Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9QUI6

- ACKR1_MOUSE

UniProt

Q9QUI6 - ACKR1_MOUSE

Protein

Atypical chemokine receptor 1

Gene

Ackr1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 2 (10 Jan 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1 and TARC. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels By similarity.By similarity

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW

    GO - Biological processi

    1. chemokine-mediated signaling pathway Source: InterPro
    2. inflammatory response Source: MGI
    3. regulation of chemokine production Source: MGI

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Atypical chemokine receptor 1
    Alternative name(s):
    Duffy antigen/chemokine receptor
    CD_antigen: CD234
    Gene namesi
    Name:Ackr1
    Synonyms:Darc, Dfy, Fy
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:1097689. Ackr1.

    Subcellular locationi

    Early endosome By similarity. Recycling endosome By similarity. Membrane; Multi-pass membrane protein
    Note: Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via caveolae. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane By similarity.By similarity

    GO - Cellular componenti

    1. early endosome Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. recycling endosome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endosome, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 334334Atypical chemokine receptor 1PRO_0000152587Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi16 – 161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi26 – 261N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi32 – 321N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi49 ↔ 274By similarity
    Disulfide bondi127 ↔ 193By similarity
    Glycosylationi285 – 2851N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ9QUI6.

    PTM databases

    PhosphoSiteiQ9QUI6.

    Expressioni

    Tissue specificityi

    Expressed in liver and brain.

    Gene expression databases

    BgeeiQ9QUI6.
    CleanExiMM_DARC.
    GenevestigatoriQ9QUI6.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000045134.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9QUI6.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 6161ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini83 – 9311CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini115 – 12713ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini152 – 16413CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini186 – 20520ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini227 – 24216CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini264 – 28522ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini307 – 33428CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei62 – 8221Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei94 – 11421Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei128 – 15124Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei165 – 18521Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei206 – 22621Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei243 – 26321Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei286 – 30621Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG28176.
    GeneTreeiENSGT00390000006372.
    HOVERGENiHBG051419.
    InParanoidiQ9QUI6.
    KOiK06574.
    OrthoDBiEOG7RFTHW.
    PhylomeDBiQ9QUI6.
    TreeFamiTF105419.

    Family and domain databases

    InterProiIPR005384. Duffy_chemokine_rcpt.
    [Graphical view]
    PANTHERiPTHR14181. PTHR14181. 1 hit.
    PRINTSiPR01559. DUFFYANTIGEN.

    Sequencei

    Sequence statusi: Complete.

    Q9QUI6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGNCLYPVET LSLDKNGTQF TFDSWNYSFE DNYSYELSSD YSLTPAAPCY    50
    SCNLLDRSSL PFFMLTSVLG MLASGSILFA ILRPFFHWQI CPSWPILAEL 100
    AVGSALFSIA VPILAPGLHS AHSTALCNLG YWVWYTSAFA QALLIGCYAC 150
    LNPRLNIGQL RGFTLGLSVG LWGAAALSGL PVALASDVYN GFCTFPSSRD 200
    MEALKYTHYA ICFTIFTVLP LTLLAAKGLK IALSKGPGPW VSVLWIWFIF 250
    WWPHGMVLIF DALVRSKTVL LYTCQSQKIL DAMLNVTEAL SMLHCVATPL 300
    LLALFCHQTT RRSLSSLSLP TRQASQMDAL AGKS 334
    Length:334
    Mass (Da):36,694
    Last modified:January 10, 2003 - v2
    Checksum:i21AC4B6147D840C8
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti10 – 101T → N in strain: BLG2/Msf, C57BL/10SnJ, HMI/Msf, MSM/Msf, NJL/Msf and SWN/Msf.
    Natural varianti56 – 561D → G in strain: BLG2/Msf, C57BL/10SnJ, HMI/Msf, MSM/Msf, NJL/Msf and SWN/Msf.
    Natural varianti61 – 611P → L in strain: BLG2/Msf.
    Natural varianti76 – 761S → G in strain: BLG2/Msf, C57BL/10SnJ, CAST/Ei, HMI/Msf, MSM/Msf, NJL/Msf and SWN/Msf.
    Natural varianti178 – 1781S → L in strain: BLG2/Msf, C57BL/10SnJ, CAST/Ei, HMI/Msf, MSM/Msf, NJL/Msf, pgn2 and SWN/Msf.
    Natural varianti188 – 1881V → A in strain: BLG2/Msf, C57BL/10SnJ, CAST/Ei, HMI/Msf, MSM/Msf, NJL/Msf and SWN/Msf.
    Natural varianti194 – 1941T → A in strain: BLG2/Msf, C57BL/10SnJ, HMI/Msf, MSM/Msf, NJL/Msf and SWN/Msf.
    Natural varianti207 – 2071T → M in strain: C57BL/10SnJ, HMI/Msf, MSM/Msf and SWN/Msf.
    Natural varianti221 – 2211L → P in strain: BLG2/Msf, C57BL/10SnJ, HMI/Msf, MSM/Msf, NJL/Msf and SWN/Msf.
    Natural varianti256 – 2561M → I in strain: NJL/Msf.
    Natural varianti268 – 2681T → I in strain: BLG2/Msf, C57BL/10SnJ, HMI/Msf, MSM/Msf, NJL/Msf and SWN/Msf.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF016697 Genomic DNA. Translation: AAC53360.1.
    AF016584 mRNA. Translation: AAC53354.1.
    AF109159 mRNA. Translation: AAF14225.1.
    U88431 Genomic DNA. Translation: AAF08328.1.
    AB039074 Genomic DNA. Translation: BAB68598.1.
    AB039075 Genomic DNA. Translation: BAB68599.1.
    AB039076 Genomic DNA. Translation: BAB68600.1.
    AB039077 Genomic DNA. Translation: BAB68601.1.
    AB039078 Genomic DNA. Translation: BAB68602.1.
    AB039079 Genomic DNA. Translation: BAB68603.1.
    AB039080 Genomic DNA. Translation: BAB68604.1.
    AB039081 Genomic DNA. Translation: BAB68605.1.
    AB039082 Genomic DNA. Translation: BAB68606.1.
    BC005583 mRNA. Translation: AAH05583.1.
    CCDSiCCDS35789.1.
    RefSeqiNP_034175.2. NM_010045.2.
    UniGeneiMm.6393.

