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Protein

Cyclin-dependent kinase-like 2

Gene

Cdkl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33ATPPROSITE-ProRule annotation1
Active sitei126Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 18ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase-like 2 (EC:2.7.11.22)
Alternative name(s):
Serine/threonine-protein kinase KKIAMRE
Gene namesi
Name:Cdkl2
Synonyms:Kkiamre, Kkm
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1858227. Cdkl2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000858161 – 568Cyclin-dependent kinase-like 2Add BLAST568

Proteomic databases

PaxDbiQ9QUK0.
PRIDEiQ9QUK0.

PTM databases

iPTMnetiQ9QUK0.
PhosphoSitePlusiQ9QUK0.

Expressioni

Tissue specificityi

Expressed in testis, kidney, lung and brain.1 Publication

Gene expression databases

BgeeiENSMUSG00000029403.
ExpressionAtlasiQ9QUK0. baseline and differential.
GenevisibleiQ9QUK0. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000084199.

Structurei

3D structure databases

ProteinModelPortaliQ9QUK0.
SMRiQ9QUK0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 289Protein kinasePROSITE-ProRule annotationAdd BLAST286

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi45 – 51[NKR]KIAxRE7

Domaini

The [NKR]KIAxRE motif seems to be a cyclin-binding region.

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0593. Eukaryota.
ENOG410XNSW. LUCA.
GeneTreeiENSGT00830000128262.
HOGENOMiHOG000233024.
HOVERGENiHBG080204.
InParanoidiQ9QUK0.
KOiK08824.
OMAiSTSLRDC.
OrthoDBiEOG091G0BZP.
PhylomeDBiQ9QUK0.
TreeFamiTF101031.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9QUK0-1) [UniParc]FASTAAdd to basket
Also known as: KKIAMRE-beta

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEKYENLGLV GEGSYGMVMK CRNKDSGRIV AIKKFLESDD DKMVKKIAMR
60 70 80 90 100
EIKLLKQLRH ENLVNLLEVC KKKKRWYLVF EFVDHTILDD LKLFPNGLDY
110 120 130 140 150
QVVQKYLFQI INGIGFCHSH NIIHRDIKPE NILVSQSGVV KLCDFGFART
160 170 180 190 200
LAAPGEVYTD YVATRWYRAP ELLVGDVKYG KAVDIWAIGC LVIEMLMGQP
210 220 230 240 250
LFPGESDIDQ LHHIMTCLGN LIPRHQELFY KNPVFAGVRL PEVKDAEAEP
260 270 280 290 300
LESRYPKLPE AVISLAKKCL HIDPDKRPFC ADLLRHDFFQ MDGFAERFSQ
310 320 330 340 350
ELQLKIEKDA RNNSLPKKSQ NRKKEKDDAL GEERKTLVVQ DTNADPKIKD
360 370 380 390 400
SKVFKVKGSK IDVEKMEKGS RASNANCLHD NGTNHKGLAS TSLRDCSNVN
410 420 430 440 450
IDHSRNPGTA IPPLTHNLSA VAPGINAGMG TIPGVQNYRV DEKTKKYCNP
460 470 480 490 500
FVKPNQPPPA GIYNMNVSTS VSGEKYLLQA NKKRKEYPKA DVRLPELNYN
510 520 530 540 550
HLPELRALEG IARNSRLIKK ENKCLSESRI PSLAAIDLHV SSVASHQGAG
560
SPLSDDSEAD LPRMEHQH
Length:568
Mass (Da):64,056
Last modified:May 1, 2000 - v1
Checksum:iA43B75E2E9EB86C4
GO
Isoform 2 (identifier: Q9QUK0-2) [UniParc]FASTAAdd to basket
Also known as: KKIAMRE-gamma

The sequence of this isoform differs from the canonical sequence as follows:
     548-564: GAGSPLSDDSEADLPRM → MLPALEMTSSCTRALIP
     565-568: Missing.

Show »
Length:564
Mass (Da):63,641
Checksum:iDACDEF630CCE82D5
GO

Sequence cautioni

The sequence BAE43274 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti56K → Q in BAE43274 (PubMed:16141072).Curated1
Sequence conflicti321 – 322NR → KK in BAA88428 (PubMed:14605869).Curated2
Sequence conflicti325 – 329EKDDA → KKKKK in BAA88428 (PubMed:14605869).Curated5
Sequence conflicti330 – 568Missing in BAA88428 (PubMed:14605869).CuratedAdd BLAST239

