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Q9QUK0 (CDKL2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cyclin-dependent kinase-like 2

EC=2.7.11.22
Alternative name(s):
Serine/threonine-protein kinase KKIAMRE
Gene names
Name:Cdkl2
Synonyms:Kkiamre, Kkm
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length568 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Tissue specificity

Expressed in testis, kidney, lung and brain. Ref.1

Domain

The [NKR]KIAxRE motif seems to be a cyclin-binding region.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence caution

The sequence BAE43274.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentCytoplasm
Nucleus
   Coding sequence diversityAlternative splicing
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Serine/threonine-protein kinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcentrosome

Inferred from electronic annotation. Source: Ensembl

cytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

cyclin-dependent protein serine/threonine kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9QUK0-1)

Also known as: KKIAMRE-beta;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9QUK0-2)

Also known as: KKIAMRE-gamma;

The sequence of this isoform differs from the canonical sequence as follows:
     548-564: GAGSPLSDDSEADLPRM → MLPALEMTSSCTRALIP
     565-568: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 568568Cyclin-dependent kinase-like 2
PRO_0000085816

Regions

Domain4 – 289286Protein kinase
Nucleotide binding10 – 189ATP By similarity
Motif45 – 517[NKR]KIAxRE

Sites

Active site1261Proton acceptor By similarity
Binding site331ATP By similarity

Natural variations

Alternative sequence548 – 56417GAGSP…DLPRM → MLPALEMTSSCTRALIP in isoform 2.
VSP_016146
Alternative sequence565 – 5684Missing in isoform 2.
VSP_016147

Experimental info

Sequence conflict561K → Q in BAE43274. Ref.2
Sequence conflict321 – 3222NR → KK in BAA88428. Ref.1
Sequence conflict325 – 3295EKDDA → KKKKK in BAA88428. Ref.1
Sequence conflict330 – 568239Missing in BAA88428. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (KKIAMRE-beta) [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: A43B75E2E9EB86C4

FASTA56864,056
        10         20         30         40         50         60 
MEKYENLGLV GEGSYGMVMK CRNKDSGRIV AIKKFLESDD DKMVKKIAMR EIKLLKQLRH 

        70         80         90        100        110        120 
ENLVNLLEVC KKKKRWYLVF EFVDHTILDD LKLFPNGLDY QVVQKYLFQI INGIGFCHSH 

       130        140        150        160        170        180 
NIIHRDIKPE NILVSQSGVV KLCDFGFART LAAPGEVYTD YVATRWYRAP ELLVGDVKYG 

       190        200        210        220        230        240 
KAVDIWAIGC LVIEMLMGQP LFPGESDIDQ LHHIMTCLGN LIPRHQELFY KNPVFAGVRL 

       250        260        270        280        290        300 
PEVKDAEAEP LESRYPKLPE AVISLAKKCL HIDPDKRPFC ADLLRHDFFQ MDGFAERFSQ 

       310        320        330        340        350        360 
ELQLKIEKDA RNNSLPKKSQ NRKKEKDDAL GEERKTLVVQ DTNADPKIKD SKVFKVKGSK 

       370        380        390        400        410        420 
IDVEKMEKGS RASNANCLHD NGTNHKGLAS TSLRDCSNVN IDHSRNPGTA IPPLTHNLSA 

       430        440        450        460        470        480 
VAPGINAGMG TIPGVQNYRV DEKTKKYCNP FVKPNQPPPA GIYNMNVSTS VSGEKYLLQA 

       490        500        510        520        530        540 
NKKRKEYPKA DVRLPELNYN HLPELRALEG IARNSRLIKK ENKCLSESRI PSLAAIDLHV 

       550        560 
SSVASHQGAG SPLSDDSEAD LPRMEHQH 

« Hide

Isoform 2 (KKIAMRE-gamma) [UniParc].

Checksum: DACDEF630CCE82D5
Show »

FASTA56463,641

References

« Hide 'large scale' references
[1]"Postnatal expression of Cdkl2 in mouse brain revealed by LacZ inserted into the Cdkl2 locus."
Sassa T., Gomi H., Itohara S.
Cell Tissue Res. 315:147-156(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
Strain: 129/SvJ and C57BL/6.
Tissue: Brain.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: C57BL/6J.
Tissue: Lung and Pituitary.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB029066 mRNA. Translation: BAA88428.1.
AB029067 mRNA. Translation: BAA88429.1.
AB029073 Genomic DNA. Translation: BAA88439.1.
AB029065 mRNA. Translation: BAA88427.1.
AK030598 mRNA. Translation: BAE43274.1. Different initiation.
AK144574 mRNA. Translation: BAE25943.1.
AK145688 mRNA. Translation: BAE26590.1.
CCDSCCDS19425.1. [Q9QUK0-2]
CCDS19426.1. [Q9QUK0-1]
RefSeqNP_001263244.1. NM_001276315.1. [Q9QUK0-2]
NP_058608.1. NM_016912.2. [Q9QUK0-1]
NP_796244.2. NM_177270.4. [Q9QUK0-2]
XP_006535186.1. XM_006535123.1. [Q9QUK0-1]
XP_006535187.1. XM_006535124.1. [Q9QUK0-1]
UniGeneMm.44963.

3D structure databases

ProteinModelPortalQ9QUK0.
SMRQ9QUK0. Positions 1-310.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ9QUK0.

Proteomic databases

PRIDEQ9QUK0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000069937; ENSMUSP00000063617; ENSMUSG00000029403. [Q9QUK0-2]
ENSMUST00000086978; ENSMUSP00000084199; ENSMUSG00000029403. [Q9QUK0-1]
ENSMUST00000113140; ENSMUSP00000108765; ENSMUSG00000029403. [Q9QUK0-1]
ENSMUST00000113143; ENSMUSP00000108768; ENSMUSG00000029403. [Q9QUK0-2]
GeneID53886.
KEGGmmu:53886.
UCSCuc008ycc.1. mouse. [Q9QUK0-1]
uc008ycd.1. mouse. [Q9QUK0-2]

Organism-specific databases

CTD8999.
MGIMGI:1858227. Cdkl2.

Phylogenomic databases

eggNOGCOG0515.
GeneTreeENSGT00650000093115.
HOGENOMHOG000233024.
HOVERGENHBG080204.
InParanoidQ9QUK0.
KOK08824.
OMASTSLRDC.
OrthoDBEOG7992PS.
PhylomeDBQ9QUK0.
TreeFamTF101031.

Gene expression databases

ArrayExpressQ9QUK0.
BgeeQ9QUK0.
GenevestigatorQ9QUK0.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio310771.
PROQ9QUK0.
SOURCESearch...

Entry information

Entry nameCDKL2_MOUSE
AccessionPrimary (citable) accession number: Q9QUK0
Secondary accession number(s): Q3UL60 expand/collapse secondary AC list , Q3V3X7, Q9QYI1, Q9QYI2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot