Duffy antigen/chemokine receptor - Mus musculus (Mouse)

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Q9QUI6 (DUFFY_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 91. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Duffy antigen/chemokine receptor

Alternative name(s):
CD_antigen=CD234

Gene names

Name:	Darc
Synonyms:	Dfy, Fy

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	334 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Non-specific receptor for many chemokines By similarity.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in liver and brain.
Sequence similarities	Belongs to the G-protein coupled receptor Duffy family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	chemokine-mediated signaling pathway Inferred from electronic annotation. Source: GOC inflammatory response Inferred from mutant phenotype PubMed 10961863. Source: MGI regulation of chemokine production Inferred from mutant phenotype PubMed 20643340. Source: MGI
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	chemokine receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 334

334

Duffy antigen/chemokine receptor

PRO_0000152587

Regions

Topological domain

1 – 61

Extracellular Potential

Transmembrane

62 – 82

Helical; Name=1; Potential

Topological domain

83 – 93

Cytoplasmic Potential

Transmembrane

94 – 114

Helical; Name=2; Potential

Topological domain

115 – 127

Extracellular Potential

Transmembrane

128 – 151

Helical; Name=3; Potential

Topological domain

152 – 164

Cytoplasmic Potential

Transmembrane

165 – 185

Helical; Name=4; Potential

Topological domain

186 – 205

Extracellular Potential

Transmembrane

206 – 226

Helical; Name=5; Potential

Topological domain

227 – 242

Cytoplasmic Potential

Transmembrane

243 – 263

Helical; Name=6; Potential

Topological domain

264 – 285

Extracellular Potential

Transmembrane

286 – 306

Helical; Name=7; Potential

Topological domain

307 – 334

Cytoplasmic Potential

Amino acid modifications

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

285

N-linked (GlcNAc...) Potential

Disulfide bond

49 ↔ 274

By similarity

Disulfide bond

127 ↔ 193

By similarity

Natural variations

Natural variant

T → N in strain: BLG2/Msf, C57BL/10SnJ, HMI/Msf, MSM/Msf, NJL/Msf and SWN/Msf.

Natural variant

D → G in strain: BLG2/Msf, C57BL/10SnJ, HMI/Msf, MSM/Msf, NJL/Msf and SWN/Msf.

Natural variant

P → L in strain: BLG2/Msf.

Natural variant

S → G in strain: BLG2/Msf, C57BL/10SnJ, CAST/Ei, HMI/Msf, MSM/Msf, NJL/Msf and SWN/Msf.

Natural variant

178

S → L in strain: BLG2/Msf, C57BL/10SnJ, CAST/Ei, HMI/Msf, MSM/Msf, NJL/Msf, pgn2 and SWN/Msf.

Natural variant

188

V → A in strain: BLG2/Msf, C57BL/10SnJ, CAST/Ei, HMI/Msf, MSM/Msf, NJL/Msf and SWN/Msf.

Natural variant

194

T → A in strain: BLG2/Msf, C57BL/10SnJ, HMI/Msf, MSM/Msf, NJL/Msf and SWN/Msf.

Natural variant

207

T → M in strain: C57BL/10SnJ, HMI/Msf, MSM/Msf and SWN/Msf.

Natural variant

221

L → P in strain: BLG2/Msf, C57BL/10SnJ, HMI/Msf, MSM/Msf, NJL/Msf and SWN/Msf.

Natural variant

256

M → I in strain: NJL/Msf.

Natural variant

268

T → I in strain: BLG2/Msf, C57BL/10SnJ, HMI/Msf, MSM/Msf, NJL/Msf and SWN/Msf.

Sequences

Sequence

Length

Mass (Da)

Tools

Q9QUI6 [UniParc].

