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Q9QUM0

- ITA2B_MOUSE

UniProt

Q9QUM0 - ITA2B_MOUSE

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Protein
Integrin alpha-IIb
Gene
Itga2b
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi273 – 2819 Reviewed prediction
Calcium bindingi327 – 3359 Reviewed prediction
Calcium bindingi395 – 4039 Reviewed prediction
Calcium bindingi456 – 4649 Reviewed prediction

GO - Molecular functioni

  1. extracellular matrix binding Source: MGI
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. cell-matrix adhesion Source: MGI
  2. integrin-mediated signaling pathway Source: UniProtKB-KW
  3. platelet aggregation Source: Ensembl
  4. positive regulation of leukocyte migration Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Integrin, Receptor

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_196606. ECM proteoglycans.
REACT_215461. Signal transduction by L1.
REACT_216309. Integrin cell surface interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-IIb
Alternative name(s):
GPalpha IIb
Short name:
GPIIb
Platelet membrane glycoprotein IIb
CD_antigen: CD41
Cleaved into the following 2 chains:
Gene namesi
Name:Itga2b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:96601. Itga2b.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini32 – 988957Extracellular Reviewed prediction
Add
BLAST
Transmembranei989 – 101426Helical; Reviewed prediction
Add
BLAST
Topological domaini1015 – 103319Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. external side of plasma membrane Source: MGI
  2. focal adhesion Source: MGI
  3. integrin complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 1033Integrin alpha-IIb light chain By similarityPRO_0000016280
Signal peptidei1 – 3131 By similarity
Add
BLAST
Chaini32 – 10331002Integrin alpha-IIb
PRO_0000016278Add
BLAST
Chaini32 – ?Integrin alpha-IIb heavy chain By similarityPRO_0000016279

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi46 – 461N-linked (GlcNAc...) Reviewed prediction
Glycosylationi75 – 751N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi87 ↔ 96 By similarity
Disulfide bondi138 ↔ 161 By similarity
Disulfide bondi177 ↔ 197 By similarity
Disulfide bondi503 ↔ 514 By similarity
Disulfide bondi520 ↔ 575 By similarity
Glycosylationi600 – 6001N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi632 ↔ 638 By similarity
Disulfide bondi704 ↔ 717 By similarity
Glycosylationi710 – 7101N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi856 ↔ 905Interchain (between heavy and light chains) By similarity
Disulfide bondi911 ↔ 916 By similarity
Glycosylationi957 – 9571N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9QUM0.
PaxDbiQ9QUM0.
PRIDEiQ9QUM0.

PTM databases

PhosphoSiteiQ9QUM0.

Expressioni

Gene expression databases

BgeeiQ9QUM0.
CleanExiMM_ITGA2B.
GenevestigatoriQ9QUM0.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-IIb associates with beta-3. Directly interacts with RNF181. Interacts (via C-terminus cytoplasmic tail region) with CIB1; the interaction is direct and calcium-dependent. Interacts (via C-terminus cytoplasmic tail region) with CIB2, CIB3 and CIB4; the interactions are stabilized/increased in a calcium and magnesium-dependent manner By similarity.

Protein-protein interaction databases

IntActiQ9QUM0. 1 interaction.
MINTiMINT-4098793.

Structurei

3D structure databases

ProteinModelPortaliQ9QUM0.
SMRiQ9QUM0. Positions 32-1024.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati35 – 9662FG-GAP 1
Add
BLAST
Repeati109 – 17365FG-GAP 2
Add
BLAST
Repeati184 – 23754FG-GAP 3
Add
BLAST
Repeati252 – 30958FG-GAP 4
Add
BLAST
Repeati310 – 37061FG-GAP 5
Add
BLAST
Repeati372 – 43160FG-GAP 6
Add
BLAST
Repeati433 – 49563FG-GAP 7
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1017 – 10215GFFKR motif

Sequence similaritiesi

Contains 7 FG-GAP repeats.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG26407.
GeneTreeiENSGT00750000117267.
HOGENOMiHOG000231603.
HOVERGENiHBG006186.
InParanoidiQ3U3R7.
KOiK06476.
OMAiCFNIQMC.
OrthoDBiEOG7TMZQZ.
TreeFamiTF105391.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
[Graphical view]
PfamiPF01839. FG-GAP. 1 hit.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
[Graphical view]
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QUM0-1 [UniParc]FASTAAdd to Basket

