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Q9QUM0

- ITA2B_MOUSE

UniProt

Q9QUM0 - ITA2B_MOUSE

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Protein

Integrin alpha-IIb

Gene

Itga2b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi273 – 2819Sequence Analysis
Calcium bindingi327 – 3359Sequence Analysis
Calcium bindingi395 – 4039Sequence Analysis
Calcium bindingi456 – 4649Sequence Analysis

GO - Molecular functioni

  1. extracellular matrix binding Source: MGI
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell-matrix adhesion Source: MGI
  2. integrin-mediated signaling pathway Source: UniProtKB-KW
  3. platelet aggregation Source: Ensembl
  4. positive regulation of leukocyte migration Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Integrin, Receptor

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_196606. ECM proteoglycans.
REACT_215461. Signal transduction by L1.
REACT_216309. Integrin cell surface interactions.
REACT_240371. p130Cas linkage to MAPK signaling for integrins.
REACT_246176. Integrin alphaIIb beta3 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-IIb
Alternative name(s):
GPalpha IIb
Short name:
GPIIb
Platelet membrane glycoprotein IIb
CD_antigen: CD41
Cleaved into the following 2 chains:
Gene namesi
Name:Itga2b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:96601. Itga2b.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini32 – 988957ExtracellularSequence AnalysisAdd
BLAST
Transmembranei989 – 101426HelicalSequence AnalysisAdd
BLAST
Topological domaini1015 – 103319CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. blood microparticle Source: Ensembl
  2. external side of plasma membrane Source: MGI
  3. focal adhesion Source: MGI
  4. integrin complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 1033Integrin alpha-IIb light chainBy similarityPRO_0000016280
Signal peptidei1 – 3131By similarityAdd
BLAST
Chaini32 – 10331002Integrin alpha-IIbPRO_0000016278Add
BLAST
Chaini32 – ?Integrin alpha-IIb heavy chainBy similarityPRO_0000016279

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi46 – 461N-linked (GlcNAc...)Sequence Analysis
Glycosylationi75 – 751N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi87 ↔ 96By similarity
Disulfide bondi138 ↔ 161By similarity
Disulfide bondi177 ↔ 197By similarity
Disulfide bondi503 ↔ 514By similarity
Disulfide bondi520 ↔ 575By similarity
Glycosylationi600 – 6001N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi632 ↔ 638By similarity
Disulfide bondi704 ↔ 717By similarity
Glycosylationi710 – 7101N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi856 ↔ 905Interchain (between heavy and light chains)By similarity
Disulfide bondi911 ↔ 916By similarity
Glycosylationi957 – 9571N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9QUM0.
PaxDbiQ9QUM0.
PRIDEiQ9QUM0.

PTM databases

PhosphoSiteiQ9QUM0.

Expressioni

Gene expression databases

BgeeiQ9QUM0.
CleanExiMM_ITGA2B.
GenevestigatoriQ9QUM0.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-IIb associates with beta-3. Directly interacts with RNF181. Interacts (via C-terminus cytoplasmic tail region) with CIB1; the interaction is direct and calcium-dependent. Interacts (via C-terminus cytoplasmic tail region) with CIB2, CIB3 and CIB4; the interactions are stabilized/increased in a calcium and magnesium-dependent manner (By similarity).By similarity

Protein-protein interaction databases

IntActiQ9QUM0. 1 interaction.
MINTiMINT-4098793.

Structurei

3D structure databases

ProteinModelPortaliQ9QUM0.
SMRiQ9QUM0. Positions 32-1024.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati35 – 9662FG-GAP 1Add
BLAST
Repeati109 – 17365FG-GAP 2Add
BLAST
Repeati184 – 23754FG-GAP 3Add
BLAST
Repeati252 – 30958FG-GAP 4Add
BLAST
Repeati310 – 37061FG-GAP 5Add
BLAST
Repeati372 – 43160FG-GAP 6Add
BLAST
Repeati433 – 49563FG-GAP 7Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1017 – 10215GFFKR motif

Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated
Contains 7 FG-GAP repeats.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG26407.
GeneTreeiENSGT00760000118782.
HOGENOMiHOG000231603.
HOVERGENiHBG006186.
InParanoidiQ9QUM0.
KOiK06476.
OMAiCFNIQMC.
OrthoDBiEOG7TMZQZ.
TreeFamiTF105391.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
[Graphical view]
PfamiPF01839. FG-GAP. 1 hit.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
[Graphical view]
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QUM0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARASCAWHS LWLLQWTPLF LGPSAVPPVW ALNLDSEKFS VYAGPNGSHF
60 70 80 90 100
GFSVDFHKDK HGSVSIVVGA PRALNASQEE TGAVFLCPWK ANGGKCNPLL
110 120 130 140 150
FDLRDETRNL GFQIFQTFKT GQGLGASVVS WNDVIVACAP WQHWNVLEKR
160 170 180 190 200
DEAEKTPVGG CFLAQLQSGG RAEYSPCRAN TMSSVYAESF RGDKRYCEAG
210 220 230 240 250
FSLAVTQAGE LVLGAPGGYF FLGLLARVPI ENIISSYRPG TLLWHVSNQR
260 270 280 290 300
FTYDNSNPVF FDGYRGYSVA VGEFDGDPST TEYVSGAPTW SWTLGAVEIL
310 320 330 340 350
DSYYQPLHRL HGEQMASYFG HSVAVTDVNG DGRHDLLVGA PLYMESRADR
360 370 380 390 400
KLAEVGRVYL FLQPKGPQAL STPTLLLTGT QLYGRFGSAI APLGDLNRDG
410 420 430 440 450
YNDIAVAAPY GGPSGQGQVL IFLGQSEGLS PRPSQVLDSP FPTGSGFGFS
460 470 480 490 500
LRGAVDIDDN GYPDLIVGAY GASKVAVYRA QPVVMATVQL MVQDSLNPTL
510 520 530 540 550
KNCVLDQTKT PVSCFNIQMC VGATGHNIPQ KLHLKAELQL DLQKPRQGRR
560 570 580 590 600
VLLLASQQAS LTLSLDLGGR DKPICHTTGA FLRDEADFRD KLSPIVLSLN
610 620 630 640 650
VSLPPEETGG APAVVLHGET HVQEQTRIIL DCGEDDLCVP QLRLTATAGD
660 670 680 690 700
SPLLIGADNV LELKIEAAND GEGAYEAELA VHLPPGAHYM RALSNIEGFE
710 720 730 740 750
RLVCTQKKEN ESRVALCELG NPMKKDTRIG ITMLVSVENL EEAGESVSFQ
760 770 780 790 800
LQVRSKNSQN PNSKVVMLPV AIQAEATVEL RGNSFPASLV VAAEEGDREQ
810 820 830 840 850
EDLDRWVSRL EHTYELHNIG PGTVNGLRLL IHIPGQSQPS DLLYILDVQP
860 870 880 890 900
QGGLLCSTQP SPKVDWKLST PSPSSIRPVH HQRERRQAFL QGPKPGQQDP
910 920 930 940 950
VLVSCDGSAS CTVVECELRE MVRGQRAMVT VQVMLGLSSL RQRPQEQFVL
960 970 980 990 1000
QSHAWFNVSS LPYSVPVVSL PSGQARVQTQ LLRALEERAI PVWWVLVGVL
1010 1020 1030
GGLLLLTLLV LAMWKAGFFK RNRPPLEEDE EEE
Length:1,033
Mass (Da):112,678
Last modified:July 27, 2011 - v2
Checksum:i7B4826E32B9130B1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti236 – 2361S → T in AAF06996. (PubMed:10572112)Curated
Sequence conflicti236 – 2361S → T in AAD56216. (PubMed:10572112)Curated
Sequence conflicti270 – 2701A → S in AAF06996. (PubMed:10572112)Curated
Sequence conflicti270 – 2701A → S in AAD56216. (PubMed:10572112)Curated
Sequence conflicti464 – 4641D → G in AAF43997. (PubMed:10713093)Curated
Sequence conflicti471 – 4711G → W in AAF06996. (PubMed:10572112)Curated
Sequence conflicti471 – 4711G → W in AAD56216. (PubMed:10572112)Curated
Sequence conflicti483 – 4831V → G in AAF06996. (PubMed:10572112)Curated
Sequence conflicti483 – 4831V → G in AAD56216. (PubMed:10572112)Curated
Sequence conflicti805 – 8051R → S in AAF06996. (PubMed:10572112)Curated
Sequence conflicti805 – 8051R → S in AAD56216. (PubMed:10572112)Curated
Sequence conflicti834 – 8341P → H in AAD02339. 1 PublicationCurated
Sequence conflicti848 – 8492VQ → LR in AAD02339. 1 PublicationCurated
Sequence conflicti865 – 8651D → E in AAB23054. (PubMed:1512266)Curated
Sequence conflicti933 – 9331V → A in AAF06996. (PubMed:10572112)Curated
Sequence conflicti933 – 9331V → A in AAD56216. (PubMed:10572112)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF169829 Genomic DNA. Translation: AAF06996.1.
AF170316 mRNA. Translation: AAD56216.1.
AK142289 mRNA. Translation: BAE25013.1.
AK154619 mRNA. Translation: BAE32718.1.
AL596258 Genomic DNA. Translation: CAM18010.1.
BC120493 mRNA. Translation: AAI20494.1.
S43388 mRNA. Translation: AAB23054.2.
AF045019 mRNA. Translation: AAD02339.1.
AF166384 mRNA. Translation: AAF43997.1.
CCDSiCCDS25500.1.
PIRiA43430.
RefSeqiNP_034705.2. NM_010575.2.
UniGeneiMm.26646.