Last modified January 10, 2003. Version 2.
Checksum: 21AC4B6147D840C8
Show »

FASTA

334

36,694

        10         20         30         40         50         60 
MGNCLYPVET LSLDKNGTQF TFDSWNYSFE DNYSYELSSD YSLTPAAPCY SCNLLDRSSL 

        70         80         90        100        110        120 
PFFMLTSVLG MLASGSILFA ILRPFFHWQI CPSWPILAEL AVGSALFSIA VPILAPGLHS 

       130        140        150        160        170        180 
AHSTALCNLG YWVWYTSAFA QALLIGCYAC LNPRLNIGQL RGFTLGLSVG LWGAAALSGL 

       190        200        210        220        230        240 
PVALASDVYN GFCTFPSSRD MEALKYTHYA ICFTIFTVLP LTLLAAKGLK IALSKGPGPW 

       250        260        270        280        290        300 
VSVLWIWFIF WWPHGMVLIF DALVRSKTVL LYTCQSQKIL DAMLNVTEAL SMLHCVATPL 

       310        320        330 
LLALFCHQTT RRSLSSLSLP TRQASQMDAL AGKS

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning, characterization, and mapping of a murine promiscuous chemokine receptor gene: homolog of the human Duffy gene." Luo H., Chaudhuri A., Johnson K.R., Neote K., Zbrzezna V., He Y., Pogo A.O. Genome Res. 7:932-941(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]	"Murine skeletal muscle duffy antigen/receptor for chemokine glycoprotein (DARC)." Tournamille C., Colin Y. Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Skeletal muscle.
[3]	"Molecular cloning and characterization of a mouse gene with homology to the Duffy-antigen receptor for chemokines." Tang T., Owen J.D., Du J., Walker C.L., Richmond A. DNA Seq. 9:129-143(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Conspicuous differences among gene genealogies of 21 nuclear genes of five Mus musculus subspecies." Liu Y., Kitano T., Koide T., Shiroishi T., Moriwaki K., Saitou N. Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: BFM/2Msf, BLG2/Msf, C57BL/10SnJ, CAST/Ei, HMI/Msf, MSM/Msf, NJL/Msf, Pgn2 and SWN/Msf.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF016697 Genomic DNA. Translation: AAC53360.1. AF016584 mRNA. Translation: AAC53354.1. AF109159 mRNA. Translation: AAF14225.1. U88431 Genomic DNA. Translation: AAF08328.1. AB039074 Genomic DNA. Translation: BAB68598.1. AB039075 Genomic DNA. Translation: BAB68599.1. AB039076 Genomic DNA. Translation: BAB68600.1. AB039077 Genomic DNA. Translation: BAB68601.1. AB039078 Genomic DNA. Translation: BAB68602.1. AB039079 Genomic DNA. Translation: BAB68603.1. AB039080 Genomic DNA. Translation: BAB68604.1. AB039081 Genomic DNA. Translation: BAB68605.1. AB039082 Genomic DNA. Translation: BAB68606.1. BC005583 mRNA. Translation: AAH05583.1.
IPI	IPI00177281.
RefSeq	NP_034175.2. NM_010045.2.
UniGene	Mm.6393.
3D structure databases
ProteinModelPortal	Q9QUI6.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000045134.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q9QUI6.
Proteomic databases
PRIDE	Q9QUI6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000038227; ENSMUSP00000045134; ENSMUSG00000037872.
GeneID	13349.
KEGG	mmu:13349.
Organism-specific databases
CTD	2532.
MGI	MGI:1097689. Darc.
Phylogenomic databases
eggNOG	NOG28176.
GeneTree	ENSGT00390000006372.
HOVERGEN	HBG051419.
InParanoid	Q9QUI6.
KO	K06574.
OrthoDB	EOG4N30PF.
Gene expression databases
Bgee	Q9QUI6.
CleanEx	MM_DARC.
Genevestigator	Q9QUI6.
GermOnline	ENSMUSG00000037872. Mus musculus.
Family and domain databases
InterPro	IPR005384. Duffy_chemokine_rcpt. [Graphical view]
PANTHER	PTHR14181. PTHR14181. 1 hit.
PRINTS	PR01559. DUFFYANTIGEN.
ProtoNet	Search...
Other
NextBio	283672.
SOURCE	Search...

Entry information

Entry name

DUFFY_MOUSE

Accession

Primary (citable) accession number: Q9QUI6
Secondary accession number(s): O35970

Q920X3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2003
Last sequence update:	January 10, 2003
Last modified:	May 1, 2013
This is version 91 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents