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Q9QUJ7

- ACSL4_MOUSE

UniProt

Q9QUJ7 - ACSL4_MOUSE

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Protein

Long-chain-fatty-acid--CoA ligase 4

Gene

Acsl4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates.

Catalytic activityi

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

Cofactori

Mg2+By similarity

GO - Molecular functioni

  1. arachidonate-CoA ligase activity Source: Ensembl
  2. ATP binding Source: UniProtKB-KW
  3. long-chain fatty acid-CoA ligase activity Source: MGI
  4. very long-chain fatty acid-CoA ligase activity Source: Ensembl

GO - Biological processi

  1. dendritic spine development Source: Ensembl
  2. embryonic process involved in female pregnancy Source: MGI
  3. fatty acid transport Source: Ensembl
  4. lipid biosynthetic process Source: Ensembl
  5. long-chain fatty acid metabolic process Source: GOC
  6. negative regulation of prostaglandin secretion Source: Ensembl
  7. neuron differentiation Source: MGI
  8. positive regulation of cell growth Source: Ensembl
  9. regulation of fatty acid metabolic process Source: MGI
  10. response to interleukin-15 Source: Ensembl
  11. response to nutrient Source: Ensembl
  12. triglyceride metabolic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

ATP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

BRENDAi6.2.1.3. 3474.
ReactomeiREACT_252780. Synthesis of very long-chain fatty acyl-CoAs.

Names & Taxonomyi

Protein namesi
Recommended name:
Long-chain-fatty-acid--CoA ligase 4 (EC:6.2.1.3)
Alternative name(s):
Long-chain acyl-CoA synthetase 4
Short name:
LACS 4
Short name:
mACS4
Gene namesi
Name:Acsl4
Synonyms:Acs4, Facl4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:1354713. Acsl4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei8 – 2821Helical; Signal-anchor for type III membrane proteinSequence AnalysisAdd
BLAST
Topological domaini29 – 711683CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. extracellular vesicular exosome Source: Ensembl
  3. integral component of membrane Source: UniProtKB-KW
  4. lipid particle Source: Ensembl
  5. mitochondrial outer membrane Source: UniProtKB-KW
  6. mitochondrion Source: MGI
  7. neuronal cell body Source: Ensembl
  8. peroxisome Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome, Mitochondrion, Mitochondrion outer membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 711711Long-chain-fatty-acid--CoA ligase 4PRO_0000193110Add
BLAST

Proteomic databases

MaxQBiQ9QUJ7.
PaxDbiQ9QUJ7.
PRIDEiQ9QUJ7.

PTM databases

PhosphoSiteiQ9QUJ7.

Expressioni

Tissue specificityi

Abundant in steroidogenic tissues, also found in the kidney, brain and liver.

Inductioni

Induced by adrenocorticotropic hormone (ACTH) and suppressed by glucocorticoid.

Gene expression databases

BgeeiQ9QUJ7.
CleanExiMM_ACSL4.
ExpressionAtlasiQ9QUJ7. baseline and differential.
GenevestigatoriQ9QUJ7.

Interactioni

Protein-protein interaction databases

BioGridi206122. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9QUJ7.
SMRiQ9QUJ7. Positions 122-598.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1022.
GeneTreeiENSGT00690000102168.
HOGENOMiHOG000159459.
HOVERGENiHBG106947.
InParanoidiQ9QUJ7.
KOiK01897.
OMAiNAMKLER.
OrthoDBiEOG7P2XRD.
TreeFamiTF314012.