Genome annotation databases

EnsembliENSMUST00000103086; ENSMUSP00000099375; ENSMUSG00000034664.
GeneIDi16399.
KEGGimmu:16399.
UCSCiuc007lrx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF169829 Genomic DNA. Translation: AAF06996.1 .
AF170316 mRNA. Translation: AAD56216.1 .
AK142289 mRNA. Translation: BAE25013.1 .
AK154619 mRNA. Translation: BAE32718.1 .
AL596258 Genomic DNA. Translation: CAM18010.1 .
BC120493 mRNA. Translation: AAI20494.1 .
S43388 mRNA. Translation: AAB23054.2 .
AF045019 mRNA. Translation: AAD02339.1 .
AF166384 mRNA. Translation: AAF43997.1 .
CCDSi CCDS25500.1.
PIRi A43430.
RefSeqi NP_034705.2. NM_010575.2.
UniGenei Mm.26646.

3D structure databases

ProteinModelPortali Q9QUM0.
SMRi Q9QUM0. Positions 32-1024.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9QUM0. 1 interaction.
MINTi MINT-4098793.

PTM databases

PhosphoSitei Q9QUM0.

Proteomic databases

MaxQBi Q9QUM0.
PaxDbi Q9QUM0.
PRIDEi Q9QUM0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000103086 ; ENSMUSP00000099375 ; ENSMUSG00000034664 .
GeneIDi 16399.
KEGGi mmu:16399.
UCSCi uc007lrx.2. mouse.

Organism-specific databases

CTDi 3674.
MGIi MGI:96601. Itga2b.

Phylogenomic databases

eggNOGi NOG26407.
GeneTreei ENSGT00760000118782.
HOGENOMi HOG000231603.
HOVERGENi HBG006186.
InParanoidi Q9QUM0.
KOi K06476.
OMAi CFNIQMC.
OrthoDBi EOG7TMZQZ.
TreeFami TF105391.

Enzyme and pathway databases

Reactomei REACT_196606. ECM proteoglycans.
REACT_215461. Signal transduction by L1.
REACT_216309. Integrin cell surface interactions.
REACT_240371. p130Cas linkage to MAPK signaling for integrins.
REACT_246176. Integrin alphaIIb beta3 signaling.

Miscellaneous databases

NextBioi 289549.
PROi Q9QUM0.
SOURCEi Search...

Gene expression databases

Bgeei Q9QUM0.
CleanExi MM_ITGA2B.
Genevestigatori Q9QUM0.

Family and domain databases

InterProi IPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
[Graphical view ]
Pfami PF01839. FG-GAP. 1 hit.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
[Graphical view ]
PRINTSi PR01185. INTEGRINA.
SMARTi SM00191. Int_alpha. 5 hits.
[Graphical view ]
PROSITEi PS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the murine platelet alphaIIb gene and encoded cDNA."
    Thornton M.A., Poncz M.
    Blood 94:3947-3950(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Heart.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. "Identification of the alpha IIb beta 3 integrin in murine tumor cells."
    Chen Y.Q., Gao X., Timar J., Tang D., Grossi I.M., Chelladurai M., Kunicki T.J., Fligiel S.E., Taylor J.D., Honn K.V.
    J. Biol. Chem. 267:17314-17320(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 805-865.
  6. Rout U.K., Armant D.R.
    Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE OF 790-1022.
  7. "Multiple discontinuous ligand-mimetic antibody binding sites define a ligand binding pocket in integrin alphaIIbbeta3."
    Puzon-McLaughlin W., Kamata T., Takada Y.
    J. Biol. Chem. 275:7795-7802(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-484.

Entry informationi

Entry nameiITA2B_MOUSE
AccessioniPrimary (citable) accession number: Q9QUM0
Secondary accession number(s): Q3U3R7, Q64229, Q9Z2M0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 27, 2011
Last modified: November 26, 2014
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3