAB23054.2.
AF045019 mRNA. Translation: AAD02339.1.
AF166384 mRNA. Translation: AAF43997.1.
CCDSiCCDS25500.1.
PIRiA43430.
RefSeqiNP_034705.2. NM_010575.2.
UniGeneiMm.26646.

Genome annotation databases

EnsembliENSMUST00000103086; ENSMUSP00000099375; ENSMUSG00000034664.
GeneIDi16399.
KEGGimmu:16399.
UCSCiuc007lrx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF169829 Genomic DNA. Translation: AAF06996.1.
AF170316 mRNA. Translation: AAD56216.1.
AK142289 mRNA. Translation: BAE25013.1.
AK154619 mRNA. Translation: BAE32718.1.
AL596258 Genomic DNA. Translation: CAM18010.1.
BC120493 mRNA. Translation: AAI20494.1.
S43388 mRNA. Translation: AAB23054.2.
AF045019 mRNA. Translation: AAD02339.1.
AF166384 mRNA. Translation: AAF43997.1.
CCDSiCCDS25500.1.
PIRiA43430.
RefSeqiNP_034705.2. NM_010575.2.
UniGeneiMm.26646.

3D structure databases

ProteinModelPortaliQ9QUM0.
SMRiQ9QUM0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9QUM0. 1 interactor.
MINTiMINT-4098793.
STRINGi10090.ENSMUSP00000099375.

PTM databases

iPTMnetiQ9QUM0.
PhosphoSitePlusiQ9QUM0.
SwissPalmiQ9QUM0.

Proteomic databases

MaxQBiQ9QUM0.
PaxDbiQ9QUM0.
PRIDEiQ9QUM0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000103086; ENSMUSP00000099375; ENSMUSG00000034664.
GeneIDi16399.
KEGGimmu:16399.
UCSCiuc007lrx.2. mouse.

Organism-specific databases

CTDi3674.
MGIiMGI:96601. Itga2b.

Phylogenomic databases

eggNOGiKOG3637. Eukaryota.
ENOG410XPVZ. LUCA.
GeneTreeiENSGT00760000118782.
HOGENOMiHOG000231603.
HOVERGENiHBG006186.
InParanoidiQ9QUM0.
KOiK06476.
OMAiLWLLEWV.
OrthoDBiEOG091G05Z4.
TreeFamiTF105391.

Enzyme and pathway databases

ReactomeiR-MMU-114608. Platelet degranulation.
R-MMU-216083. Integrin cell surface interactions.
R-MMU-3000178. ECM proteoglycans.
R-MMU-354192. Integrin alphaIIb beta3 signaling.
R-MMU-354194. GRB2:SOS provides linkage to MAPK signaling for Integrins.
R-MMU-372708. p130Cas linkage to MAPK signaling for integrins.
R-MMU-445144. Signal transduction by L1.

Miscellaneous databases

PROiQ9QUM0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034664.
CleanExiMM_ITGA2B.
GenevisibleiQ9QUM0. MM.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR032695. Integrin_dom.
[Graphical view]
PfamiPF01839. FG-GAP. 2 hits.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
[Graphical view]
SUPFAMiSSF69179. SSF69179. 3 hits.
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiITA2B_MOUSE
AccessioniPrimary (citable) accession number: Q9QUM0
Secondary accession number(s): Q3U3R7, Q64229, Q9Z2M0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 27, 2011
Last modified: November 30, 2016
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.