Family and domain databases

InterProiIPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform Long (identifier: Q9QUJ7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNLKLNVLTI ILLPVHLLIT IYSALIFIPW YFLTNAKKKN AMAKRIKAKP
60 70 80 90 100
TSDKPGSPYR SVTHFDSLAV IDIPGADTLD KLFDHAVAKF GKKDSLGTRE
110 120 130 140 150
ILSEENEMQP NGKVFKKLIL GNYKWINYLE VNCRVNNFGS GLTALGLKPK
160 170 180 190 200
NTIAIFCETR AEWMIAAQTC FKYNFPLVTL YATLGREAVV HGLNESEASY
210 220 230 240 250
LITSVELLES KLKAALVDIN CVKHIIYVDN KTINRAEYPE GLEIHSMQSV
260 270 280 290 300
EELGAKPENL SVPPSRPTPS DMAIVMYTSG STGRPKGVMM HHSNLIAGMT
310 320 330 340 350
GQCERIPGLG PKDTYIGYLP LAHVLELTAE ISCFTYGCRI GYSSPLTLSD
360 370 380 390 400
QSSKIKKGSK GDCTVLKPTL MAAVPEIMDR IYKNVMSKVQ EMNYVQKTLF
410 420 430 440 450
KIGYDYKLEQ IKKGYDAPLC NLILFKKVKA LLGGNVRMML SGGAPLSPQT
460 470 480 490 500
HRFMNVCFCC PIGQGYGLTE SCGAGTVTEV TDYTTGRVGA PLICCEIKLK
510 520 530 540 550
DWQEGGYTVH DKPNPRGEIV IGGQNISMGY FKNEEKTAED YCVDENGQRW
560 570 580 590 600
FCTGDIGEFH PDGCLQIIDR KKDLVKLQAG EYVSLGKVEA ALKNCPLIDN
610 620 630 640 650
ICAFAKSDQS YVISFVVPNQ KKLTLLAQQK GVEGSWVDIC NNPAMEAEIL
660 670 680 690 700
KEIREAANAM KLERFEIPIK VRLSPEPWTP ETGLVTDAFK LKRKELKNHY
710
LKDIERMYGG K
Length:711
Mass (Da):79,077
Last modified:July 27, 2011 - v2
Checksum:i84ACA29CADDD6A3A
GO
Isoform Short (identifier: Q9QUJ7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-41: Missing.

Show »
Length:670
Mass (Da):74,339
Checksum:i017C3441FA031F48
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti288 – 2881V → L in BAA85929. (PubMed:10924347)Curated
Sequence conflicti288 – 2881V → L in BAA85930. (PubMed:10924347)Curated
Sequence conflicti288 – 2881V → L in BAA85931. (PubMed:10924347)Curated
Sequence conflicti293 – 2931S → T in BAA85929. (PubMed:10924347)Curated
Sequence conflicti293 – 2931S → T in BAA85930. (PubMed:10924347)Curated
Sequence conflicti293 – 2931S → T in BAA85931. (PubMed:10924347)Curated
Sequence conflicti430 – 4323ALL → DLV in BAA85929. (PubMed:10924347)Curated
Sequence conflicti430 – 4323ALL → DLV in BAA85930. (PubMed:10924347)Curated
Sequence conflicti430 – 4323ALL → DLV in BAA85931. (PubMed:10924347)Curated
Sequence conflicti441 – 4411S → Y in BAA85929. (PubMed:10924347)Curated
Sequence conflicti441 – 4411S → Y in BAA85930. (PubMed:10924347)Curated
Sequence conflicti441 – 4411S → Y in BAA85931. (PubMed:10924347)Curated
Sequence conflicti458 – 4581F → L in BAA85929. (PubMed:10924347)Curated
Sequence conflicti458 – 4581F → L in BAA85930. (PubMed:10924347)Curated
Sequence conflicti458 – 4581F → L in BAA85931. (PubMed:10924347)Curated
Sequence conflicti584 – 5841S → F in BAA85929. (PubMed:10924347)Curated
Sequence conflicti584 – 5841S → F in BAA85930. (PubMed:10924347)Curated
Sequence conflicti584 – 5841S → F in BAA85931. (PubMed:10924347)Curated
Sequence conflicti704 – 7041I → V in BAA85929. (PubMed:10924347)Curated
Sequence conflicti704 – 7041I → V in BAA85930. (PubMed:10924347)Curated
Sequence conflicti704 – 7041I → V in BAA85931. (PubMed:10924347)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4141Missing in isoform Short. 2 PublicationsVSP_000239Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033887 mRNA. Translation: BAA85931.1.
AB033886 mRNA. Translation: BAA85930.1.
AB033885 mRNA. Translation: BAA85929.1.
AJ243502 mRNA. Translation: CAB95965.1.
AL731672 Genomic DNA. Translation: CAM15883.1.
BC058663 mRNA. Translation: AAH58663.1.
CCDSiCCDS30448.1. [Q9QUJ7-1]
CCDS41156.1. [Q9QUJ7-2]
RefSeqiNP_001028772.1. NM_001033600.1. [Q9QUJ7-2]
NP_062350.3. NM_019477.3. [Q9QUJ7-2]
NP_997508.1. NM_207625.2. [Q9QUJ7-1]
XP_006528969.1. XM_006528906.1. [Q9QUJ7-2]
XP_006528970.1. XM_006528907.1. [Q9QUJ7-2]
UniGeneiMm.391337.

