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Protein

Protein CLN8

Gene

Cln8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Could play a role in cell proliferation during neuronal differentiation and in protection against cell death.By similarity

GO - Biological processi

  • adult locomotory behavior Source: MGI
  • adult walking behavior Source: MGI
  • age-dependent response to oxidative stress Source: MGI
  • associative learning Source: MGI
  • cellular macromolecule catabolic process Source: MGI
  • cellular protein catabolic process Source: MGI
  • cellular protein metabolic process Source: MGI
  • ceramide metabolic process Source: UniProtKB
  • cholesterol metabolic process Source: UniProtKB
  • L-glutamate uptake involved in synaptic transmission Source: MGI
  • lysosome organization Source: MGI
  • mitochondrial membrane organization Source: MGI
  • musculoskeletal movement Source: MGI
  • negative regulation of apoptotic process Source: MGI
  • nervous system development Source: UniProtKB
  • neurofilament cytoskeleton organization Source: MGI
  • neuromuscular process controlling balance Source: MGI
  • neuromuscular process controlling posture Source: MGI
  • phospholipid metabolic process Source: UniProtKB
  • photoreceptor cell maintenance Source: MGI
  • regulation of cell size Source: MGI
  • retina development in camera-type eye Source: MGI
  • social behavior Source: MGI
  • somatic motor neuron differentiation Source: MGI
  • spinal cord motor neuron differentiation Source: MGI
  • visual perception Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein CLN8
Gene namesi
Name:Cln8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1349447. Cln8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei26 – 4621HelicalSequence AnalysisAdd
BLAST
Transmembranei71 – 9121HelicalSequence AnalysisAdd
BLAST
Transmembranei103 – 12321HelicalSequence AnalysisAdd
BLAST
Transmembranei131 – 15121HelicalSequence AnalysisAdd
BLAST
Transmembranei225 – 24521HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Involvement in diseasei

Defects in Cln8 are the cause of the phenotype motor neuron degeneration (mnd). Mnd is a naturally occurring mutant It is characterized by progressive motor system degeneration. It has intracellular autofluorescent inclusions similar to those seen in human Cln8.

Keywords - Diseasei

Neurodegeneration, Neuronal ceroid lipofuscinosis

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288Protein CLN8PRO_0000185538Add
BLAST

Proteomic databases

MaxQBiQ9QUK3.
PaxDbiQ9QUK3.
PRIDEiQ9QUK3.

Expressioni

Gene expression databases

BgeeiQ9QUK3.
CleanExiMM_CLN8.
ExpressionAtlasiQ9QUK3. baseline and differential.
GenevisibleiQ9QUK3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027554.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini62 – 262201TLCPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi285 – 2884ER-retrieval signal

Sequence similaritiesi

Contains 1 TLC (TRAM/LAG1/CLN8) domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG239251.
GeneTreeiENSGT00390000001315.
HOGENOMiHOG000111792.
HOVERGENiHBG028338.
InParanoidiQ9QUK3.
KOiK12360.
OMAiFHCRMVL.
PhylomeDBiQ9QUK3.
TreeFamiTF331146.

Family and domain databases

InterProiIPR006634. TLC-dom.
[Graphical view]
PfamiPF03798. TRAM_LAG1_CLN8. 1 hit.
[Graphical view]
SMARTiSM00724. TLC. 1 hit.
[Graphical view]
PROSITEiPS50922. TLC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9QUK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPVSSHGLA ESIFDLDYAS WKIRSTLAVA GFVFYLGVFV VCHQLSSSLN
60 70 80 90 100
ATYRSLAAKE KVFWNLAATR AVFGVQSTTA GLWALLGDPV LYADKALGQQ
110 120 130 140 150
NWCWFHITTA TGFFFFENVA VHLSNLFFRT FDLFLVVHHL FAFLGFLGSA
160 170 180 190 200
INLRAGHYLA MTTLLLEMST PFTCISWMLL KAGWSDSLFW KANQWLMIHM
210 220 230 240 250
FHCRMILTYH MWWVCFCHWD ALTSSLHLPH WALFLFGLAL LTAVINPYWT
260 270 280
HKKTQQLLHP VDWNFAQEEA KGSRQERTNG QVPRKKRL
Length:288
Mass (Da):33,109
Last modified:May 1, 2000 - v1
Checksum:iA11225DE3CD7DEA5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF125308 mRNA. Translation: AAF04462.1.
AF125307 mRNA. Translation: AAF04461.1.
BC021625 mRNA. Translation: AAH21625.1.
CCDSiCCDS40239.1.
RefSeqiNP_036130.1. NM_012000.3.
XP_006508869.1. XM_006508806.2.
XP_006508870.1. XM_006508807.2.
UniGeneiMm.254027.

Genome annotation databases

EnsembliENSMUST00000027554; ENSMUSP00000027554; ENSMUSG00000026317.
GeneIDi26889.
KEGGimmu:26889.
UCSCiuc009kze.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF125308 mRNA. Translation: AAF04462.1.
AF125307 mRNA. Translation: AAF04461.1.
BC021625 mRNA. Translation: AAH21625.1.
CCDSiCCDS40239.1.
RefSeqiNP_036130.1. NM_012000.3.
XP_006508869.1. XM_006508806.2.
XP_006508870.1. XM_006508807.2.
UniGeneiMm.254027.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027554.

Proteomic databases

MaxQBiQ9QUK3.
PaxDbiQ9QUK3.
PRIDEiQ9QUK3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027554; ENSMUSP00000027554; ENSMUSG00000026317.
GeneIDi26889.
KEGGimmu:26889.
UCSCiuc009kze.1. mouse.

Organism-specific databases

CTDi2055.
MGIiMGI:1349447. Cln8.

Phylogenomic databases

eggNOGiNOG239251.
GeneTreeiENSGT00390000001315.
HOGENOMiHOG000111792.
HOVERGENiHBG028338.
InParanoidiQ9QUK3.
KOiK12360.
OMAiFHCRMVL.
PhylomeDBiQ9QUK3.
TreeFamiTF331146.

Miscellaneous databases

NextBioi304715.
PROiQ9QUK3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9QUK3.
CleanExiMM_CLN8.
ExpressionAtlasiQ9QUK3. baseline and differential.
GenevisibleiQ9QUK3. MM.

Family and domain databases

InterProiIPR006634. TLC-dom.
[Graphical view]
PfamiPF03798. TRAM_LAG1_CLN8. 1 hit.
[Graphical view]
SMARTiSM00724. TLC. 1 hit.
[Graphical view]
PROSITEiPS50922. TLC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The neuronal ceroid lipofuscinoses in human EPMR and mnd mutant mice are associated with mutations in CLN8."
    Ranta S., Zhang Y., Ross B., Lonka L., Takkunen E., Messer A., Sharp J., Wheeler R., Kusumi K., Mole S., Liu W., Soares M.B., Bonaldo M.F., Hirvasniemi A., de la Chapelle A., Gilliam T.C., Lehesjoki A.-E.
    Nat. Genet. 23:233-236(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Salivary gland.

Entry informationi

Entry nameiCLN8_MOUSE
AccessioniPrimary (citable) accession number: Q9QUK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: May 1, 2000
Last modified: July 22, 2015
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.