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Reviewed, UniProtKB/Swiss-Prot Q9QUL6 (NSF_RAT)

Last modified June 16, 2009. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Vesicle-fusing ATPase
    EC=3.6.4.6
Alternative name(s):
    N-ethylmaleimide-sensitive fusion protein
      Short name=NEM-sensitive fusion protein
    Vesicular-fusion protein NSF
Gene names
Name: Nsf
Synonyms: Erg1
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length744 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seem to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin By similarity.

Catalytic activity

ATP + H2O = ADP + phosphate.

Cofactor

Binds 1 magnesium ion per subunit By similarity.

Subunit structure

Homohexamer. Interacts with GABARAP and GABARAPL2 By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the AAA ATPase family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

GabarapP605171EBI-925794,EBI-925812
Gria2P194914EBI-925794,EBI-77718

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 744744Vesicle-fusing ATPase
PRO_0000263087

Regions

Nucleotide binding260 – 2678ATP Potential
Nucleotide binding543 – 5508ATP Potential

Sites

Metal binding5501Magnesium By similarity

Amino acid modifications

Modified residue2591Phosphotyrosine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9QUL6-1 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 82978187FC3E0E03

FASTA74482,652
        10         20         30         40         50         60 
MAGRTMQAAR CPTDELSLSN CAVVNEKDYQ SGQHVMVRTS PNHKYIFTLR THPSVVPGCI 

        70         80         90        100        110        120 
AFSLPQRKWA GLSIGQDIEV ALYSFDKAKQ CIGTMTIEID FLQKKNIDSN PYDTDKMAAE 

       130        140        150        160        170        180 
FIQQFNHQAF SVGQQLVFSF NDKLFGLLVK DIEAMDPSIL KGEPASGKRQ KIEVGLVVGN 

       190        200        210        220        230        240 
SQVAFEKAEN SSLNLIGKAK TKENRQSIIN PDWNFEKMGI GGLDKEFSDI FRRAFASRVF 

       250        260        270        280        290        300 
PPEIVEQMGC KHVKGILLYG PPGCGKTLLA RQIGKMLNAR EPKVVNGPEI LNKYVGESEA 

       310        320        330        340        350        360 
NIRKLFADAE EEQRRLGANS GLHIIIFDEI DAICKQRGSM AGSTGVHDTV VNQLLSKIDG 

       370        380        390        400        410        420 
VEQLNNILVI GMTNRPDLID EALLRPGRLE VKMEIGLPDE KGRLQILHIH TARMRGHQLL 

       430        440        450        460        470        480 
SADVDIKELA VETKNFSGAE LEGLVRAAQS TAMNRHIKAS TKVEVDMEKA ESLQVTRGDF 

       490        500        510        520        530        540 
LASLENDIKP AFGTNQEDYA SYIMNGIIKW GDPVTRVLDD GELLVQQTKN SDRTPLVSVL 

       550        560        570        580        590        600 
LEGPPHSGKT ALAAKIAEES NFPFIKICSP DKMIGFSETA KCQAMKKIFD DAYKSQLSCV 

       610        620        630        640        650        660 
VVDDIERLLD YVPIGPRFSN LVLQALLVLL KKAPPQGRKL LIIGTTSRKD VLQEMEMLNA 

       670        680        690        700        710        720 
FSTTIHVPNI ATGEQLLEAL ELLGNFKDKE RTTIAQQVKG KKVWIGIKKL LMLIEMSLQM 

       730        740 
DPEYRVRKFL ALMREEGASP LDFD 

« Hide

References

[1]Guan Z., Lu L.R., Zheng Z.C., Liu X.Y.
Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Brain.
[2]Viswanathan V., Vincent S.R.
Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
[3]Lubec G., Afjehi-Sadat L., Diao W.
Submitted (APR-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 11-27; 69-87; 170-187; 218-232; 255-266; 316-335; 338-357; 404-413; 435-446; 534-549; 556-566; 595-631 AND 708-725, MASS SPECTROMETRY.
Strain: Sprague-Dawley.
Tissue: Hippocampus and Spinal cord.

Cross-references

Sequence databases

AF142097 mRNA. Translation: AAD39485.1.
AF189019 mRNA. Translation: AAF01051.1.
IPIIPI00210635.
RefSeqNP_068516.1.
UniGeneRn.13345

3D structure databases

HSSPHSSP built from PDB template 1NSF based on UniProtKB P18708.
SMRQ9QUL6. Positions 1-201, 489-735.
ModBaseSearch...

Protein-protein interaction databases

IntActQ9QUL6. 3 interactions.

PTM databases

PhosphoSiteQ9QUL6.

Proteomic databases

PRIDEQ9QUL6.

Genome annotation databases

EnsemblENSRNOG00000003905. Rattus norvegicus. [Contig view]
GeneID60355.
KEGGrno:60355.

Organism-specific databases

RGD621594. Nsf.

Phylogenomic databases

HOVERGENQ9QUL6.

Enzyme and pathway databases

BRENDA3.6.4.6. 248.

Gene expression databases

ArrayExpressQ9QUL6.
GermOnlineENSRNOG00000003905. Rattus norvegicus.

Family and domain databases

InterProIPR003593. ATPase_AAA+_core.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR003338. ATPase_AAA_VAT_N.
IPR004201. Cell_division_protein_CDC48_2.
IPR001984. Peptidase_S16_C.
[Graphical view]
PfamPF00004. AAA. 2 hits.
PF02933. CDC48_2. 1 hit.
PF02359. CDC48_N. 1 hit.
[Graphical view]
PRINTSPR00830. ENDOLAPTASE.
SMARTSM00382. AAA. 2 hits.
[Graphical view]
PROSITEPS00674. AAA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio612027.

Entry information

Entry nameNSF_RAT
AccessionPrimary (citable) accession number: Q9QUL6
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: May 1, 2000
Last modified: June 16, 2009
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents