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Protein

Atypical chemokine receptor 1

Gene

Ackr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1 and TARC. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • chemokine-mediated signaling pathway Source: InterPro
  • inflammatory response Source: MGI
  • regulation of chemokine production Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Atypical chemokine receptor 1
Alternative name(s):
Duffy antigen/chemokine receptor
CD_antigen: CD234
Gene namesi
Name:Ackr1
Synonyms:Darc, Dfy, Fy
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1097689. Ackr1.

Subcellular locationi

  • Early endosome By similarity
  • Recycling endosome By similarity
  • Membrane; Multi-pass membrane protein

  • Note: Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via caveolae. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane (By similarity).By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 61ExtracellularSequence analysisAdd BLAST61
Transmembranei62 – 82Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini83 – 93CytoplasmicSequence analysisAdd BLAST11
Transmembranei94 – 114Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini115 – 127ExtracellularSequence analysisAdd BLAST13
Transmembranei128 – 151Helical; Name=3Sequence analysisAdd BLAST24
Topological domaini152 – 164CytoplasmicSequence analysisAdd BLAST13
Transmembranei165 – 185Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini186 – 205ExtracellularSequence analysisAdd BLAST20
Transmembranei206 – 226Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini227 – 242CytoplasmicSequence analysisAdd BLAST16
Transmembranei243 – 263Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini264 – 285ExtracellularSequence analysisAdd BLAST22
Transmembranei286 – 306Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini307 – 334CytoplasmicSequence analysisAdd BLAST28

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001525871 – 334Atypical chemokine receptor 1Add BLAST334

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi16N-linked (GlcNAc...)Sequence analysis1
Glycosylationi26N-linked (GlcNAc...)Sequence analysis1
Glycosylationi32N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi49 ↔ 274By similarity
Disulfide bondi127 ↔ 193By similarity
Glycosylationi285N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9QUI6.
PRIDEiQ9QUI6.

PTM databases

iPTMnetiQ9QUI6.
PhosphoSitePlusiQ9QUI6.

Expressioni

Tissue specificityi

Expressed in liver and brain.

Gene expression databases

BgeeiENSMUSG00000037872.
CleanExiMM_DARC.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045134.

Structurei

3D structure databases

ProteinModelPortaliQ9QUI6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHK3. Eukaryota.
ENOG41119V5. LUCA.
HOVERGENiHBG051419.
InParanoidiQ9QUI6.
KOiK06574.
PhylomeDBiQ9QUI6.
TreeFamiTF105419.

Family and domain databases

InterProiIPR005384. Duffy_chemokine_rcpt.
[Graphical view]
PANTHERiPTHR14181. PTHR14181. 1 hit.
PRINTSiPR01559. DUFFYANTIGEN.

Sequencei

Sequence statusi: Complete.

Q9QUI6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNCLYPVET LSLDKNGTQF TFDSWNYSFE DNYSYELSSD YSLTPAAPCY
60 70 80 90 100
SCNLLDRSSL PFFMLTSVLG MLASGSILFA ILRPFFHWQI CPSWPILAEL
110 120 130 140 150
AVGSALFSIA VPILAPGLHS AHSTALCNLG YWVWYTSAFA QALLIGCYAC
160 170 180 190 200
LNPRLNIGQL RGFTLGLSVG LWGAAALSGL PVALASDVYN GFCTFPSSRD
210 220 230 240 250
MEALKYTHYA ICFTIFTVLP LTLLAAKGLK IALSKGPGPW VSVLWIWFIF
260 270 280 290 300
WWPHGMVLIF DALVRSKTVL LYTCQSQKIL DAMLNVTEAL SMLHCVATPL
310 320 330
LLALFCHQTT RRSLSSLSLP TRQASQMDAL AGKS
Length:334
Mass (Da):36,694
Last modified:January 10, 2003 - v2
Checksum:i21AC4B6147D840C8
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti10T → N in strain: BLG2/Msf, C57BL/10SnJ, HMI/Msf, MSM/Msf, NJL/Msf and SWN/Msf. 1
Natural varianti56D → G in strain: BLG2/Msf, C57BL/10SnJ, HMI/Msf, MSM/Msf, NJL/Msf and SWN/Msf. 1
Natural varianti61P → L in strain: BLG2/Msf. 1
Natural varianti76S → G in strain: BLG2/Msf, C57BL/10SnJ, CAST/Ei, HMI/Msf, MSM/Msf, NJL/Msf and SWN/Msf. 1
Natural varianti178S → L in strain: BLG2/Msf, C57BL/10SnJ, CAST/Ei, HMI/Msf, MSM/Msf, NJL/Msf, pgn2 and SWN/Msf. 1
Natural varianti188V → A in strain: BLG2/Msf, C57BL/10SnJ, CAST/Ei, HMI/Msf, MSM/Msf, NJL/Msf and SWN/Msf. 1
Natural varianti194T → A in strain: BLG2/Msf, C57BL/10SnJ, HMI/Msf, MSM/Msf, NJL/Msf and SWN/Msf. 1
Natural varianti207T → M in strain: C57BL/10SnJ, HMI/Msf, MSM/Msf and SWN/Msf. 1
Natural varianti221L → P in strain: BLG2/Msf, C57BL/10SnJ, HMI/Msf, MSM/Msf, NJL/Msf and SWN/Msf. 1
Natural varianti256M → I in strain: NJL/Msf. 1
Natural varianti268T → I in strain: BLG2/Msf, C57BL/10SnJ, HMI/Msf, MSM/Msf, NJL/Msf and SWN/Msf. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016697 Genomic DNA. Translation: AAC53360.1.
AF016584 mRNA. Translation: AAC53354.1.
AF109159 mRNA. Translation: AAF14225.1.
U88431 Genomic DNA. Translation: AAF08328.1.
AB039074 Genomic DNA. Translation: BAB68598.1.
AB039075 Genomic DNA. Translation: BAB68599.1.
AB039076 Genomic DNA. Translation: BAB68600.1.
AB039077 Genomic DNA. Translation: BAB68601.1.
AB039078 Genomic DNA. Translation: BAB68602.1.
AB039079 Genomic DNA. Translation: BAB68603.1.
AB039080 Genomic DNA. Translation: BAB68604.1.
AB039081 Genomic DNA. Translation: BAB68605.1.
AB039082 Genomic DNA. Translation: BAB68606.1.
BC005583 mRNA. Translation: AAH05583.1.
CCDSiCCDS35789.1.
RefSeqiNP_034175.2. NM_010045.2.
UniGeneiMm.6393.

Genome annotation databases

GeneIDi13349.
KEGGimmu:13349.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016697 Genomic DNA. Translation: AAC53360.1.
AF016584 mRNA. Translation: AAC53354.1.
AF109159 mRNA. Translation: AAF14225.1.
U88431 Genomic DNA. Translation: AAF08328.1.
AB039074 Genomic DNA. Translation: BAB68598.1.
AB039075 Genomic DNA. Translation: BAB68599.1.
AB039076 Genomic DNA. Translation: BAB68600.1.
AB039077 Genomic DNA. Translation: BAB68601.1.
AB039078 Genomic DNA. Translation: BAB68602.1.
AB039079 Genomic DNA. Translation: BAB68603.1.
AB039080 Genomic DNA. Translation: BAB68604.1.
AB039081 Genomic DNA. Translation: BAB68605.1.
AB039082 Genomic DNA. Translation: BAB68606.1.
BC005583 mRNA. Translation: AAH05583.1.
CCDSiCCDS35789.1.
RefSeqiNP_034175.2. NM_010045.2.
UniGeneiMm.6393.

3D structure databases

ProteinModelPortaliQ9QUI6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045134.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9QUI6.
PhosphoSitePlusiQ9QUI6.

Proteomic databases

PaxDbiQ9QUI6.
PRIDEiQ9QUI6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi13349.
KEGGimmu:13349.

Organism-specific databases

CTDi2532.
MGIiMGI:1097689. Ackr1.

Phylogenomic databases

eggNOGiENOG410IHK3. Eukaryota.
ENOG41119V5. LUCA.
HOVERGENiHBG051419.
InParanoidiQ9QUI6.
KOiK06574.
PhylomeDBiQ9QUI6.
TreeFamiTF105419.

Miscellaneous databases

PROiQ9QUI6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037872.
CleanExiMM_DARC.

Family and domain databases

InterProiIPR005384. Duffy_chemokine_rcpt.
[Graphical view]
PANTHERiPTHR14181. PTHR14181. 1 hit.
PRINTSiPR01559. DUFFYANTIGEN.
ProtoNetiSearch...

Entry informationi

Entry nameiACKR1_MOUSE
AccessioniPrimary (citable) accession number: Q9QUI6
Secondary accession number(s): O35970
, Q91VB6, Q920X0, Q920X1, Q920X2, Q920X3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: January 10, 2003
Last modified: November 2, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.