Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Heat shock protein beta-7

Gene

Hspb7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • response to heat Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein beta-7
Short name:
HspB7
Alternative name(s):
Cardiovascular heat shock protein
Short name:
cvHsp
Gene namesi
Name:Hspb7
Synonyms:Cvhsp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi62021. Hspb7.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity
  • NucleusCajal body By similarity

  • Note: Resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›90›90Heat shock protein beta-7PRO_0000125943Add
BLAST

Proteomic databases

PaxDbiQ9QUK5.

Expressioni

Tissue specificityi

Found in both cardiac and skeletal muscle.

Interactioni

Subunit structurei

Interacts with C-terminal domain of actin-binding protein 280.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000042240.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1 – 88Poly-Ser

Sequence similaritiesi

Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3591. Eukaryota.
ENOG410YERS. LUCA.
InParanoidiQ9QUK5.

Family and domain databases

InterProiIPR002068. A-crystallin/Hsp20_dom.
IPR031107. HSP20.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PANTHERiPTHR11527. PTHR11527. 1 hit.
PfamiPF00011. HSP20. 1 hit.
[Graphical view]
SUPFAMiSSF49764. SSF49764. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q9QUK5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
SSSSSSASRA LPAQDPPMEK ALSMFSEDFG SFMLPHSEPL TFPARPGGQG
60 70 80 90
NIKTLGDAYE FTVDMRDFSP EDIIVTTSNN HIEVRAEKKP
Length:90
Mass (Da):9,804
Last modified:May 1, 2000 - v1
Checksum:i9D122DB6443ED1FE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei90 – 901

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243193 mRNA. Translation: CAB63268.1.
AF155910 mRNA. Translation: AAF20024.1.
UniGeneiRn.21809.

Genome annotation databases

UCSCiRGD:62021. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243193 mRNA. Translation: CAB63268.1.
AF155910 mRNA. Translation: AAF20024.1.
UniGeneiRn.21809.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000042240.

Proteomic databases

PaxDbiQ9QUK5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:62021. rat.

Organism-specific databases

RGDi62021. Hspb7.

Phylogenomic databases

eggNOGiKOG3591. Eukaryota.
ENOG410YERS. LUCA.
InParanoidiQ9QUK5.

Family and domain databases

InterProiIPR002068. A-crystallin/Hsp20_dom.
IPR031107. HSP20.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PANTHERiPTHR11527. PTHR11527. 1 hit.
PfamiPF00011. HSP20. 1 hit.
[Graphical view]
SUPFAMiSSF49764. SSF49764. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Identification and characterization of cvHsp. A novel human small stress protein selectively expressed in cardiovascular and insulin-sensitive tissues."
    Krief S., Faivre J.-F., Robert P., Le Douarin B., Brument-Larignon N., Lefrere I., Bouzyk M.M., Anderson K.M., Greller L.D., Tobin F.L., Souchet M., Bril A.
    J. Biol. Chem. 274:36592-36600(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart.

Entry informationi

Entry nameiHSPB7_RAT
AccessioniPrimary (citable) accession number: Q9QUK5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 2000
Last modified: December 9, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.