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Protein

Cyclin-dependent kinase-like 2

Gene

Cdkl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331ATPPROSITE-ProRule annotation
Active sitei126 – 1261Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase-like 2 (EC:2.7.11.22)
Alternative name(s):
Serine/threonine-protein kinase KKIAMRE
Gene namesi
Name:Cdkl2
Synonyms:Kkiamre, Kkm
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1858227. Cdkl2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 568568Cyclin-dependent kinase-like 2PRO_0000085816Add
BLAST

Proteomic databases

PRIDEiQ9QUK0.

PTM databases

PhosphoSiteiQ9QUK0.

Expressioni

Tissue specificityi

Expressed in testis, kidney, lung and brain.1 Publication

Gene expression databases

BgeeiQ9QUK0.
ExpressionAtlasiQ9QUK0. baseline and differential.
GenevisibleiQ9QUK0. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000084199.

Structurei

3D structure databases

ProteinModelPortaliQ9QUK0.
SMRiQ9QUK0. Positions 1-310.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 289286Protein kinasePROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi45 – 517[NKR]KIAxRE

Domaini

The [NKR]KIAxRE motif seems to be a cyclin-binding region.

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000119242.
HOGENOMiHOG000233024.
HOVERGENiHBG080204.
InParanoidiQ9QUK0.
KOiK08824.
OMAiSTSLRDC.
OrthoDBiEOG7992PS.
PhylomeDBiQ9QUK0.
TreeFamiTF101031.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9QUK0-1) [UniParc]FASTAAdd to basket

Also known as: KKIAMRE-beta

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEKYENLGLV GEGSYGMVMK CRNKDSGRIV AIKKFLESDD DKMVKKIAMR
60 70 80 90 100
EIKLLKQLRH ENLVNLLEVC KKKKRWYLVF EFVDHTILDD LKLFPNGLDY
110 120 130 140 150
QVVQKYLFQI INGIGFCHSH NIIHRDIKPE NILVSQSGVV KLCDFGFART
160 170 180 190 200
LAAPGEVYTD YVATRWYRAP ELLVGDVKYG KAVDIWAIGC LVIEMLMGQP
210 220 230 240 250
LFPGESDIDQ LHHIMTCLGN LIPRHQELFY KNPVFAGVRL PEVKDAEAEP
260 270 280 290 300
LESRYPKLPE AVISLAKKCL HIDPDKRPFC ADLLRHDFFQ MDGFAERFSQ
310 320 330 340 350
ELQLKIEKDA RNNSLPKKSQ NRKKEKDDAL GEERKTLVVQ DTNADPKIKD
360 370 380 390 400
SKVFKVKGSK IDVEKMEKGS RASNANCLHD NGTNHKGLAS TSLRDCSNVN
410 420 430 440 450
IDHSRNPGTA IPPLTHNLSA VAPGINAGMG TIPGVQNYRV DEKTKKYCNP
460 470 480 490 500
FVKPNQPPPA GIYNMNVSTS VSGEKYLLQA NKKRKEYPKA DVRLPELNYN
510 520 530 540 550
HLPELRALEG IARNSRLIKK ENKCLSESRI PSLAAIDLHV SSVASHQGAG
560
SPLSDDSEAD LPRMEHQH
Length:568
Mass (Da):64,056
Last modified:May 1, 2000 - v1
Checksum:iA43B75E2E9EB86C4
GO
Isoform 2 (identifier: Q9QUK0-2) [UniParc]FASTAAdd to basket

Also known as: KKIAMRE-gamma

The sequence of this isoform differs from the canonical sequence as follows:
     548-564: GAGSPLSDDSEADLPRM → MLPALEMTSSCTRALIP
     565-568: Missing.

Show »
Length:564
Mass (Da):63,641
Checksum:iDACDEF630CCE82D5
GO

Sequence cautioni

The sequence BAE43274.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti56 – 561K → Q in BAE43274 (PubMed:16141072).Curated
Sequence conflicti321 – 3222NR → KK in BAA88428 (PubMed:14605869).Curated
Sequence conflicti325 – 3295EKDDA → KKKKK in BAA88428 (PubMed:14605869).Curated
Sequence conflicti330 – 568239Missing in BAA88428 (PubMed:14605869).CuratedAdd
BLAST

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei548 – 56417GAGSP…DLPRM → MLPALEMTSSCTRALIP in isoform 2. 1 PublicationVSP_016146Add
BLAST
Alternative sequencei565 – 5684Missing in isoform 2. 1 PublicationVSP_016147

