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Q9QUI6

- ACKR1_MOUSE

UniProt

Q9QUI6 - ACKR1_MOUSE

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Protein

Atypical chemokine receptor 1

Gene
Ackr1, Darc, Dfy, Fy
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1 and TARC. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels By similarity.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW

GO - Biological processi

  1. chemokine-mediated signaling pathway Source: InterPro
  2. inflammatory response Source: MGI
  3. regulation of chemokine production Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Atypical chemokine receptor 1
Alternative name(s):
Duffy antigen/chemokine receptor
CD_antigen: CD234
Gene namesi
Name:Ackr1
Synonyms:Darc, Dfy, Fy
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1097689. Ackr1.

Subcellular locationi

Early endosome By similarity. Recycling endosome By similarity. Membrane; Multi-pass membrane protein
Note: Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via caveolae. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6161Extracellular Reviewed predictionAdd
BLAST
Transmembranei62 – 8221Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini83 – 9311Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei94 – 11421Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini115 – 12713Extracellular Reviewed predictionAdd
BLAST
Transmembranei128 – 15124Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini152 – 16413Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei165 – 18521Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini186 – 20520Extracellular Reviewed predictionAdd
BLAST
Transmembranei206 – 22621Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini227 – 24216Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei243 – 26321Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini264 – 28522Extracellular Reviewed predictionAdd
BLAST
Transmembranei286 – 30621Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini307 – 33428Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. early endosome Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. recycling endosome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 334334Atypical chemokine receptor 1PRO_0000152587Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi16 – 161N-linked (GlcNAc...) Reviewed prediction
Glycosylationi26 – 261N-linked (GlcNAc...) Reviewed prediction
Glycosylationi32 – 321N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi49 ↔ 274 By similarity
Disulfide bondi127 ↔ 193 By similarity
Glycosylationi285 – 2851N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ9QUI6.

PTM databases

PhosphoSiteiQ9QUI6.

Expressioni

Tissue specificityi

Expressed in liver and brain.

Gene expression databases

BgeeiQ9QUI6.
CleanExiMM_DARC.
GenevestigatoriQ9QUI6.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045134.

Structurei

3D structure databases

ProteinModelPortaliQ9QUI6.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG28176.
GeneTreeiENSGT00390000006372.
HOVERGENiHBG051419.
InParanoidiQ9QUI6.
KOiK06574.
OrthoDBiEOG7RFTHW.
PhylomeDBiQ9QUI6.
TreeFamiTF105419.

Family and domain databases

InterProiIPR005384. Duffy_chemokine_rcpt.
[Graphical view]
PANTHERiPTHR14181. PTHR14181. 1 hit.
PRINTSiPR01559. DUFFYANTIGEN.

Sequencei

Sequence statusi: Complete.

Q9QUI6-1 [UniParc]FASTAAdd to Basket

« Hide

MGNCLYPVET LSLDKNGTQF TFDSWNYSFE DNYSYELSSD YSLTPAAPCY    50
SCNLLDRSSL PFFMLTSVLG MLASGSILFA ILRPFFHWQI CPSWPILAEL 100
AVGSALFSIA VPILAPGLHS AHSTALCNLG YWVWYTSAFA QALLIGCYAC 150
LNPRLNIGQL RGFTLGLSVG LWGAAALSGL PVALASDVYN GFCTFPSSRD 200
MEALKYTHYA ICFTIFTVLP LTLLAAKGLK IALSKGPGPW VSVLWIWFIF 250
WWPHGMVLIF DALVRSKTVL LYTCQSQKIL DAMLNVTEAL SMLHCVATPL 300
LLALFCHQTT RRSLSSLSLP TRQASQMDAL AGKS 334
Length:334
Mass (Da):36,694
Last modified:January 10, 2003 - v2
Checksum:i21AC4B6147D840C8
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti10 – 101T → N in strain: BLG2/Msf, C57BL/10SnJ, HMI/Msf, MSM/Msf, NJL/Msf and SWN/Msf.
Natural varianti56 – 561D → G in strain: BLG2/Msf, C57BL/10SnJ, HMI/Msf, MSM/Msf, NJL/Msf and SWN/Msf.
Natural varianti61 – 611P → L in strain: BLG2/Msf.
Natural varianti76 – 761S → G in strain: BLG2/Msf, C57BL/10SnJ, CAST/Ei, HMI/Msf, MSM/Msf, NJL/Msf and SWN/Msf.
Natural varianti178 – 1781S → L in strain: BLG2/Msf, C57BL/10SnJ, CAST/Ei, HMI/Msf, MSM/Msf, NJL/Msf, pgn2 and SWN/Msf.
Natural varianti188 – 1881V → A in strain: BLG2/Msf, C57BL/10SnJ, CAST/Ei, HMI/Msf, MSM/Msf, NJL/Msf and SWN/Msf.
Natural varianti194 – 1941T → A in strain: BLG2/Msf, C57BL/10SnJ, HMI/Msf, MSM/Msf, NJL/Msf and SWN/Msf.
Natural varianti207 – 2071T → M in strain: C57BL/10SnJ, HMI/Msf, MSM/Msf and SWN/Msf.
Natural varianti221 – 2211L → P in strain: BLG2/Msf, C57BL/10SnJ, HMI/Msf, MSM/Msf, NJL/Msf and SWN/Msf.
Natural varianti256 – 2561M → I in strain: NJL/Msf.
Natural varianti268 – 2681T → I in strain: BLG2/Msf, C57BL/10SnJ, HMI/Msf, MSM/Msf, NJL/Msf and SWN/Msf.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF016697 Genomic DNA. Translation: AAC53360.1.
AF016584 mRNA. Translation: AAC53354.1.
AF109159 mRNA. Translation: AAF14225.1.
U88431 Genomic DNA. Translation: AAF08328.1.
AB039074 Genomic DNA. Translation: BAB68598.1.
AB039075 Genomic DNA. Translation: BAB68599.1.
AB039076 Genomic DNA. Translation: BAB68600.1.
AB039077 Genomic DNA. Translation: BAB68601.1.
AB039078 Genomic DNA. Translation: BAB68602.1.
AB039079 Genomic DNA. Translation: BAB68603.1.
AB039080 Genomic DNA. Translation: BAB68604.1.
AB039081 Genomic DNA. Translation: BAB68605.1.
AB039082 Genomic DNA. Translation: BAB68606.1.
BC005583 mRNA. Translation: AAH05583.1.
CCDSiCCDS35789.1.
RefSeqiNP_034175.2. NM_010045.2.
UniGeneiMm.6393.