Genome annotation databases

EnsembliENSMUST00000033634; ENSMUSP00000033634; ENSMUSG00000031278. [Q9QUJ7-1]
ENSMUST00000112903; ENSMUSP00000108524; ENSMUSG00000031278. [Q9QUJ7-2]
ENSMUST00000112904; ENSMUSP00000108525; ENSMUSG00000031278. [Q9QUJ7-2]
ENSMUST00000112907; ENSMUSP00000108528; ENSMUSG00000031278. [Q9QUJ7-1]
GeneIDi50790.
KEGGimmu:50790.
UCSCiuc009ulu.1. mouse. [Q9QUJ7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033887 mRNA. Translation: BAA85931.1 .
AB033886 mRNA. Translation: BAA85930.1 .
AB033885 mRNA. Translation: BAA85929.1 .
AJ243502 mRNA. Translation: CAB95965.1 .
AL731672 Genomic DNA. Translation: CAM15883.1 .
BC058663 mRNA. Translation: AAH58663.1 .
CCDSi CCDS30448.1. [Q9QUJ7-1 ]
CCDS41156.1. [Q9QUJ7-2 ]
RefSeqi NP_001028772.1. NM_001033600.1. [Q9QUJ7-2 ]
NP_062350.3. NM_019477.3. [Q9QUJ7-2 ]
NP_997508.1. NM_207625.2. [Q9QUJ7-1 ]
XP_006528969.1. XM_006528906.1. [Q9QUJ7-2 ]
XP_006528970.1. XM_006528907.1. [Q9QUJ7-2 ]
UniGenei Mm.391337.

3D structure databases

ProteinModelPortali Q9QUJ7.
SMRi Q9QUJ7. Positions 122-598.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 206122. 2 interactions.

PTM databases

PhosphoSitei Q9QUJ7.

Proteomic databases

MaxQBi Q9QUJ7.
PaxDbi Q9QUJ7.
PRIDEi Q9QUJ7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000033634 ; ENSMUSP00000033634 ; ENSMUSG00000031278 . [Q9QUJ7-1 ]
ENSMUST00000112903 ; ENSMUSP00000108524 ; ENSMUSG00000031278 . [Q9QUJ7-2 ]
ENSMUST00000112904 ; ENSMUSP00000108525 ; ENSMUSG00000031278 . [Q9QUJ7-2 ]
ENSMUST00000112907 ; ENSMUSP00000108528 ; ENSMUSG00000031278 . [Q9QUJ7-1 ]
GeneIDi 50790.
KEGGi mmu:50790.
UCSCi uc009ulu.1. mouse. [Q9QUJ7-1 ]

Organism-specific databases

CTDi 2182.
MGIi MGI:1354713. Acsl4.

Phylogenomic databases

eggNOGi COG1022.
GeneTreei ENSGT00690000102168.
HOGENOMi HOG000159459.
HOVERGENi HBG106947.
InParanoidi Q9QUJ7.
KOi K01897.
OMAi NAMKLER.
OrthoDBi EOG7P2XRD.
TreeFami TF314012.

Enzyme and pathway databases

BRENDAi 6.2.1.3. 3474.
Reactomei REACT_252780. Synthesis of very long-chain fatty acyl-CoAs.

Miscellaneous databases

ChiTaRSi Acsl4. mouse.
NextBioi 307771.
PROi Q9QUJ7.
SOURCEi Search...

Gene expression databases

Bgeei Q9QUJ7.
CleanExi MM_ACSL4.
ExpressionAtlasi Q9QUJ7. baseline and differential.
Genevestigatori Q9QUJ7.

Family and domain databases

InterProi IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
[Graphical view ]
PROSITEi PS00455. AMP_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Regulation by adrenocorticotropic hormone and arachidonate of the expression of acyl-CoA synthetase 4, an arachidonate-preferring enzyme expressed in steroidogenic tissues."
    Cho Y.-Y., Kang M.-J., Ogawa S., Yamashita Y., Fujino T., Yamamoto T.T.
    Biochem. Biophys. Res. Commun. 274:741-745(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT).
  2. "Identification and characterization of mouse orthologs of the AMMECR1 and FACL4 genes deleted in AMME syndrome: orthology of Xq22.3 and MmuXF1-F3."
    Vitelli F., Meloni I., Fineschi S., Favara F., Tiziana Storlazzi C., Rocchi M., Renieri A.
    Cytogenet. Cell Genet. 88:259-263(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
    Tissue: Embryo.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG).
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiACSL4_MOUSE
AccessioniPrimary (citable) accession number: Q9QUJ7
Secondary accession number(s): Q5D071, Q9JHT4, Q9R0H3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: July 27, 2011
Last modified: November 26, 2014
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3