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Q9QUK0

- CDKL2_MOUSE

UniProt

Q9QUK0 - CDKL2_MOUSE

Protein

Cyclin-dependent kinase-like 2

Gene

Cdkl2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei33 – 331ATPPROSITE-ProRule annotation
    Active sitei126 – 1261Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 189ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent kinase-like 2 (EC:2.7.11.22)
    Alternative name(s):
    Serine/threonine-protein kinase KKIAMRE
    Gene namesi
    Name:Cdkl2
    Synonyms:Kkiamre, Kkm
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1858227. Cdkl2.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. centrosome Source: Ensembl
    2. cytoplasm Source: UniProtKB-SubCell
    3. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 568568Cyclin-dependent kinase-like 2PRO_0000085816Add
    BLAST

    Proteomic databases

    PRIDEiQ9QUK0.

    PTM databases

    PhosphoSiteiQ9QUK0.

    Expressioni

    Tissue specificityi

    Expressed in testis, kidney, lung and brain.1 Publication

    Gene expression databases

    ArrayExpressiQ9QUK0.
    BgeeiQ9QUK0.
    GenevestigatoriQ9QUK0.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QUK0.
    SMRiQ9QUK0. Positions 1-310.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 289286Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi45 – 517[NKR]KIAxRE

    Domaini

    The [NKR]KIAxRE motif seems to be a cyclin-binding region.

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00650000093115.
    HOGENOMiHOG000233024.
    HOVERGENiHBG080204.
    InParanoidiQ9QUK0.
    KOiK08824.
    OMAiSTSLRDC.
    OrthoDBiEOG7992PS.
    PhylomeDBiQ9QUK0.
    TreeFamiTF101031.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9QUK0-1) [UniParc]FASTAAdd to Basket

    Also known as: KKIAMRE-beta

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEKYENLGLV GEGSYGMVMK CRNKDSGRIV AIKKFLESDD DKMVKKIAMR    50
    EIKLLKQLRH ENLVNLLEVC KKKKRWYLVF EFVDHTILDD LKLFPNGLDY 100
    QVVQKYLFQI INGIGFCHSH NIIHRDIKPE NILVSQSGVV KLCDFGFART 150
    LAAPGEVYTD YVATRWYRAP ELLVGDVKYG KAVDIWAIGC LVIEMLMGQP 200
    LFPGESDIDQ LHHIMTCLGN LIPRHQELFY KNPVFAGVRL PEVKDAEAEP 250
    LESRYPKLPE AVISLAKKCL HIDPDKRPFC ADLLRHDFFQ MDGFAERFSQ 300
    ELQLKIEKDA RNNSLPKKSQ NRKKEKDDAL GEERKTLVVQ DTNADPKIKD 350
    SKVFKVKGSK IDVEKMEKGS RASNANCLHD NGTNHKGLAS TSLRDCSNVN 400
    IDHSRNPGTA IPPLTHNLSA VAPGINAGMG TIPGVQNYRV DEKTKKYCNP 450
    FVKPNQPPPA GIYNMNVSTS VSGEKYLLQA NKKRKEYPKA DVRLPELNYN 500
    HLPELRALEG IARNSRLIKK ENKCLSESRI PSLAAIDLHV SSVASHQGAG 550
    SPLSDDSEAD LPRMEHQH 568
    Length:568
    Mass (Da):64,056
    Last modified:May 1, 2000 - v1
    Checksum:iA43B75E2E9EB86C4
    GO
    Isoform 2 (identifier: Q9QUK0-2) [UniParc]FASTAAdd to Basket

    Also known as: KKIAMRE-gamma

    The sequence of this isoform differs from the canonical sequence as follows:
         548-564: GAGSPLSDDSEADLPRM → MLPALEMTSSCTRALIP
         565-568: Missing.

    Show »
    Length:564
    Mass (Da):63,641
    Checksum:iDACDEF630CCE82D5
    GO

    Sequence cautioni

    The sequence BAE43274.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti56 – 561K → Q in BAE43274. (PubMed:16141072)Curated
    Sequence conflicti321 – 3222NR → KK in BAA88428. (PubMed:14605869)Curated
    Sequence conflicti325 – 3295EKDDA → KKKKK in BAA88428. (PubMed:14605869)Curated
    Sequence conflicti330 – 568239Missing in BAA88428. (PubMed:14605869)CuratedAdd
    BLAST

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei548 – 56417GAGSP…DLPRM → MLPALEMTSSCTRALIP in isoform 2. 1 PublicationVSP_016146Add
    BLAST
    Alternative sequencei565 – 5684Missing in isoform 2. 1 PublicationVSP_016147