Genome annotation databases

EnsembliENSMUST00000038227; ENSMUSP00000045134; ENSMUSG00000037872.
GeneIDi13349.
KEGGimmu:13349.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF016697 Genomic DNA. Translation: AAC53360.1 .
AF016584 mRNA. Translation: AAC53354.1 .
AF109159 mRNA. Translation: AAF14225.1 .
U88431 Genomic DNA. Translation: AAF08328.1 .
AB039074 Genomic DNA. Translation: BAB68598.1 .
AB039075 Genomic DNA. Translation: BAB68599.1 .
AB039076 Genomic DNA. Translation: BAB68600.1 .
AB039077 Genomic DNA. Translation: BAB68601.1 .
AB039078 Genomic DNA. Translation: BAB68602.1 .
AB039079 Genomic DNA. Translation: BAB68603.1 .
AB039080 Genomic DNA. Translation: BAB68604.1 .
AB039081 Genomic DNA. Translation: BAB68605.1 .
AB039082 Genomic DNA. Translation: BAB68606.1 .
BC005583 mRNA. Translation: AAH05583.1 .
CCDSi CCDS35789.1.
RefSeqi NP_034175.2. NM_010045.2.
UniGenei Mm.6393.

3D structure databases

ProteinModelPortali Q9QUI6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000045134.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q9QUI6.

Proteomic databases

PRIDEi Q9QUI6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000038227 ; ENSMUSP00000045134 ; ENSMUSG00000037872 .
GeneIDi 13349.
KEGGi mmu:13349.

Organism-specific databases

CTDi 2532.
MGIi MGI:1097689. Ackr1.

Phylogenomic databases

eggNOGi NOG28176.
GeneTreei ENSGT00390000006372.
HOVERGENi HBG051419.
InParanoidi Q9QUI6.
KOi K06574.
OrthoDBi EOG7RFTHW.
PhylomeDBi Q9QUI6.
TreeFami TF105419.

Miscellaneous databases

NextBioi 283672.
PROi Q9QUI6.
SOURCEi Search...

Gene expression databases

Bgeei Q9QUI6.
CleanExi MM_DARC.
Genevestigatori Q9QUI6.

Family and domain databases

InterProi IPR005384. Duffy_chemokine_rcpt.
[Graphical view ]
PANTHERi PTHR14181. PTHR14181. 1 hit.
PRINTSi PR01559. DUFFYANTIGEN.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, characterization, and mapping of a murine promiscuous chemokine receptor gene: homolog of the human Duffy gene."
    Luo H., Chaudhuri A., Johnson K.R., Neote K., Zbrzezna V., He Y., Pogo A.O.
    Genome Res. 7:932-941(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  2. "Murine skeletal muscle duffy antigen/receptor for chemokine glycoprotein (DARC)."
    Tournamille C., Colin Y.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Skeletal muscle.
  3. "Molecular cloning and characterization of a mouse gene with homology to the Duffy-antigen receptor for chemokines."
    Tang T., Owen J.D., Du J., Walker C.L., Richmond A.
    DNA Seq. 9:129-143(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Conspicuous differences among gene genealogies of 21 nuclear genes of five Mus musculus subspecies."
    Liu Y., Kitano T., Koide T., Shiroishi T., Moriwaki K., Saitou N.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BFM/2Msf, BLG2/Msf, C57BL/10SnJ, CAST/Ei, HMI/Msf, MSM/Msf, NJL/Msf, Pgn2 and SWN/Msf.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiACKR1_MOUSE
AccessioniPrimary (citable) accession number: Q9QUI6
Secondary accession number(s): O35970
, Q91VB6, Q920X0, Q920X1, Q920X2, Q920X3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: January 10, 2003
Last modified: September 3, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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