    Genome annotation databases

    EnsembliENSMUST00000038227; ENSMUSP00000045134; ENSMUSG00000037872.
    GeneIDi13349.
    KEGGimmu:13349.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF016697 Genomic DNA. Translation: AAC53360.1 .
    AF016584 mRNA. Translation: AAC53354.1 .
    AF109159 mRNA. Translation: AAF14225.1 .
    U88431 Genomic DNA. Translation: AAF08328.1 .
    AB039074 Genomic DNA. Translation: BAB68598.1 .
    AB039075 Genomic DNA. Translation: BAB68599.1 .
    AB039076 Genomic DNA. Translation: BAB68600.1 .
    AB039077 Genomic DNA. Translation: BAB68601.1 .
    AB039078 Genomic DNA. Translation: BAB68602.1 .
    AB039079 Genomic DNA. Translation: BAB68603.1 .
    AB039080 Genomic DNA. Translation: BAB68604.1 .
    AB039081 Genomic DNA. Translation: BAB68605.1 .
    AB039082 Genomic DNA. Translation: BAB68606.1 .
    BC005583 mRNA. Translation: AAH05583.1 .
    CCDSi CCDS35789.1.
    RefSeqi NP_034175.2. NM_010045.2.
    UniGenei Mm.6393.

    3D structure databases

    ProteinModelPortali Q9QUI6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000045134.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q9QUI6.

    Proteomic databases

    PRIDEi Q9QUI6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000038227 ; ENSMUSP00000045134 ; ENSMUSG00000037872 .
    GeneIDi 13349.
    KEGGi mmu:13349.

    Organism-specific databases

    CTDi 2532.
    MGIi MGI:1097689. Ackr1.

    Phylogenomic databases

    eggNOGi NOG28176.
    GeneTreei ENSGT00390000006372.
    HOVERGENi HBG051419.
    InParanoidi Q9QUI6.
    KOi K06574.
    OrthoDBi EOG7RFTHW.
    PhylomeDBi Q9QUI6.
    TreeFami TF105419.

    Miscellaneous databases

    NextBioi 283672.
    PROi Q9QUI6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9QUI6.
    CleanExi MM_DARC.
    Genevestigatori Q9QUI6.

    Family and domain databases

    InterProi IPR005384. Duffy_chemokine_rcpt.
    [Graphical view ]
    PANTHERi PTHR14181. PTHR14181. 1 hit.
    PRINTSi PR01559. DUFFYANTIGEN.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, characterization, and mapping of a murine promiscuous chemokine receptor gene: homolog of the human Duffy gene."
      Luo H., Chaudhuri A., Johnson K.R., Neote K., Zbrzezna V., He Y., Pogo A.O.
      Genome Res. 7:932-941(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    2. "Murine skeletal muscle duffy antigen/receptor for chemokine glycoprotein (DARC)."
      Tournamille C., Colin Y.
      Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Skeletal muscle.
    3. "Molecular cloning and characterization of a mouse gene with homology to the Duffy-antigen receptor for chemokines."
      Tang T., Owen J.D., Du J., Walker C.L., Richmond A.
      DNA Seq. 9:129-143(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Conspicuous differences among gene genealogies of 21 nuclear genes of five Mus musculus subspecies."
      Liu Y., Kitano T., Koide T., Shiroishi T., Moriwaki K., Saitou N.
      Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BFM/2Msf, BLG2/Msf, C57BL/10SnJ, CAST/Ei, HMI/Msf, MSM/Msf, NJL/Msf, Pgn2 and SWN/Msf.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiACKR1_MOUSE
    AccessioniPrimary (citable) accession number: Q9QUI6
    Secondary accession number(s): O35970
    , Q91VB6, Q920X0, Q920X1, Q920X2, Q920X3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2003
    Last sequence update: January 10, 2003
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3