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB029066 mRNA. Translation: BAA88428.1.
    AB029067 mRNA. Translation: BAA88429.1.
    AB029073 Genomic DNA. Translation: BAA88439.1.
    AB029065 mRNA. Translation: BAA88427.1.
    AK030598 mRNA. Translation: BAE43274.1. Different initiation.
    AK144574 mRNA. Translation: BAE25943.1.
    AK145688 mRNA. Translation: BAE26590.1.
    CCDSiCCDS19425.1. [Q9QUK0-2]
    CCDS19426.1. [Q9QUK0-1]
    RefSeqiNP_001263244.1. NM_001276315.1. [Q9QUK0-2]
    NP_058608.1. NM_016912.2. [Q9QUK0-1]
    NP_796244.2. NM_177270.4. [Q9QUK0-2]
    XP_006535186.1. XM_006535123.1. [Q9QUK0-1]
    XP_006535187.1. XM_006535124.1. [Q9QUK0-1]
    UniGeneiMm.44963.

    Genome annotation databases

    EnsembliENSMUST00000069937; ENSMUSP00000063617; ENSMUSG00000029403. [Q9QUK0-2]
    ENSMUST00000086978; ENSMUSP00000084199; ENSMUSG00000029403. [Q9QUK0-1]
    ENSMUST00000113140; ENSMUSP00000108765; ENSMUSG00000029403. [Q9QUK0-1]
    ENSMUST00000113143; ENSMUSP00000108768; ENSMUSG00000029403. [Q9QUK0-2]
    GeneIDi53886.
    KEGGimmu:53886.
    UCSCiuc008ycc.1. mouse. [Q9QUK0-1]
    uc008ycd.1. mouse. [Q9QUK0-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB029066 mRNA. Translation: BAA88428.1 .
    AB029067 mRNA. Translation: BAA88429.1 .
    AB029073 Genomic DNA. Translation: BAA88439.1 .
    AB029065 mRNA. Translation: BAA88427.1 .
    AK030598 mRNA. Translation: BAE43274.1 . Different initiation.
    AK144574 mRNA. Translation: BAE25943.1 .
    AK145688 mRNA. Translation: BAE26590.1 .
    CCDSi CCDS19425.1. [Q9QUK0-2 ]
    CCDS19426.1. [Q9QUK0-1 ]
    RefSeqi NP_001263244.1. NM_001276315.1. [Q9QUK0-2 ]
    NP_058608.1. NM_016912.2. [Q9QUK0-1 ]
    NP_796244.2. NM_177270.4. [Q9QUK0-2 ]
    XP_006535186.1. XM_006535123.1. [Q9QUK0-1 ]
    XP_006535187.1. XM_006535124.1. [Q9QUK0-1 ]
    UniGenei Mm.44963.

    3D structure databases

    ProteinModelPortali Q9QUK0.
    SMRi Q9QUK0. Positions 1-310.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9QUK0.

    Proteomic databases

    PRIDEi Q9QUK0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000069937 ; ENSMUSP00000063617 ; ENSMUSG00000029403 . [Q9QUK0-2 ]
    ENSMUST00000086978 ; ENSMUSP00000084199 ; ENSMUSG00000029403 . [Q9QUK0-1 ]
    ENSMUST00000113140 ; ENSMUSP00000108765 ; ENSMUSG00000029403 . [Q9QUK0-1 ]
    ENSMUST00000113143 ; ENSMUSP00000108768 ; ENSMUSG00000029403 . [Q9QUK0-2 ]
    GeneIDi 53886.
    KEGGi mmu:53886.
    UCSCi uc008ycc.1. mouse. [Q9QUK0-1 ]
    uc008ycd.1. mouse. [Q9QUK0-2 ]

    Organism-specific databases

    CTDi 8999.
    MGIi MGI:1858227. Cdkl2.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00650000093115.
    HOGENOMi HOG000233024.
    HOVERGENi HBG080204.
    InParanoidi Q9QUK0.
    KOi K08824.
    OMAi STSLRDC.
    OrthoDBi EOG7992PS.
    PhylomeDBi Q9QUK0.
    TreeFami TF101031.

    Miscellaneous databases

    NextBioi 310771.
    PROi Q9QUK0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9QUK0.
    Bgeei Q9QUK0.
    Genevestigatori Q9QUK0.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Postnatal expression of Cdkl2 in mouse brain revealed by LacZ inserted into the Cdkl2 locus."
      Sassa T., Gomi H., Itohara S.
      Cell Tissue Res. 315:147-156(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
      Strain: 129/SvJ and C57BL/6.
      Tissue: Brain.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Lung and Pituitary.

    Entry informationi

    Entry nameiCDKL2_MOUSE
    AccessioniPrimary (citable) accession number: Q9QUK0
    Secondary accession number(s): Q3UL60
    , Q3V3X7, Q9QYI1, Q9QYI2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3