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Q9QUK0

- CDKL2_MOUSE

UniProt

Q9QUK0 - CDKL2_MOUSE

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Protein
Cyclin-dependent kinase-like 2
Gene
Cdkl2, Kkiamre, Kkm
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331ATP By similarity
Active sitei126 – 1261Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase-like 2 (EC:2.7.11.22)
Alternative name(s):
Serine/threonine-protein kinase KKIAMRE
Gene namesi
Name:Cdkl2
Synonyms:Kkiamre, Kkm
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1858227. Cdkl2.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. centrosome Source: Ensembl
  2. cytoplasm Source: UniProtKB-SubCell
  3. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 568568Cyclin-dependent kinase-like 2
PRO_0000085816Add
BLAST

Proteomic databases

PRIDEiQ9QUK0.

PTM databases

PhosphoSiteiQ9QUK0.

Expressioni

Tissue specificityi

Expressed in testis, kidney, lung and brain.1 Publication

Gene expression databases

ArrayExpressiQ9QUK0.
BgeeiQ9QUK0.
GenevestigatoriQ9QUK0.

Structurei

3D structure databases

ProteinModelPortaliQ9QUK0.
SMRiQ9QUK0. Positions 1-310.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 289286Protein kinase
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi45 – 517[NKR]KIAxRE

Domaini

The [NKR]KIAxRE motif seems to be a cyclin-binding region.

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00650000093115.
HOGENOMiHOG000233024.
HOVERGENiHBG080204.
InParanoidiQ9QUK0.
KOiK08824.
OMAiSTSLRDC.
OrthoDBiEOG7992PS.
PhylomeDBiQ9QUK0.
TreeFamiTF101031.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9QUK0-1) [UniParc]FASTAAdd to Basket

Also known as: KKIAMRE-beta

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEKYENLGLV GEGSYGMVMK CRNKDSGRIV AIKKFLESDD DKMVKKIAMR    50
EIKLLKQLRH ENLVNLLEVC KKKKRWYLVF EFVDHTILDD LKLFPNGLDY 100
QVVQKYLFQI INGIGFCHSH NIIHRDIKPE NILVSQSGVV KLCDFGFART 150
LAAPGEVYTD YVATRWYRAP ELLVGDVKYG KAVDIWAIGC LVIEMLMGQP 200
LFPGESDIDQ LHHIMTCLGN LIPRHQELFY KNPVFAGVRL PEVKDAEAEP 250
LESRYPKLPE AVISLAKKCL HIDPDKRPFC ADLLRHDFFQ MDGFAERFSQ 300
ELQLKIEKDA RNNSLPKKSQ NRKKEKDDAL GEERKTLVVQ DTNADPKIKD 350
SKVFKVKGSK IDVEKMEKGS RASNANCLHD NGTNHKGLAS TSLRDCSNVN 400
IDHSRNPGTA IPPLTHNLSA VAPGINAGMG TIPGVQNYRV DEKTKKYCNP 450
FVKPNQPPPA GIYNMNVSTS VSGEKYLLQA NKKRKEYPKA DVRLPELNYN 500
HLPELRALEG IARNSRLIKK ENKCLSESRI PSLAAIDLHV SSVASHQGAG 550
SPLSDDSEAD LPRMEHQH 568
Length:568
Mass (Da):64,056
Last modified:May 1, 2000 - v1
Checksum:iA43B75E2E9EB86C4
GO
Isoform 2 (identifier: Q9QUK0-2) [UniParc]FASTAAdd to Basket

Also known as: KKIAMRE-gamma

The sequence of this isoform differs from the canonical sequence as follows:
     548-564: GAGSPLSDDSEADLPRM → MLPALEMTSSCTRALIP
     565-568: Missing.

Show »
Length:564
Mass (Da):63,641
Checksum:iDACDEF630CCE82D5
GO

Sequence cautioni

The sequence BAE43274.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei548 – 56417GAGSP…DLPRM → MLPALEMTSSCTRALIP in isoform 2.
VSP_016146Add
BLAST
Alternative sequencei565 – 5684Missing in isoform 2.
VSP_016147

