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Protein

Group IIE secretory phospholipase A2

Gene

Pla2g2e

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.

Catalytic activityi

Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.PROSITE-ProRule annotation

Cofactori

Ca2+Note: Binds 1 Ca2+ ion per subunit.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi45 – 451Calcium; via carbonyl oxygenBy similarity
Metal bindingi47 – 471Calcium; via carbonyl oxygenBy similarity
Metal bindingi49 – 491Calcium; via carbonyl oxygenBy similarity
Active sitei65 – 651PROSITE-ProRule annotation
Metal bindingi66 – 661CalciumBy similarity
Active sitei109 – 1091PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BRENDAi3.1.1.4. 3474.
ReactomeiR-MMU-1482788. Acyl chain remodelling of PC.
R-MMU-1482801. Acyl chain remodelling of PS.
R-MMU-1482839. Acyl chain remodelling of PE.
R-MMU-1482922. Acyl chain remodelling of PI.
R-MMU-1482925. Acyl chain remodelling of PG.
R-MMU-1483166. Synthesis of PA.

Names & Taxonomyi

Protein namesi
Recommended name:
Group IIE secretory phospholipase A2 (EC:3.1.1.4)
Short name:
GIIE sPLA2
Short name:
sPLA2-IIE
Alternative name(s):
Phosphatidylcholine 2-acylhydrolase 2E
Gene namesi
Name:Pla2g2e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1349660. Pla2g2e.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL4201.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 142123Group IIE secretory phospholipase A2PRO_0000022758Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi44 ↔ 135By similarity
Disulfide bondi46 ↔ 62By similarity
Disulfide bondi61 ↔ 115By similarity
Disulfide bondi67 ↔ 142By similarity
Disulfide bondi68 ↔ 108By similarity
Disulfide bondi77 ↔ 101By similarity
Disulfide bondi95 ↔ 106By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9QUL3.
PRIDEiQ9QUL3.

Expressioni

Tissue specificityi

Highly expressed in uterus, and at lower levels in various other tissues.

Gene expression databases

BgeeiQ9QUL3.
CleanExiMM_PLA2G2E.
ExpressionAtlasiQ9QUL3. baseline and differential.
GenevisibleiQ9QUL3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030531.

Chemistry

BindingDBiQ9QUL3.

Structurei

3D structure databases

ProteinModelPortaliQ9QUL3.
SMRiQ9QUL3. Positions 20-142.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phospholipase A2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4087. Eukaryota.
ENOG411283D. LUCA.
GeneTreeiENSGT00760000119160.
HOGENOMiHOG000231749.
HOVERGENiHBG008137.
InParanoidiQ9QUL3.
KOiK01047.
OMAiFGVMIER.
OrthoDBiEOG7N63PF.
PhylomeDBiQ9QUL3.
TreeFamiTF319283.

Family and domain databases

Gene3Di1.20.90.10. 1 hit.
InterProiIPR001211. PLipase_A2.
IPR016090. PLipase_A2_dom.
IPR033113. PLipase_A2_His_AS.
[Graphical view]
PfamiPF00068. Phospholip_A2_1. 1 hit.
[Graphical view]
PRINTSiPR00389. PHPHLIPASEA2.
SMARTiSM00085. PA2c. 1 hit.
[Graphical view]
SUPFAMiSSF48619. SSF48619. 1 hit.
PROSITEiPS00118. PA2_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9QUL3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPPIALACL CLLVPLAGGN LVQFGVMIER MTGKPALQYN DYGCYCGVGG
60 70 80 90 100
SHWPVDETDW CCHAHDCCYG RLEKLGCDPK LEKYLFSITR DNIFCAGRTA
110 120 130 140
CQRHTCECDK RAALCFRHNL NTYNRKYAHY PNKLCTGPTP PC
Length:142
Mass (Da):15,943
Last modified:May 1, 2000 - v1
Checksum:i8B0E3CC710A1F946
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF166098 mRNA. Translation: AAF04499.1.
AF112984 mRNA. Translation: AAF22290.1.
BC027524 mRNA. Translation: AAH27524.1.
CCDSiCCDS18835.1.
RefSeqiNP_036174.1. NM_012044.2.
XP_006539010.1. XM_006538947.2.
UniGeneiMm.296007.

