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Q9QUM0

- ITA2B_MOUSE

UniProt

Q9QUM0 - ITA2B_MOUSE

Protein

Integrin alpha-IIb

Gene

Itga2b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi273 – 2819Sequence Analysis
    Calcium bindingi327 – 3359Sequence Analysis
    Calcium bindingi395 – 4039Sequence Analysis
    Calcium bindingi456 – 4649Sequence Analysis

    GO - Molecular functioni

    1. extracellular matrix binding Source: MGI
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell-matrix adhesion Source: MGI
    2. integrin-mediated signaling pathway Source: UniProtKB-KW
    3. platelet aggregation Source: Ensembl
    4. positive regulation of leukocyte migration Source: Ensembl

    Keywords - Molecular functioni

    Integrin, Receptor

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Calcium, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_196606. ECM proteoglycans.
    REACT_215461. Signal transduction by L1.
    REACT_216309. Integrin cell surface interactions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Integrin alpha-IIb
    Alternative name(s):
    GPalpha IIb
    Short name:
    GPIIb
    Platelet membrane glycoprotein IIb
    CD_antigen: CD41
    Cleaved into the following 2 chains:
    Gene namesi
    Name:Itga2b
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:96601. Itga2b.

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: MGI
    2. focal adhesion Source: MGI
    3. integrin complex Source: InterPro

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 1033Integrin alpha-IIb light chainBy similarityPRO_0000016280
    Signal peptidei1 – 3131By similarityAdd
    BLAST
    Chaini32 – 10331002Integrin alpha-IIbPRO_0000016278Add
    BLAST
    Chaini32 – ?Integrin alpha-IIb heavy chainBy similarityPRO_0000016279

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi46 – 461N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi75 – 751N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi87 ↔ 96By similarity
    Disulfide bondi138 ↔ 161By similarity
    Disulfide bondi177 ↔ 197By similarity
    Disulfide bondi503 ↔ 514By similarity
    Disulfide bondi520 ↔ 575By similarity
    Glycosylationi600 – 6001N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi632 ↔ 638By similarity
    Disulfide bondi704 ↔ 717By similarity
    Glycosylationi710 – 7101N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi856 ↔ 905Interchain (between heavy and light chains)By similarity
    Disulfide bondi911 ↔ 916By similarity
    Glycosylationi957 – 9571N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ9QUM0.
    PaxDbiQ9QUM0.
    PRIDEiQ9QUM0.

    PTM databases

    PhosphoSiteiQ9QUM0.

    Expressioni

    Gene expression databases

    BgeeiQ9QUM0.
    CleanExiMM_ITGA2B.
    GenevestigatoriQ9QUM0.

    Interactioni

    Subunit structurei

    Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-IIb associates with beta-3. Directly interacts with RNF181. Interacts (via C-terminus cytoplasmic tail region) with CIB1; the interaction is direct and calcium-dependent. Interacts (via C-terminus cytoplasmic tail region) with CIB2, CIB3 and CIB4; the interactions are stabilized/increased in a calcium and magnesium-dependent manner By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ9QUM0. 1 interaction.
    MINTiMINT-4098793.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QUM0.
    SMRiQ9QUM0. Positions 32-1024.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini32 – 988957ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1015 – 103319CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei989 – 101426HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati35 – 9662FG-GAP 1Add
    BLAST
    Repeati109 – 17365FG-GAP 2Add
    BLAST
    Repeati184 – 23754FG-GAP 3Add
    BLAST
    Repeati252 – 30958FG-GAP 4Add
    BLAST
    Repeati310 – 37061FG-GAP 5Add
    BLAST
    Repeati372 – 43160FG-GAP 6Add
    BLAST
    Repeati433 – 49563FG-GAP 7Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1017 – 10215GFFKR motif

    Sequence similaritiesi

    Belongs to the integrin alpha chain family.Curated
    Contains 7 FG-GAP repeats.Curated

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG26407.
    GeneTreeiENSGT00750000117267.
    HOGENOMiHOG000231603.
    HOVERGENiHBG006186.
    InParanoidiQ3U3R7.
    KOiK06476.
    OMAiCFNIQMC.
    OrthoDBiEOG7TMZQZ.
    TreeFamiTF105391.

    Family and domain databases

    InterProiIPR013517. FG-GAP.
    IPR013519. Int_alpha_beta-p.
    IPR000413. Integrin_alpha.
    IPR013649. Integrin_alpha-2.
    IPR018184. Integrin_alpha_C_CS.
    [Graphical view]
    PfamiPF01839. FG-GAP. 1 hit.
    PF00357. Integrin_alpha. 1 hit.
    PF08441. Integrin_alpha2. 1 hit.
    [Graphical view]
    PRINTSiPR01185. INTEGRINA.
    SMARTiSM00191. Int_alpha. 5 hits.
    [Graphical view]
    PROSITEiPS51470. FG_GAP. 7 hits.
    PS00242. INTEGRIN_ALPHA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9QUM0-1 [UniParc]FASTAAdd to Basket

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    MARASCAWHS LWLLQWTPLF LGPSAVPPVW ALNLDSEKFS VYAGPNGSHF     50
    GFSVDFHKDK HGSVSIVVGA PRALNASQEE TGAVFLCPWK ANGGKCNPLL 100
    FDLRDETRNL GFQIFQTFKT GQGLGASVVS WNDVIVACAP WQHWNVLEKR 150
    DEAEKTPVGG CFLAQLQSGG RAEYSPCRAN TMSSVYAESF RGDKRYCEAG 200
    FSLAVTQAGE LVLGAPGGYF FLGLLARVPI ENIISSYRPG TLLWHVSNQR 250
    FTYDNSNPVF FDGYRGYSVA VGEFDGDPST TEYVSGAPTW SWTLGAVEIL 300
    DSYYQPLHRL HGEQMASYFG HSVAVTDVNG DGRHDLLVGA PLYMESRADR 350
    KLAEVGRVYL FLQPKGPQAL STPTLLLTGT QLYGRFGSAI APLGDLNRDG 400
    YNDIAVAAPY GGPSGQGQVL IFLGQSEGLS PRPSQVLDSP FPTGSGFGFS 450
    LRGAVDIDDN GYPDLIVGAY GASKVAVYRA QPVVMATVQL MVQDSLNPTL 500
    KNCVLDQTKT PVSCFNIQMC VGATGHNIPQ KLHLKAELQL DLQKPRQGRR 550
    VLLLASQQAS LTLSLDLGGR DKPICHTTGA FLRDEADFRD KLSPIVLSLN 600
    VSLPPEETGG APAVVLHGET HVQEQTRIIL DCGEDDLCVP QLRLTATAGD 650
    SPLLIGADNV LELKIEAAND GEGAYEAELA VHLPPGAHYM RALSNIEGFE 700
    RLVCTQKKEN ESRVALCELG NPMKKDTRIG ITMLVSVENL EEAGESVSFQ 750
    LQVRSKNSQN PNSKVVMLPV AIQAEATVEL RGNSFPASLV VAAEEGDREQ 800
    EDLDRWVSRL EHTYELHNIG PGTVNGLRLL IHIPGQSQPS DLLYILDVQP 850
    QGGLLCSTQP SPKVDWKLST PSPSSIRPVH HQRERRQAFL QGPKPGQQDP 900
    VLVSCDGSAS CTVVECELRE MVRGQRAMVT VQVMLGLSSL RQRPQEQFVL 950
    QSHAWFNVSS LPYSVPVVSL PSGQARVQTQ LLRALEERAI PVWWVLVGVL 1000
    GGLLLLTLLV LAMWKAGFFK RNRPPLEEDE EEE 1033
    Length:1,033
    Mass (Da):112,678
    Last modified:July 27, 2011 - v2
    Checksum:i7B4826E32B9130B1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti236 – 2361S → T in AAF06996. (PubMed:10572112)Curated
    Sequence conflicti236 – 2361S → T in AAD56216. (PubMed:10572112)Curated
    Sequence conflicti270 – 2701A → S in AAF06996. (PubMed:10572112)Curated
    Sequence conflicti270 – 2701A → S in AAD56216. (PubMed:10572112)Curated
    Sequence conflicti464 – 4641D → G in AAF43997. (PubMed:10713093)Curated
    Sequence conflicti471 – 4711G → W in AAF06996. (PubMed:10572112)Curated
    Sequence conflicti471 – 4711G → W in AAD56216. (PubMed:10572112)Curated
    Sequence conflicti483 – 4831V → G in AAF06996. (PubMed:10572112)Curated
    Sequence conflicti483 – 4831V → G in AAD56216. (PubMed:10572112)Curated
    Sequence conflicti805 – 8051R → S in AAF06996. (PubMed:10572112)Curated
    Sequence conflicti805 – 8051R → S in AAD56216. (PubMed:10572112)Curated
    Sequence conflicti834 – 8341P → H in AAD02339. 1 PublicationCurated
    Sequence conflicti848 – 8492VQ → LR in AAD02339. 1 PublicationCurated
    Sequence conflicti865 – 8651D → E in AAB23054. (PubMed:1512266)Curated
    Sequence conflicti933 – 9331V → A in AAF06996. (PubMed:10572112)Curated
    Sequence conflicti933 – 9331V → A in AAD56216. (PubMed:10572112)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF169829 Genomic DNA. Translation: AAF06996.1.
    AF170316 mRNA. Translation: AAD56216.1.
    AK142289 mRNA. Translation: BAE25013.1.
    AK154619 mRNA. Translation: BAE32718.1.
    AL596258 Genomic DNA. Translation: CAM18010.1.
    BC120493 mRNA. Translation: AAI20494.1.
    S43388 mRNA. Translation: AAB23054.2.
    AF045019 mRNA. Translation: AAD02339.1.
    AF166384 mRNA. Translation: AAF43997.1.
    CCDSiCCDS25500.1.
    PIRiA43430.
    RefSeqiNP_034705.2. NM_010575.2.
    UniGeneiMm.26646.

    Genome annotation databases

    EnsembliENSMUST00000103086; ENSMUSP00000099375; ENSMUSG00000034664.
    GeneIDi16399.
    KEGGimmu:16399.
    UCSCiuc007lrx.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF169829 Genomic DNA. Translation: AAF06996.1 .
    AF170316 mRNA. Translation: AAD56216.1 .
    AK142289 mRNA. Translation: BAE25013.1 .
    AK154619 mRNA. Translation: BAE32718.1 .
    AL596258 Genomic DNA. Translation: CAM18010.1 .
    BC120493 mRNA. Translation: AAI20494.1 .
    S43388 mRNA. Translation: AAB23054.2 .
    AF045019 mRNA. Translation: AAD02339.1 .
    AF166384 mRNA. Translation: AAF43997.1 .
    CCDSi CCDS25500.1.
    PIRi A43430.
    RefSeqi NP_034705.2. NM_010575.2.
    UniGenei Mm.26646.

    3D structure databases

    ProteinModelPortali Q9QUM0.
    SMRi Q9QUM0. Positions 32-1024.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9QUM0. 1 interaction.
    MINTi MINT-4098793.

    PTM databases

    PhosphoSitei Q9QUM0.

    Proteomic databases

    MaxQBi Q9QUM0.
    PaxDbi Q9QUM0.
    PRIDEi Q9QUM0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000103086 ; ENSMUSP00000099375 ; ENSMUSG00000034664 .
    GeneIDi 16399.
    KEGGi mmu:16399.
    UCSCi uc007lrx.2. mouse.

    Organism-specific databases

    CTDi 3674.
    MGIi MGI:96601. Itga2b.

    Phylogenomic databases

    eggNOGi NOG26407.
    GeneTreei ENSGT00750000117267.
    HOGENOMi HOG000231603.
    HOVERGENi HBG006186.
    InParanoidi Q3U3R7.
    KOi K06476.
    OMAi CFNIQMC.
    OrthoDBi EOG7TMZQZ.
    TreeFami TF105391.

    Enzyme and pathway databases

    Reactomei REACT_196606. ECM proteoglycans.
    REACT_215461. Signal transduction by L1.
    REACT_216309. Integrin cell surface interactions.

    Miscellaneous databases

    NextBioi 289549.
    PROi Q9QUM0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9QUM0.
    CleanExi MM_ITGA2B.
    Genevestigatori Q9QUM0.

    Family and domain databases

    InterProi IPR013517. FG-GAP.
    IPR013519. Int_alpha_beta-p.
    IPR000413. Integrin_alpha.
    IPR013649. Integrin_alpha-2.
    IPR018184. Integrin_alpha_C_CS.
    [Graphical view ]
    Pfami PF01839. FG-GAP. 1 hit.
    PF00357. Integrin_alpha. 1 hit.
    PF08441. Integrin_alpha2. 1 hit.
    [Graphical view ]
    PRINTSi PR01185. INTEGRINA.
    SMARTi SM00191. Int_alpha. 5 hits.
    [Graphical view ]
    PROSITEi PS51470. FG_GAP. 7 hits.
    PS00242. INTEGRIN_ALPHA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the murine platelet alphaIIb gene and encoded cDNA."
      Thornton M.A., Poncz M.
      Blood 94:3947-3950(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Heart.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    5. "Identification of the alpha IIb beta 3 integrin in murine tumor cells."
      Chen Y.Q., Gao X., Timar J., Tang D., Grossi I.M., Chelladurai M., Kunicki T.J., Fligiel S.E., Taylor J.D., Honn K.V.
      J. Biol. Chem. 267:17314-17320(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 805-865.
    6. Rout U.K., Armant D.R.
      Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE OF 790-1022.
    7. "Multiple discontinuous ligand-mimetic antibody binding sites define a ligand binding pocket in integrin alphaIIbbeta3."
      Puzon-McLaughlin W., Kamata T., Takada Y.
      J. Biol. Chem. 275:7795-7802(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-484.

    Entry informationi

    Entry nameiITA2B_MOUSE
    AccessioniPrimary (citable) accession number: Q9QUM0
    Secondary accession number(s): Q3U3R7, Q64229, Q9Z2M0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 127 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3