« Hide

MARASCAWHS LWLLQWTPLF LGPSAVPPVW ALNLDSEKFS VYAGPNGSHF     50
GFSVDFHKDK HGSVSIVVGA PRALNASQEE TGAVFLCPWK ANGGKCNPLL 100
FDLRDETRNL GFQIFQTFKT GQGLGASVVS WNDVIVACAP WQHWNVLEKR 150
DEAEKTPVGG CFLAQLQSGG RAEYSPCRAN TMSSVYAESF RGDKRYCEAG 200
FSLAVTQAGE LVLGAPGGYF FLGLLARVPI ENIISSYRPG TLLWHVSNQR 250
FTYDNSNPVF FDGYRGYSVA VGEFDGDPST TEYVSGAPTW SWTLGAVEIL 300
DSYYQPLHRL HGEQMASYFG HSVAVTDVNG DGRHDLLVGA PLYMESRADR 350
KLAEVGRVYL FLQPKGPQAL STPTLLLTGT QLYGRFGSAI APLGDLNRDG 400
YNDIAVAAPY GGPSGQGQVL IFLGQSEGLS PRPSQVLDSP FPTGSGFGFS 450
LRGAVDIDDN GYPDLIVGAY GASKVAVYRA QPVVMATVQL MVQDSLNPTL 500
KNCVLDQTKT PVSCFNIQMC VGATGHNIPQ KLHLKAELQL DLQKPRQGRR 550
VLLLASQQAS LTLSLDLGGR DKPICHTTGA FLRDEADFRD KLSPIVLSLN 600
VSLPPEETGG APAVVLHGET HVQEQTRIIL DCGEDDLCVP QLRLTATAGD 650
SPLLIGADNV LELKIEAAND GEGAYEAELA VHLPPGAHYM RALSNIEGFE 700
RLVCTQKKEN ESRVALCELG NPMKKDTRIG ITMLVSVENL EEAGESVSFQ 750
LQVRSKNSQN PNSKVVMLPV AIQAEATVEL RGNSFPASLV VAAEEGDREQ 800
EDLDRWVSRL EHTYELHNIG PGTVNGLRLL IHIPGQSQPS DLLYILDVQP 850
QGGLLCSTQP SPKVDWKLST PSPSSIRPVH HQRERRQAFL QGPKPGQQDP 900
VLVSCDGSAS CTVVECELRE MVRGQRAMVT VQVMLGLSSL RQRPQEQFVL 950
QSHAWFNVSS LPYSVPVVSL PSGQARVQTQ LLRALEERAI PVWWVLVGVL 1000
GGLLLLTLLV LAMWKAGFFK RNRPPLEEDE EEE 1033
Length:1,033
Mass (Da):112,678
Last modified:July 27, 2011 - v2
Checksum:i7B4826E32B9130B1
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti236 – 2361S → T in AAF06996. 1 Publication
Sequence conflicti236 – 2361S → T in AAD56216. 1 Publication
Sequence conflicti270 – 2701A → S in AAF06996. 1 Publication
Sequence conflicti270 – 2701A → S in AAD56216. 1 Publication
Sequence conflicti464 – 4641D → G in AAF43997. 1 Publication
Sequence conflicti471 – 4711G → W in AAF06996. 1 Publication
Sequence conflicti471 – 4711G → W in AAD56216. 1 Publication
Sequence conflicti483 – 4831V → G in AAF06996. 1 Publication
Sequence conflicti483 – 4831V → G in AAD56216. 1 Publication
Sequence conflicti805 – 8051R → S in AAF06996. 1 Publication
Sequence conflicti805 – 8051R → S in AAD56216. 1 Publication
Sequence conflicti834 – 8341P → H in AAD02339. 1 Publication
Sequence conflicti848 – 8492VQ → LR in AAD02339. 1 Publication
Sequence conflicti865 – 8651D → E in AAB23054. 1 Publication
Sequence conflicti933 – 9331V → A in AAF06996. 1 Publication
Sequence conflicti933 – 9331V → A in AAD56216. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF169829 Genomic DNA. Translation: AAF06996.1.
AF170316 mRNA. Translation: AAD56216.1.
AK142289 mRNA. Translation: BAE25013.1.
AK154619 mRNA. Translation: BAE32718.1.
AL596258 Genomic DNA. Translation: CAM18010.1.
BC120493 mRNA. Translation: AAI20494.1.
S43388 mRNA. Translation: AAB23054.2.
AF045019 mRNA. Translation: AAD02339.1.
AF166384 mRNA. Translation: AAF43997.1.
CCDSiCCDS25500.1.
PIRiA43430.
RefSeqiNP_034705.2. NM_010575.2.
UniGeneiMm.26646.