Genome annotation databases

EnsembliENSMUST00000030531; ENSMUSP00000030531; ENSMUSG00000028751.
ENSMUST00000105804; ENSMUSP00000101430; ENSMUSG00000028751.
GeneIDi26970.
KEGGimmu:26970.
UCSCiuc008vll.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF166098 mRNA. Translation: AAF04499.1.
AF112984 mRNA. Translation: AAF22290.1.
BC027524 mRNA. Translation: AAH27524.1.
CCDSiCCDS18835.1.
RefSeqiNP_036174.1. NM_012044.2.
XP_006539010.1. XM_006538947.2.
UniGeneiMm.296007.

3D structure databases

ProteinModelPortaliQ9QUL3.
SMRiQ9QUL3. Positions 20-142.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030531.

Chemistry

BindingDBiQ9QUL3.
ChEMBLiCHEMBL4201.

Proteomic databases

PaxDbiQ9QUL3.
PRIDEiQ9QUL3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030531; ENSMUSP00000030531; ENSMUSG00000028751.
ENSMUST00000105804; ENSMUSP00000101430; ENSMUSG00000028751.
GeneIDi26970.
KEGGimmu:26970.
UCSCiuc008vll.1. mouse.

Organism-specific databases

CTDi30814.
MGIiMGI:1349660. Pla2g2e.

Phylogenomic databases

eggNOGiKOG4087. Eukaryota.
ENOG411283D. LUCA.
GeneTreeiENSGT00760000119160.
HOGENOMiHOG000231749.
HOVERGENiHBG008137.
InParanoidiQ9QUL3.
KOiK01047.
OMAiFGVMIER.
OrthoDBiEOG7N63PF.
PhylomeDBiQ9QUL3.
TreeFamiTF319283.

Enzyme and pathway databases

BRENDAi3.1.1.4. 3474.
ReactomeiR-MMU-1482788. Acyl chain remodelling of PC.
R-MMU-1482801. Acyl chain remodelling of PS.
R-MMU-1482839. Acyl chain remodelling of PE.
R-MMU-1482922. Acyl chain remodelling of PI.
R-MMU-1482925. Acyl chain remodelling of PG.
R-MMU-1483166. Synthesis of PA.

Miscellaneous databases

NextBioi304911.
PROiQ9QUL3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9QUL3.
CleanExiMM_PLA2G2E.
ExpressionAtlasiQ9QUL3. baseline and differential.
GenevisibleiQ9QUL3. MM.

Family and domain databases

Gene3Di1.20.90.10. 1 hit.
InterProiIPR001211. PLipase_A2.
IPR016090. PLipase_A2_dom.
IPR033113. PLipase_A2_His_AS.
[Graphical view]
PfamiPF00068. Phospholip_A2_1. 1 hit.
[Graphical view]
PRINTSiPR00389. PHPHLIPASEA2.
SMARTiSM00085. PA2c. 1 hit.
[Graphical view]
SUPFAMiSSF48619. SSF48619. 1 hit.
PROSITEiPS00118. PA2_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "On the diversity of secreted phospholipases A2. Cloning, tissue distribution, and functional expression of two novel mouse group II enzymes."
    Valentin E., Ghomashchi F., Gelb M.H., Lazdunski M., Lambeau G.
    J. Biol. Chem. 274:31195-31202(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Structures, enzymatic properties, and expression of novel human and mouse secretory phospholipase A(2)s."
    Suzuki N., Ishizaki J., Yokota Y., Higashino K., Ono T., Ikeda M., Fujii N., Kawamoto K., Hanasaki K.
    J. Biol. Chem. 275:5785-5793(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
    Strain: BALB/cJ.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.

Entry informationi

Entry nameiPA2GE_MOUSE
AccessioniPrimary (citable) accession number: Q9QUL3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: May 1, 2000
Last modified: May 11, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.