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti56 – 561K → Q in BAE43274. 1 Publication
Sequence conflicti321 – 3222NR → KK in BAA88428. 1 Publication
Sequence conflicti325 – 3295EKDDA → KKKKK in BAA88428. 1 Publication
Sequence conflicti330 – 568239Missing in BAA88428. 1 Publication
Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB029066 mRNA. Translation: BAA88428.1.
AB029067 mRNA. Translation: BAA88429.1.
AB029073 Genomic DNA. Translation: BAA88439.1.
AB029065 mRNA. Translation: BAA88427.1.
AK030598 mRNA. Translation: BAE43274.1. Different initiation.
AK144574 mRNA. Translation: BAE25943.1.
AK145688 mRNA. Translation: BAE26590.1.
CCDSiCCDS19425.1. [Q9QUK0-2]
CCDS19426.1. [Q9QUK0-1]
RefSeqiNP_001263244.1. NM_001276315.1. [Q9QUK0-2]
NP_058608.1. NM_016912.2. [Q9QUK0-1]
NP_796244.2. NM_177270.4. [Q9QUK0-2]
XP_006535186.1. XM_006535123.1. [Q9QUK0-1]
XP_006535187.1. XM_006535124.1. [Q9QUK0-1]
UniGeneiMm.44963.

Genome annotation databases

EnsembliENSMUST00000069937; ENSMUSP00000063617; ENSMUSG00000029403. [Q9QUK0-2]
ENSMUST00000086978; ENSMUSP00000084199; ENSMUSG00000029403. [Q9QUK0-1]
ENSMUST00000113140; ENSMUSP00000108765; ENSMUSG00000029403. [Q9QUK0-1]
ENSMUST00000113143; ENSMUSP00000108768; ENSMUSG00000029403. [Q9QUK0-2]
GeneIDi53886.
KEGGimmu:53886.
UCSCiuc008ycc.1. mouse. [Q9QUK0-1]
uc008ycd.1. mouse. [Q9QUK0-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB029066 mRNA. Translation: BAA88428.1 .
AB029067 mRNA. Translation: BAA88429.1 .
AB029073 Genomic DNA. Translation: BAA88439.1 .
AB029065 mRNA. Translation: BAA88427.1 .
AK030598 mRNA. Translation: BAE43274.1 . Different initiation.
AK144574 mRNA. Translation: BAE25943.1 .
AK145688 mRNA. Translation: BAE26590.1 .
CCDSi CCDS19425.1. [Q9QUK0-2 ]
CCDS19426.1. [Q9QUK0-1 ]
RefSeqi NP_001263244.1. NM_001276315.1. [Q9QUK0-2 ]
NP_058608.1. NM_016912.2. [Q9QUK0-1 ]
NP_796244.2. NM_177270.4. [Q9QUK0-2 ]
XP_006535186.1. XM_006535123.1. [Q9QUK0-1 ]
XP_006535187.1. XM_006535124.1. [Q9QUK0-1 ]
UniGenei Mm.44963.

3D structure databases

ProteinModelPortali Q9QUK0.
SMRi Q9QUK0. Positions 1-310.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9QUK0.

Proteomic databases

PRIDEi Q9QUK0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000069937 ; ENSMUSP00000063617 ; ENSMUSG00000029403 . [Q9QUK0-2 ]
ENSMUST00000086978 ; ENSMUSP00000084199 ; ENSMUSG00000029403 . [Q9QUK0-1 ]
ENSMUST00000113140 ; ENSMUSP00000108765 ; ENSMUSG00000029403 . [Q9QUK0-1 ]
ENSMUST00000113143 ; ENSMUSP00000108768 ; ENSMUSG00000029403 . [Q9QUK0-2 ]
GeneIDi 53886.
KEGGi mmu:53886.
UCSCi uc008ycc.1. mouse. [Q9QUK0-1 ]
uc008ycd.1. mouse. [Q9QUK0-2 ]

Organism-specific databases

CTDi 8999.
MGIi MGI:1858227. Cdkl2.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00650000093115.
HOGENOMi HOG000233024.
HOVERGENi HBG080204.
InParanoidi Q9QUK0.
KOi K08824.
OMAi STSLRDC.
OrthoDBi EOG7992PS.
PhylomeDBi Q9QUK0.
TreeFami TF101031.

Miscellaneous databases

NextBioi 310771.
PROi Q9QUK0.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9QUK0.
Bgeei Q9QUK0.
Genevestigatori Q9QUK0.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Postnatal expression of Cdkl2 in mouse brain revealed by LacZ inserted into the Cdkl2 locus."
    Sassa T., Gomi H., Itohara S.
    Cell Tissue Res. 315:147-156(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
    Strain: 129/SvJ and C57BL/6.
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Lung and Pituitary.

Entry informationi

Entry nameiCDKL2_MOUSE
AccessioniPrimary (citable) accession number: Q9QUK0
Secondary accession number(s): Q3UL60
, Q3V3X7, Q9QYI1, Q9QYI2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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