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029066 mRNA. Translation: BAA88428.1.
AB029067 mRNA. Translation: BAA88429.1.
AB029073 Genomic DNA. Translation: BAA88439.1.
AB029065 mRNA. Translation: BAA88427.1.
AK030598 mRNA. Translation: BAE43274.1. Different initiation.
AK144574 mRNA. Translation: BAE25943.1.
AK145688 mRNA. Translation: BAE26590.1.
CCDSiCCDS19425.1. [Q9QUK0-2]
CCDS19426.1. [Q9QUK0-1]
RefSeqiNP_001263244.1. NM_001276315.1. [Q9QUK0-2]
NP_058608.1. NM_016912.2. [Q9QUK0-1]
NP_796244.2. NM_177270.4. [Q9QUK0-2]
XP_011247839.1. XM_011249537.1. [Q9QUK0-1]
UniGeneiMm.44963.

Genome annotation databases

EnsembliENSMUST00000069937; ENSMUSP00000063617; ENSMUSG00000029403. [Q9QUK0-2]
ENSMUST00000086978; ENSMUSP00000084199; ENSMUSG00000029403. [Q9QUK0-1]
ENSMUST00000113140; ENSMUSP00000108765; ENSMUSG00000029403. [Q9QUK0-1]
ENSMUST00000113143; ENSMUSP00000108768; ENSMUSG00000029403. [Q9QUK0-2]
GeneIDi53886.
KEGGimmu:53886.
UCSCiuc008ycc.2. mouse. [Q9QUK0-1]
uc008ycd.2. mouse. [Q9QUK0-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029066 mRNA. Translation: BAA88428.1.
AB029067 mRNA. Translation: BAA88429.1.
AB029073 Genomic DNA. Translation: BAA88439.1.
AB029065 mRNA. Translation: BAA88427.1.
AK030598 mRNA. Translation: BAE43274.1. Different initiation.
AK144574 mRNA. Translation: BAE25943.1.
AK145688 mRNA. Translation: BAE26590.1.
CCDSiCCDS19425.1. [Q9QUK0-2]
CCDS19426.1. [Q9QUK0-1]
RefSeqiNP_001263244.1. NM_001276315.1. [Q9QUK0-2]
NP_058608.1. NM_016912.2. [Q9QUK0-1]
NP_796244.2. NM_177270.4. [Q9QUK0-2]
XP_011247839.1. XM_011249537.1. [Q9QUK0-1]
UniGeneiMm.44963.

3D structure databases

ProteinModelPortaliQ9QUK0.
SMRiQ9QUK0. Positions 1-310.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000084199.

PTM databases

PhosphoSiteiQ9QUK0.

Proteomic databases

PRIDEiQ9QUK0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000069937; ENSMUSP00000063617; ENSMUSG00000029403. [Q9QUK0-2]
ENSMUST00000086978; ENSMUSP00000084199; ENSMUSG00000029403. [Q9QUK0-1]
ENSMUST00000113140; ENSMUSP00000108765; ENSMUSG00000029403. [Q9QUK0-1]
ENSMUST00000113143; ENSMUSP00000108768; ENSMUSG00000029403. [Q9QUK0-2]
GeneIDi53886.
KEGGimmu:53886.
UCSCiuc008ycc.2. mouse. [Q9QUK0-1]
uc008ycd.2. mouse. [Q9QUK0-2]

Organism-specific databases

CTDi8999.
MGIiMGI:1858227. Cdkl2.

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000119242.
HOGENOMiHOG000233024.
HOVERGENiHBG080204.
InParanoidiQ9QUK0.
KOiK08824.
OMAiSTSLRDC.
OrthoDBiEOG7992PS.
PhylomeDBiQ9QUK0.
TreeFamiTF101031.

Miscellaneous databases

NextBioi310771.
PROiQ9QUK0.
SOURCEiSearch...

Gene expression databases

BgeeiQ9QUK0.
ExpressionAtlasiQ9QUK0. baseline and differential.
GenevisibleiQ9QUK0. MM.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Postnatal expression of Cdkl2 in mouse brain revealed by LacZ inserted into the Cdkl2 locus."
    Sassa T., Gomi H., Itohara S.
    Cell Tissue Res. 315:147-156(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
    Strain: 129/SvJ and C57BL/6.
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Lung and Pituitary.

Entry informationi

Entry nameiCDKL2_MOUSE
AccessioniPrimary (citable) accession number: Q9QUK0
Secondary accession number(s): Q3UL60
, Q3V3X7, Q9QYI1, Q9QYI2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: May 1, 2000
Last modified: July 22, 2015
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.