Genome annotation databases

EnsembliENSMUST00000103086; ENSMUSP00000099375; ENSMUSG00000034664.
GeneIDi16399.
KEGGimmu:16399.
UCSCiuc007lrx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF169829 Genomic DNA. Translation: AAF06996.1 .
AF170316 mRNA. Translation: AAD56216.1 .
AK142289 mRNA. Translation: BAE25013.1 .
AK154619 mRNA. Translation: BAE32718.1 .
AL596258 Genomic DNA. Translation: CAM18010.1 .
BC120493 mRNA. Translation: AAI20494.1 .
S43388 mRNA. Translation: AAB23054.2 .
AF045019 mRNA. Translation: AAD02339.1 .
AF166384 mRNA. Translation: AAF43997.1 .
CCDSi CCDS25500.1.
PIRi A43430.
RefSeqi NP_034705.2. NM_010575.2.
UniGenei Mm.26646.

3D structure databases

ProteinModelPortali Q9QUM0.
SMRi Q9QUM0. Positions 32-1024.
ModBasei Search...

Protein-protein interaction databases

IntActi Q9QUM0. 1 interaction.
MINTi MINT-4098793.

PTM databases

PhosphoSitei Q9QUM0.

Proteomic databases

MaxQBi Q9QUM0.
PaxDbi Q9QUM0.
PRIDEi Q9QUM0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000103086 ; ENSMUSP00000099375 ; ENSMUSG00000034664 .
GeneIDi 16399.
KEGGi mmu:16399.
UCSCi uc007lrx.2. mouse.

Organism-specific databases

CTDi 3674.
MGIi MGI:96601. Itga2b.

Phylogenomic databases

eggNOGi NOG26407.
GeneTreei ENSGT00750000117267.
HOGENOMi HOG000231603.
HOVERGENi HBG006186.
InParanoidi Q3U3R7.
KOi K06476.
OMAi CFNIQMC.
OrthoDBi EOG7TMZQZ.
TreeFami TF105391.

Enzyme and pathway databases

Reactomei REACT_196606. ECM proteoglycans.
REACT_215461. Signal transduction by L1.
REACT_216309. Integrin cell surface interactions.

Miscellaneous databases

NextBioi 289549.
PROi Q9QUM0.
SOURCEi Search...

Gene expression databases

Bgeei Q9QUM0.
CleanExi MM_ITGA2B.
Genevestigatori Q9QUM0.

Family and domain databases

InterProi IPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
[Graphical view ]
Pfami PF01839. FG-GAP. 1 hit.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
[Graphical view ]
PRINTSi PR01185. INTEGRINA.
SMARTi SM00191. Int_alpha. 5 hits.
[Graphical view ]
PROSITEi PS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the murine platelet alphaIIb gene and encoded cDNA."
    Thornton M.A., Poncz M.
    Blood 94:3947-3950(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Heart.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. "Identification of the alpha IIb beta 3 integrin in murine tumor cells."
    Chen Y.Q., Gao X., Timar J., Tang D., Grossi I.M., Chelladurai M., Kunicki T.J., Fligiel S.E., Taylor J.D., Honn K.V.
    J. Biol. Chem. 267:17314-17320(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 805-865.
  6. Rout U.K., Armant D.R.
    Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE OF 790-1022.
  7. "Multiple discontinuous ligand-mimetic antibody binding sites define a ligand binding pocket in integrin alphaIIbbeta3."
    Puzon-McLaughlin W., Kamata T., Takada Y.
    J. Biol. Chem. 275:7795-7802(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-484.

Entry informationi

Entry nameiITA2B_MOUSE
AccessioniPrimary (citable) accession number: Q9QUM0
Secondary accession number(s): Q3U3R7, Q64229, Q9Z2M0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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