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_016146548 – 564GAGSP…DLPRM → MLPALEMTSSCTRALIP in isoform 2. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_016147565 – 568Missing in isoform 2. 1 Publication4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029066 mRNA. Translation: BAA88428.1.
AB029067 mRNA. Translation: BAA88429.1.
AB029073 Genomic DNA. Translation: BAA88439.1.
AB029065 mRNA. Translation: BAA88427.1.
AK030598 mRNA. Translation: BAE43274.1. Different initiation.
AK144574 mRNA. Translation: BAE25943.1.
AK145688 mRNA. Translation: BAE26590.1.
CCDSiCCDS19425.1. [Q9QUK0-2]
CCDS19426.1. [Q9QUK0-1]
RefSeqiNP_001263244.1. NM_001276315.1. [Q9QUK0-2]
NP_058608.1. NM_016912.2. [Q9QUK0-1]
NP_796244.2. NM_177270.4. [Q9QUK0-2]
XP_011247839.1. XM_011249537.2. [Q9QUK0-1]
XP_017176476.1. XM_017320987.1. [Q9QUK0-1]
XP_017176477.1. XM_017320988.1. [Q9QUK0-1]
UniGeneiMm.44963.

Genome annotation databases

EnsembliENSMUST00000069937; ENSMUSP00000063617; ENSMUSG00000029403. [Q9QUK0-2]
ENSMUST00000086978; ENSMUSP00000084199; ENSMUSG00000029403. [Q9QUK0-1]
ENSMUST00000113140; ENSMUSP00000108765; ENSMUSG00000029403. [Q9QUK0-1]
ENSMUST00000113143; ENSMUSP00000108768; ENSMUSG00000029403. [Q9QUK0-2]
GeneIDi53886.
KEGGimmu:53886.
UCSCiuc008ycc.2. mouse. [Q9QUK0-1]
uc008ycd.2. mouse. [Q9QUK0-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029066 mRNA. Translation: BAA88428.1.
AB029067 mRNA. Translation: BAA88429.1.
AB029073 Genomic DNA. Translation: BAA88439.1.
AB029065 mRNA. Translation: BAA88427.1.
AK030598 mRNA. Translation: BAE43274.1. Different initiation.
AK144574 mRNA. Translation: BAE25943.1.
AK145688 mRNA. Translation: BAE26590.1.
CCDSiCCDS19425.1. [Q9QUK0-2]
CCDS19426.1. [Q9QUK0-1]
RefSeqiNP_001263244.1. NM_001276315.1. [Q9QUK0-2]
NP_058608.1. NM_016912.2. [Q9QUK0-1]
NP_796244.2. NM_177270.4. [Q9QUK0-2]
XP_011247839.1. XM_011249537.2. [Q9QUK0-1]
XP_017176476.1. XM_017320987.1. [Q9QUK0-1]
XP_017176477.1. XM_017320988.1. [Q9QUK0-1]
UniGeneiMm.44963.

3D structure databases

ProteinModelPortaliQ9QUK0.
SMRiQ9QUK0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000084199.

PTM databases

iPTMnetiQ9QUK0.
PhosphoSitePlusiQ9QUK0.

Proteomic databases

PaxDbiQ9QUK0.
PRIDEiQ9QUK0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000069937; ENSMUSP00000063617; ENSMUSG00000029403. [Q9QUK0-2]
ENSMUST00000086978; ENSMUSP00000084199; ENSMUSG00000029403. [Q9QUK0-1]
ENSMUST00000113140; ENSMUSP00000108765; ENSMUSG00000029403. [Q9QUK0-1]
ENSMUST00000113143; ENSMUSP00000108768; ENSMUSG00000029403. [Q9QUK0-2]
GeneIDi53886.
KEGGimmu:53886.
UCSCiuc008ycc.2. mouse. [Q9QUK0-1]
uc008ycd.2. mouse. [Q9QUK0-2]

Organism-specific databases

CTDi8999.
MGIiMGI:1858227. Cdkl2.

Phylogenomic databases

eggNOGiKOG0593. Eukaryota.
ENOG410XNSW. LUCA.
GeneTreeiENSGT00830000128262.
HOGENOMiHOG000233024.
HOVERGENiHBG080204.
InParanoidiQ9QUK0.
KOiK08824.
OMAiSTSLRDC.
OrthoDBiEOG091G0BZP.
PhylomeDBiQ9QUK0.
TreeFamiTF101031.

Miscellaneous databases

PROiQ9QUK0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029403.
ExpressionAtlasiQ9QUK0. baseline and differential.
GenevisibleiQ9QUK0. MM.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDKL2_MOUSE
AccessioniPrimary (citable) accession number: Q9QUK0
Secondary accession number(s): Q3UL60
, Q3V3X7, Q9QYI1, Q9QYI2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.